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| 1 | 长期使用抗生素引起大肠埃希菌产生耐药性与基因突变的鉴定显示文摘产超广谱β内酰胺酶(ESBLs)菌株多重耐药给临床治疗造成了极大的困难,在多种耐药机制中,产生β内酰胺酶(BLA)是细菌对BLA类抗生素耐药最主要的机制[1].为此,我们对患多发性肝脓肿的一例患者进行了追踪分析,在其长期使用抗生素治疗期间,从肝脓肿穿刺液和血培养液中分离出有代表性的7株大肠埃希菌,对它们形成耐药的环境、发生突变的途径和产生突变的类型进行了探讨研究. | 戎建荣 李连青 刘小玉 王淑峰 周向红 朱庆义 Ian Booth | 2004 | 中华检验医学杂志2004，27，8： | 6 |
| 2 | 大肠埃希菌β-内酰胺酶基因分型与耐药性研究显示文摘目的了解长期使用抗菌药物患者体内大肠埃希菌耐药基因及临床常用抗菌药物耐药的相关性。方法对分离的7株大肠埃希菌,作β-内酰胺酶测定、药物敏感试验、质粒DNA转化、等电点聚焦(IEF)电泳和DNA印迹试验。结果7株大肠埃希菌,均产生超广谱β-内酰胺酶(ESBLs),随着抗菌药物的持续使用,其相应最低抑菌浓度(MIC)值不断增高;IEF结果显示,7株大肠埃希菌均产TEM型β-内酰胺酶,其中3、4、5、6、7号菌株还产生TEM型酶以外的AmpC酶,而6、7号菌株除具备以上两种酶以外,还表现有SHV型β-内酰胺酶活性。结论从肝脓肿患者不同发病时期分离的7株大肠埃希菌,随着抗菌药物的持续使用,全部产生TEM型β-内酰胺酶,其耐药性不断增强。 | 王淑峰 戎建荣 Ian Booth | 2009 | 中华医院感染学杂志2009，19，17： | 2 |
| 3 | Ultra-broadband all-OPCPA petawatt facility fully based on LBO显示文摘A petawatt facility fully based on noncollinear optical parametric chirped pulse amplification(NOPCPA)technology,Vulcan OPPEL(Vulcan OPCPA PEtawatt Laser),is presented.This system will be coupled with the existing hybridCPA/OPCPA VULCAN laser system(500 J,500 fs beamline;250 J,ns regime beamline)based on Nd:glass amplification.Its pulse duration(20 times shorter)combined with the system design will allow the auxiliary beamline and its secondary sources to be used as probe beams for longer pulses and their interactions with targets.The newly designed system will be mainly dedicated to electron beam generation,but could also be used to perform a variety of particle acceleration and optical radiation detection experimental campaigns.In this communication,we present the entire beamline design discussing the technology choices and the design supported by extensive simulations for each system section.Finally,we present experimental results and details of our commissioned NOPCPA picosecond front end,delivering 1.5 mJ,~180 nm(1/e^(2))of bandwidth compressed to sub-15 fs. | Mario Galletti Pedro Oliveira Marco Galimberti Munadi Ahmad Giedre Archipovaite Nicola Booth Emerald Dilworth Andy Frackiewicz Trevor Winstone Ian Musgrave Cristina Hernandez-Gomez | 2020 | High Power Laser Science and Engineering2020，8，4： | 2 |
| 4 | 质粒 染色体介导的大肠埃希菌β-内酰胺酶基因型与耐药性分析显示文摘目的研究产β-内酰胺酶大肠埃希菌基因型及其相关耐药性。方法对临床分离的7株大肠埃希菌,作β-内酰胺酶测定、药物敏感试验、质粒DNA转化和DNA印迹试验。结果7株大肠埃希菌,经E-test法检测,均产生超广谱β-内酰胺酶(ESBLs);质粒DNA电泳图谱显示7株大肠埃希菌均含有TEM型耐药质粒;通过大肠埃希菌质粒DNA和染色体DNA印迹试验证明7株大肠埃希菌耐药由质粒介导或由质粒与染色体共同介导。结论第一株大肠埃希菌β-内酰胺酶单纯由质粒介导,第2~7株大肠埃希菌β-内酰胺酶由质粒和染色体共同介导。由质粒与染色体双重介导的β-内酰胺酶增强了大肠埃希菌对抗生素的耐药性。 | 戎建荣 王淑峰 Ian Booth | 2008 | 山西医药杂志(上半月)2008，37，12： | 2 |
| 5 | Sensing andadaptingtoacidstress显示文摘 | Ian R Booth P Cash C O Byrne | 2002 | AntonievanLeeuwenhoek2002，81，： | 1 |
| 6 | Brain white matter damage in aging and cognitive ability in youth and older age显示文摘 | Maria del C. Valdés Hernández Tom Booth Catherine Murray Alan J. Gow Lars Penke Zoe Morris Susana Mu?oz Maniega Natalie A. Royle Benjamin S. Aribisala Mark E. Bastin John M. Starr Ian J. Deary Joanna M. Wardlaw | 2013 | Neurobiology of Aging2013，，： | 1 |
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