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| 1 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | Fractional particle swarm optimization in multidimensional search space显示文摘 | Kiranyaz S Ince T Yildirim A | 2010 | IEEE Trans on Systems Man and Cybernetics-Part B2010，40，2： | 1 |
| 3 | Development of antibiotic resistance genes in microbial communities during long-term operation of anaerobic reactors in the treatment of pharmaceutical wastewater显示文摘 | AYDIN S INCE B INCE O | 2015 | Water Res2015，83，： | 1 |
| 4 | Factors determining self - effica- cy in chronic obstructive pulmonary disease显示文摘 | Inal - Ince D Savci S Coplu L | 2005 | Saudi Med J2005，26，4： | 1 |
| 5 | Indication, timing and results of endovascular treatment of type B dissection 显示文摘 | Akin I Kische S Ince H | 2009 | Eur J Vasc Endovasc Surg2009，37，3： | 1 |
| 6 | Pro- tective effect of polydatin, a natural precursor of resvera- trol, against cisplatin-induced toxicity in rats 显示文摘 | INCE S ARSLAN ACAROZ D NEUWIRTH O | 2014 | Food Chem Toxicol2014，72，： | 1 |
| 7 | The synthesis of new polymetric sorbent and its application in preconcentration of cadmium and lead in water samples显示文摘 | Filiz S B Ince M Yavuz E | 2007 | Talanta2007，72，3： | 1 |
| 8 | Meyerson phenomenon associated with dysplastic compound nevi显示文摘 | Kus S Ince U Candan I | 2006 | J Eur Acad Dermatol Venereol2006，20，3： | 1 |
| 9 | The synthesis of new polymetric sorbent and its application in preeoncentration of cadmium and lead in water samples显示文摘 | Filiz S B Ince M Yavuz E | 2007 | Talanta2007，72，3： | 1 |
| 10 | Survey Of The OccurrenceOf Aflatoxin M1 In Cheeses Produced By Dairy Ewe'S Milk In Urfa City, Turkey 显示文摘 | Filazi A ince S Temamoaullari F | 2010 | Ankara tiniversitesi Veteriner Fakahesi Dergisi2010，57，3： | 1 |
| 11 | Classification of single trial motor imagery EEG recordings with subject adapted non-dyadic arbitrary time-frequency tilings显示文摘 | Ince N F Arica S Tewfik A | 2006 | J Neural Eng2006，3，3： | 1 |
| 12 | Dominant and diet-responsive groups of bacteria within the human colonic microbiota显示文摘 | WALKER A W INCE J DUNCAN S H | 2011 | The ISME Journal2011，5，2： | 1 |
| 13 | Occlusion-aware optical flow estimation显示文摘 | Ince S Konrad J | 2008 | IEEE Transactions on Image Processing2008，17，8： | 1 |
| 14 | Occlusion-aware optical flow estimation 显示文摘 | Ince S Konrad J | 2008 | IEEE Transactions on Image Processing2008，17，8： | 1 |
| 15 | Growth-inhibitory and tumorsuppressive functions of p53 depend on its repression of CD44 expression显示文摘 | Godar S Ince TA Bell GW | | 0，，01： | 1 |
| 16 | Aromatase cytochrome P450 enzyme expression in prolactinomas and its relationship to tumor behavior显示文摘 | Hakan Akinci Aysegul Kapucu Kadriye Akgun Dar Ozlem Celik Banu Tutunculer Gozde Sirin Buge Oz Nurperi Gazioglu Haluk Ince Süheyla Aliustaoglu Pinar Kadioglu | 2013 | Pituitary2013，，3： | 1 |
| 17 | a comparison of autogenic drainage and the active cycle of Breathing techniques in patient s with chronic ob- structive pulmonary disoasos显示文摘 | Savci S Ince DI Arikan H | 2000 | Journal of Cardiopulmonary Rehabili- tation2000，20，1： | 1 |
| 18 | Indication, timing andresults of endovascular treatment of type B dissection 显示文摘 | Akin I Kische S Ince H | 2009 | Eur J Vasc Endovasc Surg2009，37，3： | 1 |
| 19 | Personalized longterm ECG classification:A systematic approach显示文摘 | KIRANYAZ S INCE T PULKKINEN J | 2011 | Expert Systems with Applications2011，38，4： | 1 |
| 20 | Thoracic endovascular aneurysm repair for complicated type B aortic dissection显示文摘 | Nienaber CA Kische S Ince H a | 2011 | J Vasc Surg2011，54，5： | 1 |
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