| 2 | Injectable bioorthogonal hydrogel (BIOGEL) accelerates tissue regeneration in degenerated intervertebral discs显示文摘Intervertebral disc(IVD)degeneration is a leading cause of back pain and precursor to more severe conditions,including disc herniation and spinal stenosis.While traditional growth factor therapies(e.g.,TGFβ)are effective at transiently reversing degenerated disc by stimulation of matrix synthesis,it is increasingly accepted that bioscaffolds are required for sustained,complete IVD regeneration.Current scaffolds(e.g.,metal/polymer composites,non-mammalian biopolymers)can be improved in one or more IVD regeneration demands:biodegradability,noninvasive injection,recapitulated healthy IVD biomechanics,predictable crosslinking,and matrix repair induction.To meet these demands,tetrazine-norbornene bioorthogonal ligation was combined with gelatin to create an injectable bioorthogonal hydrogel(BIOGEL).The liquid hydrogel precursors remain free-flowing across a wide range of temperatures and crosslink into a robust hydrogel after 5-10 min,allowing a human operator to easily inject the therapeutic constructs into degenerated IVD.Moreover,BIOGEL encapsulation of TGFβpotentiated histological repair(e.g.,tissue architecture and matrix synthesis)and functional recovery(e.g.,high water retention by promoting the matrix synthesis and reduced pain)in an in vivo rat IVD degeneration/nucleotomy model.This BIOGEL procedure readily integrates into existing nucleotomy procedures,indicating that clinical adoption should proceed with minimal difficulty.Since bioorthogonal crosslinking is essentially non-reactive towards biomolecules,our developed material platform can be extended to other payloads and degenerative injuries. | Jeffrey Luo Anjani Darai Thanapat Pongkulapa Brian Conley Letao Yang Inbo Han Ki-Bum Lee | 2023 | Bioactive Materials2023，，5： | 0 |
| 3 | Shape-tailored whispering gallery microcavity lasers designed by transformation optics显示文摘Semiconductor microdisk lasers have great potential as low-threshold,high-speed,and small-form-factor light sources required for photonic integrated circuits because of their high-Q factors associated with long-lived whispering gallery modes(WGMs).Despite these advantages,the rotational symmetry of the disk shape restricts practical applications of the photonic devices because of their isotropic emission,which lacks directionality in far-field emission and difficulty in free-space out coupling.To overcome this problem,deformation of the disk cavity has been mainly attempted.However,the approach cannot avoid significant Q degradation owing to the broken rotational symmetry.Here,we first report a deformed shape microcavity laser based on transformation optics,which exploits WGMs free from Q degradation.The deformed cavity laser was realized by a spatially varying distribution of deep-sub-wavelength-scale(60 nm diameter)nanoholes in an InGaAsP-based multi-quantum-well heterostructure.The lasing threshold of our laser is one-third of that of the same shaped homogeneous laser and quite similar to that of a homogeneous microdisk laser.The results mean that Q spoiling caused by the boundary shape deformation is recovered by spatially varying nanohole density distribution designed by transformation optics and effective medium approximation. | YONG-HOON LEE HONGHWI PARK INBO KIM SANG-JUN PARK SUNGHWAN RIM BYOUNG JUN PARK MOOHYUK KIM YUSHIN KIM MYUNG-KI KIM WON SEOK HAN HOSUNG KIM HONGSIK PARK MUHAN CHOI | 2023 | Photonics Research2023，11，9： | 0 |
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