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| 1 | Inhibitory effects of regorafenib, a multiple tyrosine kinase inhibitor, on corneal neovascularization显示文摘AIM:To evaluate the inhibitory effects of regorafenib(BAY 73-4506),a multikinase inhibitor,on corneal neovascularization(NV).METHODS:Thirty adult male Sprague-Dawley rats weighing 250-300 g,were used.Corneal NV was induced by NaOH in the left eyes of each rat.Following the establishment of alkali burn,the animals were randomized into five groups according to topical treatment.Group 1(n=6)received 0.9%NaCl,Group 2(n=6)received dimethyl sulfoxide,Group 3(n=6)received regorafenib 1 mg/mL,Group 4(n=6)received bevacizumab 5 mg/mL and Group 5(n=6)received 0.1%dexamethasone phosphate.On the 7d,the corneal surface covered with neovascular vessels was measured on photographs as the percentage of the cornea's total area using computer-imaging analysis.The corneas obtained from rats were semiquantitatively evaluated for caspase-3 and vascular endothelial growth factor by immunostaining.RESULTS:A statistically significant difference in the percent area of corneal NV was found among the groups(P<0.001).Although the Group 5 had the smallest percent area of corneal NV,there was no difference among Groups 3,4 and 5(P>0.005).There was a statistically significant difference among the groups in apoptotic cell density(P=0.002).The staining intensity of vascular endothelial growth factor in the epithelial and endothelial layers of cornea was significantly different among the groups(P<0.05).The staining intensity of epithelial and endothelial vascular endothelial growth factor was significantly weaker in Groups 3,4 and 5 thanin Groups 1 and 2.CONCLUSION:Topical administration of regorafenib 1mg/mL is partly effective for preventing alkali-induced corneal NV in rats. | Halil Ibrahim Onder Mesut Erdurmus Yasin Yücel Bucak Hüseyin Simavli Murat Oktay Ahmet Sahap Kukner | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 2 | 两性霉素B角膜基质内注射成功治疗真菌性角膜炎1例(英文)显示文摘目的:报告1例使用5mg/L两性霉素成功治疗难治性真菌性角膜炎的病例。方法:病例报告。结果:女性患者1例,48岁,以右眼红1wk,伴视力下降和角膜混浊2d入院。否认有外伤或异物史。检查发现:右眼视力:6/12,针孔视力:6/18。注射结膜前使眼分泌物保持最少。角膜旁中央区有一全层基质脓肿-形态不规则且伴有卫星病灶及羽状边缘,不伴有上皮缺损,有前房积脓液平。左眼正常。诊断为真菌性角膜炎。尽管在此前患者经历了3wk的局部两性霉素B点眼(1次/2h),那他霉素眼液点眼(1次/4h),但并无病情恢复的迹象。相反12点出现了一个新的更大的基质脓肿病灶。我们应用5mg/L两性霉素B角膜基质注射联合穿透性角膜移植术治疗后溃疡面积明显减少,前房积脓完全消失,没有毒性反应发生。患者干预后2mo视力恢复了正常视力(6/6)。结论:使用两性霉素B5mg/L基质内注射,使用过程安全有效,是一种治疗难治性真菌性角膜炎的理想方法。 | Yanti Muslikhan Nor Sharina Yusof Khairy Shamel Sonny Teo Azhany Y aakob Mohtar Ibrahim | 2010 | 国际眼科杂志2010，10，11： | 4 |
| 3 | Fulminant hepatic failure caused by Salmonella paratyphi A infection显示文摘我们报导暴发性的肝的失败的一个案例把感染与沙门氏菌 paratyphi 联系了,在进入有二天的发烧的特别护理单位(ICU ) 的一个 29 岁的病人,头疼并且呕吐列在后面由行为变化和丧失方向感。在检查上,病人显得尖锐地病了,鼓动,糊涂,并且深深地 jaundiced。C 的温度 38.5 度,脉搏 92/min,血压 130/89 毫米汞柱。血的两件样品种了 S。paratyphi A,它对 ceftriaxone 和 ciprofloxacin 敏感。Ceftriaxon 与高剂量的地塞米松被管理。有 ceftriaxon 的二星期术后疗法,病人处于令人满意的状况被解除。 | Fahmi Yousef Khan Ahmed A Kamha Ibrahim Y Alomary | 2006 | World Journal of Gastroenterology2006，12，32： | 3 |
| 4 | Determination of Polarity Terms of Some Nitrogen-Containing Surfactants and Simulated Hydrophobic Tail Models by Gas Chromatography显示文摘Some polarity terms of two groups of nitrogen-containing surfactants (six alkanolamides and nine polyoxyethylenated long chain amines) are measured through gas chromatography. The apparent methanol carbon number (CMeOH) and polarity index (IP) values are determined on the investigated surfactants as stationary phases in packed columns. Similarly, CMeOH and IP values are determined on simulated hydrophobic tail (SHT) models. The obtained results reveal that the introduction of SHT approach permits the distinction between the polarities of different surfactants and their head groups. The measured polarity terms are discussed as related to hydrophile-lipophile balance (HLB) number and the hydrophobic group carbon number (RCN). Some equations relating the measured polarity values and these variable have been developed. | BARAKAT Y IBRAHIM V MOSTAFA N E SHAKER N O | 2005 | 色谱2005，23，4： | 3 |
| 5 | The effects on prognosis of surgical treatment of hypertensive putaminal hematomas through transsylvian transinsular approach显示文摘 | R. Alper Kaya Osman Türkmeno?lu Ibrahim M Ziyal Türker Dalkili? Yüksel ?ahin Yunus Aydin | 2003 | Surgical Neurology2003，，3： | 2 |
| 6 | Character recognition using statistical moments显示文摘 | CHIM Y C KASSIM A A IBRAHIM Y | 1999 | Image and Vision Computing1999，17，3： | 1 |
| 7 | The application of in vivo laser confoeal microscopy to the diagnosis and evaluation of meibomian gland dysfunction显示文摘 | Matsumoto Y Sato EA Ibrahim OM | 2008 | Mol Vis2008，14，： | 1 |
| 8 | Application of visante optical coherence tomography tear meniscus height measurement in the diagnosis of dry eye disease显示文摘 | Ibrahim OMA Dogru M Takano Y | 2010 | Ophthalmology2010，117，： | 1 |
| 9 | Application of visante optical coherence tomography tear meniscus height measurement in the diagnosis of dry eye disease显示文摘 | Ibrahim O Dogru M Takano Y | 2010 | Ophthalmology2010，117，10： | 1 |
| 10 | Effect of dietary protein level and strain on growth performance of heat stressed broiler chicks显示文摘 | Rashid H O S Huwaida E E M Ibrahim Y A | 2012 | International Journal of Poultry Science2012，11，10： | 1 |
| 11 | Turbulence prediction in twodimensional bundle hows using large eddy simulation显示文摘 | Hassan Y A Ibrahim W A | 1997 | Nuclear Technology Journal1997，119，： | 1 |
| 12 | Observations on applications of importance sampling in structural reliability analysis显示文摘 | Ibrahim Y | | 0，，4： | 1 |
| 13 | Gene overexpression/suppression analysis of candidate virulence factors of Candida albicans 显示文摘 | Fu Y Luo G Spellberg BJ Edwards JE Jr Ibrahim AS | 2008 | Eukaryot Cell2008，7，3： | 1 |
| 14 | The effects on prognosis of surgical treatment of hypertensive putaminal hematomas through transsylvian transinsular approach显示文摘 | R. Alper Kaya Osman Türkmeno?lu Ibrahim M Ziyal Türker Dalkili? Yüksel ?ahin Yunus Aydin | 2003 | Surgical Neurology2003，，3： | 1 |
| 15 | Application of visante optical coherence tomography tear meniscus height measurement in the diagnosis of dry eye disease显示文摘 | Ibrahim OM Dogru M Takano Y | 2010 | Ophthalmology2010，117，： | 1 |
| 16 | Improvement of functional properties of egg white protein through phosphorylation by dryheating in the presence of pyrophosphate显示文摘 | LI C P IBRAHIM H R SUGIMOTO Y | 2004 | J Agric Food Chem2004，52，： | 1 |
| 17 | New technique of mobile robot navigation using a hybrid adaptive fuzzy-potential field approach显示文摘 | MCFETRIDGE L IBRAHIM M Y | 1998 | Computers ind Engng1998，35，3： | 1 |
| 18 | Rosuvastatin induced rhabdomyolysis in a low risk patient: a ease report and review of the literature显示文摘 | KHAN F Y IBRAHIM W | 2009 | Curr Clin Pharmacol2009，4，1： | 1 |
| 19 | Treatment of Highly Polluted Paper Mill Wwastewater by Solar Photocatalytic Oxidation with Synthesized Nano TiO2 显示文摘 | Ghaly Montaser Y Jamila Tarek S E1-Seesy Ibrahim E | 2011 | Chemical Engineering Journal2011，168，1： | 1 |
| 20 | Study of gastro-intestinal helminths of scavenging chickens in four rural districts of Amhara region, Ethiopia 显示文摘 | Eshetu Y Mulualem E Ibrahim H | 2001 | Revue seientifique et technique (International Office of Epizootics)2001，20，： | 1 |
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