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| 1 | Implication of the intestinal microbiome in complications of cirrhosis显示文摘The intestinal microbiome(IM) is altered in patients with cirrhosis,and emerging literature suggests that this impacts on the development of complications.The Pub Med database was searched from January 2000 to May 2015 for studies and review articles on the composition,pathophysiologic effects and therapeutic modulation of the IM in cirrhosis.The following combination of relevant text words and MeS H terms were used,namely intestinal microbiome,microbiota,or dysbiosis,and cirrhosis,encephalopathy,spontaneous bacterial peritonitis,hepatorenal syndrome,variceal bleeding,hepatopulmonary syndrome,portopulmonary hypertension and hepatocellular carcinoma.The search results were evaluated for pertinence to the subject of IM and cirrhosis,as well as for quality of study design.The IM in cirrhosis is characterized by a decreased proportion of Bacteroides and Lactobacilli,and an increased proportion of Enterobacteriaceae compared to healthy controls.Except for alcoholic cirrhosis,the composition of the IM in cirrhosis is not affected by the etiology of the liver disease.The percentage of Enterobacteriaceae increases with worsening liver disease severity and decompensation and is associated with bacteremia,spontaneous bacterial peritonitis and hepatic encephalopathy.Lactulose,rifaximin and Lactobacillus-containing probiotics have been shown to partial y reverse the cirrhosis associated enteric dysbiosis,in conjunction with improvement in encephalopathy.The IM is altered in cirrhosis,and this may contribute to the development of complications associated with end-stage liver disease.Therapies such as lactulose,rifaximin and probiotics may,at least partially,reverse the cirrhosisassociated changes in the IM.This,in turn,may prevent or alleviate the severity of complications. | Mamatha Bhat Bianca M Arendt Venkat Bhat Eberhard L Renner Atul Humar Johane P Allard | 2016 | World Journal of Hepatology2016，8，27： | 13 |
| 2 | Design for forces induced by seismic torsion显示文摘 | Humar J M Yavari S and Saatcioglu M | 2003 | Canadian Journal of Civil Engineering2003，30，2： | 1 |
| 3 | The mitogen-activated proteinkinase p38 regulates activator protein 1 by direct phosphorylation of c-Jun 显示文摘 | Humar M Loop T Schmidt R | 2007 | Int J Biochem Cell Biol2007，39，12： | 1 |
| 4 | Effect of sesquiterpene lactones on the expression of the activation marker CD69 and of IL-2 in T-lymphocytes in whole blood 显示文摘 | Humar M Alfonso J Garcia-Pifieres AJ | 2003 | Biochem Pharmacol2003，65，9： | 1 |
| 5 | Dynamic analysis ofbuildings for earthquake resistant design 显示文摘 | SAATCIOGLU M HUMAR J M | 2003 | CanadianJournal of Civil Engineering2003，30，2： | 1 |
| 6 | Baseline serum interleukin-6 to interleukin-2 ratio is associated with the response to seasonal trivalent influenza vaccine in solid organ transplant recipients 显示文摘 | FEMANDEZ-RUIZ M HUMAR A BALUCH A | 2015 | Vaccine2015，134，10： | 1 |
| 7 | Parasight F test compared with the polymerase chain reaction and microscopy for the diagnosis of Plasmodium falciparum malaria in travelers 显示文摘 | Humar A Ohrt M Harrington MA | 1997 | Am J Trop Med Hyg1997，56，： | 1 |
| 8 | Performance of waterborne acrylic surface coatings on wood impregnated with Cu-ethanolamine preservatives显示文摘 | Humar M Pavli M lindra D | 2011 | Bulletin of Materials Science2011，34，1： | 1 |
| 9 | Thionamides inhibit the transcription factor nuclear factor-kappaB by suppression of Racl and inhibitor of kappaB kinase alpha显示文摘 | Humar M Dohrmann H Stein P | 2008 | J Pharmacol Exp Ther2008，324，3： | 1 |
| 10 | Efficacy of linseed - and tung - oil - lxeated wood against wood - decay fungi and water uptake显示文摘 | Humar M Lesar B | 2013 | International Biodeterioration & Biodegradation2013，85，： | 1 |
| 11 | Barbiturates directly inhibit the calmodulin/calcineurin complex: a novel mechanism of inhibition of nuclear factor of activated T cells 显示文摘 | Humar M Pischke SE Loop T | 2004 | Mol Pharmacol2004，65，2： | 1 |
| 12 | Accounting for overstrength in seismic design of steel structures 显示文摘 | Rahgozar M A Humar J L | 1998 | Canadian Journal of Civil Engineering1998，25，1： | 1 |
| 13 | Influence ofcarboxylic acids on fixation of copper in wood impregnated with copper amine based preservatives显示文摘 | Humar M Kalan P entjurc M | 2005 | Wood Science and Technology2005，39，8： | 1 |
| 14 | Kidney transplantation in young children: should there be a minimum age?显示文摘 | Humar A Arrazola L Mauer M | 2001 | Pediatr Nephrol2001，16，12： | 1 |
| 15 | The mitogen- activated protein kinase p38 regulates activator protein-1 by direct phosphorylation of c-Jun 显示文摘 | Humar M Loop T Schmidt R | 2007 | Int J Biochem Cell Biol2007，39，12： | 1 |
| 16 | SPECT brain perfusion abnormalities in mild or moderate traumatic brain injury显示文摘 | Abdel-Dayem HM Abu-Judeh H Humar M | 1998 | Clin Nucl Med1998，23，： | 1 |
| 17 | Influence of temperature on fixation of copper-ethanolamine-based wood preservatives显示文摘 | HUMAR M ?LINDRA D | 2007 | Building and Environment2007，42，12： | 1 |
| 18 | American Society of Transplantation recommendations for screening,monitoring and reporting of infectious complications in immunosuppression trials in recipients of organ transplantation显示文摘 | Humar A Michaels M AST ID Working Group on Infectious Disease Monitoring | | 0，，02： | 1 |
| 19 | The mitogen-activated pro- tein kinase p38 regulates activator protein-1 by direct phosphorylation of c-Jun显示文摘 | Humar M Loop T Schmidt R | 2007 | Int J Biochem Cell Biol2007，39，12： | 1 |
| 20 | Effect of second-order forces on seismic responses 显示文摘 | Humar J Mahgoub M Ghorbanie-Asl M | 2006 | Canadian Journal of Civil Engineering2006，33，： | 1 |
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