|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 2 | Finite element for rock joints and interfaces 显示文摘 | Ghaboussi J Wilson E L Isenberg J | 1973 | Journal of Soil Mechanics and Foundations ASCE1973，99，10： | 1 |
| 3 | Ingestion of yogurt containing Lactobacillus acidophilus as prophylaxis for candidal vaginitis显示文摘 | Hilton E Isenberg HD Alperstin P | 1992 | Annals of Internal Medicine1992，116，： | 1 |
| 4 | Finite element for rock joints and interfaces显示文摘 | GHABOUSSI J WILSON E L ISENBERG J | 1973 | Journal of Soil Mechanics and Foundations ASCE1973，99，10： | 1 |
| 5 | Ingestion of yogurt containing Lactobacillus acidophilus as prophylaxis for candidal vaginitis显示文摘 | Hilton E Isenberg HD Alperstein P | 1992 | Ann Intern Med1992，116，5： | 1 |
| 6 | Outcome of a cohort of 300 patients with systemic lupus erythematosus attending a dedicated clinic for over two decades显示文摘 | Moss K E Ioannou Y Sultan S M Haq I Isenberg D A | 2002 | Ann Rheum Dis2002，61，： | 1 |
| 7 | Finite element for rock joints and interfaces显示文摘 | Ghaboussi J Wilson E L Isenberg J | 1973 | Journal of Soil Mechanics and Foundations ASCE1973，99，10： | 1 |
| 8 | The Role of Oxidative Stress in Chemical Carcinogenesis显示文摘 | Klaunig J E Xu Y Isenberg J S Bachowski S Kolaja K L Jiang J Stevenson D E Walborg E F Jr | 1998 | Environ Health Perspect1998，106，1： | 1 |
| 9 | Role of the mitochondrial membrane permeability transition (MPT) in rotenone- induced apoptosis in liver cells显示文摘 | Isenberg J S Klaunig J E | 2000 | Toxicological Scienc- es2000，53，2： | 1 |
| 10 | Ce- rebrospinal fluid neuropeptides and monoamin-ergic transmitters in patients with trigeminal neuralgia 显示文摘 | Strittmatter M Grauer M Isenberg E | 1997 | Headache1997，37，4： | 1 |
| 11 | International con-sensus outcome measures for patients with idiopathic inflam-matory myopathies: development and initial validation of my-ositis activity and damage indices in patients with adult onsetdisease显示文摘 | Isenberg DA Allen E Farewell V | 2004 | Rheumatology (Oxford)2004，43，： | 1 |
| 12 | Cerebrospinal fluid neuropeptides and monoa- minergic transmitters in patients with trigeminal neuralgia 显示文摘 | Grauer M Isenberg E | 1997 | Headache1997，37，4： | 1 |
| 13 | Cerebrospinal fluid neuropeptides and monoaminergic transmitters in patients with trigeminal neuralgia显示文摘 | Strittmatter M Grauer M Isenberg E | 1997 | Headache1997，37，4： | 1 |
| 14 | Finite element for rock joint and interface显示文摘 | GHABOUSSI J WILSON E L ISENBERG J | 1973 | ASCE J of the Soil Mechanics and Foundations Division1973，99，10： | 1 |
| 15 | Ingestion of yogurt containing laetobacillus acidophilus as prophylaxis for candidal vaginitis显示文摘 | Hilton E Isenberg HD Alperstein P | 1992 | Ann Inter Med1992，116，5： | 1 |
| 16 | Absence of elevation of big endothelin in subarachnoid hemorrhage显示文摘 | Isenberg E Strittmatter H | 1993 | Stroke1993，24，： | 1 |
| 17 | Seeded conversion of recombinant prion protein to a disulfide-bonded oligomer by a reduc tion-oxidation process显示文摘 | Sangho Lee David E Isenberg | 2003 | Nature structural biology2003，10，9： | 1 |
| 18 | Cerebrospinal fluid neuropeptides and monoamincrgic transmitters in patients with trigeminal neuralgia显示文摘 | Strittmatter M Grauer M Isenberg E | 2007 | Headache2007，37，4： | 1 |
| 19 | Ingestion of yogurt containing Lactobacillus acidophilus as prophylaxis for candidal vaginitis显示文摘 | Hilton E Isenberg HD Alperstein P | | 0，，05： | 1 |
| 20 | Therapeuticbenefit of blocking interleukin-6 activity w ith an anti-in-terleukin-6 receptor monoclonal antibody in rheumatoidarthritis:a randomized,doubleblind,placebo-con-trolled,dose-escalation trial显示文摘 | Choy E H Isenberg D A Garrood T | 2002 | Arthritis Rheum2002，46，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员