|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 灯盏花中新的酚酸类化合物的结构及活性研究显示文摘目的 研究中药灯盏花 [Erigeronbreviscapus (Vant.)Hand Mazz]的心血管活性成分。 方法 用各种色谱技术进行分离 ,用IR ,UV ,MS ,1HNMR ,13CNMR ,2DNMR光谱鉴定他们的结构。以乳酸脱氢酶 (LDH)释放量为指标测定BCMEC(bovinecerebralmicrovascularendothelialcell)损伤 ,比色法测定药物体外抗氧化和抗活性氧能力。结果 从灯盏花中分离得到 2个化合物 ,分别鉴定化合物的结构为 :1 O 甲基 3 ,5 O 双咖啡酰基奎宁酸甲酯 (III)和 5 O 咖啡酰基奎宁酸丁酯 (IV)。结论 化合物III,IV为新的酚酸类化合物 。 | 张卫东 HA.Thi Bang Tam 陈万生 孔德云 李惠庭 王永红 Isabella FOURASTE | 2001 | 药学学报2001，36，5： | 33 |
| 2 | Current therapeutic strategies for advanced pancreatic cancer: A review for clinicians显示文摘Pancreatic cancer(PC) would become the second leading cause of cancer death in the near future, despite representing only 3% of new cancer diagnosis. Survival improvement will come from a better knowledge of risk factors, earlier diagnosis, better integration of locoregional and systemic therapies, as well as the development of more efficacious drugs rising from a deeper understanding of disease biology. For patients with unresectable, non-metastatic disease, combined strategies encompassing primary chemotherapy and radiation seems to be promising. In fit patients, new polychemotherapy regimens can lead to better outcomes in terms of slight but significant survival improvement associated with a positive impact on quality of life. The upfront use of these regimes can also increase the rate of radical resections in borderline resectable and locally advanced PC. Second line treatments showed to positively affect both overall survival and quality of life in fit patients affected by metastatic disease. At present, oxaliplatin-based regimens are the most extensively studied. Nonetheless, other promising drugs are currently under evaluation. Presently, in addition to surgery and conventional radiation therapy, new locoregional treatment techniques are emerging as alternative options in the multimodal approach to patients or diseases not suitable for radical surgery. As of today, in contrast with other types of cancer, targeted therapies failed to show relevant activity either alone or in combination with chemotherapy and, thus, current clinical practice does not include them. Up to now, despite the fact of extremely promising results in different tumors, also immunotherapy is not in the actual therapeutic armamentarium for PC. In the present paper, we provide a comprehensive review of the current state of the art of clinical practice and research in PC aiming to offer a guide for clinicians on the most relevant topics in the management of this disease. | Rosella Spadi Federica Brusa Agostino Ponzetti Isabella Chiappino Nadia Birocco Libero Ciuffreda Maria Antonietta Satolli | 2016 | World Journal of Clinical Oncology2016，7，1： | 15 |
| 3 | Incidence of hepatocellular carcinoma in outpatients with cirrhosis in Brazil: A 10-year retrospective cohort study显示文摘AIM To determine the incidence of hepatocellular carcinoma(HCC) and the impact of HCC surveillance on early diagnosis and survival of cirrhotic outpatients. METHODS In this retrospective cohort study, cirrhotic outpatients undergoing HCC surveillance between March 2005 and March 2014 were analyzed. Exclusion criteria were HIV coinfection; previous organ transplantation; diagnosis of HCC at first consultation; missing data in the medical chart; and less than 1 year of follow-up. Surveillance was carried out every six months using ultrasound and serum alpha-fetoprotein determination. Ten-year cumulative incidence and survival were estimated through Kaplan-Meier analysis. RESULTS Four hundred and fifty-three patients were enrolled, of which 57.6% were male. Mean age was 55 years. Hepatitis C virus and heavy use of alcohol were the main etiologic agents of cirrhosis. HCC was diagnosed in 75 patients(16.6%), with an estimated cumulative incidence of 2.6% in the 1st year, 15.4% in the 5th year, and 28.8% in the 10 th year. Median survival was estimated at 17.6 mo in HCC patients compared to 234 mo in non-HCC patients(P < 0.001). Early-stage HCC was more often detected in patients who underwent surveillance every 6 mo or less(P = 0.05). However, survival was not different between patients with early stage vs non-early stage tumors [HR = 0.54(0.15-1.89), P = 0.33].CONCLUSION HCC is a frequent complication in patients with cirrhosis and adherence to surveillance programs favors early diagnosis. | Marcelo Campos Appel-da-Silva Suelen Aparecida da Silva Miozzo Isabella de Azevedo Dossin Cristiane Valle Tovo Fernanda Branco Angelo Alves de Mattos | 2016 | World Journal of Gastroenterology2016，22，46： | 7 |
| 4 | 伊维菌素4种剂型不同给药方法对牦牛皮蝇蛆病防治的比较研究显示文摘选用伊维菌素浇泼剂、注射剂、片剂、干混悬剂4种剂型,分别按0.5,0.2,0.3,0.3mg/kg体重剂量,对1.5岁牦牛在10月中旬给药,进行不同给药方法用于防治牦牛皮蝇蛆病的给药速度、劳动强度、使用的安全性、防治效果等方面的比较研究。结果:给药速度以浇泼剂最佳,其次为注射剂,再次为干混悬剂,片剂最慢;劳动强度以浇泼剂最佳,其次为注射剂与干混悬剂,再次为片剂;伊维菌素注射剂、浇泼剂和干混悬剂的防治效果佳,其驱净率和驱虫率均达100.00%,片剂较低,平均驱净率和驱虫率分别为95.41%和96.36%;同期检查阳性对照组牦牛皮蝇蛆平均感染率33.33%、平均感染强度7.5个虫体。试验表明,伊维菌素4种剂型防治牦牛皮蝇蛆病高效安全,其中浇泼剂优势明显。 | 蔡进忠 李春花 Boulard Chantal 何国声 孙延生 冯玉诚 Isabella Romboli 李春生 | 2013 | 青海畜牧兽医杂志2013，43，2： | 6 |
| 5 | Markers of bile duct tumors显示文摘Biliary tract carcinomas are relatively rare,representing less than 1%of cancers.However,their incidence has increased in Japan and in industrialized countries like the USA.Biliary tract tumors have a poor prognosis and a high mortality rate because they are usually detected late in the course of the disease;therapeutic treatment options are often limited and of minimal utility.Recent studies have shown the importance of serum and molecularmarkers in the diagnosis and follow up of biliary tract tumors.This review aims to introduce the main features of the most important serum and molecular markers of biliary tree tumors.Some considerable tumor markers are cancer antigen 125,carbohydrate antigen 19-9,carcinoembryonic antigen,chromogranin A,mucin 1,mucin 5,alpha-fetoprotein,claudins and cytokeratins. | Giulia Malaguarnera Maria Giordano Isabella Paladina Alessandra Rando Mario Uccello Francesco Basile Antonio Biondi Santo Carnazzo Innocenza Alessandria Clorinda Mazzarino | 2011 | World Journal of Gastrointestinal Oncology2011，3，4： | 6 |
| 6 | Influence of proton pump inhibitors in the development of spontaneous bacterial peritonitis显示文摘AIM To investigate whether the use of proton pump inhibitors(PPIs) increases the incidence of spontaneous bacterial peritonitis(SBP) in patients with cirrhosis and ascites.METHODS An historical cohort study was carried out in cirrhotic outpatients with ascites followed in a specialized clinic at a tertiary hospital in Southern Brazil. Patient charts were reviewed to collect information on the variables of interest as the use of PPIs. Primary outcome was defined as development of SBP during the study period. SBP was diagnosed based on ascitic fluid polymorphonuclear cell count ≥ 250 cells/mm3 without evidence of an intraabdominal, surgically treatable source of infection.RESULTS Of 738 cirrhotic patients, 582(58.2% male) were enrolled, with mean age of 53.6 ± 12 years. Hepatitis C virus infection(36.2%) and alcohol abuse(25.6%) were the main etiologies of cirrhosis. The presence of ascites was detected in 299(51.4%) patients during the development of the study. Nineteen patients with previous diagnosis of SBP undergoing secondary prophylaxis and 22 patients with insufficient PPI data were further excluded. Of 258 patients with ascites, 151 used PPIs, and 34 developed SBP(22.5%). Among 107 non-users of PPIs, 23 developed SBP(21.5%)(HR = 1.44, 95%CI: 0.85-2.47, P = 0.176). The median follow-up time of patients using PPI was 27 mo vs 32 mo for non-users. Univariate analysis of the risk factors associated with the development of SBP revealed a significant association of SPB with the severity of liver disease according to the Child-Turcotte-Pugh(CTP) score. Multivariate analysis confirmed that CTP score was the only independent variable influencing the occurrence of SBP. Survival at 60 mo(Kaplan-Meier analysis) was similar in users and non-users of PPI, independently of the presence of SBP(58.4% vs 62.7% respectively, P = 0.66). For patients with SBP, survival at 60 mo was 55.1%, vs 61.7% in patients without SBP(P = 0.34). CONCLUSION In conclusion, the rate of SBP was not significantly different in users or non-users of PPIs in this cohort of cirrhotic with ascites. | Suelen A S Miozzo Jorge A John Marcelo C Appel-da-Silva Isabella A Dossin Cristiane V Tovo Angelo A Mattos | 2017 | World Journal of Hepatology2017，9，35： | 5 |
| 7 | FDG-PET/CT and parathyroid carcinoma:Review of literature and illustrative case series显示文摘Parathyroid cancer is an uncommon malignant cancer and is associated with a poor prognosis.The staging of parathyroid cancer represents an important issue both at initial diagnosis and after surgery and medical treatment.The role of positron emission tomography/computed tomography(PET/CT)with 18F-Fluorodeoxyglucose(18F-FDG)as an imaging tool in parathyroid cancer is not clearly reported in the literature,although its impact in other cancers is well-defined.The aim of the following illustrative clinical cases is to highlight the impact of PET/CT in the management of different phases of parathyroid cancer.We describe five patients with parathyroid malignant lesions,who underwent FDG PET/CT at initial staging,restaging and post-surgery evaluation.In each patient we report the value of PET/CT comparing its findings with other common imaging modalities(e.g.,CT,planar scintigraphy with 99mTcsestamibi,magnetic resonance imaging)thus determining the complementary benefit of FDG PET/CT in parathyroid carcinoma.We hope to provide an insight into the potential role of PET/CT in assessing the extent of disease and response to treatment which are the general principles used to correctly evaluate disease status. | Laura Evangelista Nadia Sorgato Francesca Torresan Isabella Merante Boschin Gianmaria Pennelli Giorgio Saladini Andrea Piotto Domenico Rubello Maria Rosa Pelizzo | 2011 | World Journal of Clinical Oncology2011，2，10： | 5 |
| 8 | A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility显示文摘Aromatase activity has commonly been associated with male infertility characterized by testicular dysfunction with low serum testosterone and/or testosterone to estradiol ratio.In this subset of patients,and particularly in those with hypogonadism,elevated levels of circulating estradiol may establish a negative feedback on the hypothalamic–pituitary–testicular axis by suppressing follicle-stimulating hormone(FSH)and luteinizing hormone(LH)production and impaired spermatogenesis.Hormonal manipulation via different agents such as selective estrogen modulators or aromatase inhibitors to increase endogenous testosterone production and improve spermatogenesis in the setting of infertility is an off-label option for treatment.We carried out a systematic review and meta-analysis of the literature of the past 30 years in order to evaluate the benefits of the use of aromatase inhibitors in the medical management of infertile/hypoandrogenic males.Overall,eight original articles were included and critically evaluated.Either steroidal(Testolactone)or nonsteroidal(Anastrozole and Letrozole)aromatase inhibitors were found to statistically improve all the evaluated hormonal and seminal outcomes with a safe tolerability profile.While the evidence is promising,future prospective randomized placebo-controlled multicenter trials are necessary to better define the efficacy of these medications. | Francesco Del Giudice Gian Maria Busetto Ettore De Berardinis Isabella Sperduti Matteo Ferro Martina Maggi Martin S Gross Alessandro Sciarra Michael L Eisenberg | 2020 | Asian Journal of Andrology2020，22，4： | 5 |
| 9 | 饵料浓度和成体密度对汤氏纺锤水蚤(Acartia tonsa)产粪粒数、产卵和孵化的影响显示文摘采用静水法研究了不同饵料浓度和成体密度对汤氏纺锤水蚤产粪粒数(FP)、产卵(EP)和孵化(HS)的影响。根据碳含量设定250、500、1000、1500、2000和3000μgC/L六个饵料浓度梯度,以及40、80和160个/L三个成体密度进行实验。结果表明,在成体密度为40和80个/L时,汤氏纺锤水蚤的平均产粪粒数随着饵料浓度的增加而增加;在饵料密度高于500μgC/L时,成体密度为160个/L的产粪粒数显著低于其它两组(P<0.05)。饵料浓度和成体密度对产卵量影响显著,在相同成体密度下,产卵量随着饵料密度的提高而增加;在饵料密度高于500μgC/L时,成体密度为160个/L的产卵量显著低于其它两组(P<0.05)。汤氏纺锤水蚤卵的孵化率受饵料浓度和成体密度的影响不大。 | 张建设 ISABELLA Buttino 朱爱意 吴常文 | 2013 | 海洋与湖沼2013，44，1： | 4 |
| 10 | Induced pluripotent stem cells for modeling neurological disorders显示文摘Several diseases have been successfully modeled since the development of induced pluripotent stem cell(i PSC) technology in 2006. Since then, methods for increased reprogramming efficiency and cell culture maintenance have been optimized and many protocols for differentiating stem cell lines have been successfully developed, allowing the generation of several cellular subtypes in vitro. Gene editing technologies have also greatly advanced lately, enhancing disease-specific phenotypes by creating isogenic cell lines, allowing mutations to be corrected in affected samples or inserted in control lines. Neurological disorders have benefited the most from i PSC-disease modeling for its capability for generating disease-relevant cell types in vitro from the central nervous system, such as neurons and glial cells, otherwise only available from post-mortem samples. Patient-specific i PSC-derived neural cells can recapitulate the phenotypes of these diseases and therefore, considerably enrich our understanding of pathogenesis, disease mechanism and facilitate the development of drug screening platforms for novel therapeutic targets. Here, we review the accomplishments and the current progress in human neurological disorders by using i PSC modeling for Alzheimer's disease, Parkinson's disease, Huntington's disease, spinal muscular atrophy, amyotrophic lateral sclerosis, duchenne muscular dystrophy, schizophrenia and autism spectrum disorders, which include Timothy syndrome, Fragile X syndrome, Angelman syndrome, Prader-Willi syndrome, PhelanMc Dermid, Rett syndrome as well as Nonsyndromic Autism. | Fabiele B Russo Fernanda R Cugola Isabella R Fernandes Graciela C Pignatari Patricia C B Beltrão-Braga | 2015 | World Journal of Transplantation2015，5，4： | 4 |
| 11 | Endoscopic papillary balloon dilation for diffi cult common bile duct stones:Our experience显示文摘AIM: To evaluate the eff icacy and safety of endoscopic balloon dilation(EBD) performed for common bile duct(CBD) stones.METHODS: From a computer database, we retrospectively analyzed the data relating to EBD performed in patients at the gastrointestinal unit of the Sandro Pertini Hospital of Rome(small center with low case volume) who underwent endoscopic retrograde cholangiopancreatography(ERCP) for CBD from January 1, 2010 to February 29, 2012. All patients had a proven diagnosis of CBD stones studied with echography, RMN cholangiography and, when necessary, with computed tomography of the abdomen(for example, in cases with pace-makers). Prophylactic therapies, with gabexate mesilate 24 h before the procedure and with an antibiotic(ceftriaxone 2 g) 1 h before, were administered in all patients. The duodenum was intubated with a side-viewing endoscope under deep sedation with intravenous midazolam and propofol. The patients were placed in the supine position in almost all cases. EBDof the ampulla was performed under endoscopic and f luoroscopic guidance with a balloon through the scope(Hercules, wireguided balloon, Cook Ireland Ltd. and CRE, Microvasive, Boston Scientific Co., Natick, MA, United States). RESULTS: A total of 14 patients(9 female, 5 male; mean age of 73 years; range 57-82 years) were enrolled in the study, in whom a total of 15 EBDs were performed. All patients underwent minor endoscopic sphincterotomy(ES) prior to the EBD. The size of balloon insuff lation depended on stone size and CBD dilation and this was performed until it reached 16 mm in diameter. EBD was performed under endoscopic and f luoroscopic guidance. The balloon was gradually f illed with diluted contrast agent and was maintained inf lated in position for 45 to 60 s before def lation and removal. The need for precutting the major papilla was 21.4%. In one patient(an 81-year-old), EBD was performed in a Billroth Ⅱ. Periampullary diverticula were found only in a 74-year-old female. The adverse event related to the procedures(ERCP + ES) was only an intra procedural bleeding(6.6%) that occurred after ES and was treated immediately with adrenaline sclerotherapy. No postoperative complications were reported.CONCLUSION: With the current endoscopic techniques, very few patients with choledocholithiasis require surgery. EBD is an eff icacious and safe procedure. | Maddalena Zippi Isabella De Felici Roberta Pica Giampiero Traversa Giuseppe Occhigrossi | 2013 | World Journal of Clinical Cases2013，1，1： | 4 |
| 12 | Cultivable Microfungal Communities Inhabiting Biological Soil Crusts in the Tengger Desert, China显示文摘Biological soil crusts are essential components of arid ecosystems. We examined the variations in microfungal communities inhabiting different biological crust types in the vicinity of the Shapotou Research Station in the Tengger Desert, China. A total of134 species from 66 genera were isolated using the soil dilution plate method. The mycobiota of the crusts from the Tengger Desert,similar to that of the Negev Desert in Israel, was dominated by melanin-containing species with large multicellular spores. Abundance of these xeric species increased spatially with increasing xeric conditions from moss-dominated to cyanobacterial crusts. Density of microfungal isolates displayed the opposite trend and was positively correlated with chlorophyll content, indicating the possible significant influence of organic matter content and wetness duration on fungal biomass. Within a chronosequence of the localities of different periods after sand stabilization with revegetation, little variations were revealed in species composition and isolate density of the crust microfungal communities, while a tendency towards a decrease in the community diversity level with the crust age was noted Microfungal communities from stabilized localities differed from those of the natural localities in abundance of the dominant and some frequent species, and in the fluctuations of diversity characteristics between the cyanobacterial and moss-dominated crusts.The variations in mycobiotic parameters in the soil crusts of the Tengger Desert were apparently associated with the topographically induced variations in abiotic conditions, while the differences in microfungal community of soil crusts between the Tengger and Negev deserts, such as the significantly higher abundance of thermotolerant species in the crusts of the Tengger Deserts, were caused by the principal differences in their precipitation regimes, associated with different rainy seasons, winter and summer in the Negev and Tengger deserts, respectively. | Isabella GRISHKAN JIA Rong-Liang Giora J.KIDRON LI Xin-Rong | 2015 | Pedosphere2015，25，3： | 4 |
| 13 | Focus on intracytoplasmic morphologically selected sperm injection (IMSI). a mini-review显示文摘Intracytoplasmic 精子注射(ICSI ) 是在坏分子不孕的许多情况中的推荐治疗。几研究表明了在最佳的精子形态学和积极 ICSI 结果之间的积极关联。事实上,有头的严重畸形的精子很好被记录与低使肥沃,培植和怀孕率被联系。然而,作为 ‘ 被分类的一个精子;由在低放大的显微镜的观察的 normal' 能包含损害使肥沃过程和胚胎的开发的 ultrastructural 缺点。intracytoplasmic 词法上选择了注射(IMSI ) 过程改变了的精子对注射合适的一个精子应该显得怎么样的感觉。精子选择在 × 被执行; 6000 放大,允许改进了对精子原子核的评价。当前,标准化了临床的指示因为 IMSI 正在缺乏,候选人在他们的病历或精子暂停的小心的分析的根据上被选择。进一步未来的使随机化的研究被需要在病人的特定的组证实 IMSI 的优点。除了提供 IMSI 过程的简短概述,这研究试图考察文学,它解释理论基础和这种技术的临床的结果。IMSI 与改进培植和临床的怀孕被联系的几报告表演象更低的流产率一样评价什么时候与 ICSI 相比。尽管在精子的反常原子核形状,增加的 DNA 破碎和否定实验室和临床的结果之间的可能的关联长被调查了,结果正在冲突。 | Giuseppe Lo Monte Fabien Murisier Isabella Piva Marc Germond Roberto Marci | 2013 | Asian Journal of Andrology2013，15，5： | 3 |
| 14 | A demonstration project of Global Alliance against Chronic Respiratory Diseases:Prediction of interactions between air pollution and allergen exposure—the Mobile Airways Sentinel NetworK-Impact of air POLLution on Asthma and Rhinitis approach显示文摘This review analyzes the state and recent progress in the field of information support for pollen allergy sufferers.For decades,information available for the patients and allergologists consisted of pollen counts,which are vital but insufficient.New technology paves the way to substantial increase in amount and diversity of the data.This paper reviews old and newly suggested methods to predict pollen and air pollutant concentrations in the air and proposes an allergy risk concept,which combines the pollen and pollution information and transforms it into a qualitative risk index.This new index is available in an app(Mobile Airways Sentinel NetworK-air)that was developed in the frame of the European Union grant Impact of Air POLLution on sleep,Asthma and Rhinitis(a project of European Institute of Innovation and Technology-Health).On-going transformation of the pollen allergy information support is based on new technological solutions for pollen and air quality monitoring and predictions.The new information-technology and artificial-intelligence-based solutions help to convert this information into easy-to-use services for both medical practitioners and allergy sufferers. | Mikhail Sofiev Yuliia Palamarchuk Annabelle Bedard Xavier Basagana Josep M.Anto Rostislav Kouznetsov Rodrigo Delgado Urzua Karl Christian Bergmann Joao A.Fonseca Govert De Vries Michiel Van Erd Isabella Annesi-Maesano Daniel Laune Jean Louis Pepin Ingrid Jullian-Desayes Stephane Zeng Wienczyslawa Czarlewski Jean Bousquet | 2020 | Chinese Medical Journal2020，，13： | 3 |
| 15 | Addressing challenges in the clinical applications associated with CRISPR/Cas9 technology and ethical questions to prevent its misuse显示文摘 | Xiang Jin Kang Chiong Isabella Noelle Caparas Boon Seng Soh Yong Fan | 2017 | Protein & Cell2017，8，11： | 3 |
| 16 | Heat shock protein 47 promotes tumor survival and therapy resistance by modulating AKT signaling via PHLPP1 in colorectal cancer显示文摘Objective:Heat shock protein 47(HSP47)is a collagen-specific molecular chaperone that facilitates collagen maturation.Its role in cancer remains largely unknown.In this study,we investigated the roles o f HSP47 in colorectal cancer(CRC)and therapy resistance.Methods:Expression o f HSP47 in CRC tissues was examined(1)in paired human CRC/adjacent normal tissues,using real time quantitative reverse transcription polymerase chain reaction(qRT-PCR),The Cancer Genome Atlas(TCGA)database,and 22 independent m icroarray databases(curated CRC).In vitro studies on several CRC cell lines(H C T 116,RKO and C C L228)with modulated HSP47 expression were conducted to assess cell viability and apoptosis(TU N EL assay and caspase-3/-7)during exposure to chemotherapy.AKT signaling and co-imm unoprecipitation studies were performed to examine HSP47 and PHLPP1 interaction.In vivo studies using tumor xenografts were conducted to assess the effects of HSP47 modulation on tum or growth and therapy response.Results:HSP47 was upregulated in CRC and was associated with poor prognosis in individuals with CRC.In vitro,HSP47 overexpression supported the survival of CRC cells,whereas its knockdown sensitized cells to 5-fluorouracil(5-FU).HSP47 promoted survival by inhibiting apoptosis,enhancing AKT phosphorylation,and decreasing expression of the AKT-specific phosphatase PHLPP1 when cells were exposed to chemotherapy.These effects were partly results of the interaction between HSP47 and PHLPP1,which decreased PHLPP1 stability and led to more persistent AKT activity.In vivoy HSP47 supported tumor growth despite 5-FU treatment.Conclusions:HSP47 supports the growth of CRC tumors and suppresses the efficacy of chemotherapy via modulation of AKT signaling. | Yijye Chern Peter Zhang Hyelim Ju Isabella T.Tai | 2020 | Cancer Biology & Medicine2020，17，2： | 3 |
| 17 | Identification of the second CFTR mutation in patients with congenital bilateral absence of vas deferens undergoing ART protocols显示文摘管 deferens (CBAVD ) 的先天的双边的缺席是膀胱的纤维变性(CF ) 的最轻微的形式的表明并且被妨碍的精子缺乏在不那样健康的病人描绘。由于帮助繁殖技术的可获得性, CBAVD 病人能生孩子。这些父亲在播送 CF transmembrane 传导力管理者(CFTR ) 的变异的等位基因的风险基因,为 CF 负责,到他们的后代。在在 CBAVD 病人的两 CFTR 等位基因的变化的鉴定是为如果女搭挡是一个健康 CF 搬运人,计算与全面 CF 生产一个孩子的风险的一个关键要求。在 CBAVD 病人的多数,然而,常规变化屏蔽不能在两 CFTR 等位基因检测变化,并且这个困难妨碍正确基因 counselling 的实行。为了关于大多数获得信息,在 CBAVD 病人代表了 CFTR 变化,我们分析了 23 个 CBAVD 病人,其中 15 个在为 36 个变化和 5T 等位基因屏蔽以后有一个单个 CFTR 变化。为在这些情况中的第二个 CFTR 变化的搜索被使用一条三重的途径执行:(i) 第一,反向的点污点分析被执行与地区性的影响检测变化;(ii ) 下次,多重结扎依赖者探查扩大试金被进行寻找大重新整理;并且(iii ) 最后,使中毒高效的液体层析被用来在全部编码区域寻找点变化。用这些途径,第二个 CFTR 变化在六个病人被检测,它增加了最后的察觉率到 60.8% 。 | Rossella.Giuliani Ivana Antonucci Isabella Torrente Paola Grammatico Giandomenico Palka Liborio Stuppia | 2010 | Asian Journal of Andrology2010，12，6： | 3 |
| 18 | Embryonal rhabdomyosarcoma in the maxillary sinus with orbital involvement in a pediatric patient:Case report显示文摘This report presents a case of embryonal rhabdomyosarcoma(e RMS) located in the left maxillary sinus and invading the orbital cavity in a ten-year-old male patient who was treated at a referral hospital.The images provided from the computed tomography showed a heterogeneous mass with soft-tissue density,occupying part of the left half of the face inside the maxillary sinus,and infiltrating and destroying the bone structure of the maxillary sinus,left orbit,ethmoidal cells,nasal cavity,and sphenoid sinus.An analysis of the histological sections revealed an undifferentiated malignant neoplasm infiltrating the skeletal muscle tissue.The immunohistochemical analysis was positive for the antigens:MyoD 1,myogenin,desmin,and Ki67(100% positivity in neoplastic cells),allowing the identification of the tumour as an eR MS.The treatment protocol included initial chemotherapy followed by radiotherapy and finally surgery.The total time of the treatment was nine months,and in 18-mo of follow-up period did not show no local recurrences and a lack of visual impairment. | Ana Carolina Rodrigues de Melo Tácio Candeia Lyra Isabella Lima Arrais Ribeiro Alexandre Rolim da Paz Paulo Rogério Ferreti Bonan Ricardo Dias de Castro Ana Maria Gondim Valen?a | 2017 | World Journal of Clinical Cases2017，5，12： | 3 |
| 19 | Bone remodeling:an operational process ensuring survival and bone mechanical competence显示文摘Bone remodeling replaces old and damaged bone with new bone through a sequence of cellular events occurring on the same surface without any change in bone shape. It was initially thought that the basic multicellular unit(BMU) responsible for bone remodeling consists of osteoclasts and osteoblasts functioning through a hierarchical sequence of events organized into distinct stages. However, recent discoveries have indicated that all bone cells participate in BMU formation by interacting both simultaneously and at different differentiation stages with their progenitors, other cells, and bone matrix constituents. Therefore,bone remodeling is currently considered a physiological outcome of continuous cellular operational processes optimized to confer a survival advantage. Bone remodeling defines the primary activities that BMUs need to perform to renew successfully bone structural units. Hence, this review summarizes the current understanding of bone remodeling and future research directions with the aim of providing a clinically relevant biological background with which to identify targets for therapeutic strategies in osteoporosis. | Simona Bolamperti Isabella Villa Alessandro Rubinacci | 2022 | Bone Research2022，10，3： | 3 |
| 20 | Review of allergic contact dermatitis: Scratching the surface显示文摘Contact dermatitis-including allergic contact dermatitis(ACD)-n and results in over four million lost work days per year in the United States alone. ACD is a classic example of a type IV delayed hypersensitivity reaction, and represents a significant burden on the health system, economy, and patient quality of life. Thorough history taking, clinical examination, histologic evaluation, and patch testing are keys to diagnosing contact dermatitis. Patch testing, especially with comprehensive and customized panels based on the patient's exposure history, is particularly useful in identifying potential allergens inthe case of allergic contact dermatitis. ACD management requires a combination of direct medical intervention, patient education, and appropriate environmental modification to prevent exposure to offending allergens in the home or workplace. Continuing advances in the study of ACD has led to an increased understanding of the disease processes, new methods for diagnosis, and improved management. This article reviews ACD-aiming to connect recent investigational data with the current clinical understanding of disease pathophysiology, diagnostic techniques, and management strategies. | Gil S Weintraub Isabella Nga Lai Christina N Kim | 2015 | World Journal of Dermatology2015，4，2： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员