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| 1 | Hypofractionated stereotactic rad iotherapy alone without whole-brain irradiation for patien ts with solitary and oligo brain metastasis using noninvasive fixation of the skull显示文摘To evaluate the efficacy and toxicity of hypofractionated stereotactic radiotherapy(HSRT)using noninvasive fixation of the sk ull on solitary or oligo brain metastatic p atients as an alternative to stereotactic radiosurgery(SRS)using invasive fixation.The subjects were 87patients who had 4or fewer brain meta stases(50solitary,37oligometastases).Treatment was conducted on 159meta stases by using a linac-based stereotactic system.T he median isocentric dose was 35Gy in4fractions.Whole-brain irradiati on was not applied as an initial treatment.For the salvage treatmen t of metachronous brain metastases,repeat HSRT or whole-brain irradiation was applied.The actuarial1-year local tumor control rate was 81%.Treatment-related complicatio ns were observed in 4patients in the e arly period(<3months)and in 2patients in the late period.T he median survival period was 8.7mon ths.Metachronous brain metastases occurred in 30patients,and none of the 18patients who were eligible for salvage HSRT refused to re ceive it again.Hypofractionated stereotactic radiotherapy achieved tumor control and survival equivalent to those of SRS reported i n the literature.The results suggested that HSRT could be an alternative for solitary or oligo br ain metastatic patients with less to xicity and less invasiveness compared to | Aoyama H Shirato H Onimaru R Kagei K Ikeda J Ishii N Sawamura Y Miyasaka K | 2003 | 癌症2003，22，7： | 12 |
| 2 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase 显示文摘 | Watashi K Ishii N Hijikata M | 2005 | Mol Cell2005，19，1： | 1 |
| 5 | A pivotal role of cytosolic phospholipase A(2) in bleomyein -induced pulmonary fibrosis 显示文摘 | NagaseT Uozumi N Ishii S | 2003 | Nat Med2003，8，5： | 1 |
| 6 | The RRASK motif in xenopus cyclin B2 is required for the substrate recognition of Cdc25C by the cyclin B-Cdc2 complex 显示文摘 | Goda T Ishii T Nakajo N | 2003 | J Biol Chem2003，278，19： | 1 |
| 7 | Flow-Induced vibration of long-span gates,Part Ⅰ:Model development 显示文摘 | ISHII N | 1992 | J of Fluids and Structures1992，，6： | 1 |
| 8 | A pivotal role of cytosolic phospholipase A ( 2 ) in bleomycin - induced pulmonary fibrosis 显示文摘 | Nagase T Uozumi N Ishii S | 2003 | Nat Med2003，8，5： | 1 |
| 9 | Anterior decompression and fusion versus laminoplasty for cervical myelopathy caused by soft disc herniation:a prospective multicenter study显示文摘 | Koakutsu T Morozumi N Ishii Y | 2010 | J Orthop Sci2010，15，1： | 1 |
| 10 | 50 carotenoids, sarcinaxanthin, sar- cinaxanthin monoglucoside, and sarcinaxanthin diglucoside, ob- tained from Mlerococcm yunnanen~la 显示文摘 | Osawa A Ishii Y Sasamura N et aL Characterization and an- tio~ddative activities of rare C | 2010 | J Oleo Sci2010，59，12： | 1 |
| 11 | Nitric Oxide Synthesis and Oxidative Stress in the Renal Cortex of Rats with Diabetes Mellitus 显示文摘 | ISHII N PATEL K P LANE P H | 2001 | J Am Soc of Nephrol2001，12，： | 1 |
| 12 | Immunomodulatory effects of a plasmid expressing B7-2 on human immunodeficiency virus-1-specific cell-mediated immunity induced by a plasmid encoding the viral antigen显示文摘 | Hamajima K Ishii N | 1997 | Eur J Immunol1997，27，3： | 1 |
| 13 | Targets of transcriptional regulation by TGF-β :expression profile analysis using oligo nucleotider rays显示文摘 | Akiyoshi S Ishii M Nemoto N | 2001 | Jpn Cancer Res2001，92，3： | 1 |
| 14 | Study of the incidence of lacunes in relation to age, hypertension, and arteriosclerosis显示文摘 | Dozono K Ishii N nishiara Y | 1991 | Stroke1991，22，8： | 1 |
| 15 | The effect of myocardial bridge on coronary atherosclerosis and ischemia 显示文摘 | Ishii T Asuwa N Masuda S | 1998 | J Pathol1998，185，： | 1 |
| 16 | Vascular remodeling by hemo- dynamic factors 显示文摘 | Ishikawa Y Asuwa N Ishii T | 2000 | Virchowa Arch2000，437，2： | 1 |
| 17 | Bullous dermolysis of the newborn and dystrophic epidermolysis bullosa pruriginosa within the same family: two phenotypes associated with a COL7A1 mu- tation显示文摘 | Murase K Kanoh H Ishii N | 2011 | Acta Derm Venereol2011，91，6： | 1 |
| 18 | Intramedullary spinal cord germinoma-2 case reports 显示文摘 | Aoyama T Hida K Ishii N | 2007 | Surg Neurol2007，67，： | 1 |
| 19 | Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance显示文摘 | Kikuchi N Ishii Y Morishima Y | | 0，，： | 1 |
| 20 | Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages显示文摘 | Yano M Matsumura T Senokuchi T Ishii N Murata Y Taketa K | 2007 | Circ Res2007，100，10： | 1 |
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