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| 1 | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study显示文摘High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures.Here,we demonstrate that an all-optical ultrasound transducer,through which light guided by optical fibers is used to generate and receive ultrasound,is suitable for real-time invasive medical imaging in vivo.Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser.The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception.This transducer was integrated within a custom inner transseptal needle(diameter 1.08 mm;length 78 cm)that included a metallic septum to acoustically isolate the two optical fibers.The use of this needle within the beating heart of a pig provided unprecedented realtime views(50 Hz scan rate)of cardiac tissue(depth:2.5 cm;axial resolution:64μm)and revealed the critical anatomical structures required to safely perform a transseptal crossing:the right and left atrial walls,the right atrial appendage,and the limbus fossae ovalis.This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts. | Malcolm C Finlay Charles A Mosse Richard J Colchester Sacha Noimark Edward Z Zhang Sebastien Ourselin Paul C Beard Richard J Schilling Ivan P Parkin Ioannis Papakonstantinou Adrien E Desjardins | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 2 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 3 | Comparative analysis of two rates显示文摘 | Chan Ivan S F Zhang Z X | 1985 | Statistics in Medicine1985，4，： | 1 |
| 4 | Thermal and mechanical properties of glass reinforced soy-based polyurethane composites 显示文摘 | Suhreta H Ivan J Petrovic Z S | 2005 | Composites Science and Technology2005，65，1： | 1 |
| 5 | The tissue engineering of articular cartilage: cells, scaffolds and stimulating factors 显示文摘 | L'ubos D Ivan V Radoslav Z | 2012 | Exper Biol Med2012，237，1： | 1 |
| 6 | Chemical conversion synthesis and optical properties of metal sulfide hollow microspheres显示文摘 | Zhu Y F IVan H D Shen W Z | 2008 | Langmuir2008，24，11： | 1 |
| 7 | Systemic chemotherapy with epirubicin for treatment of advanced or multifocal hepatocellular carcinoma显示文摘 | Jurgen P Ivan Z Wolfgang S | | 0，，05： | 1 |
| 8 | Deciphering the complexity of Toll-like receptor signaling显示文摘 | Renato O Ivan Z Francesca G | 2010 | Cellular and Molecular Life Sciences2010，67，： | 1 |
| 9 | Expulsion detection system for resistance spot welding based on a neural network显示文摘 | Primo(z) Podr(z)aj Ivan Polajnar | 2004 | Measurement Science and Technology2004，15，5： | 1 |
| 10 | Improved hydrate equilibrium measurements in ternary gas and black oil systems 显示文摘 | IVANIC J HUO Z SLOAN E D | 2004 | Fluid Phase Equilibria2004，，： | 1 |
| 11 | The value of ultrasound in acute ankle injury: comparison with MR显示文摘 | PETRA M MARTINA S IVAN Z L | 2009 | Eur J Trauma Emerg Surg2009，35，2： | 1 |
| 12 | Activated carbon from biochar: Influence of its physicochemiealproperties on the sorption characteristics of phenanthrene显示文摘 | JUNYEONG P IVAN H GAN Z H | 2013 | Bioresource Technology2013，，149： | 1 |
| 13 | Monotone Iterative Technique for Riemann-Liouville fractional integro-differential equations with advanced arguments显示文摘 | Liu Z H Sun J H Ivan S | 2013 | Results in Mathmatics2013，63，34： | 1 |
| 14 | Multivariate and multiseale monitoring of large-size low-speed bearings using en- semble empirical mode decomposition method com- bined with principal component analysis显示文摘 | Matej Z Samo Z Ivan P | 2010 | Mechani- cal Systems and Signal Processing2010，，24： | 1 |
| 15 | Thermal and mechanical properties of glass reinforced soy-based polyurethane composites显示文摘 | Suhreta H Ivan J Petrovic Z S | 2005 | Compos Sci Techn2005，65，1： | 1 |
| 16 | An evaluation of needle exchange programmes in China显示文摘 | Liu B $uI Wu Z | 2007 | AIDS2007，21，8： | 1 |
| 17 | Effect of silica nanoparticles on morphology of segmented polyurethanes 显示文摘 | Petrovic Z S Cho Y J Ivan J | 2004 | Polymer2004，45，1： | 1 |
| 18 | Effects of dietary sunflower seeds on tureen protozoa and growth of lambs 显示文摘 | Ivan M Mir P S Mir Z | 2004 | Br J Nutr2004，92，2： | 1 |
| 19 | Effects of dietary sun-flower seeds on rumen protozoa and growth of lambs显示文摘 | Ivan M Mir P S Mir Z | 2004 | The British Journal of Nutrition2004，92，： | 1 |
| 20 | Neurovascular Stalk of the Superficial Sural Flap:Human Fetus Anatomical Study显示文摘 | Sladjana Ugrenovic Z Ivan | 2005 | Plast Reconstr Surg2005，116，2： | 1 |
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