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| 1 | Review of efficacy and safety of laxatives use in geriatrics显示文摘AIM:To study the efficacy and safety of pharmacolo-gical treatment of constipation in geriatrics.METHODS:Pub Med,MEDLINE,google scholar,and Ovid were searched to identify human studies performed on the use of laxatives in elderly with constipation,which were conducted between January1990 and January 2013 using the specified keywords.Controlled studies that enrolled geriatric patients with a diagnosis of constipation and addressed the efficacy and/or the safety of pharmacological treatments were included.Studies were excluded from this review if they were non-controlled trials,case series,or case reports.RESULTS:Out of twenty three studies we initially retrieved in our search,only nine studies met the eligibility criteria of being controlled trials within geriatrics.The laxatives examined in the nine studies were senna,lactulose,sorbital,polyethylene glycol(PEG),lubiprostone,linaclotide,and prucalopride.In those studies,senna combinations had a higher efficacy than sorbitol or lactulose as well as,a very good adverse effect profile.PEG was also shown to be safe and effective in geriatric population.Furthermore,it has been shown that PEG is as safe in geriatrics as in general population.New agents like lubiprostone and prucalopride show promising results but the data about these agents in geriatrics are still limited which warrant further investigation.CONCLUSION:Senna combinations and PEG appear to have a more favorable profile over the other traditionally used laxatives in elderly patients with constipation. | Manhal Izzy Anju Malieckal Erin Little Sury Anand | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，2： | 3 |
| 2 | Effects of moisture damage on asphalt mixtures显示文摘The reduction in the ability of bitumen to bond with the aggregate surface due to the infiltration of moisture has been recognised for years, and this deterioration phenomenon is called moisture damage. In general, the loss of bonding between bitumen and aggregate shortens the service life of the top layer of the pavement. Many investigations have been conducted to understand the mechanisms of moisture damage due to the loss of bonding strength between bitumen and aggregate and to find ways to improve and strengthen the bond to mitigate the effect of moisture. This paper reviews the extensive literature on the loss of bitumen-aggregate bonding strength due to moisture damage in asphalt mixtures.The general description of the theories and mechanisms that explain the effect of the thermodynamic, chemical, physical and mechanical characteristics of the bitumen and aggregate on the bonding phenomenon are discussed in this paper. In addition, the causes of and contributing factors to moisture damage and methods to improve the bond between bitumen and aggregates are also discussed. Moreover, a description of the test methods that can be used to evaluate moisture damage in poorly bonded and compacted mixtures are also presented. Special attention is given to a well-known method, known as the pulloff test, which has been successfully used to evaluate aggregate-binder bond strength, both for laboratory and in-situ tests. This includes the test methods, the factors that affect the bonding strength results and their correlation with other test method. A review of the failure mode of bitumen under the pull-off loading test is discussed in the final section of this paper. | Hend Ali Omar Nur Izzi MdYusoff Muhammad Mubaraki Halil Ceylan | 2020 | Journal of Traffic and Transportation Engineering(English Edition)2020，7，5： | 3 |
| 3 | Detection of autoanti- bodies against tissue transglutaminase in patients with celiac dis- ease and dermatitis herpetiformis 显示文摘 | KOOP I ILCHMANN R IZZI L | 2000 | Am J Gastroenterol2000，95，8： | 1 |
| 4 | Boc and Gasl each form distinct Shh receptor complexes with Ptchl and are required for Shh-mediated cell proliferation 显示文摘 | Izzi L L6vesque M Morin S | 2011 | Dev Cell2011，20，6： | 1 |
| 5 | Sumoylation differen- tially regulates Goosecoid-mediated transcriptional re- pression显示文摘 | Izzi L Narimatsu M Attisano L | 2008 | Exp Cell Res2008，314，7： | 1 |
| 6 | Parameterization and evaluation of the AquaCmp model for full and deficit irrigated cotton显示文摘 | Farahani H J Izzi G Oweis T Y | 2009 | Agronmy Journal2009，101，3： | 1 |
| 7 | Regulators of platelet cAMP levels: clinical and therapeutic implications 显示文摘 | Noe L Peeters K Izzi B | 2010 | Curr Med Chem2010，17，26： | 1 |
| 8 | From genetics to epigenetics in plate- let research 显示文摘 | Freson K Izzi B Van Geet C | 2012 | Thromb Res2012，129，3： | 1 |
| 9 | Brain Natriuretic Peptide ( BNP ) regulates the production of inflammatory mediators in human THP-I macrophages显示文摘 | Chiurchiu V Izzi V D'Aquilio F | 2008 | Regul Pept2008，148，13： | 1 |
| 10 | Familial aggregation of primary glomerulonephritis in an Italian population isolate:Valtrompia study显示文摘 | Izzi C Sanna-Cherchi S Prati E | | 0，，： | 1 |
| 11 | Isolated fractures of the greater tuberosity of the proximal humerus显示文摘 | Green A Izzi J Jr | 2003 | J Shoulder Elbow Surg2003，12，6： | 1 |
| 12 | Calibration and validation of FAO-AquaCrop model for irrigated and water deficient Bambara groundnut显示文摘 | Karunaratoe A S Azam-Ali S N Izzi G | 2011 | Experimental Agriculture2011，47，3： | 1 |
| 13 | Parameterization and evalua- tion of the AquaCrop Model for full and deficit irrigated cotton 显示文摘 | Farahani H J Izzi G Oweis T Y | 2009 | Agronomy Journal2009，101，3： | 1 |
| 14 | SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolism显示文摘 | BULER M AATSINKI S M IZZI V | 2014 | The FASEB Journal2014，28，7： | 1 |
| 15 | Regulation of the TGF beta signaling pathway by ubiquitin mediated degradation 显示文摘 | Izzi L Attisano L | 2004 | Oncogene2004，23，11： | 1 |
| 16 | From genetics to epigenetics in plateletresearch显示文摘 | Freson K Izzi B Van Geet C | 2011 | Thromb Res2011，10，： | 1 |
| 17 | Platelet- leukocyte interactions in thrombosis 显示文摘 | Cerletti C Tamburrelli C Izzi B | 2012 | Thromb Res2012，129，3： | 1 |
| 18 | The transcri ptional role of Smads and FAST(FoxHI)in TGF-beta and activin signalling显示文摘 | Attisano L Silvestri C Izzi L | 2008 | Mol Cell Endoc rinol2008，180，12： | 1 |
| 19 | Inhibitory action on GHRH-induced GH secretion of chronic treatment breast cancer 显示文摘 | De Marinis L Mancini A Izzi D | 2000 | Clin Endocrinol2000，52，6： | 1 |
| 20 | Regulation of the tgf beta signaling pathway by ubiquitin-mediated degradation显示文摘 | Izzi L Attisano L | 2000 | Molecular Cell2000，6，： | 1 |
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