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| 1 | 核形态学,核子学与前列腺癌的研究进展显示文摘前列腺癌是多个步骤综合发展的结果。这一过程包括启动和后来的多步骤发展,其中启动是通过各种老龄化事件及多种损伤(慢性感染,炎症,活性氧自由基引起DNA双链断裂最终造成的基因不稳定性)共同作用完成的。多步骤中包括一些遗传、表观遗传以及染色质结构的改变。这些改变由发出持续的增殖信号的癌变刺激相关事件而发生的。生长抑制因子逃逸,细胞凋亡受阻,可拷贝永生,诱导新生血管形成,促浸润和转移等事件都很容易被观察到。另外,除了上述关键的癌变驱动因素,能量代谢,免疫监测系统逃逸也可能与前列腺癌的发病机理有关。前列腺癌出现扩散和转移时,患者骨中的“肿瘤微环境”为细胞持续休眠或衰老提供了途径,最终为肿瘤细胞日后的增殖和生长提供了“种子和土壤”。当前列腺癌发生并进展时,细胞核大小,形状和异染色质(DNA转录)组织都会发生显著的改变,并且关键的核转录和结构蛋白以及多个核小体的改变常常会导致癌前病变或恶性改变。这一系列涉及细胞和组织的恶性肿瘤相关事件,可以被检测到并被量化,可用于评估前列腺癌进展及其管理。 | Robert W Veltri Christhunesa S Christudass Sumit Isharwal | 2012 | Asian Journal of Andrology2012，14，3： | 2 |
| 2 | Hypermethylation of genes detected in urine from ghanaian adults with bladder pathology asso- ciated with sehistosoma haematobium infection 显示文摘 | Zhong X Isharwal S Naples JM | 2013 | PLoS One2013，8，59： | 1 |
| 3 | Regenerated lumin- al epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate显示文摘 | LIU J PASCAL LE ISHARWAL S | 2011 | Mol Endocrinol2011，25，11： | 1 |
| 4 | long-term assessment of prostate cancer progression free survival:evaluation of pathological parameters,nuclear shape and molecular biomarkers of pathogene显示文摘 | Veltri RW Isharwal S Miller MC | 2008 | Prostate2008，68，16： | 1 |
| 5 | Valproic acid causes dose-and timedependent changes in nuclear structure in prostate cancer cells in vitro and in vivo显示文摘 | Kortenhorst MS Isharwal S van Diest PJ Chowdhury WH Marlow C Carducci MA | | 0，，04： | 1 |
| 6 | Prediction of patient-specific risk and percentile cohort risk of pathological stage outcome using continuous prostate-specific antigen measurement, clinical stage and biopsy Gleason score显示文摘 | Huang Y Isharwal S Haese A | 2011 | BJU Int2011，107，10： | 1 |
| 7 | Diet&insulin resistance : areview & Asian Indian perspective 显示文摘 | Isharwal S Misra A Wasir JS | 2009 | Indian J Med Res2009，129，8： | 1 |
| 8 | Diet & insulin resistance:a review & Asian Indian perspective显示文摘 | Isharwal S Misra A Wasir JS | | 0，，05： | 1 |
| 9 | South Asian diets and insulin resistance 显示文摘 | Misra A Khurana L Isharwal S | 2008 | Br J Nutr2008，10，9： | 1 |
| 10 | Role of preoperative magnetic resonance imaging on the surgical outcomes of radical prostatectomy:Does preoperative tumor recognition reduce the positive surgical margin in a specific location?Experience from a Thailand prostate cancer specialized center显示文摘Objective Multiparametric magnetic resonance imaging(MRI)has become the standard of care for the diagnosis of prostate cancer patients.This study aimed to evaluate the influence of preoperative MRI on the positive surgical margin(PSM)rates.Methods We retrospectively reviewed 1070 prostate cancer patients treated with radical prostatectomy(RP)at Siriraj Hospital between January 2013 and September 2019.PSM rates were compared between those with and without preoperative MRI.PSM locations were analyzed.Results In total,322(30.1%)patients underwent MRI before RP.PSM most frequently occurred at the apex(33.2%),followed by posterior(13.5%),bladder neck(12.7%),anterior(10.7%),posterolateral(9.9%),and lateral(2.3%)positions.In preoperative MRI,PSM was significantly lowered at the posterior surface(9.0%vs.15.4%,p=0.01)and in the subgroup of urologists with less than 100 RP experiences(32%vs.51%,odds ratio=0.51,p<0.05).Blood loss was also significantly decreased when a preoperative image was obtained(200 mL vs.250 mL,p=0.02).Multivariate analysis revealed that only preoperative MRI status was associated with overall PSM and PSM at the prostatic apex.Neither the surgical approach,the neurovascular bundle sparing technique,nor the perioperative blood loss was associated with PSM.Conclusion MRI is associated with less overall PSM,PSM at apex,and blood loss during RP.Additionally,preoperative MRI has shown promise in lowering the PSM rate among urologists who are in the early stages of performing RP. | Thitipat Hansomwong Pat Saksirisampant Sudhir Isharwal Pubordee Aussavavirojekul Varat Woranisarakul Siros Jitpraphai Sunai Leewansangtong Tawatchai Taweemonkongsap Sittiporn Srinualnad | 2023 | Asian Journal of Urology2023，10，4： | 0 |
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