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| 1 | Endoscopic features of early-stage signet-ring-cell carcinoma of the stomach显示文摘AIM: To identify the features of early signet ring cell gastric carcinoma using magnification endoscopy with narrow band imaging(NBI).METHODS: A retrospective review was conducted of 12 cases of early signet ring cell gastric carcinoma who underwent treatment in a single institution between January 2009 and April 2013. All patients had magnification endoscopy with NBI and indigo carmine contrast to closely examine the mucosal architecture, including the microvasculature and arrangement of gastric pits. Histologic examination of the final endoscopic submucosal dissection or gastrectomy specimen was performed and compared with the endoscopic findings to identify patterns specific to signet ring cell carcinoma.RESULTS: Twelve patients with early signet ring cell gastric carcinoma were identified; 75% were male, and average age was 61 years. Most of the lesions were stage T1a(83%), while the remainder were T1b(17%). The mean lesion size was 1.4 cm2. On standard endoscopy, all 12 patients had a pale, flat lesion without any evidence of mucosal abnormality such as ulceration, elevation, or depression. On magnification endoscopywith NBI, all of the patients had irregularities in the glands and microvasculature consistent with early gastric cancer. In addition, all 12 patients exhibited the 'stretch sign', an elongation or expansion of the architectural structure. Histologic examination of the resected specimens demonstrated an expanded and edematous mucosal layer infiltrated with tumor cells.CONCLUSION: The 'stretch sign' appears to be specific for signet ring cell carcinoma and may aid in the early diagnosis and treatment of this aggressive pathology. | Chainarong Phalanusitthepha Kevin L Grimes Haruo Ikeda Hiroki Sato Chiaki Sato Chananya Hokierti Haruhiro Inoue | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，7： | 8 |
| 2 | Transcriptional regulation of cyclooxygenase 2 by bradykinin and interleukin-lbeta in human airway smooth muscle cells:involvement of different promoter elements, transcription factors, and hi stone h4 acetylation 显示文摘 | Nie M Pang L Inoue H | 2003 | Mol Cell Biol2003，23，24： | 1 |
| 3 | Two-wheeled mobile robot motion control in dynamic environments显示文摘 | M Deng A Inoue K Sekiguchi L Jiang | | 0，，03： | 1 |
| 4 | Building market structures from consumer preferences 显示文摘 | Cooper L G Inoue A | 1996 | Journal of Marketing Re- search1996，33，3： | 1 |
| 5 | Inhibition of the leucine-rich repeat protein LINGO 1 enhances survival, structure, and function of dopaminergic neurons in Parkins's disease models 显示文摘 | Inoue H Lin L Lee X | 2007 | ProcNatlAcadSciUSA2007，104，14： | 1 |
| 6 | Plasm a levels ofC-reactive protein and serum am yloid A and gastric cancerin a nested case control stu d y : Japan Public H ealth Center-based prospective stu d y 显示文摘 | Sasazuki S Inoue M Sawada N e t a l | 2010 | Carcinogenesis2010，31，4： | 1 |
| 7 | Formation of a single ieosahedral quasicrystaline phase in Hf60 Ni15 Cu10 Ti15 metallic glass 显示文摘 | Wang L Li C Inoue A | 2001 | Journal of Alloys and Compounds2001，325，： | 1 |
| 8 | 显示文摘 | Wang L Li C Inoue A | 2001 | Mater Trans2001，42，： | 1 |
| 9 | Dose-dependent effect of anti-CTLA-4 on survival in sepsis显示文摘 | Inoue S Bo L Bian J | | 0，，01： | 1 |
| 10 | Dose-dependent effect of anti- CTLA-4 on survival in sepsis 显示文摘 | Inoue S Bo L Bian J | 2011 | Shock2011，36，1： | 1 |
| 11 | Role of the histone deacetylase complex in acute promyelocytic leukaemia 显示文摘 | Lin R J Nagy L Inoue S | 1998 | Nature1998，391，6669： | 1 |
| 12 | Materials research society symposium proceedings显示文摘 | INOUE A LIU C T | 1999 | warrendales PA:Materials Research Society1999，554，： | 1 |
| 13 | Comparative prevalence of superantigenic toxin genes in meticillin-resistant and meticillin-susceptible Staphylococcus aureus isolates 显示文摘 | HU D L OMOE K INOUE F | 2008 | J Med Microbio12008，57，9： | 1 |
| 14 | Formation and Mechanical Properties of Zr-(Ti, Nb)-Cu-Ni-Al Bulk Metallic Glass显示文摘 | Wang L Li C Inoue A | 2001 | Mater Trans JIM2001，42，4： | 1 |
| 15 | Bulk metallic glasses显示文摘 | Johnson W L Inoue A Liu C T | 1999 | Mater Res Soc1999，554，： | 1 |
| 16 | 显示文摘 | Wang L Inoue A | 2001 | Mater Trans2001，42，： | 1 |
| 17 | Bioethanol production from ball milled bagasse using an on-site produced fungal enzyme cocktail and xylose-fermenting Pichia stipitis 显示文摘 | Buaban B Inoue H Yano S Tanapongpipat S Ruanglek V Champreda V Pichyangkura R Rengpipat S Eurwilaichitr L | 2010 | Journal of Bioscience and Bioengineering2010，110，1： | 1 |
| 18 | Ultra-high strength above 5000 MPa and soft magnetic properties of Co-Fe-Ta-B bulk glassy alloys 显示文摘 | INOUE A SHEN B L KOSHIBA H | 2004 | Aeta Matefialia2004，52，6： | 1 |
| 19 | Medullar endocrine and genetic mecha- nism of arterial calcification显示文摘 | DOHERTY T M FITZPATRICK L A INOUE D | 2004 | Endocr Rev2004，25，4： | 1 |
| 20 | 显示文摘 | Inoue A Shen B L Chang C T | 2004 | Acta Mater2004，52，14： | 1 |
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