|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pathology of pancreatic ductal adenocarcinoma:Facts,challenges and future developments显示文摘Despite major improvements concerning its diagnosis and treatment,pancreatic ductal adenocarcinoma(PDAC) remains an aggressive disease with an extremely poor prognosis. Pathology,as interface discipline between basic and clinical medicine,has substantially contributed to the recent developments and has laid the basis for further progress. The definition and classification of precursor lesions of PDAC and their molecular characterization is a fundamental step for the potential identification of biomarkers and the development of imaging methods for early detection. In addition,by integrating findings in humans with the knowledge acquired through the investigation of transgenic mouse models for PDAC,a new model for pancreatic carcinogenesis has been proposed and partially validated in individuals with genetic predisposition for PDAC. The introduction and validation of a standardized system for pathology reporting based on the axial slicing technique has shown that most pancreatic cancer resections are R1 resections and that this is due to inherent anatomical and biological properties of PDAC.This standardized assessment of prognostic relevant parameters represents the basis for the successful conduction of multicentric studies and for the interpretation of their results.Finally,recent studies have shown that distinct molecular subtypes of PDAC exist and are associated with different prognosis and therapy response.The prospective validation of these results and the integration of molecular analyses in a comprehensive pathology report in the context of individualised cancer therapy represent a major challenge for the future. | Irene Esposito Bj?rn Konukiewitz Anna Melissa Schlitter Günter Kl?ppel | 2014 | World Journal of Gastroenterology2014，20，38： | 5 |
| 2 | Primary liposarcoma of esophagus:A case report显示文摘当食道的脂肪的肉瘤是一个极其稀罕的肿瘤时,脂肉瘤是在成年生命的最普通的软织物肉瘤。在世界文学,仅仅食道的脂肪的肉瘤的 14 个案例被描述了。我们报导着急地与一枚燃烧制动火箭为剧烈腹上部的疼痛进入我们的医院的一个 72 年的老男病人胸骨的感觉,坚持的恶心,呕吐并且咽下困难。钡燕子,上面胃肠(官方补给) 内视镜检查法,食道的测压法和 CT 扫描,没能精确地诊断损害。在一个食道的息肉样瘤的外科的切除术以后,组织学的考试揭示了一个区分得好的等级我脂肪的肉瘤。诊断、治疗学的工具被讨论,文学的结果被考察。 | Theodore D Liakakos Theodore G Troupis Charalambos Tzathas Konstantina Spirou Irene Nikolaou Spiridon Ladas Gabriel M Karatzas | 2006 | World Journal of Gastroenterology2006，12，7： | 5 |
| 3 | Impact of PRRSV on activation and viability of antigen presenting cells显示文摘Porcine reproductive and respiratory syndrome(PRRS) is one of the most important diseases of swine industry. The causal agent, PRRS-virus(PRRSV), is able to evade the host immune response and survive in the organism causing transient infections. Despite all scientific efforts, there are still some gaps in the knowledge of the pathogenesis of this disease. Antigen presenting cells(APCs), as initiators of the immune response, are located in the first line of defense against microorganisms, and are responsible for antigen recognition, processing and presentation. Dendritic cells(DCs) are the main type of APC involved in antigen presentation and they are susceptible to PRRSV infection. Thus, PRRSV replication in DCs may trigger off different mechanisms to impair the onset of a host effective immune response against the virus. On the one side, PRRSV may impair the basic functions of DCs by regulating the expression of major histocompatibility complex class Ⅱ and CD80/86. Other strategy followed by the virus is the induction of cell death of APCs by apoptosis, necrosis or both of them. The impairment and/or cell death ofAPCs could lead to a failure in the onset of an efficient immune response, as long as cells could not properly activate T cells. Future aspects to take into account are also discussed in this review. | Irene M Rodríguez-Gómez Jaime Gómez-Laguna Librado Carrasco | 2013 | World Journal of Virology2013，2，4： | 4 |
| 4 | Long‐term administration of rifaximin improves the prognosis of patients with decompensated alcoholic cirrhosis显示文摘 | Jiannis Vlachogiannakos Nikos Viazis Panagiota Vasianopoulou Irene Vafiadis Dimitrios G Karamanolis Spiros D Ladas | 2013 | J Gastroenterol Hepatol2013，，3： | 4 |
| 5 | Update on surgical treatment of pancreatic neuroendocrine neoplasms显示文摘Pancreatic neuroendocrine neoplasms(PNENs) are rare and account for only 2%-4% of all pancreatic neoplasms. All PNENs are potential(neurendocrine tumors PNETs) or overt(neuroendocrine carcinomas PNECs) malignant,but a subset of PNETs is low-risk. Even in case of low-risk PNETs surgical resection is frequently required to treat hormone-related symptoms and to obtain an appropriate pathological diagnosis. Low-risk PNETs in the body and the tail are ideal for minimallyinvasive approaches which should be tailored to the individual patient. Generally,surgeons must aim for parenchyma sparing in these cases. In high-risk and malignant PNENs,indications for tumor resection are much wider than for pancreatic adenocarcinoma,in many cases due to the relatively benign tumor biology. Thus,patients with locally advanced and metastatic PNETs may benefit from extensive resection. In experienced hands,even multi-organ resections are accomplished with acceptable perioperative morbidity and mortality rates and are associated with excellent long term survival. However,poorly differentiated neoplasms with high proliferation rates are associated with a dismal prognosis and may frequently only be treated with chemotherapy. The evidence on surgical treatment of PNENs stems from reviews of mostly singlecenter series and some analyses of nation-wide tumor registries. No randomized trial has been performed to compare surgical and non-surgical therapies in potentially resectable PNEN. Though such a trial would principally be desirable,ethical considerations and the heterogeneity of PNENs preclude realization of such a study. In the current review,we summarize recent advances in the surgical treatment of PNENs. | Jan G D’Haese Chiara Tosolini Güralp O Ceyhan Bo Kong Irene Esposito Christoph W Michalski J?rg Kleeff | 2014 | World Journal of Gastroenterology2014，20，38： | 4 |
| 6 | Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma显示文摘AIM: To evaluate the efficacy and the safety of azathioprine (AZA) and buthionine sulfoximine (BSO) bylocalized application into HepG2 tumor in vivo.METHODS: Different hepatoma and colon carcinoma cell lines (HepG2, HuH7, Chang liver, LoVo, RKO, SW-48, SW-480) were grown in minimal essencial medium supplemented with 10% fetal bovine serum and 1% antibiotic/antimycotic solution and maintained in a humidified 37 ℃ incubator with 5% CO2. These cells were pretreated with BSO for 24 h and then with AZA for different times. We examined the effects of this combination on some proteins and on cellular death. We also studied the eff icacy and the safety of AZA (6 mg/kg per day) and BSO (90 mg/kg per day) in HepG2 tumor growth in vivo using athymic mice. We measured safety by serological markers such as aminotransferases and creatine kinase.RESULTS: The in vitro studies revealed a new mechanism of action for the AZA plus BSO combination in the cancer cells compared with other thiopurines (6-mercaptopurine, 6-methylmercaptopurine, 6-thioguanine and 6-methylthioguanine) in combination with BSO. The cytotoxic effect of AZA plus BSO in HepG2 cells resulted from necroptosis induction in a mitochondrial-dependent manner. From kinetic studies we suggest that glutathione (GSH) depletion stimulates c-Jun amino-terminal kinase and Bax translocation in HepG2 cells with subsequent deregulation of mitochondria (cytochrome c release, loss of membrane potential), and proteolysis activation leading to loss of membrane integrity, release of lactate dehydrogenase and DNA degradation. Some of this biochemical and cellular changes could be reversed by N-acetylcysteine (a GSH replenisher). In vivo studies showed that HepG2 tumor growth was inhibited when AZA was combined with BSO.CONCLUSION: Our studies suggest that a combination of AZA plus BSO could be useful for localizedtreatment of hepatocellular carcinoma as in the currently used transarterial chemoembolization method. | Borja Hernández-Breijo Jorge Monserrat Sara Ramírez-Rubio Eva P Cuevas Diana Vara Inés Díaz-Laviada M Dolores Fernández-Moreno Irene D Román Javier P Gisbert Luis G Guijarro | 2011 | World Journal of Gastroenterology2011，17，34： | 2 |
| 7 | Database performance Optimization and capacity planning 显示文摘 | ROBERT B IRENE G | 1997 | Business Communications Re- view1997，4，16： | 1 |
| 8 | Effects of pre-commercial thinning on growth and reproduction in post-fire regeneration of Pinus halepensis Mill显示文摘 | IRENE R ENCAMA R G FELIPE B | 2013 | Annals of Forest Science2013，70，4： | 1 |
| 9 | Visual acuity and scotomas after one week levodopa administration in human amblyopia显示文摘 | Irene G Jacques Charlier Pobert DR | 1992 | Invest Ophthalmol Vis Sci1992，33，： | 1 |
| 10 | Adhesion abilities of dairy Lactobacillus plantarum strains showing an aggregation phenotype显示文摘 | Tomás García-Cayuela Ahmed M. Korany Irene Bustos Luz P. Gómez de Cadi?anos Teresa Requena Carmen Peláez M. Carmen Martínez-Cuesta | 2014 | Food Research International2014，，： | 1 |
| 11 | Citizenship and lrnmigratian:Multiculturalism,Assimilation, and Challenges to the Nation-State显示文摘 | Irene Bloemraad Anna Korteweg G Yurdakul | 2008 | AnnuM Review Sociology2008，，1： | 1 |
| 12 | Trace of Flicker Sources by Using the Quantity of Flicker Power显示文摘 | Axelberg P G V Bollen M H J Gu Irene Yu-Hua | 2008 | IEEE Trans on Power Delivery2008，23，1： | 1 |
| 13 | Genetic diversity of recent bovine viral diarrhoea viruses from the southeast of Austria ( Styria ) 显示文摘 | Stefan V Irene G W Branislav D | 2003 | Vet Microbiology2003，91，23： | 1 |
| 14 | Communication in Europe on semicarbazide and baby food 显示文摘 | Anne L G Irene V G | 2006 | Journal of Fish Research2006，9，8： | 1 |
| 15 | The effect of body position and mattress type on interface pressure in quadriplegic adults : A pilot study 显示文摘 | Parivash M Irene G Virginia YC | 2004 | Dermatology Nursing2004，16，6： | 1 |
| 16 | Metabolic modeling of fumaric acid production by Rhizopus arrhizus 显示文摘 | Irene C G William A W Frenerick A K | 1991 | Applied Biochemistry and Biotechnoiogy1991，28，29： | 1 |
| 17 | On tlae nullity of line graphs of tress显示文摘 | IVAN G IRENE S | 2001 | Discrete Math2001，232，13： | 1 |
| 18 | Infectious complications following renal transplantation显示文摘 | Irene G Siapaya V | 1998 | Surg Clin North Am1998，78，1： | 1 |
| 19 | In vivo flow cytometry: A new method for enumerating circulating cancer cells显示文摘 | Irene G Nicolas S John N | 2004 | Cancer Res2004，64，： | 1 |
| 20 | Significance of δMmeasurements in thin film media显示文摘 | Irene A Reardsley Zhu J G | 1991 | IEEE Trans Magn1991，27，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员