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| 1 | Radiofrequency ablation for treatment of hypersplenism: A feasible therapeutic option显示文摘We present a case of a patient with hypersplenism secondary to portal hypertension due to hepato-splenic schistosomiasis, which was accompanied by severe and refractory thrombocytopenia. We performed spleen ablation and measured the total spleen and ablated volumes with contrast-enhanced computed tomography and volumetry. No major complications occurred, thrombocytopenia was resolved, and platelet levels remained stable, which allowed for early treatment of the patient's underlying disease. Previous work has shown that splenic radiofrequency ablation is an attractive alternative treatment for hypersplenism induced by liver cirrhosis. We aimed to contribute to the currently sparse literature evaluating the role of radiofrequency ablation(RFA) in the management of hypersplenism. We conclude that splenic RFA appears to be a viable and promising option for the treatment of hypersplenism. | Guilherme Lopes P Martins Joao Paulo G Bernardes Marcello S Rovella Raphael G Andrade Publio Cesar C Viana Paulo Herman Giovanni Guido Cerri Marcos Roberto Menezes | 2015 | World Journal of Gastroenterology2015，21，20： | 17 |
| 2 | Development of metal organic fromwork-199 immobilized zeolite foam for adsorption of common indoor VOCs显示文摘Reticulated foam shaped adsorbents are more efficient for the removal of volatile organic compounds(VOCs),particularly from low VOC-concentration indoor air streams. In this study composite structure of zeolite and metal organic frameworks(MOFs),referred as ZMF,has been fabricated by immobilization of fine MOF-199 powder on foam shaped Zeolite Socony Mobil-5(ZSM-5)Zeolitic structure,referred as ZF. The ZMF possess a uniform and well-dispersed coating of MOF-199 on the porous framework of ZF. It shows higher surface area,pore volume,and VOCs adsorption capacity,as compared to ZF-structure.Post-fabrication changes in selective adsorption properties of ZMF were studied with three common indoor VOCs(benzene,n-hexane,and cyclohexane),using gravimetric adsorption technique. The adsorption capacity of ZMF with different VOCs follow the order of benzene > n-hexane > cyclohexane. In comparison with MOF-199 and ZF,the composite structure ZMF shows improvement in selectivity for benzene from other two VOCs. Further,improvement in efficiency and stability of prepared ZMF was found to be associated with its high MOF loading capacity and unique morphological and structural properties. The developed composite structure with improved VOCs removal and recyclability could be a promising material for small to limited scale air pollution treatment units. | Vipin K.Saini Joao Pires | 2017 | Journal of Environmental Sciences2017，29，5： | 14 |
| 3 | An updated overview on the development of new photosensitizers for anticancer photodynamic therapy显示文摘Photodynamic therapy(PDT), based on the photoactivation of photosensitizers(PSs), has become a well-studied therapy for cancer. Photofrin~?, belonging to the first generation of PS, is still widely used for the treatment of different kinds of cancers; however, it has several drawbacks that significantly limit its general clinical use. Consequently, there has been extensive research on the design of PS molecules with optimized pharmaceutical properties, with aiming of overcoming the disadvantages of traditional PS, such as poor chemical purity, long half-life, excessive accumulation into the skin, and low attenuation coefficients. The rational design of novel PS with desirable properties has attracted considerable research in the pharmaceutical field. This review presents an overview on the classical photosensitizers and the most significant recent advances in the development of PS with regard to their potential application in oncology. | Juan Zhang Chengshi Jiang Joao Paulo Figueiró Longo Ricardo Bentes Azevedo Hua Zhang Luis Alexandre Muehlmann | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 13 |
| 4 | Land Surface Displacement Geohazards Monitoring Using Multi-temporal InSAR Techniques显示文摘China has been affected by some of the world’s most serious geological disasters and experiences high economic damage every year.Geohazards occur not only in remote areas but also in highly populated cities.In the framework of the Dragon-432365 Project,this paper presents the main results and the major conclusions derived from an extensive exploitation of Sentinel-1,ALOS-2(Advanced Land Observing Satellite 2),GF-3(Gao Fen Satellite 3),and latest launched SAR(Synthetic Aperture Radar),together with methods that allow the evaluation of their importance for various geohazards.Therefore,in the scope of this project,the great benefits of recent remote sensing data(wide spatial and temporal coverage)that allow a detailed reconstruction of past displacement events and to monitor currently occurring phenomena are exploited to study different areas and geohazards problems,including:surface deformation of mountain slopes;identification and monitoring of ground movements and subsidence;landslides;ground fissure;and building inclination studies.Suspicious movements detected in the different study areas were cross validated with different SAR sensors and truth data. | Guang LIU Perski ZBIGNIEW Salvi STEFANO Thiebes BENNI Lixin WU Jinghui FAN Shibiao BAI Lianhuan WEI Shiyong YAN Rui SONG Bignami CHRISTIAN Tolomei CRISTIANO Stefan SCHNEIDERBAUER Joao Sousa JOAQUIM 无 | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 13 |
| 5 | Interdependence between transportation system and power distribution system: a comprehensive review on models and applications显示文摘The rapidly increasing penetration of electric vehicles(EVs) in modern metropolises has been witnessed during the past decade, inspired by financial subsidies as well as public awareness of climate change and environment pro-tection. Integrating charging facilities, especially highpower chargers in fast charging stations, into power distribution systems remarkably alters the traditional load flow pattern, and thus imposes great challenges on the operation of distribution network in which controllable resources are rare. On the other hand, provided with appropriate incentives, the energy storage capability of electric vehicle offers a unique opportunity to facilitate the integration of distributed wind and solar power generation into power distribution system. The above trends call for thorough investigation and research on the interdependence between transportation system and power distribution system. This paper conducts a comprehensive survey on this line of research. The basic models of transportation system and power distribution system are introduced,especially the user equilibrium model, which describes the vehicular flow on each road segment and is not familiar to the readers in power system community. The modelling of interdependence across the two systems is highlighted.Taking into account such interdependence, applications ranging from long-term planning to short-term operation are reviewed with emphasis on comparing the description of traffic-power interdependence. Finally, an outlook of prospective directions and key technologies in future research is summarized. | Wei WEI Danman WU Qiuwei WU Miadreza SHAFIE-KHAH Joao PSCATALAO | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，3： | 12 |
| 6 | Bone marrow-derived mesenchymal stem cells versus adipose-derived mesenchymal stem cells for peripheral nerve regeneration显示文摘Studies have confirmed that bone marrow-derived mesenchymal stem cells(MSCs) can be used for treatment of several nervous system diseases. However, isolation of bone marrow-derived MSCs(BMSCs) is an invasive and painful process and the yield is very low. Therefore, there is a need to search for other alterative stem cell sources. Adipose-derived MSCs(ADSCs) have phenotypic and gene expression profiles similar to those of BMSCs. The production of ADSCs is greater than that of BMSCs, and ADSCs proliferate faster than BMSCs. To compare the effects of venous grafts containing BMSCs or ADSCs on sciatic nerve injury, in this study, rats were randomly divided into four groups: sham(only sciatic nerve exposed), Matrigel(MG; sciatic nerve injury + intravenous transplantation of MG vehicle), ADSCs(sciatic nerve injury + intravenous MG containing ADSCs), and BMSCs(sciatic nerve injury + intravenous MG containing BMSCs) groups. Sciatic functional index was calculated to evaluate the function of injured sciatic nerve. Morphologic characteristics of nerves distal to the lesion were observed by toluidine blue staining. Spinal motor neurons labeled with Fluoro-Gold were quantitatively assessed. Compared with sham-operated rats, sciatic functional index was lower, the density of small-diameter fibers was significantly increased, and the number of motor neurons significantly decreased in rats with sciatic nerve injury. Neither ADSCs nor BMSCs significantly improved the sciatic nerve function of rats with sciatic nerve injury, increased fiber density, fiber diameters, axonal diameters, myelin sheath thickness, and G ratios(axonal diameter/fiber diameter ratios) in the sciatic nerve distal to the lesion site. There was no significant difference in the number of spinal motor neurons among ADSCs, BMSCs and MG groups. These results suggest that neither BMSCs nor ADSCs provide satisfactory results for peripheral nerve repair when using MG as the conductor for engraftment. | Marcela Fernandes Sandra Gomes Valente Rodrigo Guerra Sabongi Joao Baptista Gomes dos Santos Vilnei Mattioli Leite Henning Ulrich Arthur Andrade Nery Maria José da Silva Fernandes | 2018 | Neural Regeneration Research2018，13，1： | 10 |
| 7 | Research advances on the multiple uses of Moringa oleifera: a sustainable alternative for socially neglected population显示文摘Moringa oleifera Lam(Moringaceae) is a plant with high nutritional and medicinal value. Native to India, it is now widely distributed throughout tropical and subtropical regions of the world. Its different parts are sources of proteins, vitamins and minerals and present different pharmacological and biotechnological potential. Moreover, M. oleifera seeds are widely used in water and effluent treatment, for their coagulation, flocculation and sedimentation properties, their ability of improving water quality, by reducing organic matter and microbial load, with special applicability in intensive animal production systems, such as aquaculture. In addition, due to its high nutritional value and several medicinal properties, this tree may act as a nutritional and medical alternative for socially neglected populations. In this context, this review gathers information on M. oleifera, emphasizing its chemical constituents, nutritional, pharmacological and antimicrobial properties, applications in the treatment of water effluents, and ecological and social aspects. | Raimunda Samia Nogueira Brilhante Jamille Alencar Sales Vandbergue Santos Pereira Débora de Souza Collares Maia Castelo-Branco Rossana de Aguiar Cordeiro Célia Maria de Souza Sampaio Manoel de Araújo Neto Paiva Joao Bosco Feitosa dos Santos JoséJúlio CostaSidrim Marcos Fábio Gadelha Rocha | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，7： | 10 |
| 8 | Placental-derived stem cells:Culture, differentiation and challenges显示文摘Stem cell therapy is a promising approach to clinical healing in several diseases. A great variety of tissues(bone marrow, adipose tissue, and placenta) arepotentially sources of stem cells. Placenta-derived stem cells(p-SCs) are in between embryonic and mesenchymal stem cells, sharing characteristics with both, such as non-carcinogenic status and property to differentiate in all embryonic germ layers. Moreover, their use is not ethically restricted as fetal membranes are considered medical waste after birth. In this context, the present review will be focused on the biological properties, culture and potential cell therapy uses of placental-derived stem cells. Immunophenotype characterization, mainly for surface marker expression, and basic principles of p-SC isolation and culture(mechanical separation or enzymatic digestion of the tissues, the most used culture media, cell plating conditions) will be presented. In addition, some preclinical studies that were performed in different medical areas will be cited, focusing on neurological, liver, pancreatic, heart, muscle, pulmonary, and bone diseases and also in tissue engineering field. Finally, some challenges for stem cell therapy applications will be highlighted. The understanding of the mechanisms involved in the p-SCs differentiation and the achievement of pure cell populations(after differentiation) are key points that must be clarified before bringing the preclinical studies, performed at the bench, to the medical practice. | Maira S Oliveira Joao B Barreto-Filho | 2015 | World Journal of Stem Cells2015，7，4： | 10 |
| 9 | TLR2 and TLR4 polymorphisms influence m RNA and protein expression in colorectal cancer显示文摘AIM: To evaluate the effect of promoter region polymorphisms of toll-like receptor(TLR)2-196 to-174 del and TLR4-1607T/C(rs10759932) on m RNA and protein expression in tumor tissue and of TLR4+896A/G(rs4986790) on colorectal cancer(CRC) risk.METHODS: The TLR2-196 to-174 del polymorphism was investigated using allele-specific polymerase chain reaction(PCR) and the TLR4-1607T/C and TLR4+896A/G by PCR-restriction fragment length p o l y m o r p h i s m( R F L P). W e g e n o t y p e d 4 3 4 D N A samples from 194 CRC patients and 240 healthy individuals. The m RNA relative quantification(RQ) was performed in 40 tumor tissue samples by quantitative PCR Taq Man assay, using specific probes for TLR2 and TLR4 genes, and ACTB and GAPDH reference geneswere used as endogenous controls. Protein expression was analyzed by immunohistochemistry with specific primary antibodies.RESULTS: No association was found for TLR4-1607T/C and TLR4+896A/G by three statistical models(logadditive, dominant and recessive). However, based on dominant and log-additive models, the polymorphic variant TLR2-196 to-174 del was associated with increased CRC risk [dominant: odds ratio(OR) = 1.72, 95%CI: 1.03-2.89; P = 0.038 and log-additive: OR =1.59, 95%CI: 1.02-2.48; P = 0.039]. TLR2 m RNA expression was increased in tumor tissue(RQ = 2.36) when compared to adjacent normal tissue(RQ = 1; P < 0.0001), whereas the TLR4 m RNA showed a basal expression(RQ = 0.74 vs RQ = 1, P = 0.452). Immunohistochemistry analysis of TLR2 and TLR4 protein expression was concordant with the findings of m RNA expression. In addition, the TLR2-196 to-174 del variant carriers showed m RNA relative expression 2.19 times higher than wild-genotype carriers. The TLR2 protein expression was also higher for the TLR2-196 to-174 del variant carriers [117 ± 10 arbitrary unit(a.u.) vs 95 ± 4 a.u., P = 0.03]. However, for the TLR4-1607T/C polymorphism no significant difference was found for both m RNA(P = 0.56) and protein expression(P = 0.26).CONCLUSION: Our findings suggest that TLR2-196 to-174 del polymorphism increases TLR2 m RNA expression and is associated with higher CRC risk, indicating an important role in CRC genetic susceptibility. | Marcela Alcantara Proenca Juliana Garcia de Oliveira Aline Cristina Targa Cadamuro Maysa Succi Joao Gomes Netinho Eny Maria Goloni-Bertolo érika Cristina Pavarino Ana Elizabete Silva | 2015 | World Journal of Gastroenterology2015，21，25： | 9 |
| 10 | 增加附着龈宽度的改良根向复位瓣术:多个相邻牙单切口法显示文摘本文介绍了一种用于增加多个相邻牙附着龈宽度的手术方法.该方法是在以前介绍的改良根向复位瓣术(the modified apically repositioned flap.MARF)基础之上的一种改良方法。MARF法使用单一的角化组织内的水平切口,翻开半厚瓣,将瓣缝合至根方位置的骨膜上;在水平切口与瓣的冠方边缘之间的区域内骨膜处于暴露状态:暴露骨膜区的四周完全被角化组织围绕。因此。在伤口愈合期角化上皮细胞会向骨膜表面生长。从而在暴露的骨膜区形成角化的附着龈。这种手术的优点是手术简单:只使用单一的一个水平切口;因不需任何腭侧供区组织,从而并发症最低;新形成的牙龈颜色也与周围组织相匹配。 | Joao Carnio Paulo M. Camargo 欧阳翔英(译) | 2006 | 中国口腔医学继续教育杂志2006，9，3： | 9 |
| 11 | Gold nanoprisms as a hybrid in vivo cancer theranostic platform for in situ photoacoustic imaging, angiography, and localized hyperthermia显示文摘高分辨率的 nanosized photoacoustic 对比代理人的发展是令人激动的还挑战性的工艺的进展。此处,抗体(胸联系癌症的抗原 1 (Brcaa1 ) monoclonal 抗体)- 并且肽(RGD )-functionalized 金牌 nanoprisms (AuNprs ) 被用作组合方法论为在使用的 situ photoacoustic 成像, angiography,和局部性的过高热, orthotopic 和下的鼠科的胃的癌当模特儿。结合 RGD 的 PEGylated AuNprs 为结合抗体的 PEGylated AuNprs 被用于指向的肿瘤 angiography,和 Brcaa1 monoclonal 并且为是可得到的在在 orthotopic 的胃的癌的 situ 成像,肿瘤当模特儿。在 situ photoacoustic 成像允许在肿瘤地点的解剖、功能的成像。在 vivo 肿瘤 angiography,成像以一种时间依赖者方式显示出 photoacoustic 信号的改进。而且, photoacoustic 成像证明肿瘤容器清楚地在局部性的过高热以后被损坏。这作为高度敏感的对比和治疗学的代理人是用二根 AuNprs 探针的第一 proof-of-concept 为在 situ 肿瘤察觉和抑制。这些聪明的抗体 / 肽 AuNprs 能被用作一个有效 nanotheranostic 平台为在局部性的过高热处理以后在有高敏感的 vivo 肿瘤察觉,以及为指向治疗,与单个剂量的注射,它导致肿瘤的肿瘤缩放减小和增加老鼠幸存。 | Chenchen Bao Joao Conde Fei Pan Chao Li Chunlei Zhang Furong Tian Shujing Liang Jesus M. de la Fuente Daxiang Cui | 2016 | Nano Research2016，9，4： | 9 |
| 12 | Systematic review and meta-analysis of esophageal cancer in Africa:Epidemiology, risk factors, management and outcomes显示文摘BACKGROUND Esophageal cancer(EC)is associated with a poor prognosis,particularly so in Africa where an alarmingly high mortality to incidence ratio prevails for this disease.AIM To provide further understanding of EC in the context of the unique cultural and genetic diversity,and socio-economic challenges faced on the African continent.METHODS We performed a systematic review of studies from Africa to obtain data on epidemiology,risk factors,management and outcomes of EC.A non-systematic review was used to obtain incidence data from the International Agency for Research on Cancer,and the Cancer in Sub-Saharan reports.We searched EMBASE,PubMed,Web of Science,and Cochrane Central from inception to March 2019 and reviewed the list of articles retrieved.Random effects metaanalyses were used to assess heterogeneity between studies and to obtain odds ratio(OR)of the associations between EC and risk factors;and incidence rate ratios for EC between sexes with their respective 95%confidence intervals(CI).RESULTS The incidence of EC is higher in males than females,except in North Africa where it is similar for both sexes.The highest age-standardized rate is from Malawi(30.3 and 19.4 cases/year/100000 population for males and females,respectively)followed by Kenya(28.7 cases/year/100000 population for both sexes).The incidence of EC rises sharply after the age of 40 years and reaches a peak at 75 years old.Meta-analysis shows a strong association with tobacco(OR 3.15,95%CI:2.83-3.50).There was significant heterogeneity between studies on alcohol consumption(OR 2.28,95%CI:1.94-2.65)and on low socioeconomic status(OR 139,95%CI:1.25-1.54)as risk factors,but these could also contribute to increasing the incidence of EC.The best treatment outcomes were with esophagectomy with survival rates of 76.6%at 3 years,and chemo-radiotherapy with an overall combined survival time of 267.50 d.CONCLUSION Africa has high incidence and mortality rates of EC,with preventable and nonmodifiable risk factors.Men in this setting are at increased risk due to their higher prevalence of tobacco and alcohol consumption.Management requires a multidisciplinary approach,and survival is significantly improved in the setting of esophagectomy and chemoradiation therapy. | Akwi W Asombang Nathaniel Chishinga Alick Nkhoma Jackson Chipaila Bright Nsokolo Martha Manda-Mapalo Joao Filipe G Montiero Lewis Banda Kulwinder S Dua | 2019 | World Journal of Gastroenterology2019，25，31： | 9 |
| 13 | New-onset diabetes after kidney transplantation:Incidence and associated factors显示文摘AIM To determine the incidence and associated factors of new-onset diabetes after transplantation(NODAT) in a Portuguese central hospital. METHODS This single-center retrospective study involved consecutive adult nondiabetic transplant recipients, who had undergone kidney transplantation between January 2012 and March 2016. NODAT was diagnosed according to the criteria of the American Diabetes Association. Data were collected from an institutional database of the Nephrology and Kidney Transplantation Department(Santa Maria Hospital, Lisbon, Portugal) and augmented with data of laboratorial parameters collected from the corresponding patient electronic medical records. Exclusion criteria were preexisting diabetes mellitus, missing information and follow-up period of less than 12 mo. Data on demographic and clinical characteristics as well as anthropometric and laboratorial parameters were also collected. Patients were divided into two groups: With and without NODAT-for statistical comparison.RESULTS A total of 156 patients received kidney transplantduring the study period, 125 of who were included in our analysis. NODAT was identified in 27.2% of the patients(n = 34; 53% female; mean age: 49.5 ± 10.8 years; median follow-up: 36.4 ± 2.5 mo). The incidence in the first year was 24.8%. The median time to diagnosis was 3.68 ± 5.7 mo after transplantation, and 76.5% of the patients developed NODAT in the first 3 mo. In the group that did not develop NODAT(n = 91), 47% were female, with mean age of 46.4 ± 13.5 years and median follow-up of 35.5 ± 1.6 mo. In the NODAT group, the pretransplant fasting plasma glucose(FPG) levels were significantly higher [101(96.1-105.7) mg/d L vs 92(91.4-95.8) mg/d L, P = 0.007] and pretransplant impaired fasting glucose(IFG) was significantly more frequent(51.5% vs 27.7%, P = 0.01). Higher pretransplant FPG levels and pretransplant IFG were found to be predictive risk factors for NODAT development [odds ratio(OR): 1.059, P = 0.003; OR: 2.772, P = 0.017, respectively]. CONCLUSION NODAT incidence was high in our renal transplant recipients, particularly in the first 3 mo posttransplant, and higher pretransplant FPG level and IFG were risk factors. | Vania Gomes Florbela Ferreira JoséGuerra Maria Joao Bugalho | 2018 | World Journal of Diabetes2018，9，7： | 8 |
| 14 | Peripheral nerve regeneration with conduits:use of vein tubes显示文摘Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the complexity of the neurobiological nerve regenerating process. There is a greater challenge when the transected nerve ends are not amenable to primary end-to-end tensionless neurorraphy. When facing a segmental nerve defect, great effort has been made to develop an alternative to the autologous nerve graft in order to circumvent morbidity at donor site, such as neuroma formation, scarring and permanent loss of function. Tubolization techniques have been developed to bridge nerve gaps and have been extensively studied in numerous experimental and clinical trials. The use of a conduit intends to act as a vehicle for moderation and modulation of the cellular and molecular ambience for nerve regeneration. Among several conduits, vein tubes were validated for clinical application with improving outcomes over the years. This article aims to address the investigation and treatment of segmental nerve injury and draw the current panorama on the use of vein tubes as an autogenous nerve conduit. | Rodrigo Guerra Sabongi Marcela Fernandes Joao Baptista Gomes dos Santos | 2015 | Neural Regeneration Research2015，10，4： | 7 |
| 15 | Animal models of acute gastric mucosal injury: Macroscopic and microscopic evaluation显示文摘Acute gastric mucosal injury is a common disorder of the gastrointestinal tract and the search for new therapeutics is ongoing. The aim of this study is to update and expand the information related to the most widely used rat models of acute gastric ulcer, the ethanol‐induced ulcer and the indomethacin‐induced ulcer. These two models are compared in terms of macroscopic and microscopic features. Experimentally, ethanol was given orally in a single dose and indomethacin was subcutaneously injected into male Wistar rats. After ulcerative challenges, the stomachs were removed and visually inspected. Anti‐ulcerative drugs were used to validate the models. Histological analysis of the stomachs determined the microscopic score. The methodology used for model evaluation applied to macroscopic and microscopic gastric lesions. With these methods it was possible to induce lesions in the gastric mucosa. Microscopic evaluation permitted assessment of the inflammatory and apoptotic impact in the mucosa not observable by macroscopic evaluation. Groups of animals were treated with two standard drugs: sulcralfate suspension or lansoprazole solution. Both drugs reduced macroscopic and microscopic lesions, particularly the hemorrhagic ones. Both models induced acute gastric mucosal injury and no single evaluation method can address all the aspects of the pathology of gastric lesions. As a complement to macroscopic evaluation, microscopy appears to be a relevant tool to selectively identify specific aspects of the development of mucosal injury, quantify the extent of lesions, and contribute to an appropriate interpretation of results. The score systems established here offer a reliable method for testing antiulcer drugs. | Sandra Simoes Rui Lopes Maria Celeste Dias Campos Maria Joao Marruz Maria Eugenia Meirinhos da Cruz Luisa Corvo | 2019 | Animal Models and Experimental Medicine2019，2，2： | 7 |
| 16 | Physical activity in primary and secondary prevention of cardiovascular disease:Overview updated显示文摘Although the observed progress in the cardiovascular disease treatment, the incidence of new and recurrent coronary artery disease remains elevated and constitutes the leading cause of death in the developed countries. Three-quarters of deaths due to cardiovascular diseases could be prevented with adequate changes in lifestyle, including increased daily physical activity. New evidence confirms that there is an inverse dose-response relationship between physical activity and cardiovascular disease and mortality risk. However, participation in moderate to vigorous physical activity may not fully attenuate the independent effect of sedentary activities on increased risk for cardiovascular diseases. Physical activity also plays an important role in secondary prevention of cardiovascular diseases by reducing the impact of the disease, slowing its progress and preventing recurrence. Nonetheless, most of eligible cardiovascular patients still do not benefit from secondary prevention/cardiac rehabilitation programs. The present review draws attention to the importance of physical activity in the primary and secondary prevention of cardiovascular diseases. It also addresses the mechanisms by which physical activity and regular exercise can improve cardiovascular health and reduce the burden of the disease. | Alberto J Alves Joao L Viana Suiane L Cavalcante Nórton L Oliveira JoséA Duarte Jorge Mota JoséOliveira Fernando Ribeiro | 2016 | World Journal of Cardiology2016，8，10： | 6 |
| 17 | Review of small-bowel cleansing scales in capsule endoscopy: A panoply of choices显示文摘Evaluation of the quality of small-bowel cleansing is required to assess the reliability of findings in capsule endoscopy(CE). Moreover, consensus regarding the need of intestinal preparation for CE remains to be achieved. The presence of multiple grading scales for smallbowel preparation in CE, which are time-consuming and complicated, adds difficulty to the comparison of different small-bowel cleansing regimens and their application in clinical practice. Nowadays, a validated scale universally accepted for grading small-bowel cleansing is lacking. In fact, there are numerous grading systems with very different technical characteristics, namely, the parameters and the portion of the CE video that are analyzed, the objectivity of the analysis, the lesser or greater dependency on the operator, and the validation of the score. The authors performed a review which aims to systematize and summarize currently available smallbowel grading scales in CE. | Ana Ponte Rolando Pinho Adélia Rodrigues Joao Carvalho | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 6 |
| 18 | Impact of laparoscopic surgery training laboratory on surgeon's performance显示文摘Minimally invasive surgery has been replacing the open standard technique in several procedures. Similar or even better postoperative outcomes have been described in laparoscopic or robot-assisted procedures when compared to open surgery. Moreover, minimally invasive surgery has been providing less postoperative pain, shorter hospitalization, and thus a faster return to daily activities. However, the learning curve required to obtain laparoscopic expertise has been a barrier in laparoscopic spreading. Laparoscopic surgery training laboratory has been developed to aid surgeons to overcome the challenging learning curve. It may include tutorials, inanimate model skills training(box models and virtual reality simulators), animal laboratory, and operating room observation. Several different laparoscopic courses are available with specific characteristics and goals. Herein, we aim to describe the activities performed in a dry and animal-model training laboratory and to evaluate the impact of different kinds of laparoscopic surgery training courses on surgeon's performance. Several tasks are performed in dry and animal laboratory to reproduce a real surgery. A short period of training can improve laparoscopic surgical skills, although most of times it is not enough to confer laparoscopic expertise for participants. Nevertheless, this short period of training is able to increase the laparoscopic practice of surgeons in their communities. Full laparoscopic training in medical residence or fellowship programs is the best way of stimulating laparoscopic dissemination. | Fabio C M Torricelli Joao Arthur B A Barbosa Giovanni S Marchini | 2016 | World Journal of Gastrointestinal Surgery2016，8，11： | 6 |
| 19 | Advanced Fiber-Optic Acoustic Sensors显示文摘声学的察觉到是现在在现代社会起一个重要作用的一块很费力的地,用从监视到医药成像的结构的健康跨越的应用。Fiber-optics 能把许多优点带到这域,并且光纤的声学的传感器已经显示出能够基于压电的变换器与标准传感器竞争的性能层次。这评论在光纤的动态紧张察觉到的地里介绍最近的进展,特别地为声学的察觉。三种主导的技术是识别纤维布拉格栅栏, interferometric Mach-Zehnder,和 | Joao G. V. TEIXEIRA Ivo T. LEITE Susana SILVA Orlando FRAZAO | 2014 | Photonic Sensors2014，4，3： | 6 |
| 20 | Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation显示文摘BACKGROUND The impact of perioperative blood transfusion on short-and long-term outcomes in pediatric living donor liver transplantation(PLDLT)must still be ascertained,mainly among young children.Clinical and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver transplantation.AIM To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing PLDLT.METHODS We evaluated the effects of perioperative transfusion on postoperative complications in recipients up to 20 kg of body weight,submitted to PLDLT.A total of 240 patients were retrospectively allocated into two groups according to postoperative complications:Minor complications(n=109)and major complications(n=131).Multiple logistic regression analysis identified the volume of perioperative packed red blood cells(RBC)transfusion as the only independent risk factor for major postoperative complications.The receiver operating characteristic curve was drawn to identify the optimal volume of the perioperative RBC transfusion related to the presence of major postoperative complications,defining a cutoff point of 27.5 mL/kg.Subsequently,patients were reallocated to a low-volume transfusion group(LTr;n=103,RBC≤27.5 mL/kg)and a high-volume transfusion group(HTr;n=137,RBC>27.5 mL/kg)so that the outcome could be analyzed.RESULTS High-volume transfusion was associated with an increased number of major complications and mortality during hospitalization up to a 10-year follow-up period.During a short-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and bleeding complications,with a decrease in rejection complications compared to the LTr.Over a long-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and minor neoplastic complications,with a decrease in rejection complications.Additionally,Cox hazard regression found that high-volume RBC transfusion increased the mortality risk by 3.031-fold compared to low-volume transfusion.The Kaplan-Meier survival curves of the studied groups were compared using log-rank tests and the analysis showed significantly decreased graft survival,but with no impact in patient survival related to major complications.On the other hand,there was a significant decrease in both graft and patient survival,with high-volume RBC transfusion.CONCLUSION Transfusion of RBC volume higher than 27.5 mL/kg during the perioperative period is associated with a significant increase in short-and long-term postoperative morbidity and mortality after PLDLT. | Karina Gordon Estela Regina Ramos Figueira Joel Avancini Rocha-Filho Luiz Antonio Mondadori Eduardo Henrique Giroud Joaquim Joao Seda-Neto Eduardo Antunes da Fonseca Renata Pereira Sustovitch Pugliese Agustin Moscoso Vintimilla Jose Otavio Costa Auler Jr Maria Jose Carvalho Carmona Luiz Augusto Carneiro D'Alburquerque | 2021 | World Journal of Gastroenterology2021，27，12： | 6 |
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