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| 1 | Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats显示文摘AIM: To investigate the preventive effect of kefir on colitis induced with dextran sulfate sodium(DSS) in rats.METHODS: Twenty-four male Wistar-albino rats were randomized into four groups: normal control,kefircontrol,colitis,and kefir-colitis groups. Rats in the normal and kefir-control groups were administered tap water as drinking water for 14 d. Rats in the colitis and kefir-colitis groups were administered a 3% DSS solution as drinking water for 8-14 d to induce colitis. Rats in the kefir-control and kefir-colitis groups were administered 5 m L kefir once a day for 14 d while rats in the normal control and colitis group were administered an identical volume of the placebo(skim milk) using an orogastric feeding tube. Clinical colitis was evaluated with reference to the disease activity index(DAI),based on daily weight loss,stool consistency,and presence of bleeding in feces. Rats were sacrificed on the 15 th day,blood specimens were collected,and colon tissues were rapidly removed. Levels of myeloperoxidase(MPO),tumor necrosisfactor(TNF)-α,interleukin(IL)-10,malondialdehyde,and inducible nitric oxide synthase(i NOS) were measured in colon tissue.RESULTS: The DAI was lower in the kefir-colitis group than in the colitis group(on the 3rd and 5th days of colitis induction; P < 0.01). The DAI was also significantly higher in the colitis group between days 2 and 6 of colitis induction when compared to the normal control and kefir-control groups. The DAI was statistically higher only on the 6th day in the kefircolitis group when compared to that in the normal control groups. Increased colon weight and decreased colon length were observed in colitis-induced rats. Mean colon length in the colitis group was significantly shorter than that of the kefir-control group. Kefir treatment significantly decreased histologic colitis scores(P < 0.05). MPO activity in the colitis group was significantly higher than in the kefir-control group(P < 0.05). Kefir treatment significantly reduced the DSS colitis-induced TNF-α increase(P < 0.01). No statistically significant differences were observed among groups for IL-10 and MDA levels. Colon tissue i NOS levels in the colitis group were significantly higher than those in the control and kefir-colitis groups(P < 0.05).CONCLUSION: Kefir reduces the clinical DAI and histologic colitis scores in a DSS-induced colitis model,possibly via reduction of MPO,TNF-α,and i NOS levels. | Altug Senol Mehmet Isler Recep Sutcu Mete Akin Ebru Cakir Betul M Ceyhan M Cem Kockar | 2015 | World Journal of Gastroenterology2015，21，46： | 3 |
| 2 | ICP0, ICP4, or VP16 expressed from adenovirus vectors induces reactivation of latent herpes simplex virus type 1 in primary cultures of latently infected trlge minal ganglion cells 显示文摘 | Halford WP Kemp CD Isler JA | 2001 | Virol2001，75，： | 1 |
| 3 | Contact-dependent stimulation of monocytic cells and neutrophils by stimulated human T-cell clones显示文摘 | Li JM Isler P Dayer JM | 1995 | Immunology1995，84，： | 1 |
| 4 | Stochastic event capture using mobile sensors subject to a quality metric显示文摘 | BISNIK M ABOUZEID A A ISLER A A | 2007 | IEEE Trans on Robotics2007，23，4： | 1 |
| 5 | Examination of the relationship between the estrogen receptor gene and reproductive traits in swine 显示文摘 | Isler B J Irivin K M Neal S M | 2002 | J Anita Sci2002，8，9： | 1 |
| 6 | Examination of the relationship between the estrogen receptor gene and reproductive traits in swine显示文摘 | Isler BJ Irvin KM Neal SM | 2002 | Anim Sci2002，80，9： | 1 |
| 7 | Discrete abstractions for robot mo- tion planning and control in polygonal environments 显示文摘 | BELTA C ISLER V PAPPAS G J | 2005 | IEEE Trans- actions on Robotics2005，21，5： | 1 |
| 8 | Cemented rotating hinge endoprosthesis for limb salvage of distal femur tumors显示文摘 | Sharma S Turcotte RE Isler MH | 2006 | Clin Orthop Relat Res2006，450，9： | 1 |
| 9 | Giant cell tumor of long bone: a Canadian Sarcoma Group study 显示文摘 | Turcotte RE Wunder JS Isler MH | 2002 | Clin Orthop Relat Res2002，397，： | 1 |
| 10 | The Curious Luxor Obelisks显示文摘 | | 1987 | JEA731987，，： | 1 |
| 11 | Factor affecting reproductive performance in swine显示文摘 | Yen H F G A Isler W R Harver | 1987 | J Anlm Sci1987，64，： | 1 |
| 12 | Giant cell tumor of long bone:a Canadian Sarcoma Group study 显示文摘 | Turcotte RE Wunder JS Isler MH | 2002 | Clin Onhop Relat Res2002，397，： | 1 |
| 13 | The altemeier repair:outpatient treatment of rectal prolapse显示文摘 | Kimmins MH Evetts BK Isler J | 2001 | Dis Colon Rectum2001，44，9： | 1 |
| 14 | AITiN and AlTiON-coated hot work tool steels for tooling in steel thixoforming 显示文摘 | BIROL Y ISLER D | 2010 | Transactions of Nonferrous Metals Society of China2010，20，： | 1 |
| 15 | Retrospective adaptive prefetching for inter- active Web GIS applications 显示文摘 | Yesilmurat S isler V | 2012 | Geolnformatica2012，16，3： | 1 |
| 16 | Oral immunization of mice with lactic acid bacteria producing Helicobacter pylori urease B subunit partially protects against challenge with Helicobacter felis 显示文摘 | Corthesy B Boris S Isler P | 2005 | J Infect Dis2005，192，8： | 1 |
| 17 | The sensor selection problem for bounded uncertainty sensing models显示文摘 | Isler V Bajesy R | 2006 | IEEE Trans Autom Sci Eng2006，3，4： | 1 |
| 18 | Abrasive Wear Performance of A1- ON-Coated hot Work Tool Steel at Elevated Temperatures Under Three- Body Regime显示文摘 | Yucel Birol Duygu Isler | 2011 | Wear2011，270，34： | 1 |
| 19 | Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the tran seription factor NF-κB in human osteosarcoma 显示文摘 | Felx M Guyot MC Isler M | 2006 | Clin Sc (Lond)2006，110，6： | 1 |
| 20 | Analysis of splice variants of the immediate-early 1 region of human cytomegalovirus显示文摘 | Awasthi S Isler JA Alwine JC | 2004 | J Virol2004，78，15： | 1 |
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