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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Study on the structural, electrical and optical properties of M-doped ZnO films prepared by chemical spray deposition 显示文摘 | Benny Joseph Manoj P K Vaidyan V K | 2006 | Ceramics International2006，32，5： | 1 |
| 3 | IgA nephropathy 显示文摘 | James V Joseph P | 2002 | N Engl J Med2002，347，10： | 1 |
| 4 | Electrochemical deposition of Cu2O on stainless steel substrates:Promotion and suppression of oriented crystallization显示文摘 | JOSEPH S KAMATH P V | 2008 | Solid State Sci2008，10，： | 1 |
| 5 | Effect of Internal Clearance on Load Distribution and Life of Radially Loaded Ball and Roller Bearings 显示文摘 | Fred B O Erwin V Z Joseph V P | 2012 | Tribology Trans- actions2012，55，2： | 1 |
| 6 | Reality distor- tion is related to the structure of the salience network in schizo- phrenia 显示文摘 | Palaniyappan L Mallikarjun P Joseph V | 2011 | Psyehol Med2011，41，8： | 1 |
| 7 | Recent advance in techniques for hyperspectral image processing显示文摘 | Antonio P Jon A B Joseph W B Jason B Lorenzo B Gustavo C V Jocelyn C Mathieu F Paolo G Anthony G Mattia M James C T Giovanna T | 2009 | Remote Sensing of Environment2009，113，： | 1 |
| 8 | Dynamic mechanical properties of short sisal fiber reinforced polypropylene composites显示文摘 | Joseph P V Mathew G Joseph K | 2003 | Composites (part A) : Applied Science and Manufacturing2003，34，3： | 1 |
| 9 | Appreciating symptoms and deficits in schizophrenia: right posterior insula and poor insight 显示文摘 | Palaniyappan L Mallikarjun P Joseph V | 2011 | Prog Neuropsychopharmacol Biol Psychia- try2011，35，2： | 1 |
| 10 | IgA nephropathy显示文摘 | James V Danadio Joseph P | 2002 | N Engl J Med2002，347，10： | 1 |
| 11 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 12 | Role of immune cells and inflammatory cytokines in regulation of fibrosis around silicone expander implants显示文摘 | JOSEPH J MOHANTY M MOHANAN P V | 2010 | J Mater Sci Mater Med2010，21，5： | 1 |
| 13 | Ocean-atmosphere coupling over monsoon region显示文摘 | Gadgil S Joseph P V Joshi N V | 1984 | Nature1984，312，： | 1 |
| 14 | 显示文摘 | Joseph P V Mathew G Joseph K | 2003 | Journal of Applied Polymer Science2003，88，： | 1 |
| 15 | 'Andhi',The convective dust storms of North west India显示文摘 | Raipal D K Deka S N | 1980 | Mausam1980，31，： | 1 |
| 16 | Cyanate esters based on cardanol modified-phenol-formaldehyde resins:Syntheses and thermal characteristics显示文摘 | Nair C P R Bindu R L Joseph V C | 1995 | J Polym Sci Part A:Polym Chem1995，33，： | 1 |
| 17 | The thermal and crystallization studies of short sisal fibre reinforced polyprepylene composites 显示文摘 | Joseph P V Joseph K Thomas S | 2003 | Composites Part A: Applied Science and Manufacturing2003，34，： | 1 |
| 18 | Inhibition of protein kinases AKT and ERK1/2 reduce the carotid body chemoreceptor response to hypoxia in adult rats显示文摘 | Iturri P Joseph V Rodrigo G | 2015 | Adv Exp Med Biol2015，860，： | 1 |
| 19 | IgA nephropathy显示文摘 | Danadio James V Joseph P | 2002 | N Engl J Med2002，347，10： | 1 |
| 20 | Mechanical Properties of Short Sisal Fibre-Reinforced Polypropylene Composites:Comparison of Experimental Data with Theoretical Prediction显示文摘 | Mathew G Joseph K | 2003 | Journal of Applied Polymer Science2003，88，： | 1 |
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