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| 1 | Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells显示文摘AIM:To determine the effect of ellagic acid on apop-tosis and proliferation in pancreatic cancer cells and to determine the mechanism of the pro-survival effects of ellagic acid. METHODS:The effect of ellagic acid on apoptosis was assessed by measuring Phosphatidylserine externalization,caspase activity,mitochondrial membrane potential and DNA fragmentation;and proliferation by measuring DNA thymidine incorporation. Mitochondrial membrane potential was measured in permeabilized cells,and in isolated mitochondria. Nuclear factor kB(NF-kB) activity was measured by electromobility shift assay(EMSA) . RESULTS:We show that ellagic acid,a polyphenolic compound in fruits and berries,at concentrations 10 to 50 mmol/L stimulates apoptosis in human pancreatic adenocarcinoma cells. Further,ellagic acid decreases proliferation by up to 20-fold at 50 mmol/L. Ellagic acid stimulates the mitochondrial pathway of apoptosis associated with mitochondrial depolarization,cytochrome C release,and the downstream caspaseactivation. Ellagic acid does not directly affect mitochondria. Ellagic acid dose-dependently decreased NF-kB binding activity. Furthermore,inhibition of NF-kB activity using IkB wild type plasmid prevented the effect of ellagic acid on apoptosis. CONCLUSION:Our data indicate that ellagic acid stimulates apoptosis through inhibition of the prosu-rvival transcription factor NF-kB. | Mouad Edderkaoui Irina Odinokova Izumi Ohno Ilya Gukovsky Vay Liang W Go Stephen J Pandol Anna S Gukovskaya | 2008 | World Journal of Gastroenterology2008，14，23： | 30 |
| 2 | Inflammation, Autophagy, and Obesity: Common Features in the Pathogenesis of Pancreatitis and Pancreatic Cancer显示文摘 | Ilya Gukovsky Ning Li Jelena Todoric Anna Gukovskaya Michael Karin | 2013 | Gastroenterology2013，，6： | 5 |
| 3 | Which Way to Die: the Regulation of Acinar Cell Death in Pancreatitis by Mitochondria, Calcium, and Reactive Oxygen Species显示文摘 | Anna S. Gukovskaya Ilya Gukovsky | 2011 | Gastroenterology2011，，7： | 2 |
| 4 | Emerging concepts for the mechanism of alcoholic pancreatitis from experimental models显示文摘 | Stephen J. Pandol Ilya Gukovsky Akihiko Satoh Aurelia Lugea Anna S. Gukovskaya | 2003 | Journal of Gastroenterology2003，，7： | 2 |
| 5 | Localized pancreatic NF- kappaB activation and inflammatory response in taurocholate - induced pancreatitis 显示文摘 | Vaquero E Gukovsky I Zaninovic V | 2001 | Am J Physiol Gastrointest Liver Physiol2001，280，6： | 1 |
| 6 | Early NF-kappa B activation is associated with hormone-induced pancreatitis 显示文摘 | Gukovsky I Gukovskaya AS Blinman TA | 1998 | Am J Physiol1998，275，61： | 1 |
| 7 | Phosphatidylinositidc 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells显示文摘 | Gukovsky I Cheng JH Nam KJ | 2004 | Gastroenterology2004，126，2： | 1 |
| 8 | Curcumin ameliorates ethanol and nonethanol experimental pancreatitis显示文摘 | Gukovsky I Reyes CN Vaquero EC | 2003 | Am J Physiol Gastrointest Liver Physiol2003，284，1： | 1 |
| 9 | Early NF-kappaB activation is associated with hormone-induced pancreatitis显示文摘 | Gukovsky I Gukovskaya A S Blinman T A | 1998 | Am J Physiol1998，275，61： | 1 |
| 10 | Early NF-kappaB activation is associated with hormone-induced pancreatifis显示文摘 | Gukovsky I Gukovskaya AS Blinman TA | 1998 | Am J Physiol1998，275，61： | 1 |
| 11 | Molecular basis of the little mouse phenotype and implications for cell type-specific growth显示文摘 | Lin S C Lin C R Gukovsky I | 1993 | Nature1993，364，： | 1 |
| 12 | Autophagy and pancreatitis 显示文摘 | Gukovskaya AS Gukovsky I | 2012 | Am J Physiol Gastrointest Liver Physiol2012，303，9： | 1 |
| 13 | Ethanol dietincreases the sensitivith of rats to pancreatitis induced by cholecystokinin oc- tapeptide显示文摘 | Pandol ST Periskic S Gukovsky I | 1999 | Gastrenterology1999，117，： | 1 |
| 14 | A rat model reproducing key pathological responses of alcoholic chronic pancreatitis显示文摘 | Gukovsky I Lugea A Shahsahebi M | 2008 | Am J Physiol Gastrointest Liver Physiol2008，294，1： | 1 |
| 15 | Cerulein upregulates ICAM-1 in pancreatic acinar cells,which mediates neutrophil adhesion to these cells显示文摘 | Zaninovic V Gukovskaya AS Gukovsky I | 2000 | Am J Physiol Gastrointest Liver Physiol2000，279，4： | 1 |
| 16 | Early NF-kappaB activation is associated with hormone-induced pancreatitis显示文摘 | Gukovsky I Gukovskaya AS Blinman TA | 1998 | Am J Physiol1998，275，61： | 1 |
| 17 | Autophagy and pancreatitis显示文摘 | Gukovskaya AS Gukovsky I | 2012 | Am J Physiol Gastrointest Liver Physiol2012，303，9： | 1 |
| 18 | Ethanol diet increases the sensitivity of rats to pancreatitis induced by cholecystokinin octapeptide显示文摘 | Pandol ST Periskic S Gukovsky I | | 0，，： | 1 |
| 19 | Impaired autophagy underlies key pathological responses of acute pancreatitis显示文摘 | Gukovsky I Gukovskaya AS | 2010 | Autophagy2010，6，3： | 1 |
| 20 | Localized pancreatic NF-kappaB activation and inflammatory response in taurocholate- induced pancreatitis 显示文摘 | Vaquero E Gukovsky I Zaninovic V | 2001 | Am J Physiol Gastrointest Liver Physiol2001，280，6： | 1 |
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