|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Plasma Membrane H^+-ATPase Regulation in the Center of Plant Physiology显示文摘血浆膜(下午) H +-ATPase 是在植物房间膜的重要离子泵。由渗出从房间的质子并且产生一个膜潜力,这泵给与能量 PM,它是为生长的一个前提。autoinhibitory 终端域的修正激活下午 H +-ATPase 活动, andon 这 basisit 被假设了这些规章的终点是为激活或禁止质子抽的生理的因素的目标。在这评论,我们在进化、生理的上下文集中于 PM H +-ATPase 的 posttranslational 规定和泵的地方规定。新兴的图画是调整植物生长的多重信号防碍 PM H +-ATPase 的 posttranslational 规定。 | Janus Falhof Jesper Torbol Pedersen Anja Thoe Fuglsang Michael Palmgren | 2016 | Molecular Plant2016，9，3： | 27 |
| 2 | miR-20b, miR-98, miR-125b-1*, and let-7e* as new potential diagnostic biomarkers in ulcerative colitis显示文摘AIM:To use microarray-based miRNA profiling of colonic mucosal biopsies from patients with ulcerative colitis (UC), Crohn's disease (CD), and controls in order to identify new potential miRNA biomarkers in inflammatory bowel disease. METHODS:Colonic mucosal pinch biopsies from the descending part were obtained endoscopically from patients with active UC or CD, quiescent UC or CD, as well as healthy controls. Total RNA was isolated and miRNA expression assessed using the miRNA microarray Geniom Biochip miRNA Homo sapiens (Febit GmbH, Heidelberg, Germany). Data analysis was carried out by principal component analysis and projection to latent structure-discriminant analysis using the SIMCA-P+12 software package (Umetrics, Umea, Sweden). The microarray data were subsequently validated by quantitative real-time polymerase chain reaction (qPCR) performed on colonic tissue samples from active UC patients (n = 20), patients with quiescent UC (n = 19), and healthy controls (n = 20). The qPCR results were analyzed with Mann-WhitneyU test.In silico prediction analysis were performed to identify potential miRNA target genes and the predicted miRNA targets were then compared with all UC associated susceptibility genes reported in the literature. RESULTS:The colonic mucosal miRNA transcriptome differs significantly between UC and controls, UC and CD, as well as between UC patients with mucosal inflammation and those without. However, no clear differences in the transcriptome of patients with CD and controls were found. The miRNAs with the strongest differential power were identified (miR-20b, miR-99a, miR-203, miR-26b, and miR-98) and found to be upregulated more than a 10-fold in active UC as compared to quiescent UC, CD, and controls. Two miRNAs, miR-125b-1* and let-7e*, were up-regulated more than 5-fold in quiescent UC compared to active UC, CD, and controls. Four of the seven miRNAs (miR-20b, miR-98, miR-125b-1*, and let-7e*) were validated by qPCR and found to be specifically upregulated in patients with UC. Usingin silico analysis we found several predicted pro-inflammatory target genes involved in various pathways, such as mitogen-activated protein kinase and cytokine signaling, which are both key signaling pathways in UC.CONCLUSION:The present study provides the first evidence that miR-20b, miR-98, miR-125b-1*, and let7e* are deregulated in patients with UC. The level of these miRNAs may serve as new potential biomarkers for this chronic disease. | Mehmet Coskun Jacob Tveiten Bjerrum Jakob Benedict Seidelin Jesper Thorvald Troelsen JΦrgen Olsen Ole Haagen Nielsen | 2013 | World Journal of Gastroenterology2013，19，27： | 19 |
| 3 | 城市空间与交通——哥本哈根的策略与实践显示文摘简要介绍了哥本哈根通过优先可持续的交通模式,充分发挥骑车和步行给都市生活带来的积极效果,以及制订的一系列城市空间发展策略和这些策略提出的背景,并通过个案分析展示了这些策略是如何通过试验和公众参与而得到执行的。 | Jesper Dahl 李华东 王晓京 | 2011 | 建筑学报2011，，1： | 10 |
| 4 | Fitness and health benefits of team handball training for young untrained women--A cross-disciplinary RCT on physiological adaptations and motivational aspects显示文摘Purpose: The present study evaluated the effects of regular participation in small-sided team handball training on body composition, osteogenic response, physical performance, and cardiovascular risk factors, as well as well-being and motivation, in young untrained women.Methods: Twenty-eight untrained 20- to 30-year-old women were randomized to a handball training group(HG; n = 14, height 170 ± 5 cm, weight 73 ± 11 kg, VO_(2peak) 37.7 ± 4.1 mL/min/kg) that trained 1.7 ± 0.3 times per week over 12 weeks(70 min 4 v 4 handball sessions) or an inactive control group(CG; n = 14, 169 ± 5 cm, 71 ± 12 kg, 38.1 ± 3.7 mL/min/kg). Physiological and psychological and motivational training adaptations were assessed pre-and post-intervention by dual-energy X-ray Absorptiometry(DXA) scans, blood sampling, physical tests, and questionnaires.Results: The average heart rate(HR) over all training sessions was equal to 85% ± 6% HR_(max). Between-group intervention effects were observed in favor of HG for muscle mass(2.1%, p = 0.024), proximal femur bone mineral density(0.8%, p = 0.041), Yo-Yo IE1 intermittent endurance test level 1(IE1) performance(35%, p < 0.001), and incremental treadmill test performance(11.5%, p = 0.003), but not total fat mass(p = 0.176),mean arterial blood pressure(p = 0.328), resting HR(p = 0.219), or blood lipids(p = 0.298—0.854). In CG, no changes were observed in any of the measured physiological variables after the training period. Compared to CG, HG had an increase in intrinsic motivation(p < 0.001) and in the well-being subscale 'energy'(p = 0.010).Conclusion: Participation in regular recreational team handball training organized as small-sided games has marked beneficial effects on physical performance, musculoskeletal fitness, well-being, and motivation in untrained young women. | Therese Hornstrup Johan M.Wikman Bjorn Fristrup Susana Povoas Eva W.Helge Signe H.Nielsen Jorn W.Helge Jesper L.Andersen Lars Nybo Peter Krustrup | 2018 | Journal of Sport and Health Science2018，7，2： | 8 |
| 5 | 游戏讲故事?——论游戏与叙事显示文摘游戏是否在讲故事的问题,学界意见不一。许多电脑游戏包含叙事要素,大多数游戏都具有故事介绍和背景故事,玩家也可以讲述某段游戏的故事;但是游戏与故事并不能像其他叙事文本那样相互转换,互动性的'当下'与叙事的过去或'预先'之间存在固有的矛盾,读者/文本与玩家/游戏之间的关系也不同。因此游戏与叙事是具有很多差异的,而对二者差异的探讨有待进一步完善。 | Jesper Juul 关萍萍 | 2010 | 文化艺术研究2010，3，1： | 8 |
| 6 | 游戏、玩家、世界:对游戏本质的探讨显示文摘本文旨在提出游戏的定义。我描述了一个传统意义上的游戏模式:包括游戏所必备的六大特征。该定义显示游戏是跨媒介的,不存在单一游戏媒介,而是一系列游戏媒介,每种媒介都有自身的优势。电脑是最新出现的游戏媒介。而电脑游戏作为分布最广的类别,其演变已经超越了传统的游戏模式。 | Jesper Juul 关萍萍 | 2009 | 文化艺术研究2009，2，3： | 8 |
| 7 | Physical activity, obesity and gastroesophageal reflux disease in the general population显示文摘AIM: To clarify the association between physical activity and gastroesophageal reflux disease (GERD) in nonobese and obese people. METHODS: A Swedish population-based cross-sectional survey was conducted. Participants aged 40-79 years were randomly selected from the Swedish Registry of the Total Population. Data on physical activity, GERD, body mass index (BMI) and the covariates age, gender, comorbidity, education, sleeping problems, and tobacco smoking were obtained using validated questionnaires. GERD was self-reported and defined as heartburn or regurgitation at least once weekly, and having at least moderate problems from such symptoms. Frequency of physical activity was categorized into three groups: (1) 'high' (several times/week); (2) 'intermediate' (approximately once weekly); and (3) 'low' (1-3 times/mo or less). Analyses were stratified for participants with 'normal weight' (BMI < 25 kg/m 2 ), 'overweight' (BMI 25 to ≤ 30 kg/m 2 ) and 'obese' (BMI > 30 kg/m 2 ). Multivariate logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounding by covariates. RESULTS: Of 6969 eligible and randomly selected individuals, 4910 (70.5%) participated. High frequency of physical activity was reported by 2463 (50%) participants, GERD was identified in 472 (10%) participants, and obesity was found in 680 (14%). There were 226 (5%) individuals with missing information about BMI. Normal weight, overweight and obese participants were similar regarding distribution of gender and tobacco smoking status, while obese participants were on average slightly older, had fewer years of education, more comorbidity, slightly more sleeping problems, lower frequency of physical activity, and higher occurrence of GERD. Among the 2146 normal-weight participants, crude point estimates indicated a decreased risk of GERD among individuals with high frequency of physical activity (OR: 0.59, 95% CI: 0.39-0.89), compared to low frequency of physical activity. However, after adjustment for potential confounding factors, neither intermediate (OR: 1.30, 95% CI: 0.75-2.26) nor high (OR: 0.99, 95% CI: 0.62-1.60) frequency of physical activity was followed by decreased risk of GERD. Sleeping problems and high comorbidity were identified as potential confounders. Among the 1859 overweight participants, crude point estimates indicated no increased or decreased risk of GERD among individuals with intermediate or high frequency of physical activity, compared to low frequency. After adjustment for confounding, neither intermediate (OR: 0.75, 95% CI: 0.46-1.22) nor high frequency of physical activity were followed by increased or decreased risk of GERD compared to low frequency among nonobese participants. Sleeping problems and high comorbidity were identified as potential confounders for overweight participants. In obese individuals, crude ORs were similar to the adjusted ORs and no particular confounding factors were identified. Intermediate frequency of physical activity was associated with a decreased occurrence of GERD compared to low frequency of physical activity (adjusted OR: 0.41, 95% CI: 0.22-0.77). CONCLUSION: Intermediate frequency of physical activity might decrease the risk of GERD among obese individuals, while no influence of physical activity on GERD was found in non-obese people. | Therese Djrv Anna Wikman Helena Nordenstedt Asif Johar Jesper Lagergren Pernilla Lagergren | 2012 | World Journal of Gastroenterology2012，18，28： | 8 |
| 8 | Human-driven topographic effects on the distribution of forest in a flat, lowland agricultural region显示文摘复杂地形学在多山的区域对采伐森林缓冲森林。然而,如果地面也在人的影响是可能的是地面抑制的更少的低地塑造森林分发,它是未知的。在如此的区域,如果重要根本,地志的效果将取决于文化历史的因素并且因此人驱动(人为) 而非自然,除了在一般气候或极端玷污的区域,限制森林的出现。我们使用了空间回归当模特儿估计地志的因素向解释森林分发的程度(存在缺席在一 48 ? | Mette V. ODGAARD Peder K. BOCHER Tommy DALGAARD Jesper E. MOESLUND Jens-Christian SVENNING | 2014 | Journal of Geographical Sciences2014，24，1： | 6 |
| 9 | Strategies to obtain pattern fidelity in nanowire growth from large-area surfaces patterned using nanoimprint lithography显示文摘位置控制 nanowire 生长为依靠轻排放或轻吸收的基于 nanowire 的 optoelectronic 部件是重要的。为收获应用程序的太阳能, nanowires 的稠密的数组被需要;然而,到获得稠密的 nanowire 数组的一个主要障碍是种子粒子排水量并且在 nanowire 生长以前在退火的舞台期间联合。这里,我们探索三不同策略改进 nanoimprint 平版印刷术为 nanowire 生长定义的大区域的催化剂粒子数组的模式保藏。首先,我们看到在 nanoimprint 平版印刷术以前对待生长底层的热改进模式保藏。第二,我们探索由在由修改生长过程退火以前在地方修理种子粒子改进模式保藏的可能性。并且第三,我们证明一个罪恶 x 生长面具罐头充分阻止种子粒子排水量。我们显示出这些策略怎么允许我们极大地与对太阳能电池应用合适的尺寸改进成年 InP nanowire 数组的模式忠实,在取样的区域上的最终完成的 100% 模式保藏。这些策略的通用性质通过 GaAs 和差距 nanowires 的合成被支持。 | Gaute Otnes Magnus Heurlin Mariusz Graczyk Jesper Wallentin Daniel Jacobsson Alexander Berg Ivan Maximov Magnus T. Borgstrom | 2016 | Nano Research2016，9，10： | 6 |
| 10 | Application of heat shock protein expression for detecting natural adaptation and exposure to stress in natural populations显示文摘Heat-shock proteins (HSPs) play an undisputed role for maintaining cellular functioning under environmental challengesand protein denaturing conditions. Compelling evidence points to an evolutionary important role of HSPs and a strict evolutionarycontrol of these proteins as a balance between benefits and costs. While there is a great potential for using HSP expressionfor detecting natural adaptation and exposure to stress in natural populations, some obstacles and key issues await investigation.From an ecological perspective these key issues needs to be resolved in order to fully appreciate the complex responses andadaptations to stress and to increase our understanding of HSPs and other molecular chaperones for stress adaptation and potentialuse as biomarkers. Here, the current knowledge and understanding of HSPs is reviewed and a number of key issues including theinterpretation of elevated HSP levels, the complications of extrapolating between laboratory and field conditions, the effects ofchoice of traits and methodology and the larger intra-and extracellular networks of interactions that HSPs participate in are | Jesper Givskov SφRENSEN | 2010 | Current Zoology2010，56，6： | 6 |
| 11 | Effects of 3 months of full-court and half-court street basketball training on health profile in untrained men显示文摘Purpose: The aim of the present study was to investigate whether street basketball organized as 3 v 3 on either a half court(HC) with 1 basket or a full court(FC) with 2 baskets could improve fitness and health profiles of untrained men after 3 months of supervised training.Methods: Thirty-five untrained men(aged 20—42 years) completed the pre-and post-intervention testing(FC: n = 13, HC: n = 12, CO(control):n = 10). The training attendance was 2.0 ± 0.4 and 1.9 ± 0.3 times per week in FC and HC, respectively. Mean heart rate(HR) was 83.8 ± 6.0 percent of maximal heart rate(%HR_(max)) and 84.5 ± 2.9 %HR_(max) in FC and HC, respectively.Results: The 3 months of street basketball training on an FC with 2 baskets increased maximal oxygen uptake(2.4 mL/min/kg(95% confidence interval(CI): 1.0—3.9)), time to exhaustion(47 s(95%CI: 26—67)), lean body mass(0.8 kg(95%CI: 0.1—1.5)), and bone mineral density(0.021 g/cm^2(95%CI: 0.011—0.031)), whereas mean arterial pressure(—5.6 mm Hg(95%CI: —7.5 to 3.7)), body fat percentage(—1.6%,(95%CI: —2.5 to —0.7)), heart rate(—18 bpm(95%CI: —24 to —12)), and blood lactate(median: —1.4 mmol/L(interquartile range: —1.5 to —0.6)) during submaximal running were lowered. The changes were less pronounced after the training period when playing on an HC with 1 basket, but increases in maximal oxygen uptake(1.6 mL/min/kg(95%CI: —0.1 to 3.3)), time to exhaustion(28 s(95%CI: 9—47)), lean body mass(1.3 kg(95%CI: 0.3—2.4)), and lower body fat percentage(—0.9%(95%CI: —1.9 to —0.1)) were observed in this group.Conclusion: Three months of 3 v 3 street basketball training improved fitness and led to broad-spectrum improvements in variables related to overall health profile, with the most marked effects observed when playing on an FC with 2 baskets. | Morten B.Randers Marie Hagman Jonathan Brix Jesper F.Christensen Mogens T.Pedersen Jens J.Nielsen Peter Krustrup | 2018 | Journal of Sport and Health Science2018，7，2： | 5 |
| 12 | Bone mineral density in lifelong trained male football players compared with young and elderly untrained men显示文摘Purpose: The purpose of the present controlled cross-sectional study was to investigate proximal femur and whole-body bone mineral density(BMD), as well as bone turnover profile, in lifelong trained elderly male football players and young elite football players compared with untrained age-matched men.Methods: One hundred and forty healthy, non-smoking men participated in the study, including lifelong trained football players(FTE, n = 35)aged 65—80 years, elite football players(FTY, n = 35) aged 18—30 years, as well as untrained age-matched elderly(UE, n = 35) and young(UY,n = 35) men. All participants underwent a regional dual-energy X-ray Absorptiometry(DXA) scan of the proximal femur and a whole-body DXA scan to determine BMD. From a resting blood sample, the bone turnover markers(BTMs) osteocalcin, carboxy-terminal type-1 collagen crosslinks(CTX-1), procollagen type-1 amino-terminal propeptide(P1NP), and sclerostin were measured.Results: FTE had 7.3%—12.9% higher(p < 0.05) BMD of the femoral neck, wards, shaft, and total proximal femur in both legs compared to UE,and 9.3%—9.7% higher(p < 0.05) BMD in femoral trochanter in both legs compared to UY. FTY had 24.3%—37.4% higher(p < 0.001) BMD in all femoral regions and total proximal femur in both legs compared to UY. The whole-body DXA scan confirmed these results, with FTE showing similar whole-body BMD and 7.9% higher(p < 0.05) leg BMD compared to UY, and with FTY having 9.6% higher(p < 0.001) wholebody BMD and 18.2% higher(p < 0.001) leg BMD compared to UY. The plasma concentration of osteocalcin, CTX-1, and P1NP were 29%,53%, and 52% higher(p < 0.01), respectively, in FTY compared to UY.Conclusion: BMD of the proximal femur and whole-body BMD are markedly higher in lifelong trained male football players aged 65—80 years and young elite football players aged 18—30 years compared to age-matched untrained men. Elderly football players even show higher BMD in femoral trochanter and leg BMD than untrained young despite an age difference of 47 years. | Marie Hagman Eva Wulff Helge Therese Hornstrup Bjorn Fristrup Jens Jung Nielsen Niklas Rye Jorgensen Jesper Lovind Andersen Jorn Wulff Helge Peter Krustrup | 2018 | Journal of Sport and Health Science2018，7，2： | 5 |
| 13 | 急性缺血性卒中的机械取栓治疗:ESO、ESMINT、ESNR和EAN共同支持的2014/2015 ESO-卡罗林斯卡卒中更新会议共识声明显示文摘这份卒中后机械取栓治疗共识声明的原始版本于2014年11月16—18日在斯德哥尔摩召开的欧洲卒中组织(European Stroke Organisation, ESO)-卡罗林斯卡卒中更新会议期间得到批准。根据会议安排,在2015年利用新的临床试验数据对该声明进行了更新。2015年2月,在瑞士伯尔尼召开的ESO冬季培训会期间组织了面对面会议对共识声明进行修订,然后通过电子邮件交换意见,最终版本得到各学会的认可。推荐意见与原始版本一致,证据等级更新到2015年2月20日为止,在2015年5月15日获得确认。ESO-卡罗林斯卡卒中更新会议的目的在于总结卒中治疗研究的最新进展并探讨如何将这些最新研究结果应用于临床实践。共识会议选择了一些议题进行讨论,与会者草拟一份共识声明并进行讨论。该声明接受了ESO指南委员会的指导。这份共识声明包括对急性卒中后机械取栓治疗的推荐意见,得到欧洲卒中组织ESO、欧洲神经微创治疗学会(European Society of Minimally Invasive Neurological Therapy, ESMINT)、欧洲神经放射学学会(European Society of Neuroradiology, ESNR)和欧洲神经病学学会(European Academy of Neurology, EAN)的支持。 | Nils Wahlgren Tiago Moreira Patrik Michel Thorsten Steiner Olav Jansen Christophe Cognard Heinrich P Mattle Wim van Zwam Staffan Holmin Turgut Tatlisumak Jesper Petersson Valeria Caso Werner Hacke Mikael Mazighi Marcel Arnold Urs Fischer Istvan Szikora Laurent Pierot Jens Fiehler Jan Gralla Franz Fazekas Kennedy R Lees 高洁 徐格林 | 2016 | 国际脑血管病杂志2016，24，1： | 5 |
| 14 | 作物相对水分利用效率与理论节水潜力显示文摘作物水分利用效率是评价农业用水效率的重要指标,由于气候差异,采用作物水分利用效率评价不同区域的用水效率可能存在一定误差,尚缺乏深入研究。基于潜在水分利用效率指标和气象数据,计算了2014年中国小麦、玉米和水稻在充分灌溉条件下的潜在水分利用效率,分析了区域气候差异对作物水分利用效率的影响,提出了相对水分利用效率和理论节水潜力的概念和计算方法,并进行了实例研究。结果表明:各类作物在不同站点的潜在水分利用效率的标准差为0.49~1.01 kg/m 3,多数作物潜在水分利用效率的空间差异大于实际水分利用效率的空间差异;主要作物的平均相对水分利用效率为50.7%,其理论节水潜力为884.8~4 064.5 m 3/hm 2;作物水分利用效率和广义节水潜力指标可能高估或低估作物的用水效率和节水潜力。研究认为在比较区域间作物的水分利用效率时不能忽略气候差异的影响;由于考虑了区域气候差异,相对水分利用效率和理论节水潜力指标更合理。 | 代小平 周雯晶 韩宇平 窦明 冯吉 Svensson Jesper | 2019 | 水科学进展2019，30，5： | 4 |
| 15 | In Situ Etching for Total Control Over Axial and Radial Nanowire Growth显示文摘We report a method using in situ etching to decouple the axial from the radial nanowire growth pathway,independent of other growth parameters.Thereby a wide range of growth parameters can be explored to improve the nanowire properties without concern of tapering or excess structural defects formed during radial growth.We demonstrate the method using etching by HCl during InP nanowire growth.The improved crystal quality of etched nanowires is indicated by strongly enhanced photoluminescence as compared to reference nanowires obtained without etching. | Magnus T.Borgström Jesper Wallentin Johanna Trägårdh Peter Ramvall Martin Ek LReine Wallenberg Lars Samuelson Knut Deppert | 2010 | Nano Research2010，3，4： | 4 |
| 16 | Multifunctional landscapes—perspectives for the future显示文摘New methods in landscape ecology to study the link between landscape heterogeneity and landscape functionality are needed. Heterogeneity is a basic characteristic of landscape, and landscape function is the capacity to change the structural heterogeneity of a landscape system. In most developed countries the industrialisation of agriculture has in general resulted in a change of agricultural landscapes from a small-grained heterogeneous pattern towards more monotonous and monofunctional landscapes. During the 1990’s this trends seems to have changed due to a diversification of rural land use and new trends in urbanisation. Weather these phases of landscape development should be expected in developing countries is a totally open question. Dealing with the study of multifunctionality of landscapes it is proposed to distinguish between ecological functionality of landscape ecosystems, functionality pertaining to land use and social functionality. Further, the relation between function, space and scale is important by the determination of spatial and time segregation as well as spatial and time integration of multifunctionality in landscapes. | Jesper Brandt | 2003 | Journal of Environmental Sciences2003，15，2： | 4 |
| 17 | Body mass, tobacco and alcohol and risk of esophageal, gastric cardia, and gastric non-cardia adenocarcinoma among men and women in a nested case-control study显示文摘 | Mats Lindblad Luis A. García Rodríguez Jesper Lagergren | 2005 | Cancer Causes & Control2005，，3： | 3 |
| 18 | Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals显示文摘ASXL1 变化经常在 hematological 肿瘤被发现,并且 Asxl1 的损失在老鼠支持 myeloid 转变。这里我们在 vivo 在在 Histone H2A (H2AK119ub1 ) 上的 mono-ubiquitylated 离氨酸 119 的 deubiquitylation 为 ASXL1-BAP1 建筑群支持一个角色的现在的数据。Polycomb 组蛋白质在正常开发期间控制 INK4B-ARF-INK4A 地点的表达式,部分地通过催化 H2AK119 的 mono-ubiquitylation。自从地点的激活, INK4B-ARF-INK4A 玩一设有自动保险装置机制免于 tumorigenesis,我们调查了 ASXL1 依赖的 H2A deubiquitylation 是否在它的激活起一个作用。有趣地,我们发现 ASXL1 明确地为 p15 响应 oncogenic 发信号和外来的 anti-proliferative 的 INK4B 发信号。因为我们发现 ASXL1 和 BAP1 两个都在 INK4B 地点被充实,我们的结果建议 INK4B 地点的激活要求 H2AK119ub1 的 ASXL1/BAP1-mediated deubiquitylation。一致地,我们 ASXL1 变化与被联系的结果表演降低 p15 INK4B 和在主要骨头髓房间的造血的祖先的一个 proliferative 优点,和在多重房间线的 ASXL1 的那弄空导致抵抗到生长禁止的信号。一起拿,这研究连接 INK4B 表示的调停 ASXL1 的 H2A deubiquitylation 和 transcriptional 激活到它的肿瘤 suppressor 函数。 | Xudong Wu Ida Holst Bekker-Jensen Jesper Christensen Kasper Dindler Rasmussen Simone Sidoli Yan Qi Yu Kong Xi Wang Yajuan Cui Zhijian Xiao Guogang Xu Kristine Williams Juri Rappsilber Casper Kaae Sonderby Ole Winther Ole N Jensens Kristian Helin | 2015 | Cell Research2015，25，11： | 3 |
| 19 | Nonlinearity-tailored fiber laser technology for low-noise, ultra-wideband tunable femtosecond light generation显示文摘The emission wavelength of a laser is physically predetermined by the gain medium used. Consequently, arbitrary wavelength generation is a fundamental challenge in the science of light. Present solutions include optical parametric generation, requiring complex optical setups and spectrally sliced supercontinuum, taking advantage of a simpler fiber technology: a fixed-wavelength pump laser pulse is converted into a spectrally very broadband output, from which the required resulting wavelength is then optically filtered. Unfortunately, this process is associated with an inherently poor noise figure, which often precludes many realistic applications of such supercontinuum sources. Here, we show that by adding only one passive optical element—a tapered photonic crystal fiber—to a fixed-wavelength femtosecond laser, one can in a very simple manner resonantly convert the laser emission wavelength into an ultra-wide and continuous range of desired wavelengths, with very low inherent noise, and without mechanical realignment of the laser. This is achieved by exploiting the double interplay of nonlinearity and chirp in the laser source and chirp and phase matching in the tapered fiber. As a first demonstration of this simple and inexpensive technology, we present a femtosecond fiber laser continuously tunable across the entire red–green–blue spectral range. | XIAOMIN LIU JESPER LAEGSGAARD ROMAN IEGOROV ASK S.SVANE F.OMER ILDAY HAOHUA TU STEPHEN A.BOPPART DMITRY TURCHINOVICH | 2017 | Photonics Research2017，5，6： | 2 |
| 20 | Gastric stump cancer after distal gastrectomy for benign gastric ulcer in a population‐based study显示文摘 | Jesper Lagergren Anna Lindam Robert M. Mason | 2012 | Int J Cancer2012，，6： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员