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| 1 | Hydropower reservoirs on the upper Mekong River modify nutrient bioavailability downstream显示文摘Hydropower development is the key strategy in many developing countries for energy supply,climate-change mitigation and economic development.However,it is commonly assumed that river dams retain nutrients and therefore reduce downstream primary productivity and fishery catches,compromising food security and causing trans-boundary disputes.Contrary to expectation,here we found that a cascade of reservoirs along the upper Mekong River increased downstream bioavailability of nitrogen andphosphorus.The dams caused phytoplankton density to increase with hydraulic residence time and stratification of the stagnant reservoirs caused hypoxia at depth.This allowed the release of bioavailable phosphorus from the sediment and an increase in dissolved inorganic nitrogen as well as a shift in nitrogen species from nitrate to ammonium,which were transported downstream by the discharge of water from the base of the dam.Our findings provide a new perspective on the environmental impacts of river dams on nutrient cycling and ecosystem functioning,with potential implications for sustainable development of hydropower worldwide. | Qiuwen Chen Wenqing Shi Jef Huisman Stephen C.Maberly Jianyun Zhang Juhua Yu Yuchen Chen Daniele Tonina Qitao Yi | 2020 | National Science Review2020，7，9： | 15 |
| 2 | 静脉血栓栓塞症的抗血栓治疗:美国《胸科学》杂志指南显示文摘包括深静脉血栓和肺栓塞在内的静脉血栓栓塞症是癌症患者的主要并发症,发生率为4%~20%,并且是常见的潜在致命性急症。本文介绍了美国《胸科学》杂志指南中VET的抗血栓治疗的部分内容,其以第9版《美国胸内科医师学会循证临床实践指南》中的《静脉血栓栓塞症的抗血栓治疗:抗血栓治疗和阻止血栓形成》一文为参照,基于静脉血栓栓塞症治疗的Ⅲ期试验的发表年份,对口服抗凝剂(达比加群、利伐沙班、阿哌沙班、依度沙班)进行先后阐述(但是这一排序并不是指南专家组对药剂的优劣排序),以为临床医生提供参考。 | Kearon C Akl EA Ornelas J Blaivas A Jimenez D Bounameaux H Huisman M King CS MorrisT Sood N Stevens SM Vintch JRE Wells P Woller SC Moores CL 本刊编辑部 | 2016 | 中国全科医学2016，19，9： | 10 |
| 3 | 结合临床概率、D-二聚体检测和CT的决策体系在疑似肺栓塞患者临床处理中的价值显示文摘Context: Previous studies have evaluated the safety of relatively complex combinations of clinical decision rules and diagnostic tests in patients with suspected pulmonary embolism. Objective: To assess the clinical effectiveness of a simplified algorithm using a dichotomized clinical decision rule, D-dimer testing, and computed tomography(CT) in patients with suspected pulmonary embolism. Design, Setting, and Patients: Prospective cohort study of consecutive patients with clinically suspected acute pulmonary embolism, conducted in 12 centers in the Netherlands from November 2002 through December 2004. The study population of 3306 patients included 82% outpatients and 57% women. Interventions: Patients were categorized as “ pulmonary embolism unlikely” or “ pulmonary embolism likely” using a dichotomized version of the Wells clinical decision rule. Patients classified as unlikely had D-dimer testing, and pulmonary embolism was considered excluded if the D-dimer test result was normal. All other patients underwent CT, and pulmonary embolism was considered present or excluded based on the results. Anticoagulants were withheld from patients classified as excluded, and all patients were followed up for 3 months. Main Outcome Measure: Symptomatic or fatal venous thromboembolism(VTE) during 3-month follow-up. Results: Pulmonary embolism was classified as unlikely in 2206 patients(66.7% ). The combination of pulmonary embolism unlikely and a normal D-dimer test result occurred in 1057 patients(32.0% ), of whom 1028 were not treated with anticoagulants; subsequent nonfatal VTE occurred in 5 patients(0.5% [95% confidence interval {CI}, 0.2% - 1.1% ]). Computed tomography showed pulmonary embolism in 674 patients(20.4% ). Computed tomography excluded pulmonary embolism in 1505 patients, of whom 1436 patients were not treated with anticoagulants; in these patients the 3- month incidence of VTE was 1.3% (95% CI, 0.7% - 2.0% ). Pulmonary embolism was considered a possible cause of death in 7 patients after a negative CT scan(0.5% [95% CI, 0.2% - 1.0% ]). The algorithm was completed and allowed a management decision in 97.9% of patients. Conclusions: A diagnostic management strategy using a simple clinical decision rule, D-dimer testing, and CT is effective in the evaluation and management of patients with clinically suspected pulmonary embolism. Its use is associated with low risk for subsequent fatal and nonfatal VTE. | Huisman M.V. 黄浙勇 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，5： | 8 |
| 4 | A terrestrial observatory approach to the integrated investigation of the effects of deforestation on water,energy,and matter fluxes显示文摘Integrated observation platforms have been set up to investigate consequences of global change within a terrestrial network of observatories(TERENO)in Germany.The aim of TERENO is to foster the understanding of water,energy,and matter fluxes in terrestrial systems,as well as their biological and physical drivers.Part of the Lower Rhine Valley-Eifel observatory of TERENO is located within the Eifel National Park.Recently,the National Park forest management started to promote the natural regeneration of near-natural beech forest by removing a significant proportion of the spruce forest that was established for timber production after World War II.Within this context,the effects of such a disturbance on forest ecosystem functioning are currently investigated in a deforestation experiment in the Wüstebach catchment,which is one of the key experimental research sites within the Lower Rhine Valley-Eifel observatory.Here,we present the integrated observation system of the Wüstebach test site to exemplarily demonstrate the terrestrial observatory concept of TERENO that allows for a detailed monitoring of changes in hydrological and biogeochemical states and fluxes triggered by environmental disturbances.We present the observation platforms and the soil sampling campaign,as well as preliminary results including an analysis of data consistency.We specifically highlight the capability of integrated datasets to enable improved process understanding of the post-deforestation changes in ecosystem functioning. | H. R. BOGENA R BOL N. BORCHARD N. BRuGGEMANN B. DIEKKRtiGER C. DRuE J. GROH N. GOTTSELIG J. A. HUISMAN A. LuCKE A. MISSONG B. NEUWIRTH T. PuTZ M. SCHMIDT M. STOCKINGER W. TAPPE L. WEIHERMuLLER I. WIEKENKAMP H. VEREECKEN | 2015 | Science China Earth Sciences2015，58，1： | 6 |
| 5 | 应用聚合酶链反应技术检测广西儿童β地中海贫血基因突变类型显示文摘用聚合酶链反应(PCR)技术及特异性寡核苷酸探针斑点杂交方法,检测广西地区95例临床诊断为β地中海贫血患儿的190条染色体DNA。结果表明,有10种β地中海贫血珠蛋白基因突变类型和28种β珠蛋白突变基因的组合形式。其中有2例患儿分别为密码子(Codons)14-15(+G)/-29(A→G)双重杂合子和密码子41-42(-TTCT)/IVS-IL-5(G→C)双重杂合子,均属首次报道的β地中海贫血双重杂合子新类型。这一研究结果对该地区β地中海贫血的产前诊断有实用价值。 | 苏承武 梁荣 梁徐 金琪 蒋南华 唐智宁 林希平 卢桂森 黄荣宁 黄俊琳 熊宏文 THJ Huisman | 1995 | 中华儿科杂志1995，33，1： | 6 |
| 6 | A Roadmap toward Engineered Nitrogen-Fixing Nodule Symbiosis显示文摘In the late 19th century,it was discovered that legumes can establish a root nodule endosymbiosis with nitrogen-fixing rhizobia.Soon after,the question was raised whether it is possible to transfer this trait to non-leguminous crops.In the past century,an ever-increasing amount of knowledge provided unique insights into the cellular,molecular,and genetic processes controlling this endosymbiosis.In addition,recent phylogenomic studies uncovered several genes that evolved to function specifically to control nodule formation and bacterial infection.However,despite this massive body of knowledge,the long-standing objective to engineer the nitrogen-fixing nodulation trait on nonleguminous crop plants has not been achieved yet.In this review,the unsolved questions and engineering strategies toward nitrogen-fixing nodulation in non-legume plants are discussed and highlighted. | Rik Huisman Rene Geurts | 2020 | Plant Communications2020，1，1： | 4 |
| 7 | 消费电子产品寿命终期的生态效益研究(三)显示文摘 | Jaco Huisman Ab Stevels | 2005 | 家电科技2005，，6： | 3 |
| 8 | Ximelagatran与低分子肝素加华法令治疗深静脉血栓的比较 随机试验显示文摘背景:Ximelagatran是一种起效快、溶栓作用肯定的口服药,可直接抑制凝血酶。它用药简单,有望取代当前治疗急性静脉血栓栓塞的标准疗法。 | Jean-Noel Fiessinger,MD Menno V. Huisman, MD Bruce L. Davidson, MD 王莉华(译) 诸骏仁(校) | 2005 | 美国医学会杂志(中文版)2005，24，6： | 2 |
| 9 | Acute mesenteric ischemia: value of computerized tomography diagnosis显示文摘 | Huisman TA Benoit CH Traber J | 2000 | Schweiz Rundsch Med Prax2000，89，23： | 2 |
| 10 | Protein energy malnutrition predicts complications in liver cirrhosis显示文摘 | Ellen J. Huisman Evelien J. Trip Peter D. Siersema Bart van Hoek Karel J. van Erpecum | 2011 | European Journal of Gastroenterology & Hepatology2011，，11： | 2 |
| 11 | Effectiveness and safety of novel oral anticoagulants as compared with vitamin K antagonists in the treatment of acute symptomatic venous thromboembolism: a systematic review and meta‐analysis显示文摘 | T. Hulle J. Kooiman P. L. Exter O. M. Dekkers F. A. Klok M. V. Huisman | 2014 | J Thromb Haemost2014，，3： | 2 |
| 12 | Novel approaches to the treatment of non-small cell lung cancer显示文摘 | Carlos G Ferreira Cynthia Huisman Giuseppe Giaccone | 2002 | Critical Reviews in Oncology and Hematology2002，，1： | 2 |
| 13 | Diagnosis and management of splanchnic ischemia显示文摘Splanchnic or gastrointestinal ischemia is rare and randomized studies are absent. This review focuses on new developments in clinical presentation, diagnostic approaches, and treatments. Splanchnic ischemia can be caused by occlusions of arteries or veins and by physiological vasoconstriction during low-flow states. The prevalence of significant splanchnic arterial stenoses is high, but it remains mostly asymptomatic due to abundant collateral circulation. This is known as chronic splanchnic disease (CSD). Chronic splanchnic syndrome (CSS) occurs when ischemic symptoms develop. Ischemic symptoms are characterized by postprandial pain, fear of eating and weight loss. CSS is diagnosed by a test for actual ischemia. Recently, gastro-intestinal tonometry has been validated as a diagnostic test to detect splanchnic ischemia and to guide treatment. In single- vessel CSD, the complication rate is very low, but some patients have ischemic complaints, and can be treated successfully. In multi-vessel stenoses, the complication rate is considerable, while most have CSS and treatment should be strongly considered. CT and MR-based angiographic reconstruction techniques have emerged as alternatives for digital subtraction angiography for imaging of splanchnic vessels. Duplex ultrasound is still the first choice for screening purposes. The strengths and weaknesses of each modality will be discussed. CSS may be treated by minimally invasive endoscopic treatment of the celiac axis compression syndrome, endovascular antegrade stenting, or laparotomy-assisted retrograde endovascular recanalization and stenting.The treatment plan is highly individualized and is mainly based on precise vessel anatomy, body weight, co- morbidity and severity of ischemia. | Jeroen J Kolkman Marloes Bargeman Ad B Huisman Robert H Geelkerken | 2008 | World Journal of Gastroenterology2008，14，48： | 2 |
| 14 | Photoinduced reactivity of titanium dioxide显示文摘 | O. Carp C.L. Huisman A. Reller | 2004 | Progress in Solid State Chemistry2004，，1： | 2 |
| 15 | Detection of PCR inhibitors in cervical specimens by using the AMPLICOR Chlamydia trachomatis assay显示文摘 | Verkooyen RP Luijendijk A Huisman WM | 1996 | J Clin Microbiol1996，34，12： | 1 |
| 16 | Expression of the potato leafroll luteovirus coat protein gene in transgenic potato plant inhibits viral infection显示文摘 | WILLINK D P L HUISMAN M J | 1991 | Plant Molecular Biology1991，17，： | 1 |
| 17 | Photoinduced reactivity of titanium dioxide 显示文摘 | Carp O Huisman L Relier A | 2004 | Progress in Solid State Chemistry2004，32，： | 1 |
| 18 | Diffusion-weighted imaging for the evaluation of diffuse axonal injury in closed heed injury显示文摘 | Huisman TA Sorensen AG Hergan K | 2003 | J Comput Assist Tomogr2003，27，1： | 1 |
| 19 | Soil water content measurements at different scales: accuracy of time domain reflectometry and ground-penetrating radar 显示文摘 | Huisman J A Sperl C Bouten W | 2001 | Journal of Hydrology2001，245，： | 1 |
| 20 | International small business survey:a picture of entrepreneurial climate显示文摘 | HUISMAN D DE RIDDER W J | 1984 | SKIM Industrial Market Research1984，，10： | 1 |
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