4篇
您的检索式：作者名="Brian Conley"
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| 1 | A multiple modulator fractional divider显示文摘 | Miller Brian Conley R J | 1991 | IEEE Transactions on Instrumentation and Meas- urement1991，40，3： | 1 |
| 2 | A Multiple Modulator Fractional Divider 显示文摘 | Brian M Conley R J | 1991 | IEEE Trans on Instrumentation Measurement1991，40，3： | 1 |
| 3 | A multiple modulator fractional divider显示文摘 | Miller Brian Conley R J | 1991 | IEEE Transactions on Instrumentation and Measurement1991，40，3： | 1 |
| 4 | Injectable bioorthogonal hydrogel (BIOGEL) accelerates tissue regeneration in degenerated intervertebral discs显示文摘Intervertebral disc(IVD)degeneration is a leading cause of back pain and precursor to more severe conditions,including disc herniation and spinal stenosis.While traditional growth factor therapies(e.g.,TGFβ)are effective at transiently reversing degenerated disc by stimulation of matrix synthesis,it is increasingly accepted that bioscaffolds are required for sustained,complete IVD regeneration.Current scaffolds(e.g.,metal/polymer composites,non-mammalian biopolymers)can be improved in one or more IVD regeneration demands:biodegradability,noninvasive injection,recapitulated healthy IVD biomechanics,predictable crosslinking,and matrix repair induction.To meet these demands,tetrazine-norbornene bioorthogonal ligation was combined with gelatin to create an injectable bioorthogonal hydrogel(BIOGEL).The liquid hydrogel precursors remain free-flowing across a wide range of temperatures and crosslink into a robust hydrogel after 5-10 min,allowing a human operator to easily inject the therapeutic constructs into degenerated IVD.Moreover,BIOGEL encapsulation of TGFβpotentiated histological repair(e.g.,tissue architecture and matrix synthesis)and functional recovery(e.g.,high water retention by promoting the matrix synthesis and reduced pain)in an in vivo rat IVD degeneration/nucleotomy model.This BIOGEL procedure readily integrates into existing nucleotomy procedures,indicating that clinical adoption should proceed with minimal difficulty.Since bioorthogonal crosslinking is essentially non-reactive towards biomolecules,our developed material platform can be extended to other payloads and degenerative injuries. | Jeffrey Luo Anjani Darai Thanapat Pongkulapa Brian Conley Letao Yang Inbo Han Ki-Bum Lee | 2023 | Bioactive Materials2023，，5： | 0 |
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