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| 1 | Liver-first approach of colorectal cancer with synchronous hepatic metastases: A reverse strategy显示文摘Recently, there has been a change in the strategy of how synchronous colorectal hepatic metastases are attributed to the development of more valuable protocols of chemotherapy and radiotherapy for neoadjuvant treatment of colorectal neoplasms and their hepatic metastases. There is a consensus that patients with synchronous colorectal hepatic metastases have lower survival than those with metachronous colorectal hepatic metastases. Currently, controversy remains concerning the best approach is sequence in a patient with colorectal cancer and synchronous hepatic metastases resection. To obtain a better patient selection, the authors have suggested the initial realization of systemic chemotherapy in the circumstance of patients with colorectal tumor stage Ⅳ, since these patients have a systemic disease. The rationale behind this liver-first strategy is initially the control of synchronous hepatic metastases of colorectal carcinoma, which can optimize a potentially curative hepatic resection and longstanding survival. The liver-first strategy procedure is indicated for patients with colorectal hepatic metastases who require downstaging therapy to make a curative liver resection possible. Thus, the liver-first strategy is considered an option in cases of rectal carcinoma in the early stage and with limited or advanced synchronous colorectal hepatic metastases or in case of patients with asymptomatic colorectal carcinoma, but with extensive liver metastases. Patients undergoing systemic chemotherapy and with progression of neoplastic disease should not undergo hepatic resection, because it does not change the prognosis and may even make it worse. To date, there have been no randomized controlled trials on surgical approach of colorectal synchronous hepatic metastases, despite the relatively high number of available manuscripts on this subject. All of these published studies are observational, usually retrospective, and often non-comparative. The patient selection criteria for the liver-first strategy should be individualized, and the approach of these patients should be performed by a multidisciplinary team so its benefits will be fully realized. | Jaques Waisberg Ivan Gregorio Ivankovics | 2015 | World Journal of Hepatology2015，7，11： | 15 |
| 2 | Peripheral and mesenteric serum levels of CEA and cytokeratins,staging and histopathological variables in colorectal adenocarcinoma显示文摘瞄准:为了评估在外设和 mes 伤寒浆液之间存在的差别,与颜色在病人 carcinoembryonic 铺平抗原(CEA ) 和 cytokeratins 表面的腺癌。方法:有颜色的 138 个病人表面的腺癌在在 1993 年 12 月和 2000 年 3 月之间的医院 Sao Paulo (UNIFESP-EPM 的外科的肠胃病学的纪律) 经历了外科的人,回顾地被分析。CEA 和 cytokeratin (TPA-M ) 之间的差别在外部血(P) 并且在 mes 伤寒血(M) 的层次被学习。协会在外设和 mes 伤寒层次和阶段和组织病理学说的变量(细胞分化,宏观的外观,肿瘤尺寸和淋巴、静脉的侵略的存在的度) 之间被调查。结果:差别在标记层次的数字价值被观察:CEA (M)(39.10 mg/L +/- 121.19 mg/L ) 对 CEA (P)(38.5 mg/L +/- 122.55 mg/L ) , P <
0.05;TPA-M (M)(325.06 U/L +/- 527.29 U/L ) 对 TPA-M (P)(279.48 U/L +/- 455.81 U/L ) , P <
0.01。mes 伤寒 CEA 层次在更先进的肿瘤是更高的(P <
0.01 ) ,在生长损害(34.44 mg/L +/- 93.07 mg/L )(P <
0.01 ) 并且与静脉的侵略(48.41 mg/L +/- 129.86 mg/L )(P <
0.05 ) 。外部 CEA 与更先进的阶段是更高的(P <
0.01 ) 并且在有静脉的侵略的损害(53.23 mg/L +/- 158.57 mg/L )(P <
0.05 ) 。病人表明了有更多的 TPA-M 层次预付肿瘤的伤寒、外部的增加的 mes (P <
0.01 并且 P <
0.01 ) 并且在非溃烂的损害[530.45 U/L +/- 997.46 U/L (P <
0.05 ) 并且 457.95 U/L +/- 811.36 U/L (P <
0.01 )] 。结论:肿瘤标记 CEA 和 cytokeratins 的 mes 伤寒层次比在这些的外部层次渲染表面的腺癌病人高。这些生物学的肿瘤标记的高水平与癌的传播的一个先进状态被联系。 | Ivan Gregório Ivankovics Luis César Fernandes Sarhan Sydeney Saad Delcio Matos | 2008 | World Journal of Gastroenterology2008，14，43： | 4 |
| 3 | DNA end resection controls the balance between homologous and illegitimate recombination in Eseheriehiaeoli显示文摘 | Ivankovic S Demlic D | 2012 | PLoSOne2012，7，39： | 1 |
| 4 | Contact order revisited: Influence of protein size on the folding rate显示文摘 | Ivankov D N Garbuzynskiy S O Alm E | 2003 | Protein Sci2003，12，9： | 1 |
| 5 | Evaluation of different purification proceduresfor the electrochemical quantification of mussel metallothioneins 显示文摘 | Erk M Ivankovic D Raspor B | 2002 | Talanta2002，57，6： | 1 |
| 6 | Changes in Na^+-K^+-ATPase activitY, unsaturated fatty acids and metallothioneins in gills of the shore crab Carcinus aestuarii after dilute seawater acclimation 显示文摘 | LUCU C PAVICIC J IVANKOVIC D | 2008 | Comparative Biochemistry and Physiology Part A : Molecular & Integrative Physiology2008，149，4： | 1 |
| 7 | Photokilling Squamous Carcinoma Cells SCCVII with Ultrafine Particles of Selected Metal Oxides显示文摘 | Sinisa Ivankovic Marijan Gotic Mislav Jurin | 2003 | J Sol-gel Sci Technol2003，27，： | 1 |
| 8 | Genetic diversity of three donkey populations in the Croatial region显示文摘 | Ivankovic A Kavar T Caput P | 2002 | Animal Genetics2002，33，： | 1 |
| 9 | Isothermal and non-isothermal crystallization kinetics of zinc-aluminosilicate glasses显示文摘 | TKALCEE E KURAJICA S IVANKOVIC H | 2001 | Thermochimica Acta2001，378，1： | 1 |
| 10 | Sulfidic PhotochemicalPassivation of GaAs Surfaces in Alcoholic Solutions显示文摘 | SimonsmeierT Ivankov A Bauhofe W | 2005 | Jour-nal of Applied Physics2005，，08： | 1 |
| 11 | Intrahepatic cholestasis of pregnancy:A retrospective case-control study of perinatal outcome显示文摘 | Rioseco AJ Ivankovic MB Manzur A | | 0，，04： | 1 |
| 12 | Application of the finite volume method to the analysis of dynamic fracture problems显示文摘 | Ivankovic A Demirdzic I Williams J G | 1994 | International Journal of Fracture1994，66，4： | 1 |
| 13 | Organotropic carcinogenic effects of 65 various N-nitrosos-compounds on BD rats (Ger)显示文摘 | Preussmann R Ivankovic S | 1967 | Z Krebsforsch1967，69，2： | 1 |
| 14 | Microstructure and high temperature 4-point bending creep of sol-gel derived mullite ceramics 显示文摘 | IVANKOVIC H TKALCEC E REIN R | 2006 | Journal of the American Ceramic Society2006，26，： | 1 |
| 15 | High strain rate properties of selected aluminum alloys显示文摘 | IVANKOVIC A VENIZELOS G | 2000 | Materials Science and Engineering2000，278，： | 1 |
| 16 | A ten-year follow-up study of cotton textile workers 显示文摘 | Zuskin E Ivankovic D Schachter EN | 1991 | Am Rev Respir Dis1991，143，： | 1 |
| 17 | Changes in Na^+-K^+- ATPase activity, unsaturated fatty acid and metallo- thioneins in gills of the shore crab Carcinus aestuarii after dilute seawater acclimation 显示文摘 | Lucu C Pavicic J Ivankovic D | 2008 | Comparative Bio- chemistry Physiology-Part As Molecular & Integrative Physiology2008，149，4： | 1 |
| 18 | Inverse Problems for Non-stationary Transport Equation显示文摘 | Prilepko A I Ivankov A L | 1984 | Soviet Mathematics - Doklady1984，29，3： | 1 |
| 19 | Contact order revisited : influence of protein size on the folding rate 显示文摘 | Ivankov D N Garbuzynskiy S O Aim E Plaxco K W Baker D Finkelstein A V | 2003 | Protein Science2003，12，9： | 1 |
| 20 | Preparation of highly porous hydroxyapatite from cuttlefish bone 显示文摘 | IVANKOVIC H GALLEGO F G TKALCEC E | 2009 | J Mater Sci Mater Med2009，20，5： | 1 |
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