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| 1 | I.31, a new combination of probiotics, improves irritable bowel syndrome-related quality of life显示文摘AIM:To determine the dose-related effects of a novel probiotic combination,I.31,on irritable bowel syndrome(IBS)-related quality of life(IBS-QoL).METHODS:A multicenter,randomized,double-blind,placebo-controlled intervention clinical trial with three parallel arms was designed.A total of 84 patients(53female,31 male;age range 20-70 years)with IBS and diarrhea according to Rome-Ⅲcriteria were randomly allocated to receive one capsule a day for 6 wk containing:(1)I.31 high dose(n=28);(2)I.31 low dose(n=27);and(3)placebo(n=29).At baseline,and 3and 6 wk of treatment,patients filled the IBSQoL,Visceral Sensitivity Index(VSI),and global symptom relief questionnaires.RESULTS:During treatment,IBS-QoL increased in all groups,but this increment was significantly larger in patients treated with I.31 than in those receiving placebo(P=0.008).After 6 wk of treatment,IBS-QoL increased by 18±3 and 22±4 points in the high and the low dose groups,respectively(P=0.041 and P=0.023vs placebo),but only 9±3 in the placebo group.Gutspecific anxiety,as measured with VSI,also showed a significantly greater improvement after 6 wk of treatment in patients treated with probiotics(by 10±2 and14±2 points,high and low dose respectively,P<0.05for both vs 7±1 score increment in placebo).Symptom relief showed no significant changes between groups.No adverse drug reactions were reported following the consumption of probiotic or placebo capsules.CONCLUSION:A new combination of three different probiotic bacteria was superior to placebo in improving IBS-related quality of life in patients with IBS and diarrhea. | Vicente Lorenzo-Zú?iga Elba Llop Cristina Suárez Beatriz álvarez Luis Abreu Jordi Espadaler Jordi Serra | 2014 | World Journal of Gastroenterology2014，20，26： | 13 |
| 2 | Biodegradable stents in gastrointestinal endoscopy显示文摘Biodegradable stents(BDSs)are an attractive option to avoid ongoing dilation or surgery in patients with benign stenoses of the small and large intestines.The experience with the currently the only BDS for endoscopic placement,made of Poly-dioxanone,have shown promising results.However some aspects should be improved as are the fact that BDSs lose their radial force over time due to the degradable material,and that can cause stent-induced mucosal or parenchymal injury.This complication rate and modest clinical efficacy has to be carefully considered in individual patients prior to placement of BDSs.Otherwise,the price of these stents therefore it is nowadays an important limitation. | Vicente Lorenzo-Zú?iga Vicente Moreno-de-Vega Ingrid Marín Jaume Boix | 2014 | World Journal of Gastroenterology2014，20，9： | 10 |
| 3 | Endoscopic anti-reflux therapy for gastroesophageal reflux disease显示文摘Gastroesophageal reflux disease has an increasing incidence and prevalence worldwide.A significant proportion of patients have a suboptimal response to proton pump inhibitors or are unwilling to take lifelong medication due to concerns about long-term adverse effects.Endoscopic anti-reflux therapies offer a minimally invasive option for patients unwilling to undergo surgical treatment or take lifelong medication.The best candidates are those with a good response to proton pump inhibitors and without a significant sliding hiatal hernia.Transoral incisionless fundoplication and nonablative radiofrequency are the techniques with the largest body of evidence and that have been tested in several randomized clinical trials.Band-assisted ligation techniques,anti-reflux mucosectomy,antireflux mucosal ablation,and new plication devices have yielded promising results in recent noncontrolled studies.Nonetheless,the role of endoscopic procedures remains controversial due to limited long-term and comparative data,and no consensus exists in current clinical guidelines.This review provides an updated summary focused on the patient selection,technical details,clinical success,and safety of current and future endoscopic anti-reflux techniques. | Enrique Rodríguez de Santiago Eduardo Albéniz Fermin Estremera-Arevalo Carlos Teruel Sanchez-Vegazo Vicente Lorenzo-Zúñiga | 2021 | World Journal of Gastroenterology2021，27，39： | 9 |
| 4 | Estrogen-mediated downregulation of HIF-1αsignaling in B lymphocytes influences postmenopausal bone loss显示文摘In the bone marrow, B cells and bone-resorbing osteoclasts colocalize and form a specific microenvironment. How B cells functionally influence osteoclasts and bone architecture is poorly understood. Using genetically modified mice and highthroughput analyses, we demonstrate that prolonged HIF-1α signaling in B cells leads to enhanced RANKL production and osteoclast formation. In addition, deletion of HIF-1α in B cells prevents estrogen deficiency-induced bone loss in mice.Mechanistically, estrogen controls HIF-1α protein stabilization through HSP70-mediated degradation in bone marrow B cells.The stabilization of HIF-1α protein in HSP70-deficient bone marrow B cells promotes RANKL production and osteoclastogenesis.Induction of HSP70 expression by geranylgeranylacetone(GGA) administration alleviates ovariectomy-induced osteoporosis.Moreover, RANKL gene expression has a positive correlation with HIF1 A expression in human B cells. In conclusion, HIF-1αsignaling in B cells is crucial for the control of osteoclastogenesis, and the HSP70/HIF-1α axis may serve as a new therapeutic target for osteoporosis. | Xianyi Meng Zhen Lin Shan Cao Iga Janowska Koshiro Sonomoto Darja Andreev Knab Katharina Jinming Wen Karl Xaver Knaup Michael Sean Wiesener Gerhard Krönke Marta Rizzi Georg Schett Aline Bozec | 2022 | Bone Research2022，10，2： | 6 |
| 5 | Radiation dose to patients during endoscopic retrograde cholangiopancreatography显示文摘Endoscopic retrograde cholangiopancreatography (ERCP) is an important tool for the diagnosis and treatment of the hepatobiliary system. The use of fluoroscopy to aid ERCP places both the patient and the endoscopy staff at risk of radiation-induced injury. Radiation dose to patients during ERCP depends on many factors, and the endoscopist cannot control some variables, such as patient size, procedure type, or fluoroscopic equipment used. Previous reports have demonstrated a linear relationship between radiation dose and fluoroscopy duration. When fluoroscopy is used to assist ERCP, the shortest fluoroscopy time possible is recommended. Pulsed fluoroscopy and monitoring the length of fluoroscopy have been suggested for an overall reduction in both radiation exposure and fluoroscopy times. Fluoroscopy time is shorter when ERCP is performed by an endoscopist who has many years experience of performing ERCP and carried out a large number of ERCPs in the preceding year. In general, radiation exposure is greater during therapeutic ERCP than during diagnostic ERCP. Factors associated with prolonged fluoroscopy have been delineated recently, but these have not been validated. | Jaume Boix Vicente Lorenzo-Zúiga | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，7： | 5 |
| 6 | An experimental investigation of transient cavitation control on a hydrofoil using hemispherical vortex generators显示文摘Unsteady cavitation causes noise,damage,and performance decline in the marine engineering and fluid machinery systems.Therefore,finding a method to control the cavitation and its destructive effects is important for the industrial applications.In this work,we proposed a passive method to control the unsteady behavior of transient cavitation at the medium Reynolds number.For this aim,we performed an experimental study using a high-speed camera to analyze the effects of hemispherical vortex generators(VGs)on the cavitation dynamics around a hydrofoil surface.In addition,the pressure pulsations induced by the collapse of the cavity structures in the wake region of the hydrofoil were captured with a pressure transducer mounted on the wall downstream of the hydrofoil.The results showed that the instability behaviors of the cavity structures on the hydrofoil were mitigated using the proposed cavitation passive control method.In addition,the pressure pulsations in the wake region of the hydrofoil were reduced significantly.It can be concluded that the suppression of cavitation instabilities can improve the operating life and reliability of the marine and hydraulic systems. | Ebrahim Kadivar Takaho Ochiai Yuka Iga Ould el Moctar | 2021 | Journal of Hydrodynamics2021，33，6： | 3 |
| 7 | Risk of hyperamylasemia and acute pancreatitis after double-balloon enteroscopy: a prospective study显示文摘 | S. Zepeda-Gómez R. Barreto-Zu?iga S. Ponce-de-León A. Meixueiro-Daza J. Herrera-López J. Camacho F. Tellez-Avila F. Valdovinos-Andraca F. Vargas-Vorackova | 2011 | Endoscopy2011，，09： | 3 |
| 8 | Gene expression of CCL8 and CXCL10 in peripheral blood leukocytes during early pregnancy in cows显示文摘Background: The aim of the present study was to evaluate CCL8 and CXCL10 expression and its regulatory mechanism in peripheral blood leukocytes(PBLs) at the time of maternal recognition in cows. Blood samples were collected on 14, 15, 16, 17 and 18 d after artificial insemination(AI). Based on the day of return of estrus, cows were divided into three groups, pregnant(n = 5), early embryonic mortality(EEM; n = 5) and late embryonic mortality(LEM; n = 5). The gene expression levels in PBLs were assessed with quantitative real-time reverse transcription PCR.Results: The expression of CCL8 and CXCL10 mRNA in PBLs gradually increased from 14 to 18 d of pregnant cows and significant differences were observed on 18 d(P < 0.05), whereas no significant changes were observed both in EEM and LEM cows. Interferon-stimulated protein 15 k Da(ISG15), myxovirus-resistance gene(MX) 1 and MX2 mRNA expression in PBLs increased from 14 to 18 d which was significant on 18 d of pregnant cows as well as in LEM cows(P < 0.05), but no changes were observed in EEM cows. To determine whether the expression of CCL8 and CXCL10 in PBLs was regulated by pregnancy-related substances or not, expression level was assessed after exposure to interferon-τ(IFNT) and CCL16. Monocytes, granulocytes and lymphocytes were obtained using density-gradient centrifugation and flow cytometry. The addition of IFNT(100 ng/mL) and CCL16(100 ng/mL) to cultured PBLs increased the expression of CCL8 and CXCL10 mRNA(P < 0.05). The expression of ISG15, MX1 and MX2 mRNA in PBLs was also stimulated by IFNT and CCL16(P < 0.05).Conclusions: The expression of CCL8 and CXCL10 genes increased in PBLs during early pregnancy. Since IFNT stimulated CCL8 and CXCL10 expression in cultured PBLs, the increase of CCL8 and CXCL10 might be pregnancy-dependent events.The expression of both CCL8 and CXCL10 in PBLs was stimulated by CCL16 as wel as IFNT, suggesting a chemokine interaction that at least includes CCL8, CXCL10 and CCL16, and may play a role in regulating maternal recognition in cows. | Ryosuke Sakumoto Kosuke Iga Ken-Go Hayashi Shiori Fujii Hiroko Kanahara Misa Hosoe Tadashi Furusawa | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 3 |
| 9 | Prevention of late complications with coverage agents in endoscopic resection of colorectal lesions: Current landscape in gastrointestinal endoscopy显示文摘Endoscopic removal of large(≥20 mm)non-pedunculated colorectal lesions(LNPCLs)may result in major adverse events,such as delayed bleeding(DB)and delayed perforation(DP),despite closure of the mucosal defects with clips.Topical application of a coverage agent refers to the creation of a shield with a biocompatible medical device(tissue or hydrogel)with proven bioactive properties.Coverage of the eschar after endoscopic resection provides shielding protection to prevent delayed complications.The aim of the present review was to systematically collect and review the currently available literature regarding the prevention of DB and DP with coverage agents after endoscopic mucosal resection or endoscopic submucosal dissection of LNPCLs. | Vicente Lorenzo-Zúñiga Marco Bustamante-Balén Vicente Pons-Beltrán | 2021 | World Journal of Gastroenterology2021，27，15： | 2 |
| 10 | Impact of Periampullary Duodenal Diverticula at Endoscopic Retrograde Cholangiopancreatography: A Proposed Classification of Periampullary Duodenal Diverticula显示文摘 | Jaume Boix Vicente Lorenzo-Zú?iga Fidel A?a?os Eugeni Domènech Rosa M. Morillas Miguel A. Gassull | 2006 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2006，，4： | 2 |
| 11 | Impact of Capsule Endoscopy Findings in the Management of Crohn’s Disease显示文摘 | Vicente Lorenzo-Zú?iga Vicente Moreno Vega Eugeni Domènech Eduard Cabré Míriam Ma?osa Jaume Boix | 2010 | Digestive Diseases and Sciences2010，，2： | 2 |
| 12 | 显示文摘 | Kato S Iga T Hatano S | 1976 | Yogyo-Kyokai- Shi1976，84，21： | 1 |
| 13 | Effect of air density variations on greenhousetemperature model显示文摘 | Javier Leal Iga Jorge Leal Iga Carlos Leal Iga | 2008 | Mathematical and ComputerModelling2008，47，910： | 1 |
| 14 | Low bias voltage dry etching of InP by inductively coupled plasma (ICP) using SiCl4/Ar显示文摘 | Koyama F Iga K | 1998 | Japanese Journal Applied Physics1998，37，： | 1 |
| 15 | Progression of isolated tricuspid regurgitation late after mitral valve surgery for rheumatic mitral valve disease显示文摘 | Izumi C Iga K Konishi T | | 0，，3： | 1 |
| 16 | Surface-emitting laser-its birth and generation of new optoelectronics field显示文摘 | Iga K | | 0，，： | 1 |
| 17 | Assembly of TbetaRI:TbetaRII:TGFbeta ternary complex in vitro with receptor extracellular domains is cooperative and isoform-dependent 显示文摘 | Zú ñ iga JE Groppe JC Cui Y | 2005 | J Mol Biol2005，354，5： | 1 |
| 18 | Psychiatric symptoms in a patient with isolated adrenocorticotropin deficiency:case report and literature review显示文摘 | MORIGAKI Y IGA J I KAMEOKA N | 2014 | Gen Hosp Psychiatry2014，36，4： | 1 |
| 19 | Topology optimization for coupled thermal and structural problems using the level set method显示文摘 | Iga A Yamada T Nishiwaki S | 2010 | Transactions of the Japan Society of Mechanical Engineers2010，76，1： | 1 |
| 20 | A novel EVI1 gene family, MELI, lacking a PR domain (MELIS) is expressed mainly in t (1;3) (p36; q21 ) -positive AML and blocks G-CSF-induced myeloid differentiation 显示文摘 | Nishikata I Sasaki H Iga M | 2003 | Blood2003，102，9： | 1 |
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