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| 1 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 2 | Effect of the prefermentative addition of copigments on the polyphenolic composition of Tempranillo wines after malolactic fermentation 显示文摘 | Inmaculada A Aleixandre J L Garcia M J Lizama V Aleixandre-Tud6 J L | 2009 | European Food Research and Technology2009，228，： | 1 |
| 3 | CML9, an Arabidopsis calmodulin‐like protein, contributes to plant innate immunity through a flagellin‐dependent signalling pathway显示文摘 | Louis‐Jér?me Leba Cécilia Cheval Inmaculada Ortiz‐Martín Benoit Ranty Carmen R. Beuzón Jean‐Philippe Galaud Didier Aldon | 2012 | The Plant Journal2012，，6： | 1 |
| 4 | Nonparametric model comparison and uncertainty evaluation for signal strength indoor location显示文摘 | Carlos K F Inmaculada M J Alicia G C | 2009 | IEEE Transactions on Mobile Computing2009，8，9： | 1 |
| 5 | Histocompatibility in vit- ro fertilization couples显示文摘 | Balasch J Inmaculada J Martorel J | 1993 | Fertil Steril1993，59，： | 1 |
| 6 | Solving a capacitated hub location problem显示文摘 | Inmaculada R Juan J | 2008 | European Journal of Operational Research2008，，184： | 1 |
| 7 | Home Outdoor NO2 and New Onset of Self-Reported Asthma in Adults显示文摘 | Bénédicte Jacquemin Jordi Sunyer Bertil Forsberg Inmaculada Aguilera David Briggs Raquel García-Esteban Thomas G?tschi Joachim Heinrich Bengt J?rvholm Debbie Jarvis Danielle Vienneau Nino Künzli | 2009 | Epidemiology2009，，1： | 1 |
| 8 | Contrast-enhanced ultrasound in the staging of acute pancreatitis显示文摘 | Tomás Ripollés María J Martínez Estela López Inmaculada Castelló Fructuoso Delgado | 2010 | European Radiology2010，，10： | 1 |
| 9 | CaO supported on mesoporous silicas as basic catalysts for transesterification reactions 显示文摘 | Monica C G A Inmaculada J Jose S | 2008 | Applied Catalysis A: General2008，334，12： | 1 |
| 10 | Structural and functional study of two nanofiltration membranes 显示文摘 | Otero J A Gutierrez R Inmaculada A | 2006 | Desalination2006，200，123： | 1 |
| 11 | Internal structure ofthe aeolian sand dunes of El Fangar spit, Ebro Delta (Tarra-gona,Spain)显示文摘 | Inmaculada R Maria J Montoya M | 2009 | Geomorphology2009，104，2： | 1 |
| 12 | Nonparametric model comparison and uncertainty evaluation for signal strength indoor location显示文摘 | Carlos K F Inmaculada M J Alicia G C | 2009 | IEEE Transactions on Mobile Computing2009，8，9： | 1 |
| 13 | Mapping of the IgE and IgG4 sequential epitopes of milk allergens with a peptide microarray-based Immunoassay显示文摘 | Inmaculada C Zamora J | 2008 | Blood2008，122，3： | 1 |
| 14 | Effectiveness of interventions in the prevention of childhood obesity显示文摘 | Inmaculada B C Doreste J Lluis S M | 2004 | European Journal of Epidemiology2004，19，： | 1 |
| 15 | A hybrid GRASP VND heuristic for the one-commodity pickup-anddelivery traveling salesman problem显示文摘 | Hernández-Pérez H Inmaculada M Salazar-González J | 2009 | Computers&Operations Research2009，36，1： | 1 |
| 16 | Application of supereritical CO2 etraction for the elimination of odorant volatile compounds from winemaking inactive dry yeast preparation显示文摘 | MARIA P B INMACULADA A O MENDIOLA J A | 2010 | Journal of Agricultural and Food Chemistry2010，58，6： | 1 |
| 17 | Nonparametric model comparison and uncertainty evaluation for signal strength indoor location显示文摘 | Carlos K F Inmaculada M J Alicia G C | 2009 | IEEE Transactions on Mobile Computing2009，8，9： | 1 |
| 18 | Photoinhibition of photosystem Ⅱ from higer plants显示文摘 | Inmaculada Y Jose J | 1996 | Biological Chemistry1996，44，1： | 1 |
| 19 | Histocompatibility in vitro fertilization couples显示文摘 | BALASCH J INMACULADA J MARTOREL J | 1993 | Fertil Steril1993，59，： | 1 |
| 20 | Photoinhibition of photosystem II from higer plants显示文摘 | Inmaculada Y Jose J | 1996 | Biological Chemistry1996，44，1： | 1 |
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