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| 1 | Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats显示文摘AIM: To investigate the preventive effect of kefir on colitis induced with dextran sulfate sodium(DSS) in rats.METHODS: Twenty-four male Wistar-albino rats were randomized into four groups: normal control,kefircontrol,colitis,and kefir-colitis groups. Rats in the normal and kefir-control groups were administered tap water as drinking water for 14 d. Rats in the colitis and kefir-colitis groups were administered a 3% DSS solution as drinking water for 8-14 d to induce colitis. Rats in the kefir-control and kefir-colitis groups were administered 5 m L kefir once a day for 14 d while rats in the normal control and colitis group were administered an identical volume of the placebo(skim milk) using an orogastric feeding tube. Clinical colitis was evaluated with reference to the disease activity index(DAI),based on daily weight loss,stool consistency,and presence of bleeding in feces. Rats were sacrificed on the 15 th day,blood specimens were collected,and colon tissues were rapidly removed. Levels of myeloperoxidase(MPO),tumor necrosisfactor(TNF)-α,interleukin(IL)-10,malondialdehyde,and inducible nitric oxide synthase(i NOS) were measured in colon tissue.RESULTS: The DAI was lower in the kefir-colitis group than in the colitis group(on the 3rd and 5th days of colitis induction; P < 0.01). The DAI was also significantly higher in the colitis group between days 2 and 6 of colitis induction when compared to the normal control and kefir-control groups. The DAI was statistically higher only on the 6th day in the kefircolitis group when compared to that in the normal control groups. Increased colon weight and decreased colon length were observed in colitis-induced rats. Mean colon length in the colitis group was significantly shorter than that of the kefir-control group. Kefir treatment significantly decreased histologic colitis scores(P < 0.05). MPO activity in the colitis group was significantly higher than in the kefir-control group(P < 0.05). Kefir treatment significantly reduced the DSS colitis-induced TNF-α increase(P < 0.01). No statistically significant differences were observed among groups for IL-10 and MDA levels. Colon tissue i NOS levels in the colitis group were significantly higher than those in the control and kefir-colitis groups(P < 0.05).CONCLUSION: Kefir reduces the clinical DAI and histologic colitis scores in a DSS-induced colitis model,possibly via reduction of MPO,TNF-α,and i NOS levels. | Altug Senol Mehmet Isler Recep Sutcu Mete Akin Ebru Cakir Betul M Ceyhan M Cem Kockar | 2015 | World Journal of Gastroenterology2015，21，46： | 3 |
| 2 | Stochastic event capture using mobile sensors subject to a quality metric显示文摘 | BISNIK M ABOUZEID A A ISLER A A | 2007 | IEEE Trans on Robotics2007，23，4： | 1 |
| 3 | Examination of the relationship between the estrogen receptor gene and reproductive traits in swine 显示文摘 | Isler B J Irivin K M Neal S M | 2002 | J Anita Sci2002，8，9： | 1 |
| 4 | Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the tran seription factor NF-κB in human osteosarcoma 显示文摘 | Felx M Guyot MC Isler M | 2006 | Clin Sc (Lond)2006，110，6： | 1 |
| 5 | Superoxidedismutaseand glutathione peroxidasein erythrocytes of patientswithirondeficiencyanaemia:effectsofdifferenttreatmentmodalities显示文摘 | Isler M DelibasN Guclu M etal | 2002 | CroatMed2002，43，1： | 1 |
| 6 | Endothelin - 1 ( ET - 1 ) promotes MMP -2 and MMP -9 induction involving the transcription factor NF - kappaB in human osteosarcoma显示文摘 | Felx M Guyot MC Isler M | 2006 | Clin Sci (Lond)2006，110，6： | 1 |
| 7 | Diurnal changes in the radius of a subalpine Norway spruce stem: their relation to the sap flow and their use to estimate transpiration 显示文摘 | Herzog K M H~isler R Thum R | 1995 | Trees1995，10，2： | 1 |
| 8 | Examination of the relationship between the estrogen receptor gene and reproductive traits in swine显示文摘 | ISLER B J IRVIN K M NEAL S M | 2002 | J Anita Sci2002，80，9： | 1 |
| 9 | Preeclampsia: pathophysioiogy and practice considerations for the consulting nephrologist 显示文摘 | Isler C M Martin J N J | 2002 | Semin Nephrol2002，22，1： | 1 |
| 10 | Pregnancy outcome in women with preterm labor symptoms without cervical change显示文摘 | Rinehart B K Terrone D A Isler C M | 2001 | Am J Obstet Gynecol2001，184，5： | 1 |
| 11 | Combining classical HRV indices with wavelet entropy measures improves to performance in diagnosing congestive heart failure显示文摘 | Isler Y Kuntalp M | | 0，，10： | 1 |
| 12 | Immunohistoehemical study of nerves in lumbar spine ligaments 显示文摘 | Rhalmi SY Newman N Isler M | 1993 | Spine1993，18，2： | 1 |
| 13 | Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-κB in human osteosarcoma显示文摘 | Felx M Guyot M C Isler M | 2006 | Clin Sci (Lond)2006，110，： | 1 |
| 14 | Examination of the rela- tionship between the estrogen receptor gene ad reproductive traits in swine显示文摘 | ISLER B J IRVIN K M NEAL S M | 2002 | J Anim Sci2002，80，9： | 1 |
| 15 | Examination of the relationship between the estrogen receptor gene and reproductive traits in swine显示文摘 | Isler B J Irvin K M Neal S M | 2002 | J Anim Sci2002，80，9： | 1 |
| 16 | The diagnosis and management of common anorectal disorders显示文摘 | Billingham R P Isler J T Kimmins M H et aI | 2004 | Curr Probl Surg2004，41，7： | 1 |
| 17 | Stochastic event capture using mobile sensors subject to a quality metric显示文摘 | BISNIK M ABOUZEID A A ISLER A A | 2007 | IEEE Trans on Robotics2007，23，4： | 1 |
| 18 | Endothelin - 1 ( ET - 1 ) pro- motes MMP- 2 and MMP -9 induction involving the transcription factor NF- kappa B in human osteosarcoma 显示文摘 | Felx M Guyot MC Isler M | 2006 | Clinical Science2006，，110： | 1 |
| 19 | Giant cell tumor of long bone: a Canadian Sarcoma Group study显示文摘 | TURCOTTE R E WUNDER J S ISLER M H | 2002 | Clin Or- thopRelatRes2002，，397： | 1 |
| 20 | Preeclampsia: pathophysiology and practice conside rations for the consulting nephrologist 显示文摘 | Isler C M Martin J N J | 2002 | Semin Nephrol2002，22，1： | 1 |
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