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| 1 | 谷氨酰胺、精氨酸和亮氨酸在肠道中的信号传导(一)显示文摘动植物蛋白中谷氨酰胺和亮氨酸含量丰富且较稳定,而食物和动物体液中精氨酸含量差异较大。除在蛋白质合成中起作用外,这三种氨基酸可独自激活信号传导通路以促进蛋白质的合成,并可能抑制肠上皮细胞自噬介导的蛋白质降解。此外,谷氨酰胺和精氨酸可分别激活有丝分裂原活化蛋白激酶通路和哺乳动物雷帕霉素靶蛋白(mTOR)/p70(s6)激酶通路,从而加强粘膜细胞的迁移和修复。利用一氧化氮依赖型cGMP的信号级联,精氨酸可调节肠道多种生理活动,这有利于细胞的生存和维持动态平衡。动物体内外试验显示,谷氨酰胺和精氨酸可促进细胞增殖,并可针对养分损失、氧化损伤、应激和免疫应激来发挥不同的细胞保护作用。此外,一氧化氮存在时亮氨酸可加强肠道细胞的迁移。因此,通过细胞信号传导机制,精氨酸、谷氨酰胺和亮氨酸在肠道的生长发育和功能完善过程中发挥了关键作用。 | J.Marc Rhoads Guoyao Wu 邓会玲 | 2011 | 饲料与畜牧(新饲料)2011，，9： | 3 |
| 2 | Brain-targeting,acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery显示文摘Stroke is the leading cause of death and disability.Currently,there is no effective pharmacological treatment for this disease,which can be partially attributed to the inability to efficiently deliver therapeutics to the brain.Here we report the development of natural compound-derived nanoparticles(NPs),which function both as a potent therapeutic agent for stroke treatment and as an efficient carrier for drug delivery to the ischemic brain.First,we screened a collection of natural nanomaterials and identified betulinic acid(BA)as one of the most potent antioxidants for stroke treatment.Next,we engineered BA NPs for preferential drug release in acidic ischemic tissue through chemically converting BA to betulinic amine(BAM)and for targeted drug delivery through surface conjugation of AMD3100,a CXCR4 antagonist.The resulting AMD3100-conjugated BAM NPs,or A-BAM NPs,were then assessed as a therapeutic agent for stroke treatment and as a carrier for delivery of NA1,a neuroprotective peptide.We show that intravenous administration of A-BAM NPs effectively improved recovery from stroke and its efficacy was further enhanced when NA1 was encapsulated.Due to their multifunctionality and significant efficacy,we anticipate that A-BAM NPs have the potential to be translated both as a therapeutic agent and as a drug carrier to improve the treatment of stroke. | Shenqi Zhang Bin Peng Zeming Chen Jiang Yu Gang Deng Youmei Bao Chao Ma Fengyi Du Wendy C.Sheu W.Taylor Kimberly J.Marc Simard Daniel Coman Qianxue Chen Fahmeed Hyder Jiangbing Zhou Kevin N.Sheth | 2022 | Bioactive Materials2022，7，10： | 1 |
| 3 | Is reperfusion injury an important cause of mucosal damage after porcine intestinal ischemia?显示文摘 | Anthony T Blikslager Malcolm C Roberts J.Marc Rhoads Robert A Argenzio | 1997 | Surgery1997，，5： | 1 |
| 4 | Coal mining along the Warfield Fault, Mingo County, West Virginia: a tale of ups and downs显示文摘 | J.Marc Coolen | 2003 | International Journal of Coal Geology2003，，3： | 1 |
| 5 | Pharmacological induced target temperature management after cardiac arrest: the capsaicinoids显示文摘Cardiac or respiratory arrest lasting only a few minutes can inflict grave harm on numerous bodily organs,not least of all,the brain.Neurocognitive deficits,which are often severe and profoundly life altering,remain a major source of morbidity among survivors.Post-arrest brain injury is extraordinarily difficult to treat.With the exception of anti-seizure medications, | J.Marc Simard Xiaofeng Jia Volodymyr Gerzanich | 2017 | Neural Regeneration Research2017，12，10： | 0 |
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