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| 1 | Metalloproteinase expression after desflurane preconditioning in hepatectomies:A randomized clinical trial显示文摘BACKGROUND Hepatectomy with inflow occlusion results in ischemia-reperfusion injury;however,pharmacological preconditioning can prevent such injury and optimize the postoperative recovery of hepatectomized patients.The normal inflammatory response after a hepatectomy involves increased expression of metalloproteinases,which may signal pathologic hepatic tissue reformation.AIM To investigate the effect of desflurane preconditioning on these inflammatory indices in patients with inflow occlusion undergoing hepatectomy.METHODS This is a single-center,prospective,randomized controlled trial conducted at the 4th Department of Surgery of the Medical School of Aristotle University of Thessaloniki,between August 2016 and December 2017.Forty-six patients were randomized to either the desflurane treatment group for pharmacological preconditioning(by replacement of propofol with desflurane,administered 30 min before induction of ischemia)or the control group for standard intravenous propofol.The primary endpoint of expression levels of matrix metalloproteinases and their inhibitors was determined preoperatively and at 30 min posthepatic reperfusion.The secondary endpoints of neutrophil infiltration,coagulation profile,activity of antithrombin III(AT III),protein C(PC),protein S and biochemical markers of liver function were determined for 5 d postoperatively and compared between the groups.RESULTS The desflurane treatment group showed significantly increased levels of tissue inhibitor of metalloproteinases 1 and 2,significantly decreased levels of matrix metalloproteinases 2 and 9,decreased neutrophil infiltration,and less profound changes in the coagulation profile.During the 5-d postoperative period,all patients showed significantly decreased activity of AT III,PC and protein S(vs baseline values,P<0.05).The activity of AT III and PC differed significantly between the two groups from postoperative day 1 to postoperative day 5(P<0.05),showing a moderate drop in activity of AT III and PC in the desflurane treatment group and a dramatic drop in the control group.Compared to the control group,the desflurane treatment group also had significantly lower international normalized ratio values on all postoperative days(P<0.005)and lower serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase values on postoperative days 2 and 3(P<0.05).Total length of stay was significantly less in the desflurane group(P=0.009).CONCLUSION Desflurane preconditioning can lessen the inflammatory response related to ischemia-reperfusion injury and may shorten length of hospitalization. | Eleni Koraki Ioannis Mantzoros Christos Chatzakis Anna Gkiouliava Angeliki Cheva Athina Lavrentieva Freideriki Sifaki Helena Argiriadou Isaak Kesisoglou Konstantinos Galanos-Demiris Stefanos Bitsianis Konstantinos Tsalis | 2020 | World Journal of Hepatology2020，12，11： | 4 |
| 2 | Anharmonicity and the equation of state for gold显示文摘 | Anderson O L Isaak D G Yamamoto S | 1989 | J Appl Phys1989，65，： | 1 |
| 3 | The dependence of the δT upon compression at extreme conditions显示文摘 | ANDERSON O L ISAAK D G | 1993 | Phys Chem Solids1993，54，： | 1 |
| 4 | A model for computation of thermal expansivity at high compression and high temperatures:MsO as an example显示文摘 | ANDERSON O L ODA H ISAAK D G | 1992 | Geophys Res Lett1992，19，： | 1 |
| 5 | The influence of traffic flow dynamics on urban soundscapes显示文摘 | Bert De Coensel Tom De Muer Isaak Yperman Dick Botteldooren | 2004 | Applied Acoustics2004，，2： | 1 |
| 6 | The making of eeopreneur显示文摘 | ISAAK R | 2002 | Greener Management International2002，，1： | 1 |
| 7 | Ocular and systemic findings in relapsing polychondritis 显示文摘 | Isaak B L Liesegang T J Michet C J Jr | 1986 | Ophthalmology1986，93，5： | 1 |
| 8 | Another look at the core density deficit of Earth's outer eore显示文摘 | Anderson O L Isaak D G | 2002 | Physics of Earth and Planetary Interior2002，131，： | 1 |
| 9 | Characterizing Windows for Shock Wave Radiation Studies显示文摘 | Mcqueen R G Isaak I G | 1990 | Journal of Geophysical Research1990，95，21： | 1 |
| 10 | From collective learning to Silicon Valley replication:The limits to synergistic entrepreneurship in Sophia Antipolis显示文摘 | Isaak R | 2009 | Research in International Business and Finance2009，23，2： | 1 |
| 11 | Progesterone facilitates cisplatin toxicity in epithelial ovarian cancer cells and xenografts显示文摘 | Murdoch WJ van Kirk EA Isaak DD | 2008 | Gynecol Oncol2008，110，2： | 1 |
| 12 | Compositional constraints on the equation of state and the thermal properties of the lower mantle 显示文摘 | STACEY F ISAAK D G | 2001 | Geophys J Int2001，146，： | 1 |
| 13 | A broadband WR10 turnstile junction orthomode transducer显示文摘 | PISANO G PIETRANERA L ISAAK K | 2007 | IEEE Microwave and Wireless Components Letters2007，17，4： | 1 |
| 14 | The temperature dependence of the elasticity of Fe-bearing wadsleyite]显示文摘 | Isaak D G Gwanmesia G D Davis M G | 2010 | Phys- ics of the Earth Planetary Interiors2010，182，： | 1 |
| 15 | Expression and role of CR1 and CR2 on B and T lymphocytes under physiological and autoimmune conditions显示文摘 | Erdei A Isaak A Torok K | 2009 | Mol Immunol2009，46，14： | 1 |
| 16 | Gatekeeper training for suicide prevention in first nations community members: a ran- domized controlled trial 显示文摘 | Sareen J Isaak C Bolton SL | 2013 | Depression and anxiety2013，30，10： | 1 |
| 17 | Conditional indicator simula- tion :Application to a Saskatchew uranium deposit 显示文摘 | Journel A G Isaaks E H | 1984 | Mathematical Geology1984，16，7： | 1 |
| 18 | Anharmonicity and the equation of state for gold显示文摘 | ANDERSON O L ISAAK D G YAMAMOTO S | 1989 | Journal of Applied Physics1989，65，： | 1 |
| 19 | Limits on the value of δT and γ for MgSiO3 perovskite显示文摘 | Anderson O L Masuda K Isaak D G | 1996 | Phys Earth Planet Inter1996，98，： | 1 |
| 20 | High-Temperature Elastic Constant Data on Minerals Relevant to Geophysics显示文摘 | Isaak D Oda H | 1992 | Rev Geophys1992，30，： | 1 |
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