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| 1 | Photobiomodulation for the treatment of retinal diseases: a review显示文摘Photobiomodulation(PBM), also known as low level laser therapy, has recently risen to the attention of the ophthalmology community as a promising new approach to treat a variety of retinal conditions including age-related macular degeneration, retinopathy of prematurity,diabetic retinopathy, Leber's hereditary optic neuropathy,amblyopia, methanol-induced retinal damage, and possibly others. This review evaluates the existing research pertaining to PBM applications in the retina,with a focus on the mechanisms of action and clinical outcomes. All available literature until April 2015 was reviewed using Pub Med and the following keywords : 'photobiomodulation AND retina', 'low level light therapy AND retina', 'low level laser therapy AND retina', and 'FR/NIR therapy AND retina'. In addition, the relevant references listed within the papers identified through Pub Med were incorporated. The literature supports the conclusion that the low-cost and non-invasive nature of PBM, coupled with the first promising clinical reports and the numerous preclinical-studies in animal models, make PBM well-poised to become an important player in the treatment of a wide range of retinal disorders. Nevertheless, large-scale clinical trials will be necessary to establish the PBM therapeutic ranges for the various retinal diseases, as well as to gain a deeper understanding of its mechanisms of action. | Ivayla I.Geneva | 2016 | International Journal of Ophthalmology(English edition)2016，9，1： | 9 |
| 2 | A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis显示文摘Several developmental stages of spermatogenesis are transcriptionally quiescent which presents major challenges associated with the regulation of gene expression. Here we identify that the zygotene to pachytene transit!on is not only associated with the resumption of transcription but also a wave of programmed mRNA degradation that is essential for meiotic progress!on. We explored whether terminal uridydyl transferase 4-(TUT4-) or TUT7-mediated 3' mRNA uridylation contributes to this wave of mRNA degradation during pachynema. Indeed, both TUT4 and TUT7 are expressed throughout most of spermatogenesis, however, loss of either TUT4 or TUT7 does not have any major impact upon spermatogenesis. Combined TUT4 and TUT7 (TUT4/7) deficiency results in embryonic growth defects, while conditional gene targeting revealed an essential role for TUT4/7 in pachytene progression. Loss of TUT4/7 results in the reduction of miRNA, piRNA and mRNA 31 uridylation. Although this reduction does not greatly alter miRNA or piRNA expression, TUT4/7-mediated uridylation is required for the clearanee of many zygotene-expressed transcripts in pachytene cells. We find that TUT4/7-regulated transcripts in pachytene spermatocytes are characterized by having long 3Z UTRs with length-adjusted enrichment for AU-rich elements. We also observed these features in TUT4/7-regulated maternal transcripts whose dosage was recently shown to be essential for sculpting a functional maternal transcriptome and meiosis. Therefore, mRNA 3Z uridylation is a critical determinant of both male and female germline transcriptomes. In conclusion, we have identified a novel requirement for 3' uridylation-programmed zygotene mRNA clearanee in pachytene spermatocytes that is essential for male meiotic progression. | Marcos Morgan Yuka Kabayama Christian Much Ivayla Ivanova Monica Di Giacomo Tatsiana Auchynnikava Jack Michael Monahan Dimitrios Michael Vitsios Lina Vasiliauskaite Stefano Comazzetto Juri Rappsilber Robin Campbell Allshire Bo Torben Porse Anton James Enright Donal O'Carroll | 2019 | Cell Research2019，29，3： | 1 |
| 3 | SPECT/CT stabilizes the interpretation of somatostatin receptor scintigraphy findings: a retrospective analysis of inter-rater agreement显示文摘 | Ivayla Apostolova Swantje Riethdorf Ralph Buchert Thorsten Derlin Winfried Brenner Janos Mester Susanne Klutmann | 2010 | Annals of Nuclear Medicine2010，，： | 1 |
| 4 | Tenascin -R restricts posttraumatie remodeling of motoneuren innervation and functional recovery after spinal cord injury in adult mice显示文摘 | IVAYLA A ANDREY I MELITTA S | 2006 | Neumbiol Dis2006，26，30： | 1 |
| 5 | Synthesis, Spectral Properties, Antibacterial and Antitumor Activity of Salinomycin Complexes with the Transition Metal Ions Co(ll), Ni(ll), Cu(ll) and Zn(ll)显示文摘 | Juliana Ivanova Ivayla N. Pantcheva Rumyana Zhorova Georgi Momekov Svetlana Simova Radostina Stoyanova Ekaterina Zhecheva Simona Ivanova Mariana Mitewa | 2012 | Journal of Chemistry and Chemical Engineering2012，6，6： | 0 |
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