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| 1 | Wolbachia symbiosis and insect immune response显示文摘细菌的细胞内部的共生在昆虫是很普通的,有在支持生命和生物多样性的进化的重要后果。最近吸引了特别注意的细菌的组是可能在行星上代表最无所不在的 endosymbiont 的 Wolbachia pipientis。W。pipientis 是一克否定应尽细胞内部并且似母亲播送了 l-proteobacterium,那能与节肢动物和线虫建立共生协会。在节肢动物, Wolbachia pipientis 感染在 Arachnida 被描述了,在 Isopoda 并且主要在 Insecta。他们包括 Diptera,翘目,半翅类, Hymenoptera,直翅目和鳞翅目在几乎所有主要昆虫订单被报导了。提高它的传播, W。pipientis 能由导致单性生殖,女性化,男性杀死和细胞质的不兼容操作主人复制。几聚合酶链反应调查显示了多达 70% 所有昆虫种类可以感染 W。pipientis。怎么做 W。pipientis 设法变得在多样的昆虫主人种类确定了?这细胞内部的细菌的共生者种怎么在逃离宿主免疫反应是那么成功的?现在的评论在这块地里介绍最近的进展和进行中的科学努力。这域里的知识的当前的身体被总结,从可得到的 genomic 信息的展现被介绍,迄今为止未答复的问题在一次尝试被讨论介绍 W 的唯一的能力的一幅全面图画。pipientis 将建立共生并且当躲避主人的免疫系统时,操作复制。 | Stefanos Siozios Panagiotis Sapountzis Panagiotis Ioannidis Kostas Bourtzis | 2008 | Insect Science2008，15，1： | 8 |
| 2 | Atypical anastomotic malignancies of small bowel after subtotal gastrectomy with BillorthⅡgastroenterostomy for peptic ulcer:Report of three cases and review of the literature显示文摘AIM To present patients who developed small-bowel malignancy at the level of the gastrointestinal anastomosis decades after a subtotal gastrectomy for ulcer,to review relevant literature,and to attempt to interpret the reasons those cancers developed to these postsurgical non-gastric sights.METHODS For the current retrospective study and review of literature,the surgical and histopathological records dated from January 1,1993 to December 31,2017 of our department were examined,searching for patients who have undergone surgical treatment of small-bowel malignancy to identify those who have undergone subtotal gastrectomy for benign peptic ulcer.A systematic literature search was also conducted using Pub Med,EMBASE,and Cochrane Library to identify similar cases.RESULTS We identified three patients who had developed smallintestine malignancy at the level of the gastrointestinal anastomosis decades after a subtotal gastrectomy with Billroth Ⅱ gastroenterostomy for benign peptic ulcertwo patients with adenocarcinoma originated in the Braun anastomosis and one patient with lymphoma of the efferent loop.All three patients were submitted to surgical resection of the tumor with Roux-en-Y reconstruction of the digestive tract.In the literature review,we only found one case of primary small-intestinal cancer that originated in the efferent loop after Billroth Ⅱ gastrectomy because of duodenal ulcer but none reporting Braun anastomosis adenocarcinoma following partial gastrectomy for benign disease.We also did not find any case of efferent loop lymphoma following gastrectomy.CONCLUSION Anastomotic gastric cancer following distal gastrectomy for peptic ulcer is a well-established clinical entity.However,malignancies of the afferent or efferent loop of the gastrointestinal anastomosis are extremely uncommon.The substantial diversion of the potent carcinogenic pancreaticobiliary secretions through the Braun anastomosis and the stomach hypochlorhydria,allowing the formation of carcinogenic factors from food,are the two most prominent pathogenetic mechanisms for those tumors. | Efstathios Kotidis Orestis Ioannidis Manousos George Pramateftakis Konstantinos Christou Ioannis Kanellos Konstantinos Tsalis | 2018 | World Journal of Gastrointestinal Oncology2018，10，7： | 4 |
| 3 | Diabetes treatment in patients with renal disease: Is the landscape clear enough?显示文摘Diabetes is the most important risk factors for chronic kidney disease(CKD). The risk of CKD attributable to diabetes continues to rise worldwide. Diabetic patients with CKD need complicated treatment for their metabolic disorders as well as for related comorbidities. They have to treat, often intensively, hypertension, dyslipidaemia, bone disease, anaemia, and frequently established cardiovascular disease. The treatment of hypoglycaemia in diabetic persons with CKD must tie their individual goals of glycaemia(usually less tight glycaemic control) and knowledge on the pharmacokinetics and pharmacodynamics of drugs available to a person with kidney disease. The problem is complicated from the fact that in many efficacy studies patients with CKD are excluded so data of safety and efficacy for these patients are missing. This results in fear of use by lack of evidence. Metformin is globally accepted as the first choice in practically all therapeutic algorithms for diabetic subjects. The advantages of metformin are low risk of hypoglycaemia, modest weight loss, effectiveness and low cost. Data of UKPDS indicate that treatment based on metformin results in less total as well cardiovascular mortality. Metformin remains the drug of choice for patients with diabetes and CKD provided that their estimate Glomerular Filtration Rate(eGFR) remains above 30 mL/min per square meter. For diabetic patients with eGFR between 30-60 mL/min per square meter more frequent monitoring of renal function and dose reduction of metformin is needed. The use of sulfonylureas, glinides and insulin carry a higher risk of hypoglycemia in these patients and must be very careful. Lower doses and slower titration of the dose is needed. Is better to avoid sulfonylureas with active hepatic metabolites, which are renally excreted. Very useful drugs for this group of patients emerge dipeptidyl peptidase 4 inhibitors. These drugs do not cause hypoglycemia and most of them(linagliptin is an exception) require dose reduction in various stages of renal disease. | Ioannis Ioannidis | 2014 | World Journal of Diabetes2014，5，5： | 4 |
| 4 | Melatonin attenuates high fat diet-induced fatty liver disease in rats显示文摘AIM:To investigate melatonin's preventive action in oxidative stress in a rat model with high fat diet-induced non-alcoholic fatty liver disease(NAFLD).METHODS:NAFLD was induced by high fat diet(HFD)in adult,male,Wistar rats,weighing 180-230 g.After acclimatization for one week,they were randomly assigned to 6 experimental groups that comprised animals on regular diet plus 5 or 10 mg/kg melatonin,for 4 or 8 wk;animals on HFD,with or without 5 or 10 mg/kg melatonin,for 4 or 8 wk;and animals on HFD for 8 or 12 wk,with melatonin 10 mg/kg for the last 4 wk.Liver damage was assessed biochemically by the serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and histologically.Lipid peroxidation and oxidative stress were assessed by malondialdehyde and glutathione levels in liver tissue.Lipidemic indices and portal vein pressure were also measured.RESULTS:Compared to rats not receiving melatonin,rats on 5 or 10 mg/kg of melatonin had lower mean liver weight(-5.0 g and-4.9 g)(P < 0.001)and lower liver weight to body weight ratio(-1.0%)(P < 0.001),for the two doses,respectively.All rats fed HFD without melatonin developed severe,grade Ⅲ,steatosis.Rats on HFD with concurrent use of melatonin showed significantly less steatosis,with grade Ⅲ steatosis observed in 1 of 29(3.4%)rats on 10 mg/kg melatonin and in 3 of 27(11.1%)rats on 5 mg/kg melatonin.Melatonin was ineffective in reversing established steatosis.Melatonin also had no effect on any of the common lipidemic serum markers,the levels of which did not differ significantly among the rats on HFD,irrespective of the use or not of melatonin.Liver cell necrosis was significantly less in rats on HFD receiving melatonin than in those not on melatonin,with the AST levels declining by a mean of 170 U/L(P = 0.01)and 224 U/L(P = 0.001),and the ALT levels declining by a mean of 62.9 U/L(P = 0.01)and 93.4 U/L(P < 0.001),for the 5 and 10 mg/kg melatonin dose,respectively.Melatonin mitigated liver damage due to peroxidation and oxidative stress in liver tissue as indicated by a significant decline in MDA production by 12.7(P < 0.001)and 12.2(P < 0.001)μmol/L/mg protein/mg tissue,and a significant increase in glutathione by 20.1(P = 0.004)and 29.2(P < 0.001)μmol/L/mg protein/mg tissue,for the 5 and 10 mg/kg melatonin dose,respectively.CONCLUSION:Melatonin can attenuate oxidative stress,lessen liver damage,and improve liver histology in rats with high fat diet-induced NAFLD,when given concurrently with the diet. | Gregorios Hatzis Panayiotis Ziakas Nikolaos Kavantzas Aggeliki Triantafyllou Panagiotis Sigalas Ioanna Andreadou Konstantinos Ioannidis Stamatios Chatzis Konstantinos Filis Alexandros Papalampros Fragiska Sigala | 2013 | World Journal of Hepatology2013，5，4： | 4 |
| 5 | PRISMA危害报告清单:改进系统综述中危害的报告(一)显示文摘对于任何一种健康干预的疗法,我们需要同时准确把握其给人们带来的获益和危害。系统综述所纳入的原始研究常常未能对干预措施的危害进行报告或者报告不充分,导致对于危害有关系统综述的报告质量不高。虽然依据系统综述和Meta分析的优先报告条目(PRISMA)声明,可以帮助系统综述的作者撰写一份完整和透明的报告,但它主要关注干预措施的有效性。因此,PRISMA危害报告清单的制定,旨在改进系统综述中对危害的报告,以促进研究者对干预措施的获益和危害更为均衡地评估。在草拟并形成条目清单草案后,采用了改良的德尔菲法对其进行完善。它新增4个必备报告要素以改进系统综述中关于危害的报告,同时确定了在综述不良事件时需要报告的最少条目集。作为PRISMA指南的扩展,本清单旨在提高系统综述中对危害的报告,不论危害是主要结局或是次要结局。 | 胡瑞学(译) 梁宁(译) 柴倩云(译) 杨国彦(译) 韩雪燕(译) 夏如玉(译) 严毓倩(译) 王迪(译) 文玲子(译) 黄娜(译) 杨国彦(校) 李迅(校) 刘建平(校) 费宇彤(校) Zorzela Liliane Loke Yoon K Ioannidis John P | 2018 | 中国药物警戒2018，15，6： | 4 |
| 6 | 为何已发表的研究结果大多是错误的显示文摘多数发表的科研结果都是错误的,这一观点受到越来越多的关注。科研成果正确与否取决于多种因素,如:研究的把握度和偏倚,研究同一问题的小组数量,更重要的是研究所得的“真实关联”与“无关联”的比率。如果研究规模较小,效应尺度较小,被测关联的数量较大而预选量较少,设计、定义、结局和分析方式的灵活性越大,过多考虑财政和其他利益等都会减小研究成果的真实几率。对多数科研领域而言,研究成果仅仅是对主要偏倚的精确估量。 | John P. A. Ioannidis 孙菲(翻译) 胡良平(审校) | 2006 | 科学观察2006，1，4： | 3 |
| 7 | International Consensus Statement on surveillance and management of dysplasia in inflammatory bowel disease显示文摘 | Loren Laine Tonya Kaltenbach Alan Barkun Kenneth R. McQuaid Venkataraman Subramanian Roy Soetikno James E. East Francis A. Farraye Brian Feagan John Ioannidis Ralf Kiesslich Michael Krier Takayuki Matsumoto Robert P. McCabe Klaus M?nkemüller Robert Odze M | 2014 | Gastrointestinal Endoscopy2014，，： | 3 |
| 8 | 分娩所致Valsalva视网膜病变治疗方法的探讨(英文)显示文摘目的:讨论孕妇Valsalva视网膜病变保守或手术治疗方法的选择。方法:一健康孕妇在自然阴道分娩时,右眼底发生黄斑前玻璃体后界膜下出血,本文报道其保守治疗的效果。结果:右眼发病3wk时积血收缩,视力为眼前手动,但病程6mo时,积血溶解,视力恢复至6/5。结论:大多数Valsalva视网膜病变能够自愈。对一些难治性病例,采用Nd:YAG激光行内界膜切开具有一定的效果。而早期玻璃体切除术的增殖膜切除,对预防眼底新生血管膜的发生也具有一定的效果。 | Konstantinos I Papageorgiou Rashmi G Mathew AlexanderS Ioannidis Ajay Sinha Petros S Andreou | 2007 | 国际眼科杂志2007，7，3： | 3 |
| 9 | A framework for inspection of dies attachment on PCB utilizing machine learning techniques显示文摘Decision Support Systems are considered as a robust technology able to provide an advantage to several manufacturing companies.As part of the Z-Fact0r EU project Early Stage-Decision Support System,a framework for the inspection of a printed circuit boards(PCB)and the inference of faults,regarding the excess or insufficient glue,is proposed.For the inspection of the PCB,a pixel-based vector of the regions of interest is utilized and several very popular in research community machine learning algorithms are tested on their performance on fault recognition.In order to determine the most efficient and effective classifier,a schema of Monte Carlo simulations for each classification algorithm and set of hyper-parameters was performed.Simulation results show a superiority of the support vector machine(SVM)classifier with polynomial and radial basis function kernels,compared to the rest.The best overall classifier was the SVM polynomial(accuracy:81.39%,f-measure:78.72%). | Thanasis Vafeiadis Nikolaos Dimitriou Dimosthenis Ioannidis Tracy Wotherspoon Gregory Tinker Dimitrios Tzovaras | 2018 | Journal of Management Analytics2018，5，2： | 3 |
| 10 | Midgut neuroendocrine tumor presenting with acute intestinal ischemia显示文摘Neuroendocrine tumors represent a heterogeneous group of neoplasms that arise from neuroendocrine cells and secrete various peptides and bioamines. While gastrointestinal neuroendocrine tumors,commonly called carcinoids,account for about 2/3 of all neuroendocrine tumors,they are relatively rare. Small intestine neuroendocrine tumors originate from intestinal enterochromaffin cells and represent about 1/4 of small intestine neoplasms. They can be asymptomatic or cause nonspecific symptoms,which usually leads to a delayed diagnosis. Imaging modalities can aid diagnosis and surgery remains the mainstay of treatment. We present a case of a jejunal neuroendocrine tumor that caused nonspecific symptoms for about 1 year before manifesting with acute mesenteric ischemia. Abdominal X-rays revealed pneumatosis intestinalis and an abdominal ultrasound and computed tomography confirmed the diagnosis. The patient was submitted to segmental enterectomy. Histopathological study demonstrated a neuroendocrine tumor with perineural and arterial infiltration and lymph node metastasis. The postoperative course was uneventful and the patient denied any adjuvant treatment. | Ioannis Mantzoros Natalia Antigoni Savvala Orestis Ioannidis Styliani Parpoudi Lydia Loutzidou Despoina Kyriakidou Angeliki Cheva Vasileios Intzos Konstantinos Tsalis | 2017 | World Journal of Gastroenterology2017，23，45： | 2 |
| 11 | Narrow band imaging to differentiate neoplastic and non-neoplastic colorectal polyps in real time: a meta-analysis of diagnostic operating characteristics显示文摘 | Sarah K McGill Evangelos Evangelou John P A Ioannidis Roy M Soetikno Tonya Kaltenbach | 2013 | Gut2013，，12： | 2 |
| 12 | PRISMA危害报告清单:改进系统综述中危害的报告(三)显示文摘对于任何一种健康干预的疗法,我们需要同时准确把握其给人们带来的获益和危害。系统综述所纳入的原始研究常常未能对干预措施的危害进行报告或者报告不充分,导致对于危害有关系统综述的报告质量不高。虽然依据PRISMA声明(系统综述和Meta分析的优先报告条目),可以帮助系统综述的作者撰写一份完整和透明的报告,但它主要关注干预措施的有效性。因此,PRISMA危害报告清单的制定,旨在改进系统综述中对危害的报告,以促进研究者对干预措施的获益和危害更为均衡地评估。在草拟并形成条目清单草案后,采用了改良的德尔菲法对其进行完善。它新增四个必备报告要素以改进系统综述中关于危害的报告,同时确定了在综述不良事件时需要报告的最少条目集。作为PRISMA指南的扩展,本清单旨在提高系统综述中对危害的报告,不论危害是主要结局或是次要结局。 | 胡瑞学(译) 梁宁(译) 柴倩云(译) 杨国彦(译) 韩雪燕(译) 夏如玉(译) 严毓倩(译) 王迪(译) 文玲子(译) 黄娜(译) 杨国彦(校) 李迅(校) 刘建平(校) 费宇彤(校) Zorzela Liliane Loke Yoon K Ioannidis John P | 2018 | 中国药物警戒2018，15，8： | 2 |
| 13 | PRISMA危害报告清单:改进系统综述中危害的报告(二)显示文摘对于任何一种健康干预的疗法,我们需要同时准确把握其给人们带来的获益和危害。系统综述所纳入的原始研究常常未能对干预措施的危害进行报告或者报告不充分,导致对于危害有关系统综述的报告质量不高。虽然依据PRISMA声明(系统综述和Meta分析的优先报告条目),可以帮助系统综述的作者撰写一份完整和透明的报告,但它主要关注干预措施的有效性。因此,PRISMA危害报告清单的制定,旨在改进系统综述中对危害的报告,以促进研究者对干预措施的获益和危害更为均衡地评估。在草拟并形成条目清单草案后,采用了改良的德尔菲法对其进行完善。它新增4个必备报告要素以改进系统综述中关于危害的报告,同时确定了在综述不良事件时需要报告的最少条目集。作为PRISMA指南的扩展,本清单旨在提高系统综述中对危害的报告,不论危害是主要结局或是次要结局。 | 胡瑞学(译) 梁宁(译) 柴倩云(译) 杨国彦(译) 韩雪燕(译) 夏如玉(译) 严毓倩(译) 王迪(译) 文玲子(译) 黄娜(译) 杨国彦(校) 李迅(校) 刘建平(校) 费宇彤(校) Zorzela Liliane Loke Yoon K Ioannidis John P | 2018 | 中国药物警戒2018，15，7： | 2 |
| 14 | Evaluation of global image thresholding for change detection显示文摘 | Rosin P L Ioannidis E | 2003 | Pattern Recognition Letters2003，，24： | 1 |
| 15 | Intravenous glycoprotein Ⅱb/Ⅲa receptor antagonists reduce mortality after percutaneous coronary interventions显示文摘 | Karvouni E Katritsis DG Ioannidis JP | 2003 | J Am Coll Cardiol2003，41，1： | 1 |
| 16 | Percutaneous coronary intervention versus conservative therapy in nonacute coronary artery disease: a meta-analysis 显示文摘 | Katritsis DG Ioannidis JP | 2005 | Circulation2005，111，： | 1 |
| 17 | Intravenous immunoglobulin compared with cyclophosphamide for proliferative lupus nephritis显示文摘 | Boletis JN Ioannidis JP Boki KA | | 0，，： | 1 |
| 18 | Methods for meta-analysis in ge-netic association studies:a review of their potential and pitfalls显示文摘 | Kavvoura FK Ioannidis JP | | 0，，01： | 1 |
| 19 | Neoadjuvant versus adjuvant systemic treatment in breast cancer:a meta-analysis显示文摘 | Mauri D Pavlidis N Ioannidis JP | 2005 | J Natl Cancer Inst2005，97，3： | 1 |
| 20 | 循证医学 误用漏斗图的案例分析显示文摘本文要点应该使用严格的标准对循证医学中使用的方法进行评价用于检验发表偏倚的漏斗图在系统性文献综述中应用广泛漏斗图的不对称性,无论是直观上看到的或统计学检验发现的。 | Joseph Lau John P A Ioannidis Norma Terrin Christopher H Schmid Ingram Olkin 谢朝晖 | 2007 | 英国医学杂志中文版2007，10，3： | 1 |
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