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| 1 | Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study显示文摘This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19. | Guohua Chen Wen Su Jiayao Yang Dan Luo Ping Xia Wen Jia Xiuyang Li Chuan Wang Suping Lang Qingbin Meng Ying Zhang Yuhe Ke An Fan Shuo Yang Yujiao Zheng Xuepeng Fan Jie Qiao Fengmei Lian Li Wei Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，6： | 10 |
| 2 | Comprehensive test stand for high-intensity cyclotron development显示文摘A comprehensive test stand for high-intensity cyclotron development,a 10 MeV 430 μA cyclotron,has been successfully constructed at China Institute of Atomic Energy (CIAE) for the experimental verification of the viability of a 100 MeV high-intensity cyclotron (CYCIAE-100) being constructed at CIAE.The verification includes the overall design technology,detail design and engineering technology for the crucial parts of the machine,e.g.main magnet and beam diagnostics.It will also pave the way for future enhancement of the beam intensity.The test stand consists of a H-ion source,axial injection system,central region,main magnet and coil,RF resonator,stripping extraction,and auxiliary systems,which include the RF power amplifier,high voltage and DC power supplies,electric apparatus,beam diagnostics,control,vacuum,water cooling,pneumatic system,and safety interlock.This paper presents the work regarding the design and sub-system development of the test sand,and the results of the beam commissioning of the machine. | ZHANG TianJue LI ZhenGuo CHU ChengJie XING JianSheng GUAN FengPing ZHONG JunQing JI Bin GE Tao YIN ZhiGuo HOU ShiGang PAN GaoFeng YAO HongJuan LU YinLong WANG ZhenHui WU LongCheng LIN Jun JIA XianLu WEI SuMin WEN LiPeng WANG Feng XIA Le CAI HongRu XIE HuaiDong CHEN RongFan ZHANG Yan ZHANG SuPing LIU GengShou ZOU Jian AN ShiZhong YANG JianJun BI YuanJie YANG Fang | 2011 | Chinese Science Bulletin2011，56，3： | 3 |
| 3 | Compound-specific hydrogen isotopes of long-chain n-alkanes extracted from topsoil under a grassland ecosystem in northern China显示文摘To investigate characteristics of H isotope variation in long-chain n-alkanes (δDn-alkanes) from higher plants in surface soils under a single ecosystem, 12 samples from a basalt regolith were randomly collected from Damaping in Wanquan County of Zhangjiakou in North China. Molecular distribution and C (δ13Cn-alkanes) and H isotopes of long-chain n-alkanes, as well as C isotopes of TOC (δ13CTOC), were analyzed. Both δ13CTOC and δ13Cn-alkanes values from four representative dominant long-chain n-alkanes (n-C27, n-C29, n-C31, n-C33) derived from terrestrial higher plants show minor variations among the 12 samples, indicating the major contributor is from local grasses with a uniform C3 photosynthetic pathway. In contrast, variations in δDn-alkanes values of the four long-chain n-alkanes are relatively large, with the more abundant homologs generally showing more negative δDn-alkanes values and less variation. However, variation of <30‰ among weighted averaged δDn-alkanes values of the four long-chain n-alkanes is not only less than that among δDn-alkanes values for different modern terrestrial C3 grasses from the specific locations, but also less than the literature values of δDn-alkanes of long-chain n-alkanes for single species over different seasons. Thus, because the sources of long-chain n-alkanes in surface soils and sediments are similarly from multiple individual plants, our results are significant in confirming that paleoclimatic, paleoenvironmental and paleohydrological information can be interpreted more accurately from δDn-alkanes values of long-chain n-alkanes from sediments, particularly terrestrial sediments with organic matter derived from in-situ plants. | RAO ZhiGuo ZHU ZhaoYu JIA GuoDong ZHANG Xiao WANG SuPing | 2011 | Science China Earth Sciences2011，54，12： | 2 |
| 4 | Rapid assessment of DNA damage induced by polystyrene nanosphere suspension using a photoelectrochemical DNA sensor显示文摘Nanomaterials have been used increasingly in a wide variety of applications, and some of them have shown toxic effects on experimental animals and cells. In this study, a previously established photoelectrochemical DNA sensor was employed to rapidly detect DNA damage induced by polystyrene nanosphere (PSNS) suspensions. In the sensor, a double-stranded DNA film was assembled on a semiconductor electrode, and a DNA intercalator, Ru(bpy)2(dppz)2+ (bpy = 2,2'-bipyridine, dppz = dipyrido[3,2-a:2',3'-c]phenazine) was used as the photoelectrochemical signal indicator. After the DNA-modified electrode was exposed to 2.0 mg/mL PSNS suspension, photocurrent of DNA-bound Ru(bpy)2(dppz)2+ decreased by about 20%. The decrease is attributed to the chemical damage of DNA and consequently less binding of Ru(bpy)2(dppz)2+ molecules to the electrode. Gel electrophoresis of DNA samples incubated with PSNS suspension confirmed DNA damage after the chemical exposure. However, in both photoelectrochemical and gel electrophoresis experiments, extensively washed PSNS did not induce any DNA damage, and the supernatant of PSNS suspension exhibited comparable DNA damage as the unwashed PSNS suspension. Furthermore, UV-visible absorption spectrum of the supernatant displayed a pattern very similar to that of styrene oxide (SO), a compound which has been shown to induce DNA damage by forming covalent DNA adducts. It is therefore suggested that styrene oxide and other residual chemicals in the PSNS may be responsible for the observed DNA damage. The results highlight the importance of full characterization of nanomaterials before their toxicity study, and demonstrate the utility of photoelectrochemical DNA sensors in the rapid assessment of DNA damage induced by chemicals and nanomaterials. | ZHANG BinTian DU Xin JIA SuPing HE JunHui GUO LiangHong | 2011 | Science China Chemistry2011，54，8： | 1 |
| 5 | Modulation of optical absorption edge in TiO_2/SiO_2 mesoporous composites显示文摘TiO-2/SiO-2 mesoporous composite was synthesized by soaking_hydrolyzing method and its structure was characterized. The relationship between the shift of absorption edge and the amount of TiO-2 nanoparticles within the mesopores of SiO-2 as well as the annealing temperature was investigated. The results indicate that the extent of the blue shift of absorption edge increases with the decreasing amount of nanoparticles and decreases wtih the increasing annealing temperature. | FENG Suping, MENG Guowen, ZHANG Lide, JIA Junhuiand HE Guoliang Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, China | 1998 | Chinese Science Bulletin1998，43，24： | 1 |
| 6 | Self-assembly of three-dimensional CdS nanosphere/graphene networks for efficient photocatalytic hydrogen evolution显示文摘In this work, we report the construction of three-dimensional(3D) CdS nanosphere/graphene networks by a one-step hydrothermal self-assembly route. The 3D graphene networks not only enhance the light scattering, thanks to the interconnected 3D architecture, but also improve the crystallinity of deposited CdS nanospheres, and at the same time provide a direct electron pathway to quickly separate the photogenerated electron-hole pairs from CdS, which thus dramatically improve the photocatalytic activity.The optimized 3D CdS nanosphere/graphene networks with 2 wt% of graphene could produce molecular hydrogen at a rate of 2310 μmol gcatalyst^(-1) h^(-1) under visible-light illumination(λ > 400 nm). | Zhijian Wang Zhi Liu Jiazang Chen Hongbin Yang Jianqiang Luo Jiajian Gao Junming Zhang Cangjie Yang Suping Jia Bin Liu | 2019 | Journal of Energy Chemistry2019，28，4： | 1 |
| 7 | Detection and mechanistic investigation of halogenated benzoquinone induced DNA damage by photoelectrochemical DNA sensor显示文摘 | Suping Jia Ben-Zhan Zhu Liang-Hong Guo | 2010 | Analytical and Bioanalytical Chemistry2010，，6： | 1 |
| 8 | P–N co-doping induced structural recovery of TiO 2 for overall water splitting under visible light irradiation显示文摘 | Peng Zheng Haijun Wu Jialin Guo Jianhui Dong Suping Jia Zhenping Zhu | 2014 | Journal of Alloys and Compounds2014，，： | 1 |
| 9 | Effect of particle size on oxidation of silicon carbide powders 显示文摘 | JIA Quanli ZHANG Haijun LI Suping | 2007 | Ceram Int2007，33，2： | 1 |
| 10 | Positive Association of the Oxytocin Receptor Gene ( OXTR ) with Autism in the Chinese Han Population显示文摘 | Suping Wu Meixiang Jia Yan Ruan Jing Liu Yanqing Guo Mei Shuang Xiaohong Gong Yanbo Zhang Xiaoling Yang Dai Zhang | 2005 | Biological Psychiatry2005，，1： | 1 |
| 11 | Effect of particle size on oxidation of silicon carbide powders显示文摘 | JIA Quanli ZHANG Haijun LI Suping | 2007 | Ceramics International2007，33，2： | 1 |
| 12 | Multi-site observation of large-scale eddies in the surface layer of the Loess Plateau显示文摘This article aims to build a theory of atmospheric boundary layer turbulence under complex conditions. To achieve this goal, we constructed a multi-site observation and analysis method of atmospheric turbulence based on related principles.This method first requires verification for the ergodicity of the full-scale observation of surface-layer turbulence, which proves that eddies within a scale of 60 min during a four-site observation can easily meet ergodicity. Meanwhile, by applying the second-order structure function for the horizontal wind speed turbulence of a single site and upstream and downstream points, we verified the ergodicity of the turbulence observation. Comparing the turbulence spectrum to the second-order structure function for the horizontal wind speed from the four-site observation, a relatively high accordance was observed, proving the reasonability of the multi-site observation. Moreover, compared to the single-site observation, the four-site observation can improve the estimation accuracy of the surface-layer turbulence spectrum and vertical turbulent flux. As a result, we can describe the threedimensional structure of turbulence more accurately and comprehensively by combining analytical data from single-site and four-site observations. In summary, the multi-site turbulence observation method shows that the horizontal and vertical wind turbulence of the Baimiao plateau has a typical structure of a turbulence spectrum with clear spectral gaps. The result is in accordance with the scale of the turbulence spectral gaps obtained from the 6 h data. The horizontal wind speed is under the influence of the terrain, so its spectrum of large-scale eddies has higher fluctuations, but its spectral gaps can still be clearly distinguished. Although the spectral gaps of the temperature spectrum are not distinguishable, they still have the same scale as the spectral gap of the vertical and horizontal turbulence spectrum. Moreover, the temperature spectrum possesses typical structure characteristics of the boundary-layer turbulence spectrum. | Jinbei CHEN Xiaowen CHEN Wei JIA Ye YU Suping ZHAO | 2023 | Science China Earth Sciences2023，66，4： | 0 |
| 13 | Ergodicity of turbulence measurements upon complex terrain in Loess Plateau显示文摘To display the distribution characteristics of turbulence eddy under condition of complex terrain in Loess Plateau,and to enhance the precision of turbulence measurements,the research of turbulence ergodicity is considered to be the prior section of the experiment.With the statistics of single-site turbulence measurements obtained in Baimiao Tableland,Ping Liang,Gan Su,analysis result shows that not only the turbulence with scale less than 10 min,which can easily satisfy the ergodicity,the tableland terrain can also be a major cause of the coherent structure of periodic,large-scale turbulence;compared to which for the turbulence above the flat underlying surface,the distribution of 10–40 min,large-scale turbulence in the tableland region tends to be more steady and,thus,can also satisfy the ergodicity easily.Under the condition of extremely unstable stratification,the wind is comparatively low in speed and features distinctly large-scale,periodical fluctuation,and with the trend of smooth increase in temperature,large-scale wind turbulence and temperature turbulence both tend to satisfy ergodicity.In comparison,under the condition of extremely stable stratification,the aperiodicity of large-scale wind turbulence and temperature turbulence caused by intermittency is comparatively strong,and the turbulence cannot satisfy ergodicity easily. | Jinbei CHEN Xiaowen CHEN Xiaojun JING Wei JIA Ye YU Suping ZHAO | 2021 | Science China Earth Sciences2021，64，1： | 0 |
| 14 | NEDD4L inhibits cell viability,cell cycle progression,and glutamine metabolism in esophageal squamous cell carcinoma via ubiquitination of c-Myc显示文摘Esophageal squamous cell carcinoma(ESCC)is a common subtype of esophageal cancer with high incidence.Surgery remains the main strategy for treatment of ESCC at early stage.However,the treatment outcome is unsatisfactory.Therefore,finding new therapeutics is of great importance.In the present study,we measured the level of NEDD4L,an ubiquitin protein ligase,in clinical samples and investigated the effects of NEDD4L on cell viability,cell cycle progression,and glutamine metabolism in TE14 cells determined by CCK-8 assay,flow cytometry and biochemical analysis,respectively.The results show that NEDD4L is significantly decreased in ESCC specimens,and its decreased expression is associated with a poor clinical outcome.Overexpression of NEDD4L significantly inhibits cell viability,cell cycle progression,and glutamine metabolism in TE14 cells.Mechanistic study indicates that NEDD4L regulates tumor progression through ubiquitination of c-Myc and modulation of glutamine metabolism.NEDD4L inhibits cell viability,cell cycle progression,and glutamine metabolism in ESCC by ubiquitination of c-Myc to decrease the expressions of GLS1 and SLC1A5.Our findings highlight the importance of NEDD4L/c-Myc signaling in ESCC. | Wei Cheng Guiyuan Li Zhou Ye Jun Hu Lixia Gao Xiaoling Jia Suping Zhao Yan Wang Qin Zhou | 2022 | Acta Biochimica et Biophysica Sinica2022，54，5： | 0 |
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