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| 1 | Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells显示文摘AIM:To determine the effect of ellagic acid on apop-tosis and proliferation in pancreatic cancer cells and to determine the mechanism of the pro-survival effects of ellagic acid. METHODS:The effect of ellagic acid on apoptosis was assessed by measuring Phosphatidylserine externalization,caspase activity,mitochondrial membrane potential and DNA fragmentation;and proliferation by measuring DNA thymidine incorporation. Mitochondrial membrane potential was measured in permeabilized cells,and in isolated mitochondria. Nuclear factor kB(NF-kB) activity was measured by electromobility shift assay(EMSA) . RESULTS:We show that ellagic acid,a polyphenolic compound in fruits and berries,at concentrations 10 to 50 mmol/L stimulates apoptosis in human pancreatic adenocarcinoma cells. Further,ellagic acid decreases proliferation by up to 20-fold at 50 mmol/L. Ellagic acid stimulates the mitochondrial pathway of apoptosis associated with mitochondrial depolarization,cytochrome C release,and the downstream caspaseactivation. Ellagic acid does not directly affect mitochondria. Ellagic acid dose-dependently decreased NF-kB binding activity. Furthermore,inhibition of NF-kB activity using IkB wild type plasmid prevented the effect of ellagic acid on apoptosis. CONCLUSION:Our data indicate that ellagic acid stimulates apoptosis through inhibition of the prosu-rvival transcription factor NF-kB. | Mouad Edderkaoui Irina Odinokova Izumi Ohno Ilya Gukovsky Vay Liang W Go Stephen J Pandol Anna S Gukovskaya | 2008 | World Journal of Gastroenterology2008，14，23： | 30 |
| 2 | 生物炭及海藻肥对烟草生长、土壤性状及青枯病发生的影响显示文摘为研究不同用量生物炭及海藻肥对烟草生长及青枯病的影响,以烟草 NC102 为试验材料,在常年青枯病发生较严重的地块采用完全随机设计,在常规施肥基础上,设置处理 CK(空白对照)、 BC1(9000 kg/hm2生物炭)、 BC2(15 000 kg/hm2生物炭)、BC3(22 500 kg/hm2生物炭)、SW(2250 kg/hm2海藻肥)、BC2+SW(15 000 kg/hm2生物炭+2250 kg/hm2海藻肥)。结果发现,海藻肥和生物炭单一或混合施用均能促进烟草生长,最大量生物炭的处理虽然抑制烤烟团棵期生长,但可以促进烤烟旺长期的生长。生物炭和海藻肥单一或混合施用均显著提高了土壤 pH 及部分土壤养分含量,降低了烟草青枯病发病率及病情指数,有利于提高烤烟产量和中上等烟比例,协调烟叶化学成分,提升烤后烟叶内在品质。利用 Pearson 相关系数分析了不同处理土壤理化性质与烟草青枯病病情指数之间的关系,结果发现,适当提高土壤酸碱度可作为酸性土壤主产区防控烟草青枯病、提高烤烟产质量的重要策略。 | 张广雨 褚德朋 刘元德 牛纪军 陈芊如 Naila Ilyas 韦建玉 李义强 | 2019 | 中国烟草科学2019，40，5： | 24 |
| 3 | 生物炭对根际土壤微生态的调控及对烟草青枯病的防控作用显示文摘【目的】探究不同用量的生物炭对根际土壤微生态的调控及对烟草青枯病的防控作用【方法】采用稀释平板法,研究生物炭对青枯菌的吸附作用及对其生长和运动性的影响;盆栽试验研究生物炭对烟草生长及青枯病发病情况和土壤基本理化性质的影响;利用高通量测序技术,比较各处理土壤细菌群落差异。【结果】(1)生物炭对青枯菌具有抑制作用,可吸附青枯菌、抑制其生长及运动性,用量超过1.5%时效果显著;(2)生物炭提高了土壤pH、有机质、速效磷和速效钾含量,利于烟草的生长。相关性分析发现,生物炭对土壤pH和化学性质的改善,是抑制烟草青枯病发生的主要原因;(3)生物炭提高了根际土壤微生物群落的Alpha多样性和放线菌门中链霉菌属的相对丰度;(4)根际土壤细菌结构的多样性与土壤理化性质有一定的相关性,其中有效钾影响最大。【结论】生物炭通过对青枯菌的抑制作用和对土壤微生态的改善,创造了利于烟草生长的环境条件,减少了烟草青枯病的发生。 | 张广雨 胡志明 褚德朋 戴永平 尹绍静 严明雄 段焰 孙康 Naila Ilyas 尤祥伟 李义强 | 2020 | 中国烟草学报2020，26，6： | 18 |
| 4 | Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis显示文摘Alzheimer disease(AD) is the most common neurodegenerative disorder worldwide and is at present,incurable.The accumulation of toxic amyloid-beta(Aβ) peptide aggregates in AD brain is thought to trigger the extensive synaptic loss and neurodegeneration linked to cognitive decline,an idea that underlies the'amyloid hypothesis'of AD etiology in both the familal(FAD) and sporadic forms of the disease.Genetic mutations causing FAD also result in the dysregulation of neuronal calcium(Ca2+) handling and may contribute to AD pathogenesis,an idea termed the'calcium hypothesis'of AD.Mutations in presenilin proteins account for majority of FAD cases.Presenilins function as catalytic subunit ofγ-secretase involved in generation of Aβ peptide Recently,we discovered that presenilns function as low-conductance,passive ER Ca2+ leak channels,independent of γ-secretase activity.We further discovered that many FAD mutations in presenilins result in loss of ER Ca2+ leak function activity and Ca2+ overload in the ER.These results provided potential explanation for abnormal Ca2+ signaling observed in FAD cells with mutations in presenilns.Our latest work on studies of ER Ca2+ leak channel function of presenilins and implications of these findings for understanding AD pathogenesis are discussed in this article. | Charlene SUPNET Ilya BEZPROZVANNY | 2011 | Science China(Life Sciences)2011，54，8： | 17 |
| 5 | Effect of Powder Particle Shape on the Properties of In Situ Ti–TiB Composite Materials Produced by Selective Laser Melting显示文摘This work studied the preparation of starting powder mixture influenced by milling time and its effect on the particle morphology(especially the shape) and, consequently, density and compression properties of in situ Ti–Ti B composite materials produced by selective laser melting(SLM) technology. Starting powder composite system was prepared by mixing 95 wt% commercially pure titanium(CP-Ti) and 5wt% titanium diboride(TiB 2) powders and subsequently milled for two different times(i.e. 2 h and 4 h).The milled powder mixtures after 2 h and 4 h show nearly spherical and irregular shape, respectively.Subsequently, the resultant Ti–5 wt% TiB 2 powder mixtures were used for SLM processing. Scanning electron microscopy image of the SLM-processed Ti–Ti B composite samples show needle-shape TiB phase distributed across the Ti matrix, which is the product of an in-situ chemical reaction between Ti and TiB 2during SLM. The Ti–Ti B composite samples prepared from 2 h and 4 h milled Ti–TiB 2 powders show different relative densities of 99.5% and 95.1%, respectively. Also, the compression properties such as ultimate strength and compression strain for the 99.5% dense composite samples is 1421 MPa and 17.8%, respectively, which are superior to those(883 MPa and 5.5%, respectively) for the 95.1% dense sample. The results indicate that once Ti and TiB 2 powders are connected firmly to each other and powder mixture of nearly spherical shape is obtained, there is no additional benefit in increasing the milling time and, instead, it has a negative effect on the density(i.e. increasing porosity level) of the Ti–Ti B composite materials and their mechanical properties. | Hooyar Attar Konda G.Prashanth Lai-Chang Zhang Mariana Calin Ilya V.Okulov Sergio Scudino Chao Yang Jürgen Eckert | 2015 | Journal of Materials Science & Technology2015，31，10： | 12 |
| 6 | 基于自适应变异概率二进制PSO的球磨制粉系统控制(英文)显示文摘研究了一种新型自适应变异概率二进制粒子群算法。提出的自适应变异策略通过以一定的概率进行动态比特转换帮助算法更好地保持种群多样性和搜索新解,从而有效防止算法早熟。最终将提出的自适应变异概率二进制粒子群算法(adaptive mutation based pobability binary PSO,APBPSO)用于球磨制粉系统这一复杂多变量对象的PID控制器优化设计中以验证算法性能。多变量控制器分别采用了三种多目标优化目标函数,仿真结果表明提出APBPSO能有效避免陷入局部最优,其对控制器优化性能优于粒子群优化算法、离散二进制粒子群优化算法及基本的概率二进制粒子群优化算法。 | Muhammad Ilyas MENHAS 费敏锐 王灵 钱麟 | 2011 | 系统仿真学报2011，23，8： | 11 |
| 7 | Key nodes of a micro RNA network associated with the integrated mesenchymal subtype of high-grade serous ovarian cancer显示文摘Metastasis is the main cause of cancer mortality. One of the initiating events of cancer metastasis of epithelial tumors is epithelial-to-mesenchymal transition(EMT), during which cells dedifferentiate from a relatively rigid cell structure/morphology to a flexible and changeable structure/morphology often associated with mesenchymal cells. The presence of EMT in human epithelial tumors is reflected by the increased expression of genes and levels of proteins that are preferentially present in mesenchymal cells. The combined presence of these genes forms the basis of mesenchymal gene signatures, which are the foundation for classifying a mesenchymal subtype of tumors. Indeed, tumor classification schemes that use clustering analysis of large genomic characterizations, like The Cancer Genome Atlas(TCGA), have defined mesenchymal subtype in a number of cancer types, such as high-grade serous ovarian cancer and glioblastoma. However, recent analyses have shown that gene expression-based classifications of mesenchymal subtypes often do not associate with poor survival. This 'paradox' can be ameliorated using integrated analysis that combines multiple data types. We recently found that integrating m RNA and micro RNA(mi RNA) data revealed an integrated mesenchymal subtype that is consistently associated with poor survival in multiple cohorts of patients with serous ovarian cancer. This network consists of 8 major mi RNAs and 214 m RNAs. Among the 8 mi RNAs, 4 are known to be regulators of EMT. This review provides a summary of these 8 mi RNAs, which were associated with the integrated mesenchymal subtype of serous ovarian cancer. | Yan Sun Fei Guo Marina Bagnoli Feng-Xia Xue Bao-Cun Sun Ilya Shmulevich Delia Mezzanzanica Ke-Xin Chen Anil K. Sood Da Yang Wei Zhang | 2015 | Chinese Journal of Cancer2015，34，1： | 10 |
| 8 | A STUDY OF STRUCTURE AND PROPERTY CHANGES OF BIODEGRADABLE POLYGLYCOLIDE AND POLY(GLYCOLIDE-co-LACTIDE)FIBERS DURING PROCESSING AND IN VITRO DEGRADATION显示文摘Structure and properties of bioabsorbable polyglycolide (PGA) and poly(glycolide-co-lactide) (PGA-co-PLA)fibers were investigated during several industrial processing stages and in vitro degradation by means of wide-angle X-ray diffraction (WAXD), dynamic mechanical analysis (DMA) and mechanical property tests. In the orientation stage, the PGA fibers were found to have higher degrees of crystallinity than corresponding PGA-co-PLA samples produced under similar conditions. In the hot-stretching and post-annealing stages, after fibers were braided, PGA samples were found to gain more crystallinity and higher Tg than PGA-co-PLA samples. The higher crystallinity in PGA fibers resulted in a slower rate of degradation. DMA results showed that a great deal of internal stress that was built during orientation and hot-stretching stages was released in the post-annealing stage for all PGA and PGA-co-PLA samples. During earlier stages ofin vitro degradation, both PGA and PGA-co-PLA samples exhibited the typical cleavage-induced crystallization mechanism. The heat shrinkage in the glass transition area was found to disappear after 6-8 days of degradation for all PGA and PGA-co-PLA samples, indicating the amorphous portions of the polymers lost orientation after a short period in the buffer solution, most likely due to relaxation of the cleaved chains. | Bruce X.Fu Benjamin S.Hsiao Gavin Chen Jack Zhou Susan Lin Jenny Yuan Ilya Koyfman Dennis D Jamiolkowski Edward Dormier | 2003 | Chinese Journal of Polymer Science2003，21，2： | 9 |
| 9 | 晴空回波的大气风温湿结构及双偏振雷达参量分析显示文摘晴空回波有助于认识大气的风温湿结构,双偏振多普勒天气雷达为探测晴空大气提供了丰富信息。本文以2015年夏季南京信息工程大学C波段双偏振雷达探测的晴空回波为例,结合探空资料分析大气风温湿结构及晴空回波的影响因素,分析了晴空大气的反射率因子Z、径向速度Vr以及差分反射率因子ZDR回波特征。研究表明:大气温、压、湿梯度造成折射指数分布不均以及背景风场引起的湍流增强,均可造成晴空回波,其回波机理为湍流散射;差分反射率因子受到多普勒效应的影响;在风场及大气湍团干湿特性不同的情况下,晴空回波的差分反射率因子呈现不同的特征。研究结果有益于深入认识大气风温湿结构特征对雷达电磁波的散射的影响以及雷达资料质量控制。 | 黄琴 魏鸣 胡汉峰 ABRO Mohammad Ilyas | 2018 | 气象2018，44，4： | 8 |
| 10 | 大豆与海藻有机肥对烤烟生长和土壤细菌群落的影响显示文摘【目的】探究不同有机肥施用对烤烟生长和土壤细菌群落的影响。【方法】用烤烟品种中烟100进行田间试验,比较分析了大豆和海藻有机肥不同施用量对烤烟生长发育以及烟叶中氮、磷、钾含量的影响,并且从土壤理化性质以及土壤微生物群落结构的角度,分析了施用两种有机肥对烟叶生长、土壤理化性质和土壤微生物群落结构的影响。【结果】(1)与对照相比,大豆和海藻有机肥的施用,促进了团棵期和旺长期烟株的生长发育(450 kg/hm^(2)处理最佳),提高了土壤有机质和氮磷钾含量。(2)由16 S V3-V4区域扩增子测序可知,有机肥的施入改变了土壤细菌群落的丰富度和多样性,Sphingomonas、Actinospica、Pseudonocardia等有益细菌丰度增加。(3)土壤细菌群落与土壤理化性质存在一定相关性,其中土壤pH值、速效钾(AK)、硝态氮(NO_(3)^(-)-N)和铵态氮(NH_(4)^(+)-N)是主要环境影响因子。【结论】大豆和海藻有机肥的施用改善了土壤理化性质,并影响了土壤细菌群落丰富度和多样性,促进了烟株生长发育。 | 褚德朋 陈芊如 邰振益 赵福彬 张鑫 张广雨 尹绍静 杜本林 贾海江 尚宪超 ILYAS Naila 尤祥伟 黄崇峻 李义强 | 2021 | 中国烟草学报2021，27，6： | 6 |
| 11 | Large-scale molecular characterization and analysis of gastric cancer显示文摘The recent effort by The Cancer Genome Atlas(TCGA)Network has revealed that gastric cancer,which is a leading cause of cancerrelated deaths worldwide with a 5-year survival rate less than 25%,is a much more heterogeneous disease than previously thought.And yet,conventional treatment approaches and clinical trials have assumed it is a single disease. | Ilya Shmulevich | 2014 | Chinese Journal of Cancer2014，33，8： | 5 |
| 12 | 海藻提取物的农业应用研究进展显示文摘海藻以其丰富多样的营养物质成分,在植物生长发育中发挥了重要作用。近年来,随着食物安全重要性的不断上升,海藻提取物因其绿色、无毒、环保等特性,在现代有机农业和综合农业中应用范围逐渐扩大,具有极为广阔的前景。因此,阐述近年来海藻提取工艺的研究概况,包括传统提取工艺和绿色友好的新型提取工艺。此外,还综述海藻提取物在农业生产中的作用,包括提高种子发芽率,促进植物生长;促进作物增产和根系发育;改善作物胁迫管理(水、盐、温度)以提高作物品质和抵御植物病害;促进土壤有机质形成和修复土壤理化结构等。 | 陈芊如 褚德朋 Ilyas Naila 张鑫 荆常亮 王鹏 | 2021 | 江苏农业科学2021，49，20： | 5 |
| 13 | Effect of Helicobacter pylori eradication on serum ghrelin and obestatin levels显示文摘AIM: To investigate changes in serum ghrelin and obestatin levels before and after Helicobacter pylori (H. pylori ) eradication. METHODS: A total of 92 patients presenting with symptoms of dyspepsia were enrolled in the study. Upper endoscopy was performed on all patients and used to diagnose H. pylori infection according to the presence of characteristic histopathological findings; seventy patients were diagnosed with H. pylori infection and the remaining 22 non-infected patients were classified as healthy controls. H. pylori eradication was accomplished by administering the classical triple therapy drug regimen, consisting of lansoprazole 30 mg bid , amoxicillin 1 g bid , and clarithromycin 500 mg tid for 14 d. The eradication of H. pylori was assessed with C14-urea breath test, which was performed at eight weeks after treatment. Levels of serum active ghrelin and obestatin were assessed at beginning of the study (prior to treatment) and after eight weeks. The levels were comparatively analyzed between the H. pylori negative control group, the H. pylori eradicated group, and the H. pylori non-eradicated group. RESULTS: A total of 92 patients, 50 females and 42 males with a mean age of 38.2 ± 11.9 years (range: 19-64), were analyzed. H. pylori eradication success was achieved in 74.3% (52/70) of H. pylori positive patients. The initial levels of ghrelin in the H. pylori positive and control cases were 63.6 ± 19.8 pg/mL and 65.1 ± 19.2 pg/mL (P=0.78), respectively, and initial obestatin levels were 771±427 pg/mL and 830 ± 296 pg/mL (P=0.19), respectively. The difference between the initial levels and the week 8 levels of ghrelin and obestatin in the control group was insignificant [4.5% (P=0.30) and -0.9% (P=0.65), respectively]. The difference between the initial and week 8 levels of ghrelin and obestatin in the H. pylori non-eradicated group were also insignificant [0.9% (P=0.64) and 5.3% (P=0.32), respectively]. The H. pylori eradicated group had a greater change in obestatin levels when compared to the control and the non-eradicated groups (148 ± 381 pg/mL vs -12±138 pg/mL and -72.8±203 pg/mL, respectively, P=0.015), while decreases in ghrelin levels were insignificant (-7.2 pg/mL vs -1.4 pg/mL and -1.9 pg/mL, respectively, P=0.52). The ghrelin/obestatin ratio for the initial and week 8 levels changed significantly in only the H. pylori eradicated group (0.11 vs 0.08, respectively, P=0.015). For overweight patients (as designated by body mass index), we observed significant increases in obestatin levels in the eradicated group as compared to non-eradicated group (201 ± 458 pg/mL vs -5 ± 81 pg/mL, respectively, P=0.02). In the H. pylori-eradicated group, the levels did not differ between the sexes for ghrelin (-6.3 ± 26.9 pg/mL vs -8.0 ± 24.0 pg/mL, respectively, P=0.97) or obestatin (210 ± 390 pg/mL vs 96 ± 372 pg/mL, respectively, P=0.23).CONCLUSION: Serum levels of ghrelin decreased while obestatin levels increased in H. pylori eradicated subjects, especially in overweight and male patients. | Celal Ulasoglu Banu Isbilen Levent Doganay Filiz Ozen Safak Kiziltas Ilyas Tuncer | 2013 | World Journal of Gastroenterology2013，19，15： | 5 |
| 14 | Synthesis, X-ray structure and luminescent properties of Sm^(3+) ternary complex with novel heterocyclic β-diketone and 1,10-phenanthroline (Phen)显示文摘A new neutral ternary samarium complex Sm(Phen)HL3 in which Phen is 1,10-phenanthroline and HL is (1,3-bis(1,3-dimethyl-1H-pyrazol-4-yl)-1,3-propanedione) was synthesized. Molecular structure of this complex was determined by X-ray diffraction. Under UV-light this complex is demonstrated bright red luminescence (λmax=647 nm), which was corresponding to the electric dipole 4G5/2→6H9/2 transition in Sm3+ ion. UV-absorption, excitation and emission spectra of the title compound were investigated. | Ilya V. Taydakov Boris E. Zaitsev Sergey S. Krasnoselskiy Zoya A. Starikova | 2011 | Journal of Rare Earths2011，29，8： | 5 |
| 15 | New Hybrid Copper Composite Materials Based on Carbon Nanostructures显示文摘 | Tatyana S. Koltsova Larisa I. Nasibulina Ilya V. Anoshkin Vasily V. Mishin Esko I. Kauppinen Oleg V.Tolochko Albert G. Nasibulin | 2012 | 材料科学与工程(中英文B版)2012，2，4： | 5 |
| 16 | Functional implications of axon initial segment cytoskeletal disruption in stroke显示文摘轴突起始的片断(AIS ) 是轴突的近似部分,它不被髓磷脂鞘盖住并且拥有电压门离子隧道的一个特殊、专业化集会并且联系蛋白质。AIS 在中央神经原在 synaptic 集成和行动潜力产生起关键作用。最近的证据证明那击引起包围 ischemic 的神经原的 AIS 细胞骨架的快速的、不可逆的调停 calpain 的解朊作用坏死的核心。位于这 “ 下面的分子的机制的更好的理解; non-lethal”neuronal 损坏可能为改进击结果提供新治疗学的策略。这里,我们在场结构的简短概述和 AIS 的功能。我们然后讨论位于导致击的 AIS 损坏下面的可能的机制,包括 calpains 的角色和 Ca 2+ 离子的可能的来源,它为 calpains 的激活是必要的。最后,我们为 neuronal 易兴奋性讨论 AIS 细胞骨架和离子隧道簇的损失的潜在的功能的含意。 | Ohad STOLER Ilya A FLEIDERVISH | 2016 | Acta Pharmacologica Sinica2016，37，1： | 5 |
| 17 | Inflammation, Autophagy, and Obesity: Common Features in the Pathogenesis of Pancreatitis and Pancreatic Cancer显示文摘 | Ilya Gukovsky Ning Li Jelena Todoric Anna Gukovskaya Michael Karin | 2013 | Gastroenterology2013，，6： | 5 |
| 18 | Alzheimer’s disease, neural stem cells and neurogenesis: cellular phase at single-cell level显示文摘Alzheimer’s disease cannot be cured as of yet.Our current understanding on the causes of Alzheimer’s disease is limited.To develop treatments,experimental models that represent a particular cellular phase of the disease and more rigorous scrutiny of the cellular pathological mechanisms are crucial.In recent years,Alzheimer’s disease research underwent a paradigm shift.According to this tendency,Alzheimer’s disease is increasingly being conceived of a disease where not only neurons but also multiple cell types synchronously partake to manifest the pathology.Knowledge on every cell type adds an alternative approach and hope for the efforts towards the treatment.Neural stem cells and their neurogenic ability are making an appearance as a new aspect of the disease manifestation based on the recent findings that neurogenesis reduces dramatically in Alzheimer’s disease patients compared to healthy individuals.Therefore,understanding how neural stem cells can form new neurons in Alzheimer’s disease brains holds an immense potential for clinics.However,this provocative idea requires further evidence and tools for investigation.Recently,single cell sequencing appeared as a revolutionary tool to understand cellular programs in unprecedented resolution and it will undoubtedly facilitate comprehensive investigation of different cell types in Alzheimer’s disease.In this mini-review,we will touch upon recent studies that use single cell sequencing for investigating cellular response in Alzheimer’s disease and some consideration pertaining to the utilization of neural regeneration for Alzheimer’s disease research. | Mehmet Ilyas Cosacak Prabesh Bhattarai Caghan Kizil | 2020 | Neural Regeneration Research2020，15，5： | 4 |
| 19 | Spatiotemporal rotational dynamics of laser-driven molecules显示文摘Molecular alignment and orientation by laser fields has attracted significant attention in recent years,mostly due to new capabilities to manipulate the molecular spatial arrangement.Molecules can now be efficiently prepared for ionization,structural imaging,orbital tomography,and more,enabling,for example,shooting of dynamic molecular movies.Furthermore,molecular alignment and orientation processes give rise to fundamental quantum and classical phenomena like quantum revivals,Anderson localization,and rotational echoes,just to mention a few.We review recent progress on the visualization,coherent control,and applications of the rich dynamics of molecular rotational wave packets driven by laser pulses of various intensities,durations,and polarizations.In particular,we focus on the molecular unidirectional rotation and its visualization,the orientation of chiral molecules,and the three-dimensional orientation of asymmetric-top molecules.Rotational echoes are discussed as an example of nontrivial dynamics and detection of prepared molecular states. | Kang Lin Ilia Tutunnikov Junyang Ma Junjie Qiang Lianrong Zhou Olivier Faucher Yehiam Prior Ilya Sh.Averbukh Jian Wu | 2020 | Advanced Photonics2020，2，2： | 4 |
| 20 | Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis显示文摘阴囊的 microlithiasis (TM ) 是阴囊的 dysgenesis 症候群(TDS ) 的症状之一。TM 作为阴囊的细菌房间肿瘤(TGCT ) 的一个增进知识的标记特别地有趣。工具包 ligand 基因( KITLG ), BCL2 对手/杀手 1 ( BAK1 ),并且表明对手 4 的 sprouty RTK ( SPRY4 ),基因与 TGCT 的高风险被联系骨头形态基因的蛋白质 7 基因( BMP7 ),转变生长因素贝它受体 3 基因( TGFBR3 ),并且 homeobox D 簇基因( HOXD )与 TDS 有关。使用的聚合酶链反应限制碎片长度多型性( PCR-RFLP )分析,我们为 KITLG 调查了等位基因和遗传型频率( rs995030 , rs1508595 ), SPRY4 ( rs4624820 , rs6897876 ), BAK1 ( rs210138 ), BMP7 ( rs388286 ), TGFBR3 ( rs12082710 ),并且在 142 个 TGCT 病人, 137 个 TM 病人,和 153 个肥沃的人(控制组)的 HOXD ( rs17198432 )。我们在 TM 在 KITLG GG_rs995030 遗传型发现了重要差别(P = 0.01 ) 并且 TGCT 病人(P = 0.0005 ) 与控制相比。我们也揭示了在 KITLG_rs1508595 和 TM 之间的强壮的协会(G 等位基因, P = 0.003;GG 遗传型, P = 0.01 ) 并且在 KITLG_rs1508595 和 TGCT 之间(G 等位基因, P = 0.0001;GG 遗传型, P = 0.0007 ) 。而且,在在 TGCT 组和控制之间的 BMP7_rs388286 有重要差别(T 等位基因, P = 0.00004;TT 遗传型, P = 0.00006 ) 并且在 TM 组和控制之间(T 等位基因, P = 0.04 ) 。HOXD 也与 TGCT 表明了一个强壮的协会(rs17198432 A 等位基因, P = 0.0001;AA 遗传型, P = 0.001 ) 。而且,重要差别在 BAK1_rs210138 G 等位基因在 TGCT 组和控制之间被发现(P = 0.03 ) 并且 GG 遗传型(P = 0.01 ) 。KITLG 和 BMP7 基因,与 TGCT 的发展联系了,可能也与 TM 有关。在摘要, KITLG GG_rs995030, GG_rs1508595, BMP7 TT_rs388286, HOXD AA_rs17198432,和 BAK1 GG_rs210138,遗传型与 TGCT 开发的高风险被联系。 | Ilya S Dantsev Evgeniy V Ivkin Aleksey A Tryakin Dmitriy N Godlevski Oleg Yu Latyshev Victoriya V Rudenko Dmitry S Mikhaylenko Vyacheslav B Chernykh Elena A Volodko Aleksey B Okulov Oleg B Loran Marina V Nemtsova | 2018 | Asian Journal of Andrology2018，20，6： | 4 |
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