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37篇 您的检索式：作者名="ION V"

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	题名	作者	年代	出处	被引量
1	Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing.	Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann	2022	Bone Research2022，10，3：	2
2	Sc and Zn-catalyzed synthesis of cyclic carbonates from CO2 and epoxides 显示文摘	ION A PARVULESCU V JACOBS P	2009	Applied Catalysis (A) : General2009，363，：	1
3	The peculiarities of the ethylation of toluene and benzene on modified Beta zeolites显示文摘	Romannikov V N Ione K G	1994	J Catal1994，146，：	1
4	Affective discrimination of stimuli that cannot be recognized 显示文摘	Ion V R Stromeyer C F	1980	Science1980，，20：	1
5	Phase Evolution Induced by Polypyrrole in Iron Oxide-polypyrrole Nanocomposite显示文摘	Brezoi D V Ion R M		0，，01：	1
6	A novel uncertainty decoding rule with applications to transmission error robust speech recognition显示文摘	ION V HAEB-UMBACH R	2008	IEEE Transac- tions on Audio Speech and Language Processing2008，16，5：	1
7	Apoptosis and Dys- regulated Ceramide Metabolism in a Murine Model of Alcohol-En-hanced Lipopolysaccharide Hepatotoxicity 显示文摘	Ion V Deaciuc Nikolova-Karakashian M	2000	Alcoholism:Clinical and Experimental Research2000，24，15：	1
8	Thoraeoscopic thymectomy mid-term results 显示文摘	Tomuleseu V Ion V Kosa A	2006	Ann Thorac Surg2006，82，3：	1
9	Stud Surf Sci Catal显示文摘	Kikhtyanin O V Ione K G Snytnikova G P	1994	84:1 9051994，84，：	1
10	Iterate-averaging sign algorithms for adaptive filtering with applications to blind multiuser detection显示文摘	G Yin V Krishnamurthy C Ion		0，，03：	1
11	Thymectomy by thoracoscopic approach in myasthenia gravis显示文摘	Popescu I Tomulescu V Ion V		0，，04：	1
12	Thymectomy by thoraco-scopic approach in myasthenia gravis显示文摘	Popescu I Tomulescu V Ion V	2002	Surg Endosc2002，16，：	1
13	Thoracoscopic thymectomy mid-term results显示文摘	Tomulescu V Ion V Kosa A	2006	Ann Thorac Surg2006，82，3：	1
14	Thymectomy by thoracoscopic approach in myasthenia gravis 显示文摘	Popescu I Tomulescu V Ion V	2002	Surg Endosc2002，16，：	1
15	Green synthesis of carbamates from COz, amines and alcohols显示文摘	Ion A Donrslaer C V Parvulescu V	2008	Green Chemistry2008，10，：	1
16	Thymectomy by thoracoscopic approach in myasthenia gravis显示文摘	Popescu I Tomulescu V Ion V	2002	Surg Endosc2002，26，：	1
17	Zeoforming A promising process for production of unleaded gasolines显示文摘	Stepanov V G Ione K G	2000	Chemisty and Tech- nology of Fuels and Oils2000，36，1：	1
18	Synthe- sis of symmetrical or asymmetrical urea com- pounds from C02via base catalysis 显示文摘	Ion A Parvuleseu V Jacobs P	2007	Green Chemistry2007，9，2：	1
19	Sc and Zn-catalyzed synthesis of cyclic carbonates from CO2 and epoxides 显示文摘	ION A PARVULESCU V JACOBS P	2009	ApplCatal A:Gen2009，363，12：	1
20	Thoracoscopic thymectomy mid-term results显示文摘	Tomulescu V Ion V Kosa A	2006	Ann Thorac Surg2006，82，3：	1

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