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| 1 | Pancreatic involvement in chronic viral hepatitis显示文摘AIM: To elucidate the frequency and characteristics of pancreatic disorders in the course of chronic viral hepatitis. METHODS: We prospectively assessed the serum pancreatic enzyme levels and imaging findings in patients with chronic viral hepatitis and healthy control subjects. RESULTS: Serum amylase (t-Amy), salivary amylase (s-Amy), pancreatic amylase (p-Amy) and serum lipase levels were higher in hepatitis patients in comparison to control subjects. However, in asymptomatic viral carriers, only the serum t-Amy levels were higher than those of the controls. The levels of each enzyme rose with the progression of liver disease in patients with hepatitis B or C; whereas the levels of each enzyme within the same clinical stage of the disease did not differ between patients diagnosed with either hepatitis B or hepatitis C virus. Imaging findings demonstrated chronic pancreatitis in only 1 out of 202 patients (0.5%).CONCLUSION: Our data suggest that serum levels of pancreatic enzymes increase with the progression of liver disease in patients diagnosed with viral hepatitis. Pancreatic disease, asymptomatic in most cases, may represent an extrahepatic manifestation of chronic viral hepatitis. | Yoshiki Katakura Hiroshi Yotsuyanagi Kiyoe Hashizume Chiaki Okuse Noriaki Okuse Kohji Nishikawa Michihiro Suzuki Shiro Iino Fumio Itoh | 2005 | World Journal of Gastroenterology2005，11，23： | 5 |
| 2 | Fatal liver failure caused by reactivation of lamivudine-resistant hepatitis B virus:A case report显示文摘We present a case of fetal liver failure caused by the activation of lamivudine-resistant hepatitis B virus (HBV) nine months after lamivudine treatment. A 57-year old man visited our hospital for the treatment of decompensated chronic hepatitis B. Lamivudine was started in December 2001. Subsequently, serum HBV was negative for HBV DNA with seroconversion from HBeAg to anti-HBe and improvement of liver function. However, HBV DNA and HBeAg were again detected in September 2002. He was complicated by breakthrough hepatitis and admitted to our hospital in November for severely impaired liver function. Vidarabine treatment was started and serum HBV DNA and alanine aminotransferase (ALT) decreased transiently. However, after the start of α-interferon treatment, HBV DNA level increased and liver function deteriorated. He died 1 mo after admission. An analysis of amino acid sequences in the polymerase region revealed that rtM204I/V with rtL80I/V occurred at the time of viral breakthrough. After the start of antiviral treatment, rtL180M was detected in addition to rtM204I/V and rtL80I/V, and became predominant in the terminal stage of the disease. HBV clone with a high replication capacity may be produced by antiviral treatment leading to the worsening of liver function. Antiviral therapy for patients with breakthrough hepatitis in advanced liver disease should be carefully performed. | Yuka Suzuki Hiroshi Yotsuyanagi Chiaki Okuse Yoshihiko Nagase Hideaki Takahashi Kyoji Moriya Michihiro Suzuki Kazuhiko Koike Shiro Iino Fumio Itoh | 2007 | World Journal of Gastroenterology2007，13，6： | 4 |
| 3 | Risk factors for retinopathy associated with interferonα-2b and ribavirin combination therapy in patients with chronic hepatitis C显示文摘AIM: To elucidate the frequency and risk factors for retinopathy in patients with chronic hepatitis C who are treated by interferon-ribavirin combination therapy. METHODS: We prospectively analyzed 73 patients with histologically confirmed chronic hepatitis C, who underwent combination therapy for 24 wk. Optic fundi were examined before, and 2, 4, 12 and 24 wk after the start of combination therapy. RESULTS: Fourteen patients (19%) developed retinopathy, which was initially diagnosed by the appearance of a cotton wool spot in 12 patients. Retinal hemorrhage was observed in 5 patients. No patient complained of visual disturbance. Retinopathy disappeared in 9 patients (64%) despite the continuation of combination therapy. However, retinopathy persisted in 5 patients with retinal hemorrhage. A comparison of the clinical background between the groups with and without retinopathy showed no significant differences in age, gender, viral genotype, RNA level, white blood cell count, platelet count, prothrombin time, complications by diabetes mellitus or hypertension, or pretreatment arteriosclerotic changes in the optic fundi. However, multiple logistic regression analysis revealed that complication by hypertension was observed with a high frequency in the group with retinopathy (P = 0.004, OR=245.918, 95% CI=5.6-10786.2). CONCLUSION: Retinopathy associated with combination therapy of interferon a-2b and ribavirin tends to develop in patients with hypertension. | Chiaki Okuse Hiroshi Yotsuyanagi Yoshihiko Nagase Yuhtaro Kobayashi Kiyomi Yasuda Kazuhiko Koike Shiro Iino Michihiro Suzuki Fumio Itoh | 2006 | World Journal of Gastroenterology2006，12，23： | 4 |
| 4 | Current status of diagnosis and therapy for intraductal papillary neoplasm of the bile duct显示文摘Bile duct epithelial tumours showing papillary neoplasm in the bile duct lumen are present in the intrahepatic and extrahepatic bile ducts.Clinicopathological images of these tumours are distinctive and diverse,including histological images with a low to high grade dysplasia,infiltrating and noninfiltrating characteristics,excessive mucus production,and similarity to intraductal papillary mucinous neoplasm(IPMN)of the pancreas.The World Health Organization Classification of Tumours of the Digestive System in 2010 named these features,intraductal papillary neoplasm of the bile duct(IPNB),as precancerous lesion of biliary carcinoma.IPNB is currently classified into type 1 that is similar to IPMN,and type 2 that is not similar to IPMN.Many of IPNB spreads superficially,and diagnosis with cholangioscopy is considered mandatory to identify accurate localization and progression.Prognosis of IPNB is said to be better than normal bile duct cancer. | Yuji Sakai Masayuki Ohtsuka Harutoshi Sugiyama Rintaro Mikata Shin Yasui Izumi Ohno Yotaro Iino Jun Kato Toshio Tsuyuguchi Naoya Kato | 2021 | World Journal of Gastroenterology2021，27，15： | 3 |
| 5 | Total enteroscopy with a nonsurgical steerable double-balloon method显示文摘 | Hironori Yamamoto Yutaka Sekine Yukihiro Sato Toshihiko Higashizawa Tomohiko Miyata Satoru Iino Kenichi Ido Kentaro Sugano | 2001 | Gastrointestinal Endoscopy2001，，2： | 2 |
| 6 | Total enteroscopy with a nonsurgical steerable double-balloon method显示文摘 | Hironori Yamamoto Yutaka Sekine Yukihiro Sato Toshihiko Higashizawa Tomohiko Miyata Satoru Iino Kenichi Ido Kentaro Sugano | 2001 | Gastrointestinal Endoscopy2001，，2： | 2 |
| 7 | Treatment of chronic hepatitis C with high-dose interferon α-2b显示文摘 | Shiro Iino MD Kunihiko Hino MD Tetsuo Kuroki MD Hiroshi Suzuki MD Sukeo Yamamoto MD | 1993 | Digestive Diseases and Sciences1993，，4： | 2 |
| 8 | Upregulation of TRPC1 in the development of cardiac hypertrophy显示文摘 | Takayoshi Ohba Hiroyuki Watanabe Manabu Murakami Yoichiro Takahashi Kenji Iino Sadao Kuromitsu Yasuo Mori Kyoichi Ono Toshihiko Iijima Hiroshi Ito | 2006 | Journal of Molecular and Cellular Cardiology2006，，3： | 2 |
| 9 | Precore and core promoter mutations, hepatitis B virus DNA levels and progressive liver injury in chronic hepatitis B显示文摘 | Hiroshi Yotsuyanagi Kunihiko Hino Eiichi Tomita Joji Toyoda Kiyomi Yasuda Shiro Iino | 2002 | Journal of Hepatology2002，，3： | 2 |
| 10 | A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C显示文摘 | Etsuro Orito Masashi Mizokami Hiroshi Sakugawa Kojiro Michitaka Kazuyoshi Ishikawa Takafumi Ichida Takeshi Okanoue Hiroshi Yotsuyanagi Shiro Iino | 2001 | Hepatology2001，，1： | 2 |
| 11 | The effects of vasodilators on the relaxation of guinea-pig aorta during acute recoil显示文摘 | Tanaka T Iino S Takeshita K | 2002 | Int J Cardiol2002，86，： | 1 |
| 12 | Naphthalene degrading genes on plasmid NAH7 are on a defective transposon显示文摘 | Tsuda M Iino T | 1990 | Mol Gen Genet1990，223，： | 1 |
| 13 | Development of burden distribution simulation model for bellless top in a large blast furnace and its application显示文摘 | Hattori M Iino B Shimomura A | 1993 | ISIJ International1993，33，10： | 1 |
| 14 | Regeneration therapy for oral disease显示文摘 | Kamoi K Iino M Ishigum H | 2006 | Hum Cell2006，19，2： | 1 |
| 15 | In vitro synthesis of phase-specific flagellin of Salmonella显示文摘 | SUZUKI H IINO T | 1973 | J Mol Biol1973，81，： | 1 |
| 16 | Serum concentration of hepatocyte growth factor in patients with metastatic breast cancer显示文摘 | Maemura M Iino Y Yokoe T | 1998 | Cancer Lett1998，126，2： | 1 |
| 17 | Breast-conserving therapy versus modified radical mastectomy in the treatment of early breast cancer in Japan显示文摘 | Horiguchi J Iino Y Koibuchi Y | 2002 | Breast Cancer2002，9，2： | 1 |
| 18 | Extraction of coals with CS2-N-methyl-2-pyrrolidinone mixed solvent at room temperature显示文摘 | Iino M Takanohashi T Ohsuga H | 1988 | Fuel1988，67，： | 1 |
| 19 | Fl F0 - ATPase/Synthase Is Geared to the Synthesis Mode by Conformational Rearrangement of e Subunit in Response to Proton Motive Force and ADP/ATP Balance 显示文摘 | Suzuki T Murakami T Iino R | 2003 | Journal of Biology Chemistry2003，278，46： | 1 |
| 20 | Characterisation of the extracts and residues from CS2-N-methyl-2-pyrrolidinone mixed solvent extraction显示文摘 | Iino M Takanohashi T Obara S | 1989 | Fuel1989，68，： | 1 |
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