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| 1 | Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer显示文摘AIM To identify simple and sensitive markers for postoperative complications after gastrectomy, the predictive values were compared among candidate preoperative factors. METHODS Three-hundred and twelve patients with previously untreated clinical T2-4 gastric cancer who underwent a D2 standard gastrectomy(distal gastrectomy or total gastrectomy) were included in the analysis.Correlations between 21 parameters that can be determined by preoperative routine blood tests and clinically relevant postoperative complications(grade Ⅱ or higher according to the Clavien-Dindo classification) were evaluated. The optimal cutoff values and clinical significance of the selected markers were further evaluated by subgroup analyses according to age, body mass index, operative procedure and clinical disease stage.RESULTS Sixty-six patients(21.1%) experienced grade Ⅱ or higher postoperative complications. The plateletlymphocyte ratio(PLR, total lymphocyte count/platelet count × 100) exhibited the highest area under the curve value(0.639) for predicting postoperative complications among the 21 parameters, and the optimal cutoff value was determined to be 0.71(sensitivity = 70%, specificity = 56%). In the univariate analysis, the odds ratio of a low PLR for the occurrence of postoperative complications was 2.94(95%CI: 1.66-5.35, P < 0.001), and a multivariate binomial logistic analysis involving other potential risk factors identified a low PLR as an independent risk factor for postoperative complications(OR = 3.32, 95%CI: 1.82-6.25, P < 0.001). In subgroups classified according to age, body mass index, operative procedure and clinical disease stage, the low PLR group exhibited an increased incidence of postoperative complications. CONCLUSION The preoperative PLR is a simple and useful predictor of complications after curative gastrectomy in patients with clinical T2-4 gastric cancer. | Kenichi Inaoka Mitsuro Kanda Hiroaki Uda Yuri Tanaka Chie Tanaka Daisuke Kobayashi Hideki Takami Naoki Iwata Masamichi Hayashi Yukiko Niwa Suguru Yamada Tsutomu Fujii Hiroyuki Sugimoto Kenta Murotani Michitaka Fujiwara Yasuhiro Kodera | 2017 | World Journal of Gastroenterology2017，23，14： | 13 |
| 2 | Fast fluid - attenuated inversion - recovery MR of intracranial infections显示文摘 | Tsuchiya K Inaoka Y Mizutani Y | 1997 | AJNR1997，18，5： | 1 |
| 3 | Video-assisted minithoracotomy versus conventional posterolateral thoracotomy for performing lobectomy of lung carcinomas 显示文摘 | INAOKA M OBAMA T KAWAHARADE N | 2000 | Kyobu Geka2000，53，1： | 1 |
| 4 | Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone 显示文摘 | Inaoka T Bilbe G Ishibashi O | 1995 | Biochem Biophys Res Commun1995，206，： | 1 |
| 5 | Association between anticonvulsant hypersensitivity syndrome and human herpesvirus 6 reactivation and hypogammaglobulinemia 显示文摘 | Kano Y Inaoka M Shiohara T | 2004 | Arch Dermatol2004，140，2： | 1 |
| 6 | Virus reactivation and intravenous immunoglobulin (IVIG) therapy of drug-induced hypersensitivity syndrome 显示文摘 | Kano Y Inaoka M Sakuma K | 2005 | Toxicology2005，209，2： | 1 |
| 7 | Relationship between mandibular fracture and impacted lower third molar显示文摘 | Inaoka SO Carneiro SC Vasconcelos BC | 2009 | Med Oral Patol Oral Cir Bucal2009，14，7： | 1 |
| 8 | Aeroelastic behavior of tall buildings in wakes显示文摘 | Taniike Y Inaoka H | 1988 | Journal of Wind Engng Indust Aerodynam1988，28，： | 1 |
| 9 | Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay a- mong herpesvimses and anti-drug immune responses显示文摘 | Shlohara T Inaoka M Y~ano Y | 2006 | Allergol Int2006，551，： | 1 |
| 10 | Skin manifestation of arsenicosis in two villages in Bangladesh显示文摘 | Kadono T Inaoka T Murayama N | 2002 | Int J Dermatol2002，41，12： | 1 |
| 11 | Primary clear cell sarco- ma (malignant melanoma) in the right radius显示文摘 | Inaoka T Takahashi K Tandai S | 2003 | Skeletal Radi- ol2003，32，10： | 1 |
| 12 | Aeroelastic behavior of tall buildings in wakes 显示文摘 | Taniike Y Inaoka H | 1988 | Journal of Wind Engineering And Industrial Aerodynamics1988，28，13： | 1 |
| 13 | Arsenic in cooked rice in Bangladesh 显示文摘 | Bae M Watanabe C Inaoka T | 2002 | Lancet2002，360，9348： | 1 |
| 14 | Self-similarity of Banking Network显示文摘 | INAOKA H TAKAYASU H SHIMIZU T | 2004 | Physica A2004，339，： | 1 |
| 15 | Mitra valvuloplasty for the repar of mitra valve prolapse due to tendon rupture of the posterior leaflet in a father and son - case report 显示文摘 | INAOKA M KURIMOTO Y | 1997 | Nippon Kyobu Geka Gakkai Zasshi1997，45，6： | 1 |
| 16 | Virus reactivation and intravenous imrnunoglobulin(IVIG)therapy of drug-induced hypersensitivity syndrome显示文摘 | Kano Y Inaoka M Sakuma K | 2005 | Toxicology2005，209，1： | 1 |
| 17 | Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses显示文摘 | Shiohara T Inaoka M Kano Y | 2006 | Allergol Int2006，55，1： | 1 |
| 18 | Identification of the RsmG methyltransferase target as 16S rRNA nucleotide G527 and characterization of Bacillus subtilis rsmG mutants显示文摘 | Nishimura K Johansen S K Inaoka T | | 0，，16： | 1 |
| 19 | Drug-induced hypersensitivity syndrome (DIHS) : a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses 显示文摘 | Shiohara T Inaoka M Kano Y | 2006 | Allergol Int2006，55，1： | 1 |
| 20 | Allergic con- tact dermatitis due to methyl ethyl ketone peroxide, cobalt naphthenate and acrylates in the manufacture of fibre- glass-reinforced plastics 显示文摘 | Minamoto K Nagano M Inaoka T | 2002 | Contact Dermatitis2002，46，1： | 1 |
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