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| 1 | Comparison of the patient and partner satisfaction with 700CX and Titan penile prostheses显示文摘最普遍的三部件的阴茎修复术模型是 700CX 和泰坦 ? 。在第一植入以后,我们的目的是估计病人和搭挡满足。这是 multicenter,回顾,满足了在 2009 和 2013 之间的包括标准的所有病人在被包括的 nonrandomized 学习。总共, 248 个病人同意参与。评估耐心的满足,一张验证,但是修改的 11 问题问询表被完成(编辑) ;并且二条款的问询表被给搭挡的 nonvalidated。统计分析使用了一个顺序的逻辑回归模型。248 个病人(194 与 700CX 对 54 与泰坦 ?) 和 207 对夫妇完成了问询表(165 与 700CX 对 42 与泰坦 ?) 。全面满足高。为有优先的期望的性交和高依从的两个都显示出的大可靠性。大多数病人能在 6 个月以内正确地管理阴茎修复术。手术后的阴茎弄短在 42% 盒子和 46% 中导致了一些不满(700CX /Titan ?) 。重要差别在病人问询表的三个问题被发现。有更多的病人,对 700CX 满意(P = 0.0001 ) 。有泰坦 ? 的没有病人植入比 6 个月长带了去最佳的管理。仅仅,有 700CX 的 4% 病人植入与泰坦 ? 与放气被不满足,与 24% 相对照(P = 0.0031 ) 。二个搭挡问题,一个人显示出统计上重要的差别(P = 0.0026 ) 。看起来,组 700CX 将推荐到重新植入有一个更大的趋势的修复术。全面满足为两 prostheses 很高。最后的方面树立,松驰的阴茎是令人满意的,但是两个组与它的最后的尺寸显示出重要不满。搭挡外套满足高。 | Javier Romero Otero Cesar Rojas Cruz Borja Garcia Gomez Joaquim Sarquella Geli lose Medina Polo Eduard Ruiz Castane Alfredo Rodriguez Antolin | 2017 | Asian Journal of Andrology2017，19，3： | 3 |
| 2 | Processing of ingredients and diets and effects on nutritional value for pigs显示文摘A conventional diet based on corn and soybean meal fed to pigs is usually provided in a mash form and in most cases, processing other than grinding and mixing is not used. However, due to the high cost of energy in pig diets,use of high fiber ingredients such as soybean hulls, distillers dried grains with solubles, and wheat middlings has increased. High fiber concentrations in the diet usually results in reduced energy and nutrient digestibility due to the low capacity of pigs to digest fiber, which negatively impacts growth performance and carcass composition of the pigs. Feed processing technologies such as changes in grinding procedures, expansion, extrusion, pelleting, use of enzymes or chemical treatments may, however, be used to solubilize some of the cel ulose and hemicel ulose fractions that form the cel wal of plants in the ingredients, and therefore, increase nutrient availability. This may have a positive effect on energy digestibility, and therefore, also on pig growth performance and carcass composition, but effects of different feed technologies on the nutritional value of feed ingredients and diets fed to pigs are not fully understood. It has however, been demonstrated that reduced particle size of cereal grains usually results in increased digestibility of energy, primarily due to increased digestibility of starch. Extrusion or expansion of ingredients or diets may also increase energy digestibility and it appears that the increase is greater in high fiber diets than in diets with lower concentrations of fiber. Chemical treatments have not consistently improved energy or nutrient digestibility, but a number of different enzymes may be used to increase the digestibility of phosphorus, calcium, or energy. Thus, there are several opportunities for using feed technology to improve the nutritional value of diets fed to pigs. | Oscar Javier Rojas Hans Henrik Stein | 2017 | Journal of Animal Science and Biotechnology2017，8，4： | 3 |
| 3 | A heuristic method for parameter selection in LS-SVM: Application to time series prediction显示文摘 | Ginés Rubio Héctor Pomares Ignacio Rojas Luis Javier Herrera | 2010 | International Journal of Forecasting2010，，3： | 1 |
| 4 | Synthesis and inhibitory activity of dimethylamino-chalcone derivatives on the induction of nitric oxide synthase显示文摘 | JAVIER ROJAS DOMI NGUEZ JOSE N CHARRIS JAIME E | 2002 | Eur J Med Chem2002，37，： | 1 |
| 5 | Combination of squamous cell carcinoma antigen immunocomplex and alpha-fetoprotein in mid-and long-term prediction of hepatocellular carcinoma among cirrhotic patients显示文摘BACKGROUND The combination of alpha-fetoprotein(AFP)and squamous cell carcinoma antigen immunocomplex(SCCA-IgM)have been proposed for its use in the screening of hepatocellular carcinoma(HCC).Current screening programs for all cirrhotic patients are controversial and a personalized screening is an unmet need in the precision medicine era.AIM To determine the role of the combination of SCCA-IgM and AFP in predicting mid-and long-term appearance of HCC.METHODS Two-hundred and three cirrhotic patients(Child A 74.9%,B 21.2%,C 3.9%)were followed-up prospectively every six months to screen HCC by ultrasound and AFP according to European Association for the Study of the Liver guidelines.The estimation cohort was recruited in Italy(30.5%;62/203)and validation cohort from Spain(69.5%;141/203).Patients underwent to evaluate SCCA-IgM by enzyme-linked immunosorbent assay(Hepa-IC,Xeptagen,Italy)and AFP levels at baseline.Patients were followed-up for 60 mo,being censored at the time of the appearance of HCC.RESULTS There were 10.8%and 23.1%of HCC development at two-and five-years followup.Patients with HCC showed higher levels of SCCA-IgM than those without it(425.72±568.33 AU/mL vs 195.93±188.40 AU/mL,P=0.009)during the fiveyear follow-up.In multivariate analysis,after adjusting by age,sex,aspartate transaminase and Child-Pugh,the following factors were independently associated with HCC:SCCA-IgM[Hazard ratio(HR)=1.001,95%CI:1.000-1.002;P=0.003],AFP(HR=1.028,95%CI:1.009-1.046;P=0.003)and creatinine(HR=1.56495%CI:1.151-2.124;P=0.004).The log-rank test of the combination resulted in 7.488(P=0.024)in estimation cohort and 11.061(P=0.004)in the validation cohort,and a 100%of correctly classified rate identifying a low-risk group in both cohorts in the two-year follow-up.CONCLUSION We have constructed a predictive model based on the combination of SCCA-IgM and AFP that provides a new HCC screening method,which could be followed by tailored HCC surveillance for individual patients,especially for those cirrhotic patients belonging to the subgroup identified as low-risk of HCC development. | Antonio Gil-Gómez Ángela Rojas Chang-Hai Liu Rocio Gallego-Duran Rocio Muñoz-Hernandez Giorgio Fassina Patrizia Pontisso Javier Ampuero Manuel Romero-Gómez | 2021 | World Journal of Gastroenterology2021，27，48： | 1 |
| 6 | Density, heat capacity and thermal conductivity of liquid egg products显示文摘 | Jane S.R. Coimbra Ana L. Gabas Luis A. Minim Edwin E. Garcia Rojas Vania R.N. Telis Javier Telis-Romero | 2005 | Journal of Food Engineering2005，，2： | 1 |
| 7 | Food supplementation by an invasive fleshy-fruited shrub sustains body condition of a native frugivorous bird during winter显示文摘Birds tend to adjust their behavior and physiology to changes in food availability in their environment.Seasonal fluctuation of food resources may act as an energetic challenge,augmenting hypothalamus-pituitary-adrenal axis(HPA axis)activity,leading to an increase in corticosterone concentrations and promoting the metabolism of energy stores.Plant invasions may alter seasonal food fluctuations by providing a food supply during scarce seasons.This could attenuate the energetic challenge,reducing HPA axis activity and the metabolism of reserves.Using a system with seasonal fluctuation in food availability,we tested if fruit supplementation by the invasive fleshy-fruited Pyracantha angustifolia during the season of native fruit scarcity decreases the consumption of energy stores through activity attenuation of the HPA axis.We measured changes in body condition and circulating corticosterone(CORT)concentration in Turdus chiguanco occurring at sites both invaded and not invaded by P.angustifolia over 3 time periods that correspond to the periods prior to,during and after highest fruit production of the plant.Fruit scarcity in the ecosystem appears as an energetic challenge for T.chiguanco,given that body mass,fat score and residuals of body mass/tarsus length decreased during winter in a site not invaded by the exotic shrub.Conversely,the presence of the invasive plant seemed to attenuate the metabolism of energetic reserves,as we did not record changes in body condition in birds inhabiting the invaded site.Unexpectedly,plasma CORT concentration did not vary between sites or periods.Further evaluation is required to elucidate how enhanced body condition,resulting from the consumption of a fleshy-fruited invasive plant,affects survivorship and reproductive performance in T.chiguanco. | Tobias Nicolas ROJAS David Lautaro VERGARA-TABARES Diego Javier VALDEZ Marina Flavia PONZIO Susana Inés PELUC | 2019 | Integrative Zoology2019，14，3： | 0 |
| 8 | 邦普朗2169号综合体,布宜诺斯艾利斯,阿根廷显示文摘从混合空间到差异空间终于,几乎所有人都认同我们的城市应当紧凑、密集、功能多样。尽管这些方面存在数量上的微妙差别,我们大部分的努力都是为了巩固不同于《雅典宪章》中所概括的实证主义的城市模型。农村人口向城市中心的迁移使得想象中的城市密度大大增加了,这迫使我们放弃了一个大面积的地块仅实现单一功能的想法。我们设想以不同方式拓展城市功能,使其更丰富多样。被称为混合功能的大型建筑就是这种工作路线的一个例子,将不同功能集中在一个项目中。今天,我们掌握了在设想的城市模型和大型建筑物之间建立某种连续性的技巧,然而,在一般规模的建筑中,此种关系尚未得到关注。 | 塞巴斯蒂安·阿达莫 马塞洛·费登 庞凌波(译) Javier Agustin Rojas(摄影) | 2020 | 世界建筑2020，，10： | 0 |
| 9 | Glutaminolysis-ammonia-urea Cycle Axis,Non-alcoholic Fatty Liver Disease Progression and Development of Novel Therapies显示文摘The prevalence of non-alcoholic fatty liver disease(NAFLD)is increasing worldwide,reflecting the current epidemics of obesity,insulin resistance,type 2 diabetes mellitus,and metabolic syndrome.NAFLD is characterized by the accumulation of fat in the liver,and is known to be a cause of cirrhosis.Although many pathways have been proposed,the cause of NAFLD-linked fibrosis progression is still unclear,which posed challenges for the development of new therapies to prevent NASH-related cirrhosis and hepatocellular carcinoma.Cirrhosis is associated with activation of hepatic stellate cells(HSC)and accumulation of excess extracellular matrix proteins,and inhibiting the activation of HSCs would be expected to slow the progression of NAFLD-cirrhosis.Multiple molecular signals and pathways such as oxidative stress and glutaminolysis have been reported to promote HSC activation.Both mechanisms are plausible antifibrotic targets in NASH,as the activation of HSCs the proliferation of myofibroblasts depend on those processes.This review summarizes the role of the glutaminolysis-ammonia-urea cycle axis in the context of NAFLD progression,and shows how the axis could be a novel therapeutic target. | Ángela Rojas María Rosario García-Lozano Antonio Gil-Gómez Manuel Romero-Gómez Javier Ampuero | 2022 | Journal of Clinical and Translational Hepatology2022，10，2： | 0 |
| 10 | Microfluidic bubble-generator enables digital light processing 3D printing of porous structures显示文摘Three-dimensional(3D)printing is an emerging technique that has shown promising success in engineering human tissues in recent years.Further development of vatphotopolymerization printing modalities has significantly enhanced the complexity level for 3D printing of various functional structures and components.Similarly,the development of microfluidic chip systems is an emerging research sector with promising medical applications.This work demonstrates the coupling of a digital light processing(DLP)printing procedure with a microfluidic chip system to produce size-tunable,3D-printable porosities with narrow pore size distributions within a gelatin methacryloyl(GelMA)hydrogel matrix.It is found that the generation of size-tunable gas bubbles trapped within an aqueous GelMA hydrogel-precursor can be controlled with high precision.Furthermore,the porosities are printed in two-dimensional(2D)as well as in 3D using the DLP printer.In addition,the cytocompatibility of the printed porous scaffolds is investigated using fibroblasts,where high cell viabilities as well as cell proliferation,spreading,and migration are confirmed.It is anticipated that the strategy is widely applicable in a range of application areas such as tissue engineering and regenerative medicine,among others. | Philipp Weber Ling Cai Francisco Javier Aguilar Rojas Carlos Ezio Garciamendez-Mijares Maria Celeste Tirelli Francesco Nalin Jakub Jaroszewicz Wojciech Swi eszkowski Marco Costantini Yu Shrike Zhang | 2024 | Aggregate2024，5，1： | 0 |
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