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| 1 | 致病的概念和胆石病的治疗显示文摘 Gallstone disease(GD) is a chronic recurrent hepatobiliary disease,the basis for which is the impaired metabolism of cholesterol,bilirubin and bile acids,which is characterized by the formation of gallstones in the hepatic bile duct,common bile duct,or gallbladder.GD is one of the most prevalent gastrointestinal diseases with a substantial burden to health care systems.GD can result in serious outcomes,such as acute gallstone pancreatitis and gallbladder cancer.The epidemiology,pathogenesis and treatment of GD are discussed in this review.The prevalence of GD varies widely by region.The prevalence of gallstone disease has increased in recent years.This is connected with a change in lifestyle:reduction of motor activity,reduction of the physical load and changes to diets.One of the important benefits of early screening for gallstone disease is that ultrasonography can detect asymptomatic cases,which results in early treatment and the prevention of serious outcomes.The pathogenesis of GD is suggested to be multifactorial and probably develops from complex interactions between many genetic and environmental factors.It suggests that corticosteroids and oral contraceptives,which contain hormones related to steroid hormones,may be regarded as a model system of cholelithiasis development in man.The achievement in the study of the physiology of bile formation and the pathogenesis of GD has allowed expanding indications for therapeutic treatment of GD. | Vasiliy Ivanovich Reshetnyak | 2012 | World Journal of Hepatology2012，4，2： | 39 |
| 2 | 基于改进YOLOv3算法的公路车道线检测方法显示文摘针对YOLOv3算法在检测公路车道线时存在准确率低和漏检概率高的问题,提出一种改进YOLOv3网络结构的公路车道线检测方法.该方法首先将图像划分为多个网格,利用K-means++聚类算法,根据公路车道线宽高固有特点,确定目标先验框数量和对应宽高值;其次根据聚类结果优化网络Anchor参数,使训练网络在车道线检测方面具有一定的针对性;最后将经过Darknet-53网络提取的特征进行拼接,改进YOLOv3算法卷积层结构,使用GPU进行多尺度训练得到最优的权重模型,从而对图像中的车道线目标进行检测,并选取置信度最高的边界框进行标记.使用Caltech Lanes数据库中的图像信息进行对比试验,实验结果表明,改进的YOLOv3算法在公路车道线检测中平均准确率(Mean average precision, mAP)为95%,检测速度可达50帧/s,较YOLOv3原始算法mAP值提升了11%,且明显高于其他车道线检测方法. | 崔文靓 王玉静 康守强 谢金宝 王庆岩 MIKULOVICH Vladimir Ivanovich | 2022 | 自动化学报2022，48，6： | 20 |
| 3 | Significance of dormant forms of Helicobacter pylori in ulcerogenesis显示文摘Nearly half of the global population are carriers of Helicobacter pylori(H. pylori),a Gram-negative bacterium that persists in the healthy human stomach. H. pylori can be a pathogen and causes development of peptic ulcer disease in a certain state of the macroorganism. It is well established that H. pylori infection is the main cause of chronic gastritis and peptic ulcer disease(PUD). Decontamination of the gastric mucosa with various antibiotics leads to H. pylori elimination and longer remission in this disease. However,the reasons for repeated detection of H. pylori in recurrent PUD after its successful eradication remain unclear. The reason for the redetection of H. pylori in recurrent PUD can be either reinfection or ineffective anti-Helicobacter therapy. The administration of antibacterial drugs can lead not only to the emergence of resistant strains of microorganisms,but also contribute to the conversion of H. pylori into the resting(dormant) state. The dormant forms of H. pylori have been shown to play a potential role in the development of relapses of PUD. The paper discusses morphological H. pylori forms,such as S-shaped,C-shaped,U-shaped,and coccoid ones. The authors proposes the classification of H. pylori according to its morphological forms and viability. | Vasiliy Ivanovich Reshetnyak Tatiana Magomedalievna Reshetnyak | 2017 | World Journal of Gastroenterology2017，23，27： | 19 |
| 4 | Primary biliary cirrhosis: Clinical and laboratory criteria for its diagnosis显示文摘Primary biliary cirrhosis(PBC) is a chronic progressive cholestatic granulomatous, and destructive inflammatory lesion of small intralobular and septal bile ducts, which is likely to be caused by an autoimmune mechanism with a the presence of serum antimitochondrial antibodies and a potential tendency to progress to cirrhosis. Despite the fact that the etiology of this disease has beenunknown so far, there has been a considerable body of scientific evidence that can reveal the clinical and laboratory signs of PBC and the individual components of its pathogenesis and elaborate diagnostic criteria for the disease and its symptomatic therapy. Deficiencies in autoimmune tolerance are critical factors for the initiation and perpetuation of the disease. The purpose of this review is to summarize the data available in the literature and the author's findings on clinical and laboratory criteria for the diagnosis of PBC. This review describes the major clinical manifestations of the disease and the mechanisms of its development. It presents the immunological, biochemical, and morphological signs of PBC and their significance for its diagnosis. A great deal of novel scientific evidence for the problem of PBC has been accumulated. However, the inadequate efficiency of therapy for the disease lends impetus to the quest for its etiological factors and to further investigations of its pathogenetic mechanisms and, on this basis, to searches for new methods for its early diagnosis. | Vasiliy Ivanovich Reshetnyak | 2015 | World Journal of Gastroenterology2015，21，25： | 19 |
| 5 | 基于改进SAE和双向LSTM的滚动轴承RUL预测方法显示文摘针对稀疏自动编码器(Sparse auto encoder,SAE)采用sigmoid激活函数容易造成梯度消失的问题,用一种新的Tan函数替代原有的sigmoid函数;针对SAE采用Kullback-Leibler(KL)散度进行稀疏性约束在回归预测方面的局限性,以dropout机制替代KL散度实现网络的稀疏性.利用改进SAE对滚动轴承振动信号进行无监督深层特征自适应提取,无需人工设计标签进行有监督微调.同时,考虑到滚动轴承剩余使用寿命(Remaining useful life,RUL)预测方法一般仅考虑过去信息而忽略未来信息,引入双向长短时记忆网络(Bi-directional long short-term memory,Bi-LSTM)构建滚动轴承RUL的预测模型.在2个轴承数据集上的实验结果均表明,所提基于改进SAE和Bi-LSTM的滚动轴承RUL预测方法不仅可以提高模型的收敛速度而且具有较低的预测误差. | 康守强 周月 王玉静 谢金宝 MIKULOVICH Vladimir Ivanovich | 2022 | 自动化学报2022，48，9： | 13 |
| 6 | Concept on the pathogenesis and treatment of primary biliarycirrhosis显示文摘Primary biliary cirrhosis (PBC) is an organ-specific autoimmune disease that predominantly affects women and is characterized by chronic, progressive destruction of small intrahepatic bile ducts with portal inflammation and ultimately fibrosis, leading to liver failure in the absence of treatment. Little is known about the etiology of PBC. PBC is characterized by anti-mitochondrial antibodies and destruction of intrahepatic bile ducts. The serologic hallmark of PBC is the presence of auto-antibodies to mitochondria, especially to the E2 component of the pyruvate dehydrogenase complex (PDC). Current theories on the pathogenesis of PBC favor the hypothesis that the disease develops as a result of an inappropriate immune response following stimulation by an environmental or infectious agent. Some reports suggest that xenobiotics and viral infections may induce PBC. The pathogenetic mechanism is believed to be caused by a defect in immunologic tolerance, resulting in the activation and expansion of self-antigen specific T and B lymphocyte clones and the production of circulating autoantibodies in addition to a myriad of cytokines and other inflammatory mediators. This leads to ductulopenia and persistent cholestasis, by developing end-stage hepatic-cell failure. In this review are given our own and literary data about mechanisms of development of intrahepatic cholestasis and possible ways of its correction. | Vasiliy Ivanovich Reshetnyak | 2006 | World Journal of Gastroenterology2006，12，45： | 10 |
| 7 | Hepatitis G virus显示文摘A number of new hepatitis viruses (G, TT, SEN) were discovered late in the past century. We review the data available in the literature and our own findings suggesting that the new hepatitis G virus (HGV), disclosed in the late 1990s, has been rather well studied. Analysis of many studies dealing with HGV mainly suggests the lymphotropicity of this virus. HGV or GBV-C has been ascertained to influence course and prognosis in the HIV-infected patient. Until now, the frequent presence of GBV-C in coinfections, hematological diseases, and biliary pathology gives no grounds to determine it as an 'accidental tourist' that is of no significance. The similarity in properties of GBV-C and hepatitis C virus (HCV) offers the possibility of using HGV, and its induced experimental infection, as a model to study hepatitis C and to develop a hepatitis C vaccine. | Vasiliy Ivanovich Reshetnyak Tatiana Igorevna Karlovich Ljudmila Urievna Ilchenko | 2008 | World Journal of Gastroenterology2008，14，30： | 9 |
| 8 | Physiological and molecular biochemical mechanisms of bile formation显示文摘This review considers the physiological and molecular biochemical mechanisms of bile formation.The composition of bile and structure of a bile canaliculus,biosynthesis and conjugation of bile acids,bile phospholipids,formation of bile micellar structures,and enterohepatic circulation of bile acids are described.In general,the review focuses on the molecular physiology of the transporting systems of the hepatocyte sinusoidal and apical membranes.Knowledge of physiological and biochemical basis of bile formation has implications for understanding the mechanisms of development of pathological processes,associated with diseases of the liver and biliary tract. | Vasiliy Ivanovich Reshetnyak | 2013 | World Journal of Gastroenterology2013，19，42： | 6 |
| 9 | 纳米流体驱提高原油采收率的三维孔隙尺度模拟显示文摘基于不同渗透率岩心的三维微观模型,采用流体体积法对纳米流体驱油进行数值模拟;利用实验测得的含SiO_(2)纳米颗粒的悬浮液界面张力、接触角和黏度,针对质量分数为0~1%、具有不同粒径的SiO_(2)纳米颗粒的水基悬浮液,研究了纳米颗粒质量分数和粒径、驱替液流速、原油黏度和岩心渗透率对纳米流体驱油效率的影响。研究表明:采收率随着颗粒质量分数的增加而增加,纳米颗粒质量分数增加到0.5%时,与水驱相比采收率可提高约19%;纳米流体驱油采收率随着纳米颗粒粒径的减小而增加;在毛管数接近临界值的注入模式下使用纳米流体驱油对高黏低渗储集层提高采收率最为有效,且提高采收率幅度随着驱替速度的增加而减小;原油黏度越大,岩石渗透率越小,纳米流体驱油提高采收率的效果越明显。图16表2参37。 | MINAKOV Andrey Viktorovich GUZEI Dmitriy Viktorovich PRYAZHNIKOV Мaxim Ivanovich FILIMONOV Sergey Anatol'yevich VORONENKOVA Yulia Olegovna | 2021 | 石油勘探与开发2021，48，4： | 5 |
| 10 | 促进中国循环经济发展的税收政策研究 | Boris Ivanovich Sokolov 刘宇卓 | 2011 | 现代经济信息2011，0，14： | 4 |
| 11 | Helicobacter pylori:Commensal,symbiont or pathogen?显示文摘This review considers the data on Helicobacter pylori(H.pylori),which have been accumulated over 40 years since its description as an etiological factor in gastrointestinal diseases.The majority of modern publications are devoted to the study of the pathogenic properties of the microorganism in the development of chronic gastritis,peptic ulcer disease,and gastric cancer,as well as methods for its eradication.However,in recent years,there have been more and more studies which have suggested that H.pylori has a beneficial,or potentially positive,effect on the human body.The authors have attempted to objectively analyze the information accumulated in the literature on H.pylori.Some studies consider it as one of the recently identified human bacterial pathogens,and special attention is paid to the evidence suggesting that it is probably part of the composition of the human microbiome as a commensal(commensal from French to English is a table companion)or even a symbiont.The presented data discussing the presence or absence of the effect of H.pylori on human health suggest that there is an apparent ambiguity of the problem.The re-assessment of the data available on H.pylori infection is important in order to answer the question of whether it is necessary to create a program of mass H.pylori eradication or to apply a more personalized approach to treating patients with H.pylori-associated gastrointestinal diseases and to perform eradication therapy. | Vasiliy Ivanovich Reshetnyak Alexandr Igorevich Burmistrov Igor Veniaminovich Maev | 2021 | World Journal of Gastroenterology2021，27，7： | 4 |
| 12 | 腐殖质生理活性及其与化学组成关系的研究进展显示文摘腐殖质(HS)是生物体外具备生物学活性的最稳定有机物形式之一。本文综述了HS的化学组成、结构特征和生理活性,依据HS化学组成、结构特征和生理活性的相互关系探讨了HS具有生理活性的内在机制。HS化学组成具有不确定性,超分子结构假设目前被普遍接受。HS通过促进根毛形成和侧根发育、激活质膜H+-ATP酶产生有利的电化学梯度以及自身酸性官能团的螯合作用等促进植物对矿质元素的吸收利用;HS具有类激素活性,植物根际促生细菌(PGPR)分泌物或HS自体组分吲哚-3-乙酸(IAA)能够激活细胞质膜H+-ATPase,HS还能够增加内源植物激素水平,促进植物生长发育;HS通过介导信使NO激活细胞质膜H+-ATPase,清除HS与细胞作用产生的活性氧(ROS),HS通过NO和抗氧化酶调节细胞内ROS稳态,介导根系发育和形态结构。本文还着重探讨了HS生理活性与化学组成的相关性,其中官能团—COOH和—OH活性位点的作用、醌基的电子传递,以及HS亲水疏水平衡与HS生理活性密切相关。未来HS研究工作的重点在于深入研究HS分子结构、明确具备生理活性的“共性结构原件”、阐明HS诱导胞内信号传导通路之间的交叉反馈机制、揭示HS对细胞内物质和能量代谢相关基因表达的调节机制。 | 宋鸽 POPOV Alexander Ivanovich 石峰 | 2021 | 农业资源与环境学报2021，38，4： | 4 |
| 13 | Left atrial appendage aneurysm: A case report显示文摘BACKGROUND An aneurysm of the left atrial appendage is one of the rare but potentially hazardous heart defects.The risk of lethal complications grows with its size.To date,about 150 cases of this defect have been described in the literature.We present a case of left atrial appendage aneurysm with the deformation of the mitral valve and the left main coronary and circumflex artery,which required mitral valve annuloplasty and bifurcation stenting.CASE SUMMARY A 58-year-old man presented to our hospital complaining of shortness of breath,general weakness,dizziness during physical exertion,and fatigue.Based on the results of echocardiography,an aneurysm of the left atrium was suspected.A free-breathing real-time cine magnetic resonance imaging with electrocardiograph synchronization confirmed the diagnosis of left atrial appendage aneurysm.The patient underwent an aneurysmectomy via a median sternotomy with cardiopulmonary bypass.Intraoperative transesophageal echocardiography revealed relative mitral insufficiency that was corrected with an annuloplasty ring.Intraoperative coronary angiogram showed impaired blood flow in the left main coronary and circumflex artery and 60%stenosis.For this reason,bifurcation stenting was performed.The patient had an uneventful postoperative clinical course and was discharged from the hospital on the 10th day in a satisfactory condition.CONCLUSION Left atrial appendage aneurysm is a rare and dangerous heart pathology that requires surgery to prevent related complications. | Dmitry Vladimirovich Belov Vladimir Ivanovich Moskalev Dmitry Victorovich Garbuzenko Nikolay Olegovich Arefyev | 2020 | World Journal of Clinical Cases2020，8，19： | 3 |
| 14 | 变型蔡氏电路的混沌保密通信显示文摘为了产生更复杂的混沌系统,使通信更安全可靠,设计了一种产生丰富混沌行为的变型蔡氏电路,并进行了理论分析和计算机仿真。在此基础上根据驱动—响应同步原理设计了混沌保密通信电路,以方波作为输入信号进行了相应的硬件实验研究,给出了通信系统中各元件的参数和各部分的波形。结果表明:电路实验结果与计算机模拟结果完全符合,并且在响应电路和驱动电路的元件参数一致,其相对误差小于1%的条件下,当输入方波信号频率在约8kHz~9MHz时,该变型蔡氏电路的混沌保密通信系统可以实现保密通信。 | 康守强 朱建良 王玉静 MIKULOVICH Vladimir Ivanovich | 2009 | 电机与控制学报2009，13，6： | 3 |
| 15 | Runaway Electrons Pre-ionized Diffuse Discharges in SF6, Air, Argon and Nitrogen显示文摘 | Victor Fedotovich Tarasenko Dmitry Viktorovich Beloplotov Mikhail Ivanovich Lomaev Dmitry Alexeevich Sorokin | 2014 | Journal of Chemistry and Chemical Engineering2014，8，12： | 2 |
| 16 | A systematic review of multidisciplinary outcomes in themanagement of chronic low back pain显示文摘 | Lynn Shaw Birgit Prodinger Karen Jacobs Michael J. Ravenek Ian D. Hughes Nathan Ivanovich Kevin Tyrer Christopher Desrochers Lisa Klinger Lynn Shaw | 2009 | Work2009，，3： | 2 |
| 17 | Molecular mediators ofangiogenesis in bladder cancer显示文摘 | Campbell SC Volpert OV Ivanovich M | 1998 | Cancer Res1998，58，6： | 1 |
| 18 | U and Th speciation in river sediments 显示文摘 | MARTIEZ-AGUIRRE A GARCIA-LEON M IVANOVICH M | 1995 | Science of the Total Environment1995，，： | 1 |
| 19 | New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage显示文摘Primary biliary cholangitis(PBC)is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in adults.Damage to cholangiocytes triggers the development of intrahepatic cholestasis,which progresses to cirrhosis in the terminal stage of the disease.Accumulating data indicate that damage to biliary epithelial cells[(BECs),cholangiocytes]is most likely associated with the intracellular accumulation of bile acids,which have potent detergent properties and damaging effects on cell membranes.The mechanisms underlying uncontrolled bile acid intake into BECs in PBC are associated with pH change in the bile duct lumen,which is controlled by the bicarbonate(HCO3-)buffer system“biliary HCO3-umbrella”.The impaired production and entry of HCO3-from BECs into the bile duct lumen is due to epigenetic changes in expression of the X-linked microRNA 506.Based on the growing body of knowledge on the molecular mechanisms of cholangiocyte damage in patients with PBC,we propose a hypothesis explaining the pathogenesis of the first morphologic(ductulopenia),immunologic(antimitochondrial autoantibodies)and clinical(weakness,malaise,rapid fatigue)signs of the disease in the asymptomatic stage.This review focuses on the consideration of these mechanisms. | Vasiliy Ivanovich Reshetnyak Igor Veniaminovich Maev | 2023 | World Journal of Gastroenterology2023，29，37： | 1 |
| 20 | Glacial to Holocene changes in carbonate and clay sedimentation in the Equatorial Pacific Ocean estimated from thorium 230 profiles显示文摘 | Yang Yong-Liang Eldefield H Ivanovich M | 1990 | Paleoceanography1990，5，5： | 1 |
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