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| 1 | CPS Modeling of CNC Machine Tool Work Processes Using an Instruction-Domain Based Approach显示文摘Building cyber-physical system(CPS) models of machine tools is a key technology for intelligent manufacturing. The massive electronic data from a computer numerical control(CNC) system during the work processes of a CNC machine tool is the main source of the big data on which a CPS model is established. In this work-process model, a method based on instruction domain is applied to analyze the electronic big data, and a quantitative description of the numerical control(NC) processes is built according to the G code of the processes. Utilizing the instruction domain, a work-process CPS model is established on the basis of the accurate, real-time mapping of the manufacturing tasks, resources, and status of the CNC machine tool. Using such models, case studies are conducted on intelligent-machining applications, such as the optimization of NC processing parameters and the health assurance of CNC machine tools. | Jihong Chen Jianzhong Yang Huicheng Zhou Hua Xiang Zhihong Zhu Yesong Li Chen-Han Lee Guangda Xu | 2015 | Engineering2015，1，2： | 17 |
| 2 | Toward Intelligent Machine Tool显示文摘With the development of modern information technology-and particularly of the new generation of artificial intelligence(AI)technology-new opportunities are available for the development of the intelligent machine tool(IMT).Based on the three classical paradigms of intelligent manufacturing as defined by the Chinese Academy of Engineering,the concept,characteristics,and systemic structure of the IMT are presented in this paper.Three stages of machine tool evolution-from the manually operated machine tool(MOMT)to the IMT-are discussed,including the numerical control machine tool(NCMT),the smart machine tool(SMT),and the IMT.Furthermore,the four intelligent control principles of the IMT-namely,autonomous sensing and connection,autonomous learning and modeling,autonomous optimization and decision-making,and autonomous control and execution-are presented in detail.This paper then points out that the essential characteristic of the IMT is to acquire and accumulate knowledge through learning,and presents original key enabling technologies,including the instruction-domain-based analytical approach,theoretical and big-data-based hybrid modeling technology,and the double-code control method.Based on this research,an intelligent numerical control(INC)system and industrial prototypes of IMTs are developed.Three intelligent practices are conducted,demonstrating that the integration of the new generation of AI technology with advanced manufacturing technology is a feasible and convenient way to advance machine tools toward the IMT. | Jihong Chen Pengcheng Hu Huicheng Zhou Jianzhong Yang Jiejun Xie Yakun Jiang Zhiqiang Gao Chenglei Zhang | 2019 | Engineering2019，5，4： | 12 |
| 3 | Harmonic reducer in-situ fault diagnosis for industrial robots based on deep learning显示文摘The harmonic reducer is an essential kinetic transmission component in the industrial robots.It is easy to be fatigued and resulted in physical malfunction after a long period of operation.Therefore,an accurate in-situ fault diagnosis for the harmonic reducers in an industrial robot is especially important.This paper proposes a fault diagnosis method based on deep learning for the harmonic reducer of industrial robots via consecutive time-domain vibration signals.Considering the sampling signals from industrial robots are long,narrow,and channel-independent,this method combined a 1-dimensional convolutional neural network with matrix kernels(1-D MCNN)adaptive model.By adjusting the size of the convolution kernels,it can concentrate on the contextual feature extraction of consecutive time-domain data while retaining the ability to process the multi-channel fusion data.The proposed method is examined on a physical industrial robot platform,which has achieved a prediction accuracy of99%.Its performance is appeared to be superior in comparison to the traditional 2-dimensional CNN,deep sparse automatic encoding network(DSAE),multilayer perceptual network(MLP),and support vector machine(SVM). | ZHOU Xing ZHOU HuiCheng HE YiMing HUANG ShiFeng ZHU ZhiHong CHEN JiHong | 2022 | Science China(Technological Sciences)2022，65，9： | 3 |
| 4 | Improved electrochemical performance of trivalent-chrome coating on A1 6063 alloy via urea and thiourea addition 显示文摘 | Yu Huicheng Chen Baizhen Wu Haiying Sun Xiliang Li Bin | 2008 | Electrochimica Acta2008，54，： | 1 |
| 5 | Do- mestic Research Advance in Hydrostatic Gas Lubrication Technology 显示文摘 | FENG Huicheng HOU Yu CHEN Rugang | 2011 | Lubrication and Seal2011，36，4： | 1 |
| 6 | Interleukin 35 protects cardiomyocytes following ischemia/reperfusion-induced apoptosis via activation of mitochondrial STAT3显示文摘Mitochondrial reactive oxygen species(mtROS)-induced apoptosis has been suggested to contribute to myocardial ischemia/reperfusion injury.Interleukin 35(IL-35),a novel anti-inflammatory cytokine,has been shown to protect the myocardium and inhibit mtROS production.However,its effect on cardiomyocytes upon exposure to hypoxia/reoxygenation(H/R)damage has not yet been elucidated.The present study aimed to investigate the potential protective role and underlying mechanisms of IL-35 in H/R-induced mouse neonatal cardiomyocyte injury.Mouse neonatal cardiomyocytes were challenged to H/R in the presence of IL-35,and we found that IL-35 dose dependently promotes cell viability,diminishes mtROS,maintains mitochondrial membrane potential,and decreases the number of apoptotic cardiomyocytes.Meanwhile,IL-35 remarkably activates mitochondrial STAT3(mitoSTAT3)signaling,inhibits cytochrome c release,and reduces apoptosis signaling.Furthermore,co-treatment of the cardiomyocytes with the STAT3 inhibitor AG490 abrogates the IL-35-induced cardioprotective effects.Our study identified the protective role of IL-35 in cardiomyocytes following H/R damage and revealed that IL-35 protects cardiomyocytes against mtROS-induced apoptosis through the mitoSTAT3 signaling pathway during H/R. | Fengyun Zhou Ting Feng Xiangqi Lu Huicheng Wang Yangping Chen Qiuxia Zhang Xinlu Zhang Jiancheng Xiu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 0 |
| 7 | Estimation of Earthquake Hazard Parameters Based on the Unequal-Accuracy Catalog显示文摘In this paper,the maximum likelihood estimation of earthquake hazard parameters(β,Mmax)is extended to those data including incomplete and uncertain parts.We calculated earthquake hazard parameters of the Fenwei seismic belt,and the border area between Shaanxi,Sichuan,Hubei and Henan Provinces.The result is comparatively stable and gives an objective evaluation of earthquake hazard. | Sbao Huicheng,Chen Dangmin and Zhang ChunshengSeismological Bureau of Shaanxi Province,Xi’an 710068,China | 1994 | Earthquake Research in China1994，8，4： | 0 |
| 8 | Lattice confined Ru single sites in hollow Co_(9)S_(8)polyhedron triggering Co-S-Ru catalytic centers for rechargeable Zn-air battery显示文摘Single-atom catalysts with precise structure and tunable coordination nature provide opportunities for developing novel catalytic centers and understanding reaction mechanisms.Herein,hollow Co_(9)S_(8)polyhedrons with lattice-confined Ru single atoms(Ru-Co_(9)S_(8))are fabricated.Aberration-corrected scanning transmission electron microscopy and X-ray absorption spectroscopy verify the isolated Ru atoms are confined in Co_(9)S_(8)to form Co-S-Ru catalytic centers.Theoretical calculations indicate that the oxygen evolution reaction(OER)and oxygen reduction reaction(ORR)energy barriers are extensively reduced,the d-band center of Co_(9)S_(8)downshifts from the Fermi level,therefore boosting the desorption of O-containing intermediates.Consequently,the Ru-Co_(9)S_(8)exhibits an ultralow overpotential of 163 mV at 10 mA·cm^(−2)for OER and could catalyze a rechargeable Zn-air battery with a high-power density of 92.0 mW·cm^(−2).This work provides a promising approach for designing novel bifunctional catalytic active centers for energy conversion. | Xuan Liu Siru Chen Huicheng Wang Anmin Liu Shizheng Wen Liwei Mi Yanqiang Li | 2023 | Nano Research2023，16，5： | 0 |
| 9 | Phytic acid-modified CeO_(2) as Ca^(2+) inhibitor for a security reversal of tumor drug resistance显示文摘Ca^(2+)plays critical roles in the development of diseases,whereas existing various Ca regulation methods have been greatly restricted in their clinical applications due to their high toxicity and inefficiency.To solve this issue,with the help of Ca overexpressed tumor drug resistance model,the phytic acid(PA)-modified CeO_(2) nano-inhibitors have been rationally designed as an unprecedentedly safe and efficient Ca2+inhibitor to successfully reverse tumor drug resistance through Ca^(2+)negative regulation strategy.Using doxorubicin(Dox)as a model chemotherapeutic drug,the Ca^(2+)nano-inhibitors efficiently deprived intracellular excessive free Ca2+,suppressed P-glycoprotein(P-gp)expression and significantly enhanced intracellular drug accumulation in Dox-resistant tumor cells.This Ca^(2+)negative regulation strategy improved the intratumoral Dox concentration by a factor of 12.4 and nearly eradicated tumors without obvious adverse effects.Besides,nanocerias as pH-regulated nanozyme greatly alleviated the adverse effects of chemotherapeutic drug on normal cells/organs and substantially improved survivals of mice.We anticipate that this safe and effective Ca^(2+)negative regulation strategy has potentials to conquer the pitfalls of traditional Ca inhibitors,improve therapeutic efficacy of common chemotherapeutic drugs and serves as a facile and effective treatment platform of other Ca^(2+) associated diseases. | Zhimin Tian Junlong Zhao Shoujie Zhao Huicheng Li Zhixiong Guo Zechen Liang Jiayuan Li Yongquan Qu Dongfeng Chen Lei Liu | 2022 | Nano Research2022，15，5： | 0 |
| 10 | Mitochondrial deoxyguanosine kinase is required for female fertility in mice显示文摘Mitochondrial homeostasis plays a pivotal role in oocyte maturation and embryonic development.Deoxyguanosine kinase(DGUOK)is a nucleoside kinase that salvages purine nucleosides in mitochondria and is critical for mitochondrial DNA replication and homeostasis in non-proliferating cells.Dguok loss-of-function mutations and deletions lead to hepatocerebral mitochondrial DNA deletion syndrome.However,its potential role in reproduction remains largely unknown.In this study,we find that Dguok knockout results in female infertility.Mechanistically,DGUOK deficiency hinders ovarian development and oocyte maturation.Moreover,DGUOK deficiency in oocytes causes a significant reduction in mitochondrial DNA copy number and abnormal mitochondrial dynamics and impairs germinal vesicle breakdown.Only few DGUOK-deficient oocytes can extrude their first polar body during in vitro maturation,and these oocytes exhibit irregular chromosome arrangements and different spindle lengths.In addition,DGUOK deficiency elevates reactive oxygen species levels and accelerates oocyte apoptosis.Our findings reveal novel physiological roles for the mitochondrial nucleoside salvage pathway in oocyte maturation and implicate DGUOK as a potential marker for the diagnosis of female infertility. | Yake Gao Rui Dong Jiacong Yan Huicheng Chen Lei Sang Xinyi Yao Die Fan Xin Wang Xiaoyuan Zuo Xu Zhang Shengyu Yang Ze Wu Jianwei Sun | 2024 | Acta Biochimica et Biophysica Sinica2024，56，3： | 0 |
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