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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 黄芪总黄酮对扑热息痛所致肝损伤的防护机理探讨显示文摘目的 :研究黄芪总黄酮对扑热息痛所致肝损伤的防护机理。方法 :用高压液相测定扑热息痛及代谢产物和苯巴比妥诱导睡眠模型研究黄芪总黄酮 (TFA)对扑热息痛的代谢及TFA抗扑热息痛所致损伤的机理。结果 :TFA可明显降低尿中硫醚胺酸的浓度 ,其变化与TFA浓度成反比 ;但对其它代谢产物的影响无明显统计学差异。苯巴比妥诱导小鼠睡眠实验结果显示 ,TFA (10 0mg·kg-1)本身对苯巴比妥代谢无明显影响 (P >0 .0 5 ) ,扑热息痛 (40 0mg·kg-1)可显著延长小鼠的睡眠时间 (P <0 .0 0 1) ;但TFA (10 0mg·kg-1)明显缩短扑热息痛所延长的苯巴比妥诱导的睡眠时间 (P <0 .0 0 5 )。结论 | 汪德清 Critchley Julian AJH 丁保国 马艳青 赵海潞 Thomas G Neil 田亚平 Tomlinson B rian Critchley Lester AH James Anthony Edward | 2001 | 中国中药杂志2001，26，9： | 13 |
| 3 | Effect of Graphene Nanoribbons (TexasPEG) on locomotor function recovery in a rat model of lumbar spinal cord transection显示文摘A sharply transected spinal cord has been shown to be fused under the accelerating influence of membrane fusogens such as polyethylene glycol(PEG)(GEMINI protocol). Previous work provided evidence that this is in fact possible. Other fusogens might improve current results. In this study, we aimed to assess the effects of PEGylated graphene nanoribons(PEG-GNR, and called 'Texas PEG' when prepared as 1 wt% dispersion in PEG600) versus placebo(saline) on locomotor function recovery and cellular level in a rat model of spinal cord transection at lumbar segment 1(L_1) level. In vivo and in vitro experiments(n = 10 per experiment) were designed. In the in vivo experiment, all rats were submitted to full spinal cord transection at L_1 level. Five weeks later, behavioral assessment was performed using the Basso Beattie Bresnahan(BBB) locomotor rating scale. Immunohistochemical staining with neuron marker neurofilament 200(NF200) antibody and astrocytic scar marker glial fibrillary acidic protein(GFAP) was also performed in the injured spinal cord. In the in vitro experiment, the effects of Texas PEG application for 72 hours on the neurite outgrowth of SH-SY5 Y cells were observed under the inverted microscope. Results of both in vivo and in vitro experiments suggest that Texas PEG reduces the formation of glial scars, promotes the regeneration of neurites, and thereby contributes to the recovery of locomotor function of a rat model of spinal cord transfection. | C-Yoon Kim William K. A. Sikkema Jin Kim Jeong Ah Kim James Walter Raymond Dieter Hyung-Min Chung Andrea Mana James M. Tour Sergio Canavero | 2018 | Neural Regeneration Research2018，13，8： | 2 |
| 4 | A multicenter,prospective,randomized trial evaluating the X-stop interspinous process decompression system for the treatment of neurogenic intermittent claudication显示文摘 | James F Ken YH Charles AH | 2005 | Spine2005，30，12： | 1 |
| 5 | Thrombosis,thrombophilia,and thromboprophylaxis in pregnancy显示文摘 | James AH Brancazio LR Ortel TL | 2005 | Clin Adv Hematol Oncol2005，3，3： | 1 |
| 6 | A multicenter,prospective,randomized trial evaluating the XSTOP interspinous process decompression system for the treatment of neurogenic intermittent claudication显示文摘 | James F Ken YH Charles AH | 2005 | Spine2005，30，12： | 1 |
| 7 | Thromboembolism in pregnancy : recurrence risks, preven- tion and management 显示文摘 | James AH | 2008 | Curt Opin Obstet Gynecol2008，20，6： | 1 |
| 8 | Incidence and risk fac- tors for stroke in pregnancy and the puerperium显示文摘 | James AH Bushnell CD Jamison MG | 2005 | Obstet Gyneeol2005，106，： | 1 |
| 9 | Acute myocardial infarction in pregnancy:a United States population based study显示文摘 | James AH Jamison MG Biswas MS | 2006 | Circulation2006，113，： | 1 |
| 10 | Beware of the Pos- sibility of Fingerprinting Techniques Transferring DNA 显示文摘 | Roland AH Sally T James B | 2005 | J Forensic Sci2005，50，6： | 1 |
| 11 | Immobilized poly-L-histidine for chelation of metal cations and metal oxyanions显示文摘 | James AH | 2003 | Anal Chlm Acta2003，495，： | 1 |
| 12 | Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study显示文摘 | Heit JA Kobbervig CE James AH | 2005 | Ann Intern Med2005，143，10： | 1 |
| 13 | How I treat thrembocytopenia in pregnancy显示文摘 | Gernsheimer T James AH Stasi R | 2013 | Blood2013，121，1： | 1 |
| 14 | Origin,incidence,and management of nongynecologic pelvic masses seen on cross-sectional imaging显示文摘 | Dotters-Katz SK James AH Gardner C | 2015 | J Reprod Med2015，60，56： | 1 |
| 15 | A muhicenter, prospective, randomized trial evaluating the XSTOP interspinous process decompression system for the treatment of neurogenic intermittent claudication 显示文摘 | James F Ken YH Charles AH | 2005 | Spine2005，30，： | 1 |
| 16 | A multicenter, prospective, randomized trial evaluating the XSTOP interspinous process decompression system for the treatment of neurogenic intermittent claudication 显示文摘 | James F Ken YH Charles AH | 2005 | Spine2005，12，： | 1 |
| 17 | Incidence and risk factors for stroke in pregnancy and the puerperium 显示文摘 | James AH Bushnell CD Jamison MG | 2005 | Obstet Gyneeol2005，106，3： | 1 |
| 18 | Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study显示文摘 | Heit JA Kobbervig CE James AH | 2005 | Ann Intern Med2005，143，10： | 1 |
| 19 | Bleeding disorders in premenopausal women:(another)public health crisis for hematology显示文摘 | JAMES AH RAGNI MV PICOZZI VJ | 2006 | Hematology Am Soc Hematol Educ Program2006，，： | 1 |
| 20 | Incidence and risk factors for stroke in pregnancy and the puerperium显示文摘 | James AH Bushnell CD Jamison MG | 2005 | Obstet Gyne- col2005，106，： | 1 |
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