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| 1 | Do age-associated changes of voltage-gated sodium channel isoforms expressed in the mammalian heart predispose the elderly to atrial fibrillation?显示文摘Atrial fibrillation(AF)is the most common cardiac arrhythmia worldwide.The prevalence of the disease increases with age,strongly implying an age-related process underlying the pathology.At a time when people are living longer than ever before,an exponential increase in disease prevalence is predicted worldwide.Hence unraveling the underlying mechanics of the disease is paramount for the development of innovative treatment and prevention strategies.The role of voltage-gated sodium channels is fundamental in cardiac electrophysiology and may provide novel insights into the arrhythmogenesis of AF.Na_v1.5 is the predominant cardiac isoform,responsible for the action potential upstroke.Recent studies have demonstrated that Na_v1.8(an isoform predominantly expressed within the peripheral nervous system)is responsible for cellular arrhythmogenesis through the enhancement of pro-arrhythmogenic currents.Animal studies have shown a decline in Na_v1.5 leading to a diminished action potential upstroke during phase 0.Furthermore,the study of human tissue demonstrates an inverse expression of sodium channel isoforms;reduction of Na_v1.5 and increase of Na_v1.8 in both heart failure and ventricular hypertrophy.This strongly suggests that the expression of voltage-gated sodium channels play a crucial role in the development of arrhythmias in the diseased heart.Targeting aberrant sodium currents has led to novel therapeutic approaches in tackling AF and continues to be an area of emerging research.This review will explore how voltage-gated sodium channels may predispose the elderly heart to AF through the examination of laboratory and clinical based evidence. | Emmanuel Isaac Stephanie M Cooper Sandra A Jones Mahmoud Loubani | 2020 | World Journal of Cardiology2020，12，4： | 3 |
| 2 | Diabetes mellitus, revascularization and outcomes in elderly patients with myocardial infarction-related cardiogenic shock显示文摘Background The prognostic role of diabetes mellitus(DM)in elderly patients with myocardial infarction-related cardiogenic shock(MI-CS)remains controversial.Little information exists about the impact of intensive cardiac care unit(ICCU)and revascularization on outcomes of elderly patients with MI-CS.We aimed to assess the prognostic impact of DM according to age in patients with MI-CS,and to analyze the impact ICCU management and revascularization on in-hospital mortality in MI-CS patients at older ages.Methods Discharge episodes with diagnosis of CS associated with MI were selected from the Spanish National Health System’s Basic Data Set.Centers were classified according to their availability of ICCU.Main outcome measured was in-hospital mortality.Results A total of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in patients aged≥75 years.The impact of DM on in-hospital mortality was different among age subgroups.While in younger patients,DM was associated to a higher mortality risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2<0.001),this association became non-significant in older patients(0.76 vs.0.81,χ^2=0.09).Adjusted mortality rate of MI-CS aged≥75 years was lower in patients admitted to hospitals with ICCU(adjusted mortality rate:74.2%vs.77.7%,P<0.001)and in patients undergoing revascularization(74.9%vs.77.3%,P<0.001).Conclusions Prognostic impact of DM in patients with MI-CS was different according to age,with a significantly lower impact at older ages.The availability of ICCU and revascularization were associated with better outcomes in these complex patients. | Miquel Gual Albert Ariza-Solé María García Márquez Cristina Fernández JoséL Bernal Francesc Formiga María-Isabel Barrionuevo JoséC Sánchez-Salado Victòria Lorente Júlia Pascual Isaac Llaó Oriol Alegre Angel Cequier Javier Elola | 2020 | Journal of Geriatric Cardiology2020，17，10： | 2 |
| 3 | Determination of the gene structure of human GFAP and absence of coding region mutations associated with frontotemporal dementia with Parkinsonism linkedm to chromosome 17显示文摘 | Isaacs A Baker M Wavrant-De Vrieze F | 1998 | Genomics1998，，51： | 2 |
| 4 | Effect of cortical cooling on interictal epileptiform activities显示文摘 | Ablah E Tran M P Isaac M | 2009 | Seizure2009，18，1： | 1 |
| 5 | Automorphisms of matrix algebras over commutative rings显示文摘 | | 1980 | Linear Algebra Appl1980，31，： | 1 |
| 6 | Acoustic emission study of failure mechanism of ceramic matrix composite under longitudinal tensile loading显示文摘 | Shi-Chang Woob Isaac M Daniel | 1995 | Journal of Composite Materials1995，29，15： | 1 |
| 7 | A study of the transient liquid phase bonding process applied to a Ag/Cu/Ag sandwich joint显示文摘 | Isaac Tuah-Poku Dollar M Massalaki T B | 1988 | Metallurgical Transactions A1988，19，2： | 1 |
| 8 | Pulmonary blasto- ma:a rare childhood malignancy显示文摘 | Senac M O Jr Wood B P Isaacs H | 1991 | Radiology1991，179，3： | 1 |
| 9 | Quality of reporting and ev- idence in American Academy of Pediatrics guidelines 显示文摘 | Isaac A Saginur M Hartling L | 2013 | Pediat- rics2013，131，4： | 1 |
| 10 | Silent synapses during development of thalamocortical input 显示文摘 | CRAIR M C NICOLL R A | 1997 | Neuron1997，18，： | 1 |
| 11 | Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium显示文摘 | Hudde T Rayner SA Comer RM Weber M Isaacs JD Waldmann H | 1999 | Gene Ther1999，6，5： | 1 |
| 12 | Comparative study of the electrocatalytic activity of cobalt phthalocyanine and cobalt naphthalocyanine for the reduction of oxygen and the oxidation of hydrazine 显示文摘 | Isaacs M AguirreM J Toro-LabbeA | 1998 | Electrochimica Acta1998，43，1213： | 1 |
| 13 | The eggshell lech- nique for prevention of cement leakage during kyphoplasty 显示文摘 | Greene D L Isaac R Neuwirth M | 2007 | Spinal Disord Tech2007，20，3： | 1 |
| 14 | Crystal structure of an integral membrane light-harvesting complex from photosynthtic bacteria显示文摘 | McDermott G Prince S M Freer A A Hawthorthwaite-Lawless A M Papiz M Z Cogdell R J Isaacs N W | 1995 | Nature1995，374，6： | 1 |
| 15 | Effect of pressure on processes modelling the Maillard reaction显示文摘 | Isaacs N S Coulson M | 1996 | Journal of Physical Organic Chemistry1996，，9： | 1 |
| 16 | The impact of glycosylation on HLA-DR1 -restricted T cell recognition of type II collagen in a mouse model 显示文摘 | Delwig A Altmann D M Isaacs J D | 2007 | Arthritis Rheum2007，54，： | 1 |
| 17 | Im- muno modulatory IL-18 binding protein is produced by prostate cancer cells and its levels in urine and serum correlate with tumor status显示文摘 | Kazutoshi Fujita Charles M Ewing William B Isaacs | 2011 | Int J Cancer2011，129，： | 1 |
| 18 | The role of the GluR2 sub- unit in AMPA receptor function and synaptic plasticity 显示文摘 | ISAAC J T ASHBY M C MCBAIN C J | 2007 | Neuron2007，54，6： | 1 |
| 19 | Finite group elements where no irreducible character vanishes显示文摘 | Isaacs I M Navarro G Wolf T R | 1999 | J Algebra1999，222，： | 1 |
| 20 | An expert- mental investigation of the hahn-noll revenue neutral auction for emissions licenses显示文摘 | FRANCIOSI R ISAAC R M PINGRY D E | 1993 | Journal of Environmental Economics and Management1993，24，1： | 1 |
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