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| 1 | Gastric adenocarcinoma of fundic gland type spreading to heterotopic gastric glands显示文摘Herein, we present a case of gastric adenocarcinoma of fundic gland type(GA-FG) spreading to heterotopic gastric glands(HGG) in the submucosa. A 58-year-old man with epigastric pain was referred to our hospital and underwent an esophagogastroduodenoscopy. A Borrmann type II gastric cancer at the antrum and a 10 mm submucosal tumor-like lesion in the lesser curvature of the upper third of the stomach were detected. Histological examination of the biopsy specimens obtained from the submucosal tumorlike lesion suggested a GA-FG. Therefore, endoscopic submucosal dissection was performed as excisional biopsy, and histopathological examination of the resected specimen confirmed a GA-FG and HGG proximal to the GA-FG. Although the GA-FG invaded the submucosal layer slightly, the submucosal lesion of the GA-FG had a poor stromal reaction and was located just above the HGG in the submucosa. Therefore, wefinally diagnosed the lesion as a GA-FG invading the submucosal layer by spreading to HGG. | Shigeo Manabe Ken-ichi Mukaisho Takayuki Yasuoka Fumitaka Usui Tatsuzo Matsuyama Ikuhiro Hirata Yoshio Boku Shuji Takahashi | 2017 | World Journal of Gastroenterology2017，23，38： | 6 |
| 2 | Endoscopic submucosal dissection as excisional biopsy for anorectal malignant melanoma:A case report显示文摘BACKGROUND Anorectal malignant melanoma (AMM) is a rare disorder with an extremely poor prognosis. Although there is currently no consensus on the treatment methods for AMM, surgical procedures have been the most common treatment methods used until now. We recently encountered a case of AMM that we diagnosed using endoscopic submucosal dissection (ESD). To our knowledge, this is the first case of ESD for AMM, suggesting that ESD can potentially be a diagnostic and treatment method for AMM. CASE SUMMARY A 77-year-old woman visited our hospital with a chief complaint of anal bleeding and a palpable rectal mass. Colonoscopy revealed a 20-mm protruded lesion in the lower rectum. After obtaining biopsy specimens from the lesion, although a malignant rectal tumor was suspected, a definitive diagnosis was not made. Endoscopic ultrasonography revealed tumor invasion into the submucosal layer but not the muscular layer. Therefore, we performed an excisional biopsy using ESD. Immunohistochemical examination of the ESD-resected specimen revealed tumor cells positive for Human Melanin Black-45, Melan-A, and S-100. Moreover, the tumor cells lacked melanin pigment;thus, a diagnosis of amelanotic AMM was made. Although the AMM had massively invaded the submucosal layer and both lymphatic and venous invasion were present, we closely monitored the patient without any additional therapy on the basis of her request. Six months after ESD, local recurrence was detected, and the patient consented to wide local excision. CONCLUSION It is suggested that ESD is a potential diagnostic and treatment method for AMM. | Shigeo Manabe Yoshio Boku Michiyo Takeda Fumitaka Usui Ikuhiro Hirata Shuji Takahashi | 2019 | World Journal of Clinical Cases2019，7，13： | 6 |
| 3 | Skull metastasis from hepatocellular carcinoma with chronic hepatitis B显示文摘A 56-year-old male visited our hospital for evaluation of an occipital mass.Contrast computed tomography showed hypervascular enhancement with osteolytic change in the skull and a huge enhanced mass in the liver.Magnetic resonance imaging showed bone metastasis in the thoracic vertebrae.Assays for hepatitis B surface antigen and hepatitis B core antibody were positive and his liver condition was Child-Pugh grade A.Our diagnosis was hepatocellular carcinoma(HCC) with skull and vertebrae metastases on chronic hepatitis B.He was treated with radiation therapy for bone metastases and transcatheter arterial chemoembolization for HCC.But he developed acute respiratory failure because of aspiration pneumonia,congestion and oedema with haemorrhage of the lungs and died.Dissection showed HCC with multiple bone metastases.The liver tumor was categorized as well-differentiated HCC,Edmondson classification Ⅰ,trabecular type and pseudoglandular type.In the liver mild infiltration of lymphocytes was seen in Glisson's capsules which were signif icantly enlarged with well preserved limiting plates.Piecemeal necrosis was not obvious.No fibrosis was noted.An 8 cm × 7 cm × 3 cm metastatic lesion had formed in the left occipitotemporal part of the cranial bone.The lesion was osteolytic and showed invasion into the dura mater.Neither the subdural cavity nor the brain showed involvement from the metastatic tumor.However,skull metastasis from HCC is very rare and it affects the patient's prognosis and the quality of life.Therefore,it is very important to make an early diagnosis and carry out proper management of skull metastasis from HCC. | Takashi Goto Takahiro Dohmen Kouichi Miura Shigetoshi Ohshima Kazuo Yoneyama Tomomi Shibuya Ei Kataoka Daisuke Segawa Wataru Sato Yumiko Anezaki Hajime Ishii Daigo Kon Ikuhiro Yamada Kentaro Kamada Hirohide Ohnishi | 2010 | World Journal of Gastrointestinal Oncology2010，2，3： | 2 |
| 4 | Construction of a linkage map for watermelon (Citrullus lanatus (Thunb.) Matsum & Nakai) using random amplified polymorphic DNA (RAPD)显示文摘 | Toshiharu Hashizume Ikuhiro Shimamoto Yoshiaki Harushima Mamiko Yui Takanori Sato Tsuyoshi Imai Masashi Hirai | 1996 | Euphytica1996，，3： | 1 |
| 5 | Flame Retardancy of Poly(butylene terephthalate) Blended with Phosphorous Compounds显示文摘 | Tomoyuki Ishikawa Ikuhiro Maki Kunihiko Takeda | 2004 | Journal of Applied Polymer Science2004，92，4： | 1 |
| 6 | Sereening for primary hyperparathyroidism (PHPT) in elinie patients : differential diagnosis between PHPT and malignancy associated hypercalcemia by routine blood test显示文摘 | Seungjin K Eiichi S Ikuhiro M | 2001 | Clinica Chimica Aeta2001，305，： | 1 |
| 7 | Carcinoembryonic antigen levels In the peritoneal cavity: useful guide to peritoneal recurrence and prognosis for gastric cancer显示文摘 | Masahiko N Ikuhiro T Takashi T | 1995 | World J Surg1995，19，1： | 1 |
| 8 | Screening for primary hyperparathyrotdism (PHPT) in clinic patients: differential diagnosis between PHVF and malignancyassociated hypercalcemia by routine blood tests显示文摘 | Seungjin K Eiichi S Ikuhiro M | 2001 | Clmica Chimica Acta2001，305，： | 1 |
| 9 | Initial solidification control of continuous casting using electromagnetic oscillation method显示文摘 | IKUHIRO S HIROSHI S SHINICHI N | 2003 | ISIJ International2003，43，6： | 1 |
| 10 | Screening for primary hyperparathyroidism(PHPT) in elinie patients differential diagnosis between PHPT and malignancy associated hypercalcemia by routine blood test显示文摘 | Seungjin K Eiichi S Ikuhiro M | 2001 | Clinica Chimica Acta2001，305，： | 1 |
| 11 | Determination of genetic purity of hybrid seed in watermelon(Cirtullus lanatus)and tomato(Lycopersicon esculentum)using RAPD显示文摘 | Toshiharn H Ikuhiro S Yoshiaki H | 1993 | Japan Breed1993，43，： | 1 |
| 12 | Effect of flux dispersion behavior on desulfurization of hot metal 显示文摘 | Yoshie Nakai Ikuhiro Sumi Hidetoshi Matsuno | 2010 | ISIJ International2010，50，3： | 1 |
| 13 | Involvement of reactive oxygen species in indomethacin-induced apoptosis of small intestinal epithelial cells显示文摘 | Tatsushi Omatsu Yuji Naito Osamu Handa Natsuko Hayashi Katsura Mizushima Ying Qin Ikuhiro Hirata Satoko Adachi Tetsuya Okayama Etsuko Kishimoto Tomohisa Takagi Satoshi Kokura Hiroshi Ichikawa Toshikazu Yoshikawa | 2009 | Journal of Gastroenterology2009，，19： | 1 |
| 14 | Screening for primary hyperparathyroidism (PHPT) in clinic patients:differential diagnosis between PHPT and malignancy-associated hypercalcemia by routine blood tests显示文摘 | Seungjin K Eiichi S Ikuhiro M | 2001 | Clinica Chimica Acta2001，305，： | 1 |
| 15 | Screen-ing for primary hyperparathyroidism(PHPT)in clinic patients:dif-ferential diagnosis between PHPT and malignancy-associated hy-percalcemia by routine blood tests显示文摘 | Seung Jin Kim Eiichi Shiba Ikuhiro Maeda | 2001 | Clinica Chimica Acta2001，305，12： | 1 |
| 16 | 减压条件下的氧气顶吹射流行为显示文摘氧气顶吹射流应用在各种炼钢精炼过程中,是精炼过程的重要因素。人们对常压下的射流行为进行过大量的研究,但对真空精炼过程中减压条件下的射流行为了解不多。通过测量射流的动压研究减压条件下的射流行为,采用大量射流数值模型具体解释射流行为。对比模拟结果与实验数据得出结论,数值模拟方法有效。数学模型模拟了射流行为,详细说明了环境压力对射流行为的影响。当环境压力减小时,射流速度核心区延长,说明在减压条件下,射流衰减程度较常压下的小。采用该模型还可以解释喷口形状对RH实际顶吹过程中二次燃烧行为的影响。 | Ikuhiro SUMI 何立波 | 2008 | 鞍钢技术2008，，3： | 0 |
| 17 | Progress of ulcerative colitis patients during the COVID-19 pandemic显示文摘BACKGROUND We have previously demonstrated that the first wave of the coronavirus disease 2019(COVID-19)pandemic caused exacerbations in ulcerative colitis(UC)patients,probably through psychological and physical stress.However,successive waves of the COVID-19 pandemic continuously followed the first.The effects of this chronic stress on the disease condition in UC patients are of interest.AIM To clarify the effect of chronic stress from COVID-19 on disease condition in patients aggravated after the first wave.METHODS Our previous study investigated 289 consecutive UC outpatients treated in one center during March and April 2020,the period of the first wave of the COVID-19 pandemic.In this study,an identical group of 289 UC patients was evaluated using UC-disease activity index(UC-DAI),endoscopic mucosal appearance score,and Matts pathological grade scoring.RESULTS Of the 289 UC patients included in the study in 2020,10 patients dropped out as of 2021 and another 11 patients dropped out as of 2022,making three groups for 2020,2021 and 2022.No significant differences in characteristics were found among the three groups.UC-DAI scores had aggravated during the period of the first wave of the COVID-19 pandemic,but significantly recovered in 2021 and remained stable in 2022.Matts grade scores significantly recovered in 2021 from those in 2020 and remained stable in 2022.CONCLUSION Disease activity of UC patients recovered in 2021 and remained stable in 2022,aggravated by the stress of the first wave of COVID-19 in 2020 despite persistence of the pandemic. | Toshikuni Suda Morio Takahashi Yasumi Katayama Koichi Soga Ikuhiro Kobori Yumi Kusano Masaya Tamano | 2023 | World Journal of Clinical Cases2023，11，23： | 0 |
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