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	题名	作者	年代	出处	被引量
1	Pathogenesis of hepatitis B virus infection显示文摘	F.V. Chisari M. Isogawa S.F. Wieland	2009	Pathologie Biologie2009，，4：	4
2	Characteristics of escape mutations from occult hepatitis B virus infected patients with hematological malignancies in South Egypt显示文摘AIM To investigate the prevalence and virological characteristics of occult hepatitis B virus(HBV) infections in patients with hematological malignancies in South Egypt.METHODS Serum samples were collected from 165 patients with hematological malignancies to monitor titers of HBV DNA, hepatitis B surface antigen(HBs Ag), and antibodies to HBV core(anti-HBc) and surface antigens. Serum samples negative for HBs Ag and positive for anti-HBc were subjected to nucleic acid extraction and HBV DNA detection by real-time polymerase chain reaction. DNA sequences spanning the S region were analyzed in cases with occult HBV infection. In vitro comparative study of constructed 1.24-fold wild type and S protein mutant HBV genotype D clones was further performed. RESULTS HBV DNA was detected in 23(42.6%) of 54 patients with hematological malignancies who were HBsA g negative, but anti-HBc positive, suggesting the presence of occult HBV infection. The complete HBV genome was retrieved from 6 occult HBV patients, and P120 T and S143 L were detected in 3 and 2 cases, respectively. Site directed mutagenesis was done to produce 1.24-fold genotype D clones with amino acid mutations T120 and L143. The in vitro analyses revealed that a lower level of extracellular HBsA g was detected by chemiluminescence enzyme immunoassay(CLEIA) with the clone containing T120 mutation, compared with the wild type or the clone with S143 L mutation despite the similar levels of extracellular and intracellular HBs Ag detected by Western blot. Southern blot experiments showed that the levels of intracellular HBV DNA were not different between these clones. CONCLUSION Occult HBV infection is common in patients with hematological malignancies and associated with P120 T and S143 L mutations. 120 T mutation impairs the detection of HBsA g by CLEIA.	Abeer Elkady Sayuki Iijima Sahar Aboulfotuh Elsayed Mostafa Ali Douaa Sayed Nashwa M Abdel-Aziz Amany M Ali Shuko Murakami Masanori Isogawa Yasuhito Tanaka	2017	World Journal of Hepatology2017，9，9：	2
3	Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes显示文摘	Sitia G Isogawa M Kakimi K	2002	Proc Natl Acad Sci USA2002，99，：	2
4	Pathogenesis of hapatitis Bvirus infection显示文摘	Chisari FV Isogawa M Wieland SF	2010	pathol Biol (Paris)2010，58，4：	1
5	Pathogenesis of hepatitis B virus infection显示文摘	F.V. Chisari M. Isogawa S.F. Wieland	2009	Pathologie Biologie2009，，4：	1
6	Tomographie im- aging using photonieally generated low-coherence terahertz noise sources 显示文摘	Isogawa T Kumashiro T Song H J	2012	Terahertz Science and Technology IEEE Transactions on2012，2，5：	1
7	Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes 显示文摘	Sitia G Isogawa M Kakimi K	2002	Proc Natl Acad Sci2002，99，13：	1
8	PD-1 : PD-L1 interactions contribute to the functional suppression of virus-specific CD8^+T lymphocytes in the liver显示文摘	Maier H Isogawa M Freeman GJ	2007	J Immunol2007，178，5：	1
9	MMPs are required for recruitment of antigen -nonspecific mononuclear cells in- to the liver by CTLs显示文摘	Sitia G Isogawa M lannacone M	2004	J Clin Invest2004，113，8：	1
10	Salivary alpha-amylase and cortisol re- sponsiveness following electrical stimulation stress in panic disorder patients 显示文摘	Tanaka Y Ishitobi Y Maruyama Y Kawano A An- do T Imanaga J Okamoto S Kanehisa H Higuma H Ninomiya T Tsuru J Hanada H Isogawa K Akiyoshi J	2012	NeurosciRes2012，73，2：	1
11	Association of a genetic polymorphism of the E-cadherin gene with prostate cancer in a Japanese population 显示文摘	Kamoto T Isogawa Y Shimizu Y	2005	Jpn J Clin Oncol2005，35，3：	1
12	Pathogenesis of hepatitis B virus infection 显示文摘	Chisari FV Isogawa M Wieland SF	2010	Pathol Biol ( Paris)2010，58，4：	1
13	The effectiveness of lira- lutide I non- alcoholic fatty liver disease patients with type 2 dia- betes mellitus compared to sitagliptin and pioglitazone 显示文摘	Ohki T Isogawa A Iwamoto M	2012	Sci World J2012，20，1：	1
14	Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral avtivity of hepatitis B virusspecific eytotoxie T lymphoeytes显示文摘	Sitia G Isogawa M Kakimi K	2002	Proc Natl Acad Sci U S A2002，99，13：	1
15	Improvement of the Form- ability of 17--4 Precipition Hardening Stainless by Ausforming显示文摘	Isogawa S Yoshida H	1998	Materials Processing Technology1998，74，：	1
16	Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins:implications for immunotherapy of persistent viral infections显示文摘	KAKIMI K ISOGAWA M CHUNG J	2002	J Virol2002，76，17：	1
17	Platelets mediate cytotoxic T lymphocyte-induced liver damage显示文摘	Iannacone M Sitia G Isogawa M		0，，11：	1
18	Cav- itation versus debonding during deformation of rubber-modi- fiedpoly (vinyl chloride) 显示文摘	DOMPAS D GROENINCKX G ISOGAWA M	1995	Polymer1995，36，3：	1
19	The induction of enamel and dentin complexes by subcutaneous implantation of reconstructed human and murine tooth germ elements显示文摘	Isogawa N Terashima T Nakano Y	2004	Arch Histol Cytol2004，67，1：	1
20	Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: implications for immunotherapy of persistent viral infections 显示文摘	Kakimi K Isogawa M Chunq J	2002	J Viral2002，76，17：	1

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