|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 2 | Increased hepcidin expression in colorectal carcinogenesis显示文摘AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism. | Douglas G Ward Keith Roberts Matthew J Brookes Howard Joy Ashley Martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 3 | Limbal stem cells: Central concepts of corneal epithelial homeostasis显示文摘A strong cohort of evidence exists that supports the localisation of corneal stem cells at the limbus. The distinguishing characteristics of limbal cells as stem cells include slow cycling properties, high proliferative potential when required, clonogenicity, absence of differentiation marker expression coupled with positive expression of progenitor markers, multipotency, centripetal migration, requirement for a distinct niche environment and the ability of transplanted limbal cells to regenerate the entire corneal epithelium. The existence of limbal stem cells supports the prevailing theory of corneal homeostasis, known as the XYZ hypothesis where X represents proliferation and stratification of limbal basal cells, Y centripetal migration of basal cells and Z desquamation of superficial cells. To maintain the mass of cornea, the sum of X and Y must equal Z and very elegant cell tracking experiments provide strong evidence in support of this theory. However, several recent stud-ies have suggested the existence of oligopotent stem cells capable of corneal maintenance outside of the limbus. This review presents a summary of data which led to the current concepts of corneal epithelial homeostasis and discusses areas of controversy surrounding the existence of a secondary stem cell reservoir on the corneal | Jinny J Yoon Salim Ismail Trevor Sherwin | 2014 | World Journal of Stem Cells2014，6，4： | 11 |
| 4 | Hypoglycemic and anti-hyperglycemic study of Gynura procumbens leaf extracts显示文摘Objective:To study the antidiabetic activity of Gynura procumbens(G.procumbens)used in the traditional management of diabetes in Southern Asia.Methods:G.procumbens leaves were extracted sequentially with graded percentage of ethanol in water(95%,75%,50%,25%and 0%),and the extracts were tested for antidiabetic activity using acute(7 h),subcutaneous glucose tolerance test and sub-chronic(14 d)test in non-diabetic and streptozotocin-induced diabetic rats.The extracts were further subjected to phytochemical studies.Results:In acute dose(1 g/kg),the extracts significantly lowered fasting blood glucose(FBG)in streptozotocin-induced diabetic rats(P<0.05).However,the FBG-lowering effect of the 25%extract compared to the other extracts,was rapid(47%after 2 h)and the highest:53%,53%and 60%in the 3rd,5th,and 7th h,respectively(P<0.05),comparable only to the effect of metformin.Furthermore,the extracts suppressed peak FBG in subcutaneous glucose tolerance test,but only the 0%and 25%extracts,and metformin sustained the decrease until the 90th min(P<0.05).Moreover,in the 14 days study,the 25%extract exerted the highest FBG-lowering effect,namely 49.38%and 65.43%on days 7 and 14,respectively(P<0.05),similar to the effect of metformin(46.26%and 65.42%).Total flavanoid and phenolic contents in the extracts were found to decrease with increase in polarity of extraction solvents.The composition of reference compounds(chlorogenic acid,rutin,astragalin and kaempferol-3-O-nrtinoside)followed a similar trend.Conclusions:G.procumbens contains antidiabetic principles,most extracted in 25%ethanol.Interaction among active components appears to determine the antidiabetic efficacy,achieved likely by a metformin-like mechanism. | Khalid Algariri Kuong Y Meng Item J Atangwho Mohd Z Asmawi Amirin Sadikun Vikneswaran Murugaiyah Norhyati Ismail | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，5： | 4 |
| 5 | Purification and a dehydrin involved in chilling tolerance during seedling emergence of cowpea 显示文摘 | Ismail A M Hall A E Close T partial characterization of Sequence and their Biology J | 1999 | Plant Physiology1999，120，1： | 1 |
| 6 | Prediction of flow distributions and pressure changes in multi-layered annular packed beds显示文摘 | Heggs P J Ellis D I Ismail M S | | 0，，04： | 1 |
| 7 | Optimizing network selection to support end-user QoS requirements for next generation networks显示文摘 | JAWAD M S ISMAIL W SINGH M S J | 2008 | International Journal of Computer Science and Network Security2008，8，6： | 1 |
| 8 | Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections 显示文摘 | Mattner J Debord KL Ismail N | 2005 | Nature2005，434，7032： | 1 |
| 9 | Effects of oleoresin-tocopherol combinations on lipid oxidation, off-odor, and color of irradiated raw and cooked pork patties 显示文摘 | Nam K C Ko K Y Min B R Ismail H Lee E J Cordray J Ahn D U | 2007 | Meat Science2007，，： | 1 |
| 10 | A 70 GHz fT low operating bias self-aligned p-type SiGe MODFET 显示文摘 | ARAFA M CHU J O ISMAIL K | 1996 | IEEE Electron Device Letters1996，17，12： | 1 |
| 11 | A methodology for estimating the at- tendance and economic impact of an open-gate festival显示文摘 | TYRRELL B ISMAIL J | 2005 | E- vent Manage2005，9，： | 1 |
| 12 | RUSLE2 model application for soil erosion assessment using remote sensing and GIS显示文摘 | ISMAIL J RAV1CHANDRAN S | 2008 | Water Resources Management2008，22，1： | 1 |
| 13 | Renal replacement therapies in the elderly part in renal transplantation显示文摘 | ISMAIL N HAKIM R M HELDERMAN J H | 1994 | Am J Kidney Dis1994，23，： | 1 |
| 14 | Dynamics structural identification tasks and methods显示文摘 | TLUSTY J ISMAIL F | 1980 | CIRP Annals - Manufacturing Technology1980，29，1： | 1 |
| 15 | Novel approaches to the diagnosis and treat- ment of breast cancer显示文摘 | Ismail J Benson J R | 2014 | Future Oncol2014，10，4： | 1 |
| 16 | Edible oil analysis by FTIR spectroscopy显示文摘 | Van de Voort F R Sedman J Ismail A A | 1998 | Laboratory Robotics and Automation1998，8，4： | 1 |
| 17 | Characterizing the Saltol quantitative trait locus for salinity tolerance in rice 显示文摘 | Thomson M J Ocampo M Egdane J Rahman M A Sajise A G Adorada D L Tumimbang-Raiz E Blumwald E Seraj Z I Singh R K Gregorio G B Ismail A M | 2010 | Rice2010，3，2： | 1 |
| 18 | A recent progress in thin film composite membrane:a review显示文摘 | Lau W J Ismail A F Misdan N | 2012 | Desalination2012，287，： | 1 |
| 19 | A survey of trust and reputation systems for online service provision显示文摘 | Jφsang A Ismail R Boyd C | 2007 | Decision Support Systems2007，43，2： | 1 |
| 20 | Newfrontiers in obstructive sleep apnoea显示文摘 | Najib T Ayas Allen A J Hirsch Ismail Laher | 2014 | Clinical Science2014，127，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员