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| 1 | Getting to the bottom of Taxol biosynthesis by fungi显示文摘t Taxol(paclitaxel)is a highly-oxygenated diterpenoid natural product first isolated from the pacific yew tree(Taxus brevifolia).It is one of the most widely used anticancer drugs.Soon after the discovery of its unique mode of action and the resulting high demand,an extensive search was initiated for alternative sources to replace the slow-growing and scarce pacific yew.Thus far,however,Taxol and related compounds have only been found in the genus Taxus,which comprises a small number of slow-growing plants with a broad but generally isolated geographical distribution.In 1993,Stierle and colleagues reported the independent biosynthesis of Taxol in an endophytic fungus isolated from Taxus brevifolia,which resulted in more than 160 subsequent publications and patents addressing the biosynthesis of Taxol and related taxanes by microorganisms.The literature on fungal taxane synthesis contains numerous inconsistencies,prompting us to thoroughly re-examine Taxol biosynthesis in endophytic fungi associated with Taxus spp.Using a combination of phytochemistry,molecular biology and genome sequencing,we were unable to find any evidence for independent taxane biosynthesis in any of the endophytes,including the isolate described in the original publication(Taxomyces andreanae)and several more recent isolates from Taxus trees.Our findings therefore resolve a long-standing mystery concerning the evolution of a complex terpenoid biosynthetic pathway in two distantly-related organisms. | Uwe Heinig Susanne Scholz Stefan Jennewein | 2013 | Fungal Diversity2013，，3： | 3 |
| 2 | Toward a consistent design of structural concrete 显示文摘 | Schlaich J Schafer K Jennewein M | 1987 | Journal of the Prestressed Concrete Institute1987，32，3： | 1 |
| 3 | Quantum teleportation across the Danube: A real-world experiment marks a step towards worldwide quantum communication显示文摘 | Ursin R Jennewein T Aspelmeyer M | 2004 | Nature2004，，： | 1 |
| 4 | Quantum cryptography with entangled photons 显示文摘 | Jennewein T Simon C Weihs G | 2000 | Phys Rev Lett2000，84，20： | 1 |
| 5 | Space-QUEST Experiments with quantum entanglement in space 显示文摘 | Ursin R Jennewein T Kofler J | 2009 | Europhysics News (S0531-7479)2009，40，3： | 1 |
| 6 | Nature显示文摘 | Zeilinger A Weihs G Jennewein T | 2005 | 433: 230-2382005，433，： | 1 |
| 7 | Long-distance quantum communication with entangled photons using satellites 显示文摘 | Aspelmeyer M Jennewein T Pfennigbauer M | 2003 | IEEE Journal of Selected Topics in Quantum Electronics2003，9，6： | 1 |
| 8 | Identification of a novel pro-apoptotic role of NF-kappaB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells显示文摘 | Jennewein C Karl S Baumann B | 2012 | Oncogene2012，31，11： | 1 |
| 9 | Toward a consist- ent design of structural concrete 显示文摘 | Schlaich J Schafer K Jennewein M | 1987 | Journal of the Prestressed Concrete Institute1987，32，3： | 1 |
| 10 | Experimental verification of the feasibility of a quantum channel between space and earth 显示文摘 | Villoresi P Jennewein T Tamburini F | 2008 | New Journal of Physics2008，10，03： | 1 |
| 11 | Quantum cryptography with entangled photons 显示文摘 | Jennewein T Simon C Weihs G | 2000 | Phys Rev Lett2000，84，20： | 1 |
| 12 | MicroRNA- 27b contributes to lipopolysaccharide-mediated peroxisome pro- lfferator-activated receptor gamma (PPARgamma)mRNA desta- bilization 显示文摘 | Jennewein C Von Knethen A Schmid T Brune B | 2010 | J Biol Chem2010，285，11： | 1 |
| 13 | Novel aspects of fibrin (ogen) fragments daring inflammation 显示文摘 | Jennewein C Tran N Paulus P | 2011 | Mol Med2011，17，56： | 1 |
| 14 | Taxol:biosynthesis,moleculargenetics,and biotechnological applications显示文摘 | Jennewein S Croteau R | 2001 | Appl Microbiol Biotechnol2001，57，： | 1 |
| 15 | High level IL-12production by murine dendritic cells:upregulation via MHC class Ⅱ and CD40 molecules and downregulation by IL-4 and IL-10显示文摘 | Koch F Stanzl U Jennewein P | 1996 | J Exp Med1996，184，： | 1 |
| 16 | Bioengineered 2'-fucosyllactose and 3-fucosyllactose inhibit the adhesion of Pseudomonas aeruginosa and enteric pathogens to human intestinal and respiratory cell lines 显示文摘 | Weichert S Jennewein S Hufner E | 2013 | Nutr Res2013，33，10： | 1 |
| 17 | Taxol biosynthesis:molecular cloning and characterization of a cytochrome P450taxoid 7 β-hydroxylase显示文摘 | CHAU M JENNEWEIN S Walker K | 2004 | Chemistry and Biology2004，11，： | 1 |
| 18 | Toward a Consistent Design of Structural Concrete 显示文摘 | Schlaich J Schofer K Jennewein M | 1987 | Journal of the Prestressed Concrete Institute1987，32，3： | 1 |
| 19 | NF-KB is required for Smac mimetic-mediated sensitization of glioblastoma ceils for y-irradiation-induced apoptosis显示文摘 | Berger R Jennewein C Marschall V | 2011 | Mol Cancer Ther2011，10，10： | 1 |
| 20 | High level IL-12 production by murine dendritic cells: Upregulation via MHC class Ⅱ and CD40 molecules and downregulation by IL-4 andlL-10 显示文摘 | Koch F Stanzl U Jennewein P | 1996 | JExpMed1996，184，： | 1 |
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