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| 1 | Lamivudine resistance mutations in patients infected with hepatitis B virus genotype D显示文摘AIM: To determine the distribution of viral genotypes for primary or acquired lamivudine resistance. METHODS: A total of 283 patients with chronic hepatitis B virus (HBV) infection (245 patients with chronic hepatitis B and 38 inactive hepatitis B surface antigen carriers) were included in the study. The HBV geno-type was determined by using quantitative real-time polymerase chain reaction and sequence analysis, and tyrosine-methionine-aspartate-aspartate (YMDD) motif mutations were determined using the reverse transcriptase hybridization method. RESULTS: Lamivudine resistance was determined in a total of 25 (10.7%) chronic hepatitis B patients. Eight subjects (4%) had primary resistance to lamivudine, and 17 (53.1%) had secondary resistance to lamivudine. Genotype D, which was isolated from 267 of the patients with chronic HBV infection, was the dominant genotype in Turkey. CONCLUSION: Identification of YMDD motif mutations should have a positive impact on the selection of proper antiviral medication for patients, even for those who are nucleoside nave. | Orhan Yιldιz Bilgehan Aygen Nese Demirtürk Tuna Demirdal Dilara Inan Taner Yιldιrmak Arzu Kantürk Ediz Tütüncü Hepatitis B Study Group | 2011 | World Journal of Gastroenterology2011，17，45： | 3 |
| 2 | Applications of A Numerical Model to Wave Propagation on Mild Slopes显示文摘Based on the mild slope equation that has been decomposed into three equations related to wave phase function, wave amplitude and wave approach angle, a refraction-diffraction model is developed. The finite difference method has been selected as the solution method. The model results are compared with experimental results and the model is applied to coastal waters of the Fethiye Bay, which is located at the Mediterranean Sea of Turkey. | Asu INAN Lale BALAS | 2002 | China Ocean Engineering2002，17，4： | 3 |
| 3 | Effect of growth hormone on small intestinal homeostasis relation to cellular mediators IGF-I and IGFBP-3显示文摘AIM:To evaluate the effects of growth hormone(GH) on the histology of small intestines which might be related to the role of insulin like growth factor(IGF)-I, IGF-binding protein 3(IGFBP-3)and its receptors. METHODS:Twelve week-old adult male Wistar albino rats were divided into two groups.The study group(n =10),received recombinant human growth hormone (rGH)at a dose of 2 mg/kg per day subcutaneously for 14 d and the control group(n=10)received physiologic serum.Paraffin sections of jejunum were stained with periodic acid shift(PAS)and hematoxylin and eosin(HE) for light microscopy.They were also examined for IGF-I, IGFBP-3 and IGF-receptor immunoreactivities.Staining intensity was graded semi-quantitatively using the HS- CORE. RESULTS:Goblet cells and the cells in crypt epitheliawere significantly increased in the study group compared to that of the control group.We have demonstrated an increase of IGF-I and IGFBP-3 immunoreactivities in surface epithelium of the small intestine by GH application.IGF-I receptor immunoreactivities of crypt,villous columnar cells,enteroendocrine cells and muscularis mucosae were also more strongly positive in the study group compared to those of in the control group. CONCLUSION:These findings confirm the important trophic and protective role of GH in the homeostasis of the small intestine.The trophic effect is mediated by an increase in IGF-I synthesis in the small intestine, but the protective effect is not related to IGF-I. | Betul Ersoy Kemal Ozbilgin Erhun Kasirga Sevinc Inan Senol Coskun Ibrahim Tuglu | 2009 | World Journal of Gastroenterology2009，15，43： | 2 |
| 4 | Transcriptional profiling of granulosa cells from a patient with recurrent empty follicle syndrome显示文摘 | Mehmet Sait Inan Saad Al-Hassan Pinar Ozand Serdar Coskun | 2006 | Reproductive BioMedicine Online2006，，： | 2 |
| 5 | A halophyte and cryophyte Arabidopsis relative model system andits applicability to molecular genetic analyses of growth and development of extremophiles显示文摘 | INAN G ZHANGQ LI P H | 2004 | Plant Physiol2004，135，： | 1 |
| 6 | Treatment of type Ⅲ A open fractures of tibial shaft with Ilizamv external fixator versus unreamed tibial nailing显示文摘 | Inan M Halici M Ayan I | 2007 | Arch Orthop Trauma Surg2007，8，： | 1 |
| 7 | Administration of wild-type p53 adenoviral vector synergistically enhances the cytotoxicity of anti-cancer drugs in human lung cancer cells irrespective of the status of p53 gene 显示文摘 | Inane A Narumi K Matsubara N | 2000 | Cancer Letters2000，157，1： | 1 |
| 8 | Postoperative analgesic efficacy of intravenous dexketoprofen in lumbar disc surgery 显示文摘 | Yazar MA Inan N Ceyhan A | 2011 | J Neurosurg Anesthesiol2011，23，3： | 1 |
| 9 | Surgically induced astigmatism after superotemporal and superonasal clear corneal incisions in phacoemulsification显示文摘 | Ermis SS Inan UU Ozturk F | 2004 | J Cataract Refract Surg2004，30，6： | 1 |
| 10 | Minocycline prevents focal neurological deterioration due to cerebral hyperperfusion after extracranial-intracranial bypass for moyamoya disease 显示文摘 | Fujimura M Niizuma K Inane T | 2014 | Neurosurgery2014，74，17： | 1 |
| 11 | C2/C3 nerve blocks and greater occipital nerve block in cervicogenic headache treatment 显示文摘 | Inan N Ceyhan A Inan L | 2001 | Funct Neurol2001，16，3： | 1 |
| 12 | Diagnostic performance of conventional diffusion weighted imaging and diffusion tensor ima- ging for the liver fibrosis and inflammation 显示文摘 | Tosun M Inan N Sarisoy HT | 2013 | Eur J Radial2013，，82： | 1 |
| 13 | Diagnostic and therapeutic aspects of Hashimoto’s encephalopathy显示文摘 | Inan Olmez Harold Moses Subramaniam Sriram Howard Kirshner Andre H. Lagrange Siddharama Pawate | 2013 | Journal of the Neurological Sciences . 2013 (1-2)2013，，1： | 1 |
| 14 | Data model for the collaboration between land administration systems and agricultural land parcel identification systems 显示文摘 | Halil Ibrahim Inan Valentina Sagris | 2010 | Journal of Environmental Management2010，91，12： | 1 |
| 15 | A 1-to 12-year clinical evaluation of 106 endosseous implants supporting fixed and removable prostheses 显示文摘 | Aykent F Inan O Ozyesil AG | 2007 | Int J Periodontics Restorative Dent2007，27，4： | 1 |
| 16 | Establishment of a high sensitivity plas- ma assay for human pentraxin 3 as a marker for unstable angina pectoris显示文摘 | Inane K Sugiyama A Reid PC | 2007 | Artcrioscler Thromb Vase Biol2007，27，1： | 1 |
| 17 | Detection of traumatic brain in- juriesusing fuzzy logic algorithm 显示文摘 | Inan G Ayse T Eyyu G | 2008 | Exp Syst Appl2008，34，2： | 1 |
| 18 | Smart parking applications using RFID technology 显示文摘 | Pala Z Inan N | 2007 | RFID Eurasia2007，，： | 1 |
| 19 | Prevention of posterior capsule opacification by intraoperative Single-dose pharmacologic agents显示文摘 | Inan UU Ozturk F Kaynak S | 2001 | J Cataract Refract Surg2001，27，7： | 1 |
| 20 | Endocardial fibroelastosis of the right ventricle and tricuspid valve in a young adult with Behcet's disease显示文摘 | Ucak A Onan B Inan K | 2010 | J Card Surg2010，25，3： | 1 |
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