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| 1 | High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation:Role of endoplasmic-reticulum-stress显示文摘AIM To elucidate how high diet-induced endoplasmic reticulum-stress upregulates thioredoxin interacting protein expression in Müller cells leading to retinal inflammation. METHODS Male C57Bl/J mice were fed either normal diet or 60% high fat diet for 4-8 wk. During the 4 wk study, mice received phenyl-butyric acid(PBA); endoplasmic reticulum-stress inhibitor; for 2 wk. Insulin resistance was assessed by oral glucose tolerance. Effects of palmitate-bovine serum albumin(BSA)(400 μmol/L) were examined in retinal Müller glial cell line and primary Müller cells isolated from wild type and thioredoxin interacting protein knock-out mice. Expression of thioredoxin interacting protein, endoplasmic reticulum-stress markers, mi R-17-5p m RNA, as well as nucleotide-binding oligomerization domain-like receptor protein(NLRP3) and IL1β protein was determined.RESULTS High fat diet for 8 wk induced obesity and insulin resistance evident by increases in body weight and impaired glucose tolerance. By performing quantitative real-time polymerase chain reaction, we found that high fat diet triggered the expression of retinal endoplasmic reticulum-stress markers(P < 0.05). These effects were associated with increased thioredoxin interacting protein and decreased mi R-17-5p expression, whichwere restored by inhibiting endoplasmic reticulumstress with PBA(P < 0.05). In vitro, palmitate-BSA triggered endoplasmic reticulum-stress markers, which was accompanied with reduced mi R-17-5p and induced thioredoxin interacting protein m RNA in retinal Müller glial cell line(P < 0.05). Palmitate upregulated NLRP3 and IL1β expression in primary Müller cells isolated from wild type. However, using primary Müller cells isolated from thioredoxin interacting protein knock-out mice abolished palmitate-mediated increase in NLRP3 and IL1β.CONCLUSION Our work suggests that targeting endoplasmic reticulumstress or thioredoxin interacting protein are potential therapeutic strategies for early intervention of obesityinduced retinal inflammation. | Maha Coucha Islam N Mohamed Sally L Elshaer Osinakachuk Mbata Megan L Bartasis Azza B El-Remessy | 2017 | World Journal of Diabetes2017，8，2： | 8 |
| 2 | Thioredoxin interacting protein,a key molecular switch between oxidative stress and sterile inflammation in cellular response显示文摘Tissue and systemic inflammation have been the main culprit behind the cellular response to multiple insults and maintaining homeostasis.Obesity is an independent disease state that has been reported as a common risk factor for multiple metabolic and microvascular diseases including nonalcoholic fatty liver disease(NAFLD),retinopathy,critical limb ischemia,and impaired angiogenesis.Sterile inflammation driven by high-fat diet,increased formation of reactive oxygen species,alteration of intracellular calcium level and associated release of inflammatory mediators,are the main common underlying forces in the pathophysiology of NAFLD,ischemic retinopathy,stroke,and aging brain.This work aims to examine the contribution of the pro-oxidative and pro-inflammatory thioredoxin interacting protein(TXNIP)to the expression and activation of NLRP3-inflammasome resulting in initiation or exacerbation of sterile inflammation in these disease states.Finally,the potential for TXNIP as a therapeutic target and whether TXNIP expression can be modulated using natural antioxidants or repurposing other drugs will be discussed. | Islam N Mohamed Luling Li Saifudeen Ismael Tauheed Ishrat Azza B El-Remessy | 2021 | World Journal of Diabetes2021，12，12： | 6 |
| 3 | Source identification, contamination status and health risk assessment of heavy metals from road dusts in Dhaka, Bangladesh显示文摘In this study, concentrations of Cr, Mn, Ni, Cu, Zn, Cd and Pb were determined in road dusts collected from different locations in Dhaka to assess source, contamination status and health risk. Energy-dispersive X-ray fluorescence spectroscopy and energy-dispersive X-ray spectroscopy were used to determine Cr, Mn, Ni, Cu, Zn, Cd and Pb and their mean concentrations were 162.27 ± 29.46, 721.18 ± 180.14, 35.65 ± 12.55, 104.56 ± 128.33, 515.32 ± 321.90,BDL, and 342.82 ± 591.20 mg/kg, respectively. Among the heavy metals, highest concentrations of Cu, Zn and Pb were found at urban sites-7(municipal waste dumping) and 8(medical waste incineration). Highest concentration of Cr followed by Cu and Zn was found at site-5(Tejgaon, urban). Principal component analysis revealed that anthropogenic activities are the potential sources for Cr, Ni, Cu, Zn and Pb while earth crust for Mn. Pollution index and pollution load index results suggested that all the sites were contaminated and/or degraded by Cr, Cu, Zn and Pb except sites-9(urban), 10(sub-urban), 11(rural) while sites-7 and 8(urban) were extremely degraded. For noncarcinogenic health risk, hazard quotient values for dermal were higher compared to that of inhalation/ingestion. Though hazard index values were less than 1 at all the sites, these were at least one order of magnitude higher for children group than that of adult group, thus the children group may face more noncarcinogenic health risk at sites -7 and 8. Values of incremental lifetime cancer risk were from 10to 10showed no carcinogenic health risk by road dusts contaminated with the heavy metals. | Aklima Nargis Ahsan Habib Md Nazrul Islam Kai Chen Md Shafiqul Islam Sarker A N M Al-Razee Wenbin Liu Guorui Liu Minggang Cai | 2022 | Journal of Environmental Sciences2022，34，11： | 3 |
| 4 | Functional Heterogeneity of Cancer-Associated Fibroblasts from Human Colon Tumors Shows Specific Prognostic Gene Expression Signature显示文摘 | Mercedes Herrera Abul B.M.M.K. Islam Alberto Herrera Paloma Martín Vanesa García Javier Silva Jose M. Garcia Clara Salas Ignacio Casal Antonio García de Herreros Félix Bonilla Cristina Pe?a | 2013 | Clinical Cancer Research2013，，21： | 2 |
| 5 | Growth Empirics :A Panel Data Approach 显示文摘 | Islam N | 1995 | Quarterly Journal of Economics1995，，110： | 1 |
| 6 | Effect of nanosecond pulsed electric fields on the human prostate cancer cell line LNCaP显示文摘 | Donthula V Camps R B Islam N E | 2009 | IEEE Transactions on Dielectrics and Electrical Insulation2009，16，5： | 1 |
| 7 | Inertintxaocular eyelash foreign body following phacoemulsification cataract surgery显示文摘 | Islam N Dabbagh A | 2006 | Acta Ophthalmol Scand2006，84，3： | 1 |
| 8 | Decreased accumulation of glutelin types in rice grains constitutively expressing a sunflower seed albumin gene 显示文摘 | Islam N Upadhyaya N M Campbell P M | 2005 | Phytochemistry2005，66，21： | 1 |
| 9 | Fiber parametric amplifiers for wavelength band conversion 显示文摘 | ISLAM M N BOYRAZ O | 2002 | IEEE Journal of Selected Topics in Quantum Electronics2002，3，8： | 1 |
| 10 | Clinical and haemato- pathological characteristics of adult acute lymphoblastic leukaemia显示文摘 | Islam N Rahman MM Aziz MA | 2014 | Mymensingh Med J2014，23，： | 1 |
| 11 | Growth empirics: a panel data approach显示文摘 | ISLAM N | 1995 | Quarterly Journal of Economics1995，110，4： | 1 |
| 12 | Transient monocular blindness : The controversial role of the ophthalmic artery 显示文摘 | Petzold A Islam N Plant GT | 2004 | J Neurol2004，251，7： | 1 |
| 13 | Growth Empirics: A Panel Data Approach 显示文摘 | Islam N | 1995 | Quarterly Journal of Economics1995，，04： | 1 |
| 14 | Interaction of mitoxantrone with human serum albumin: Spectroscopic and molecular modeling studies显示文摘 | Khan S N Islam B Yennamalli R et aI | 2008 | Eur J Pharm Sci2008，35，： | 1 |
| 15 | Growth Empirics: A Panel Data Approach 显示文摘 | ISLAM N | 1995 | The Quarterly Journal of Economics1995，110，4： | 1 |
| 16 | The synergistic effect between erosion and corrosion of API pipeline in CO2 and saline medium显示文摘 | Aminul Islam M Farhat Zoheir N | 2013 | Tribology International2013，68，： | 1 |
| 17 | Growth Empirics: A Panel Data Approach显示文摘 | Islam N | 1995 | Quarterly Journal of Economics1995，110，4： | 1 |
| 18 | Hydrostatic pressure induces apoptosis in human cbondrocytes from osteoarthritic cartilage through up-regulation of tumor necrosis factor-alpha, inducible nitric oxide synthase, p53,c-myc, and bax-alpha, and suppression of bcl-2 显示文摘 | Islam N Haqqi TM Jepsen KJ | 2002 | J Cell Biochem2002，87，3： | 1 |
| 19 | Protein extraction from mature rice leaves for two-dimensional gel electrophoresis and its application in proteome analysis显示文摘 | Islam N Lonsdale M Upadhyaya N M | | 0，，04： | 1 |
| 20 | Effectiveness of scallop powder ice in reducing bacterial load on fresh whole fish and in the melted ice water显示文摘 | AHMED S AKAND N R ISLAM M T | 2015 | LWT - Food Science and Technology2015，64，1： | 1 |
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