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| 1 | Mismatch repair enzyme expression in primary and castrate resistant prostate cancer显示文摘Objective:Although the utility of immunohistochemistry(IHC)for assessing mismatch repair(MMR)protein expression has been demonstrated in solid tumors including primary prostate cancer(PCa),its utility has not been assessed in castration-resistant PCa(CRPC).Methods:Tissue microarrays were constructed from 127 radical prostatectomies and 155 CRPC metastases from 50 patients.MMR(MLH1,MSH2,MSH6,and PMS2)expression was assessed by IHC and gene expression arrays.Associations between MMR protein expression in PCa and CRPC and biochemical recurrence(BCR)or time from diagnosis to death respectively were determined.Results:There was no correlation between levels of MMR protein and BCR.Absence of MSH2 and MSH6 was the most pronounced at 15%and 22%in PCa and 17.8%and 16%in CRPC patients,respectively.MSH2 and MSH6 protein were absent in 9.4%and 8%of PCa and CRPC respectively.Absence of individual MMR proteins did not correlate with BCR or time from diagnosis to death.However absent MSH2/MSH6 in CRPC was associated with shorter time to death(pZ0.0006).Loss of MSH2 was verified at the gene expression level.This finding correlated with microsatellite instability previously reported in this CRPC cohort. | Belinda Nghiem Xiaotun Zhang Hung-Ming Lam Lawrence DTrue Ilsa Coleman Celestia SHigano Peter SNelson Colin CPritchard Colm Morrissey | 2016 | Asian Journal of Urology2016，3，4： | 2 |
| 2 | Robust quantification of the SMN gene copy number by real-time TaqMan PCR显示文摘 | Ilsa Gómez-Curet Karyn G. Robinson Vicky L. Funanage Thomas O. Crawford Mena Scavina Wenlan Wang | 2007 | Neurogenetics2007，，4： | 1 |
| 3 | Two new Ig VH gene families in Oncorhynchus mykiss显示文摘 | Gwynne D. Brown Ilsa M. Kaattari Stephen L. Kaattari | 2006 | Immunogenetics2006，，11： | 1 |
| 4 | The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression显示文摘 | Sharma Ankur Yeow Wen-Shuz Ertel Adam Coleman Ilsa Clegg Nigel Thangavel Chellappagounder Morrissey Colm Zhang Xiaotun Comstock Clay E S Witkiewicz Agnieszka K Gomella Leonard Knudsen Erik S Nelson Peter S Knudsen Karen E | 2010 | Journal of Clinical Investigation2010，，12： | 1 |
| 5 | Endothelial progenitor cells as putative targets for angiostatin 显示文摘 | ITO H ILSA I ROVIRA I I | 1999 | Cancer Res1999，59，23： | 1 |
| 6 | Endothelial progenitor cells as putative targets for angiostatin显示文摘 | Ilsa I Rovira II | 1999 | Cancer Res1999，59，23： | 1 |
| 7 | The Impact of College Experience on Political and Social Attitude显示文摘 | Ilsa L.Lottes Peter J.Kuriloff | | 0，，1： | 1 |
| 8 | 重生的光芒显示文摘如今的废旧物品大致有两条路可走,一条是真的安息;另一条则是变身为另一样可用的物品,焕发新生。所以,那些弃置的广告牌、录音磁带、废弃光盘、啤酒瓶子等毫不起眼被当作垃圾的东西,如果能遇到设计师的巧思妙想,或许可以' | Chan Wan Ki Chen Siu Wa Suen Ka Hei Transparent House Sarah Turne Jerry Kott Henny Van Nistelrooy Ilsa Parry Alessandro Marelli 王四美 | 2011 | 现代装饰(家居)2011，0，10： | 0 |
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