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| 1 | Relationships of early esophageal cancer with human papillomavirus and alcohol metabolism显示文摘BACKGROUND It is well known that an alcohol consumption habit together with inactive heterozygous aldehyde dehydrogenase-2(ALDH2)is an important risk factor for the development of esophageal squamous cell carcinoma(ESCC).It remains controversial whether human papillomavirus(HPV)infection contributes to the occurrence/development of ESCC.There has been no study in which the relationship between ESCC and HPV in addition to alcohol dehydrogenase-1B(ADH1B)and ALDH2 genotypes was evaluated.AIM To evaluate relationships between HPV infection and development of esophageal cancer,particularly early esophageal cancer,based on ADH1B/ALDH2 polymorphisms.METHODS We conducted an exploratory retrospective study using new specimens,and we enrolled 145 patients who underwent endoscopic resection for superficial ESCC and had been observed for more than two years by both physical examination and endoscopic examination in Hokkaido University Hospital.Saliva was collected to analyze genetic polymorphisms of ADH1B/ALDH2.We performed in situ hybridization for resected specimens to detect HPV by using an HPV type 16/18 probe.RESULTS HPV was detected in 15(10.3%)of the 145 patients with ESCC.HPV-positive rates in inactive ALDH2*1/*2 and ALDH2*1/*1+*2/*2 were 10.8%and 9.8%,respectively(P=1.00).HPV-positive rates in slow-metabolizing ADH1B*1/*1 and ADH1B*1/*2+*2/*2 were 12.0%and 10.0%,respectively(P=0.72).HPV-positive rates in the heavy or moderate alcohol consumption group and the light or rare consumption group were 11.1%and 8.7%,respectively(P=0.68).HPV-positive rates in the heavy smoking group and the light or no smoking group were 11.8%and 8.3%,respectively(P=0.59).The 3-year incidence rates of secondary ESCC or head and neck cancer after initial treatment in the HPV-positive and HPVnegative groups were 14.4%and 21.4%(P=0.22),respectively.CONCLUSION In the present situation,HPV status is considered to be less important than other risk factors,such as alcohol consumption,smoking habit,ADH1B/ALDH2 polymorphisms,and HPV status would therefore have no effect on ESCC risk management. | Masaki Inoue Yuichi Shimizu Marin Ishikawa Satoshi Abiko Yoshihiko Shimoda Ikko Tanaka Sayoko Kinowaki Masayoshi Ono Keiko Yamamoto Shoko Ono Naoya Sakamoto | 2020 | World Journal of Gastroenterology2020，26，39： | 2 |
| 2 | Hydrogenation of nitrate in water to nitrogen over Pd- Cu supported on active carbon 显示文摘 | Yusuke Y Tomonobu A Ikko M | 2002 | Journal of Catalysis2002，207，： | 1 |
| 3 | The impact of clinical governance on the library and information service: Chnical librarian case study 显示文摘 | Reid L Ikkos G | 2001 | IFMH Information2001，12，1： | 1 |
| 4 | Coagulation processof soymilk characterized by electrical impedance spectroscopy 显示文摘 | Xingshu Li Kiyohiko Toyoda Ikko Ihara | 2011 | Journal of Food Engineering2011，105，3： | 1 |
| 5 | Successful treatment of a hepatic abscess that formed secondary to fish bone penetration by percutaneous transhepatic removal of the foreign body: Report of a case显示文摘 | Katsuhiko Horii Osamu Yamazaki Mitsuharu Matsuyama Ikko Higaki Shuichi Kawai Yoshihiro Sakaue | 1999 | Surgery Today1999，，9： | 1 |
| 6 | A cose of severe hy- permetabolism of nonthyroid origin with a defect in the ma- intenance of mitochondrial respiratory control: a correlated clinical, biochemical and morphological study显示文摘 | Luft R Ikkos D Palmizeri G | 1962 | Clin In- vest1962，41，： | 1 |
| 7 | Radioiodine-131 treatment of throtoxicosis: dose required for and some factors affecting the early induction of hypothyroidism 显示文摘 | Alevizaki CC Alevizaki Harhalaki MC Ikkos DG | 1985 | ur J Nucl Med1985，10，： | 1 |
| 8 | Selective degradation of tetracycline antibiotics present in raw milk by electro?chemical method显示文摘 | Yumika K Ikko I Gen Y | 2012 | Journal of Hazard Material2012，243，2： | 1 |
| 9 | Molecular Cloning and Expression of a Novel Human Aquaporin from Adipose Tissue with Glycerol Permeability显示文摘 | Hiroshi Kuriyama Shoko Kawamoto Narihiro Ishida Ikko Ohno Shiro Mita Yuji Matsuzawa Kenichi Matsubara Kousaku Okubo | 1997 | Biochemical and Biophysical Research Communications1997，，1： | 1 |
| 10 | A case of severe hypermetabolism of nonthyroid origin with a defect in the maintenance of mitochondrial respiratory control:a correlated clinical,biochemical,and morphological study显示文摘 | Luft R Ikkos D Palmieri G | | 0，，12： | 1 |
| 11 | New In2O3(ZnO) mPhotocatalysts with Laminat Structure for Visible light-induced H2 or O2 Evolution from Aqueous Solutions Containing Sacrificial Reagents显示文摘 | Mikami Ikko | 1998 | Chemistry Letters1998，1027，： | 1 |
| 12 | Psychological state and quality of life in patients having behavioral- treatment ( biofeedback ) for intractable constipation 显示文摘 | Mason H J Serrano Ikkos E Kamm MA | 2002 | A m J Gastroenterol2002，97，12： | 1 |
| 13 | Body water and sodium in patients with acro- megaly显示文摘 | Ikkos D Luft R Sjogren B | 1954 | J Clin Invest1954，33，4： | 1 |
| 14 | Photocatalytic O 2 evolution under visible light irradiation on BiVO 4 in aqueous AgNO 3 solution显示文摘 | Akihiko Kudo Kazuhiro Ueda Hideki Kato Ikko Mikami | 1998 | Catalysis Letters1998，，3： | 1 |
| 15 | The effect of suppressive oral acyclovir on the psychological morbidity associated with recurrent genital herpes 显示文摘 | Carney O Ross E Ikkos G | 1993 | Genitoufin Med1993，69，6： | 1 |
| 16 | Suppressors of Cytokine Signaling (SOCS) Proteins and JAK/STAT Pathways: Regulation of T-Cell Inflammation by SOCS1 and SOCS3显示文摘 | Taiga Tamiya Ikko Kashiwagi Reiko Takahashi Hideo Yasukawa Akihiko Yoshimura | 2011 | Arteriosclerosis Thrombosis and Vascular Biology2011，，5： | 1 |
| 17 | Coagulation process of soymilk characterized by electrical impedance spectroscopy显示文摘 | Xingshu Li Kiyohiko Toyoda Ikko Ihara | 2011 | Journal of Food Engineering2011，，3： | 1 |
| 18 | A case of severe hyperme- tabolism of nonthyroid origin with a defect in the maintenance of mitochondrial respiratory control: a correlated clinical, bio- chemical, and morphological study显示文摘 | Luft R Ikkos D Palmieri G | 1962 | J Clin Invest1962，41，： | 1 |
| 19 | Psychological morbidity in women with idiopdthic constipation 显示文摘 | Mason H J Serrano Ikkos E Kamm M A | 2000 | Am J Gastroenterol2000，95，10： | 1 |
| 20 | Psychological state and quality of life in patients having behavioral treatment(biofeedback) for intractable constipation显示文摘 | Mason H J Serrano Ikkos E Kamm M A | 2002 | AM J Gastroenterol2002，97，12： | 1 |
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