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| 1 | Complex role for the immune system in initiation and progression of pancreatic cancer显示文摘The immune system plays a complex role in the development and progression of pancreatic cancer. Inflammation can promote the formation of premalignant lesions and accelerate pancreatic cancer development. Conversely, pancreatic cancer is characterized by an immunosuppressive environment, which is thought to promote tumor progression and invasion. Here we review the current literature describing the role of the immune response in the progressive development of pancreatic cancer, with a focus on the mechanisms that drive recruitment and activation of immune cells at the tumor site, and our current understanding of the function of the immune cell types at the tumor. Recent clinical and preclinical data are reviewed, detailing the involvement of the immune response in pancreatitis and pancreatic cancer, including the role of specific cytokines and implications for disease outcome. Acute pancreatitis is characterized by a predominantly innate immune response, while chronic pancreatitis elicits an immune response that involves both innate and adaptive immune cells, and often results in profound sys-temic immune-suppression. Pancreatic adenocarcinoma is characterized by marked immune dysfunction driven by immunosuppressive cell types, tumor-promoting immune cells, and defective or absent inflammatory cells. Recent studies reveal that immune cells interact with cancer stem cells and tumor stromal cells, and these interactions have an impact on development and progression of pancreatic ductal adenocarcinoma(PDAC). Finally, current PDAC therapies are reviewed and the potential for harnessing the actions of the immune response to assist in targeting pancreatic cancer using immunotherapy is discussed. | Kristin S Inman Amanda A Francis Nicole R Murray | 2014 | World Journal of Gastroenterology2014，20，32： | 11 |
| 2 | Endothelin-receptor blockade mitigates the adverse effect of preretrieval warm ischemia on posttransplantation renal function in rats 显示文摘 | INMAN S R PLOTT W K POMILEE R A | 2003 | Transplantation2003，75，10： | 1 |
| 3 | The relation- ship between physical activity, self-esteem and academic a- chievement in 12-year-old children显示文摘 | TREMBLAY M S INMAN J W WILLMS J 12) | 2000 | Pediatri Exe Sci2000，12，31： | 1 |
| 4 | A Host-Guest Complex Between a Metal-Organic Cyclotriveratrylene Analog and a Polyoxometalate: 2 PM12 040 ( M = Mo or W) 显示文摘 | Knaust J M Inman C Keller S W | 2004 | Chem Commun2004，，： | 1 |
| 5 | Electron microscopic observations of the stratum corneum intercellular lipids in normal and atopic dogs显示文摘 | Inman A O Olivry T O Dunston S M | 2001 | Vet Pathol2001，38，： | 1 |
| 6 | Clinical utility and cost-effectiveness of an air suspension bed in the prevention of pressure uleers显示文摘 | Inman K J Sibbald W J Rutledge F S etal | 1993 | JAMA1993，269，9： | 1 |
| 7 | Tissue-engineered buccal mucosa urethroplasty-clinical outcomes显示文摘 | Bhargava S Patterson JM Inman RD | | 0，，： | 1 |
| 8 | Structural health monitoring using electro-mechanical impedance sensors显示文摘 | PARK S YUN C B INMAN D J | 2008 | Fatigue & Fracture of Engineering Materials & Structures2008，52，： | 1 |
| 9 | Tissue-engineered buccal mucosa urethroplasty-clinical outcomes显示文摘 | Bhargava S Patterson JM Inman RD | 2008 | Eur Urol2008，53，6： | 1 |
| 10 | The decomposition of phthalate esters in soil显示文摘 | Inman J C straehan s D sommers L E | 1984 | Journal of Environmental science and Health1984，19，2： | 1 |
| 11 | Piezoelectric En- ergy Harvesting from Broadband Random Vibrations 显示文摘 | Adhikari S Friswell M I Inman D J | 2009 | Smart Materials and Structures2009，18，11： | 1 |
| 12 | Comments on the free vibrations of beams with a single-edge crack显示文摘 | Carneiro S H S Inman D J | 2001 | Journal of Sound and Vibration2001，244，4： | 1 |
| 13 | Shorerise and bar - berm profiles on ocean beaches 显示文摘 | Inman D L Elwany M H S Jenkins S A | 1993 | Journal of Geophysical Research: Oceans (1978--2012)1993，98，18： | 1 |
| 14 | Monitoring andManaging the Health of Infrastructure Systems显示文摘 | Chase S Inman D | 2001 | Proceeding of the 2001 SPIE Conference on Health Monitoring of Highway Transportation Infrastructure2001，，3： | 1 |
| 15 | prevalence and progression of subclinical hpothyroidism in women with type 2diabetes:the fremantle diabetes study显示文摘 | Chubb S A Davis W A Inman Z | 2005 | Clin Endocrinol2005，62，： | 1 |
| 16 | Some design considerations for active and passive constrained layer damping treatments 显示文摘 | HUANG S C INMAN D J AUSTEIN E M | 1995 | Journal of Smart Materials and Structures1995，5，3： | 1 |
| 17 | Microscopy of Glazed Layers Formed During High Temperature Sliding Wear at 750 'C 显示文摘 | Inman I A Datta S Du H L | 2003 | Wear2003，254，56： | 1 |
| 18 | Lovastatin preserves renal functior in experimental diabetes显示文摘 | Inman S Stowe N Cressman M | | 0，，： | 1 |
| 19 | (Epidermal growth factor in-duced tyrosine phosphor) lation of nnclear proteins associated with translocatlon of epidermal gTowth factor receptor into the nucleus显示文摘 | Hoh S J Alexander B Inman CB | 1994 | Biochem Pharmaeol1994，47，： | 1 |
| 20 | Modal analysis of ro- tating composite cantilever plates 显示文摘 | Yoo H H Kim S K Inman D J | 2002 | Journal of Sound and Vibration2002，258，2： | 1 |
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