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| 1 | Transformation of hepatitis B serologic markers in babies born to hepatitis B surface antigen positive mothers显示文摘AIM: To better understand the clinical significance of hepatitis B serologic markers in babies born to hepatitis B surface antigen (HBsAg) positive mothers, the incidence of maternal serologic markers of hepatitis B via placenta and its transformation in these babies were investigated.METHODS: Mothers with positive HBsAg were selected in the third trimester of pregnancy. Their babies received immunoprophylaxis with hepatitis B immunoglobulin and hepatitis B vaccine after birth, and were consecutively followed up for hepatitis B serologic markers and HBV DNA at birth, mo 1, 4, 7, 12, and 24. RESULTS: Forty-two babies entered the study, including 16 born to hepatitis B e antigen (HBeAg)-positive HBsAg carrier mothers and 26 to HBeAg-negative HBsAg carrier mothers. Apart from four babies born to HBeAg-positive carrier mothers and demonstrated persistent positive HBeAg eventually became HBV carriers, all other babies developed anti-HBs before 12 mo of age. Among the other 12 babies born to HBeAg-positive carrier mothers,HBeAg was detected in 7 at birth, in 4 at mo 1, and in none of them thereafter. No antibody response to the transplacental HBeAg was detected. Among the babies born to HBeAg-negative carrier mothers, anti-HBe was detected 100% at birth and mo 1, in 88.5% at mo 4, in 46.2% at mo 7, in 4.2% at mo 12 and none in mo 24. Among all the immunoprophylaxis-protected babies born to either HBeAg-positive or HBeAg-negative carrier mothers, anti-HBc was detected in 100% at birth, mo 1 and mo 4, in 78.9% at mo 7, in 36.1% at mo 12 and in none at mo 24.CONCLUSION: HBeAg can pass through human placenta from mother to fetus and become undetectable before 4 mo of age, but no antibodies response to the transplacental HBeAg can be detected till mo 24 in the immunoprophylaxisprotected babies. The sole existence of anti-HBe before 1 year of age or anti-HBc before 2 years of age in babies born to HBsAg carrier mothers may simply represent the transplacental maternal antibodies, instead of indicators of HBV infection status. | Jian-SheWang HuiChen Qi-RongZhu | 2005 | World Journal of Gastroenterology2005，11，23： | 37 |
| 2 | Influence of Temperature on Stacking Fault Energy and Creep Mechanism of a Single Crystal Nickel-based Superalloy显示文摘The influence of temperatures on the stacking fault energies and deformation mechanism of a Recontaining single crystal nickel-based superalloy during creep at elevated temperatures was investigated by means of calculating the stacking fault energy of alloy, measuring creep properties and performing contrast analysis of dislocation configuration. The results show that the alloy at 760 °C possesses lower stacking fault energy, and the stacking fault of alloy increases with increasing temperature. The deformation mechanism of alloy during creep at 760 °C is γ′ phase sheared by <110> super-dislocations, which may be decomposed to form the configuration of Shockley partials plus super-lattice intrinsic stacking fault, while the deformation mechanism of alloy during creep at 1070 °C is the screw or edge superdislocations shearing into the rafted γ′ phase. But during creep at 760 and 980 °C, some superdislocations shearing into γ′ phase may cross-slip from the {111} to {100} planes to form the K–W locks with non-plane core structure, which may restrain the dislocations slipping to enhance the creep resistance of alloy at high temperature. The interaction between the Re and other elements may decrease the diffusion rate of atoms to improve the microstructure stability, which is thought to be the main reason why the K–W locks are to be kept in the Re-containing superalloy during creep at 980 °C. | Sugui Tian Xinjie Zhu Jing Wu Huichen Yu Delong Shu Benjiang Qian | 2016 | Journal of Materials Science & Technology2016，32，8： | 7 |
| 3 | An experimental investigation on acoustic emission characteristics of sandstone rockburst with different moisture contents显示文摘Rockburst occurred frequently during deep mining in China. The mechanism of rockburst is very complicated and related to many factors. In order to investigate the influence of moisture contents of rockmass on rockburst, we conducted a series of laboratory rockburst experiments of sandstone under three different moisture contents by the Modified True-Triaxial Apparatus (MTTA),in which the acoustic emission (AE) system was employed to monitor the internal damage of rock mass. A high-speed video camera was utilized to record the detail of rockburst. Based on the experimental results, the AE characteristics, such as AE count,AE energy, and AE frequency, were analyzed. The rockburst process, type, and indensity under different moisture contents were discussed. The research results show that with the increase of moisture contents, rock strength was soften, the elastic and the cumulative damage of the rock were reduced, resulting in a gradual decrease in AE cumulative counts and cumulative energy over the course of rockburst. This study provides an experimental basis and reference for better understanding to the rockburst mechanism and control. | SUN XiaoMing XU HuiChen ZHENG LianGe HE ManChao GONG WeiLi | 2016 | Science China(Technological Sciences)2016，59，10： | 7 |
| 4 | Transparency and amplification in a hybrid system of the mechanical resonator and circuit QED显示文摘We theoretically study the transparency and amplification of a weak probe field applied to the cavity in hybrid systems formed by a driven superconducting circuit QED system and a mechanical resonator,or a driven optomechanical system and a superconducting qubit.We find that both the mechanical resonator and the superconducting qubit can result in the transparency to a weak probe field in such hybrid systems when a strong driving field is applied to the cavity.We also find that the weak probe field can be amplified in some parameter regimes.We further study the statistical properties of the output field via the degrees of second-order coherence.We find that the nonclassicality of the output field strongly depends on the system parameters.Our studies show that one can control single-photon transmission in the optomechanical system via a tunable artificial atom or in the circuit QED system via a mechanical resonator. | WANG Hui SUN HuiChen ZHANG Jing LIU YuXi | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 6 |
| 5 | Infective viruses produced from full-length complementary DNA of swine vesicular disease viruses HK/70 strain显示文摘The full-length cDNA clone of swine vesicular disease virus HK/70 strain named pSVOK12 was constructed in order to study the antigenicity, replication, maturation and pathogenicity of swine vesicular disease virus. In vitro transcription RNA from pSVOK12 transfected IBRS-2 cells and the re- covered virus RNA were isolated and sequenced, then indirect hemagglutination test, indirect im- munofluorescence assays, eleectron microscope test, 50% tissue culture infecting dose (TCID50) assays and mouse virulence studies were performed to study the antigenicity and virulence of the recovered virus. The result showed that the infectious clones we ob- tained and the virus derived from pSVOK12 had the same biological properties as the parental strain HK/70. The full-length infectious cDNA clone, pSVOK12, will be very useful in studies of the anti- genicity, virulence, pathogenesis, maturation and replication of SVDV. | ZHENG Haixue LIU Xiangtao SHANG Youiun WU Jinyan BAI Xingwen JIN Ye SUN Shiqi GUO Huichen TIAN Hong FENG Xia YIN Shuanghui GUO Jianhong CONG Guozheng LIU Zaixin CHANG Huiyun MA Junwu XIE Qingge | 2006 | Chinese Science Bulletin2006，51，17： | 6 |
| 6 | Construction and analysis of SSH cDNA library of human vascular endothelial cells related to gastrocarcinoma显示文摘AIM: To construct subtracted cDNA libraries of human vascular endothelial cells (VECs) related to gastrocarcinoma using suppression substractive hybridization (SSH) and to analyze cDNA libraries of gastrocarcinoma and VECs in Cancer Gene Anatomy Project (CGAP) database.METHODS: Human VECs related to gastric adenocarcinoma and corresponding normal tissue were separated by magnetic beads coupled with antibody CD31 (Dynabeads CD31). A few amount of total RNA were synthesized and amplified by SMARTTM PCR cDNA Synthesis Kit. Then, using SSH and T/A cloning techniques, cDNA fragments of differentially expressed genes in human VECs of gastric adenocarcinoma were inserted into JM109 bacteria. One hundred positive bacteria clones were randomly picked and identified by colony PCR method. To analyze cDNA libraries of gastrocarcinoma and VECs in CGAP database, the tools of Library Finder,cDNA xProfiler, Digital GENE Expression Displayer (DGED),and Digital Differential Display (DDD) were used.RESULTS: Forward and reverse subtraction cDNA libraries of human VECs related to gastrocarcinoma were constructed successfully with SSH and T/A cloning techniques. Analysis of CGAP database indicated that no appropriate library of VECs related to carcinoma was constructed.CONCLUSION: Construction of subtraction cDNA libraries of human VECs related to gastrocarcinoma was successful and necessary, which laid a foundation for screening and cloning new and specific genes of VECs related to gastrocardnoma. | Yong-BoLiu Zhao-XiaWei LiLi Hang-ShengLi HuiChen Xiao-WenLi | 2003 | World Journal of Gastroenterology2003，9，11： | 4 |
| 7 | Gradient-Based Approach for Fine Registration of Panorama Images显示文摘This paper studies the application of gradient-based motion detection techniques (i.e., optical flow methods) for registration of adjacent images taken using a hand-held camera for the purposes of building a panorama. A general 8-parameter model or a more compact 3-parameter model is commonly used for transformation estimation. However, both models are approximations to the real situation when viewpoint position is not absolutely fixed but includes a small translation, and thus distortion and blurring are sometimes present in the final registration results. This paper proposes a new 5-parameter model that shows better result and has less strict requirement on good choice of unknown initial parameters. An analysis of disparity recovery range and its enlargement using Gaussian filter is also given. | HuiChen | 2004 | Journal of Computer Science & Technology2004，19，5： | 3 |
| 8 | Structural and molecular basis for foot-andmouth disease virus neutralization by two potent protective antibodies显示文摘Dear Editor,Foot-and-mouth disease(FMD)is an economically devastating and highly contagious viral disease of cloven-hoofed animals with a global distribution.The causative agent,FMD virus(FMDV)is a small non-enveloped RNA virus,belonging to the Aphthoviruses genus within Picornaviridae family(Tuthill et al.,2010).Control of FMD has been largely reliant on vaccinations with inactivated virus vaccines.However,significant antigenic diversity within FMDV serotypes and inability of the vaccines to induce immune protection for a long duration of time impinge on the efficacy of available vaccines.The roles of neutralizing antibodies(NAbs)as the principal protective components of the immune responses to FMDV vaccination or infection have been well established(Pay and Hingley,1987;Juleff et al.,2009).Passive immunization of NAbs has also been demonstrated to be effective in curing FMD and many viral diseases(Harmsen et al.,2007;Qiu et al.,2018).A deep understanding of the molecular basis for viral neutralization by antibodies and the identification of key viral epitopes would aid in the development of potent rationally designed broad-spectrum vaccine. | Hu Dong Pan Liu Manyuan Bai Kang Wang Rui Feng Dandan Zhu Yao Sun Suyu Mu Haozhou Li Michiel Harmsen Shiqi Sun Xiangxi Wang Huichen Guo | 2022 | Protein & Cell2022，13，6： | 3 |
| 9 | Out of phase thermal mechanical fatigue investigation of a directionally solidified superalloy DZ125显示文摘Out of phase(OP) thermal mechanical fatigue(TMF) behavior of a directionally solidified(DS) superalloy DZ125 was experimentally and numerically studied. Two different temperature conditions, which are 500–1000 °C and 400–900 °C, were considered in the present research.Stress and strain responses as well as fatigue life results were presented and discussed. Scanning electron microscope(SEM) and metallographic analysis were used to study the damage mechanism. An oxidation assisted crack initiation and propagation phenomenon were found to explain the shorted life under TMF cycles. In order to characterize the stress and strain deformations under TMF loadings, a modified Chaboche's constitutive model was applied. Additionally, the TMF life of the material was modeled and predicted by Neu–Sehitoglu damage law with high accuracy. | Hu Xiaoan Yang Xiaoguang Shi Duoqi Yu Huichen | 2016 | Chinese Journal of Aeronautics2016，29，1： | 3 |
| 10 | Wideband underwater sonar imaging via compressed sensing with scaling effect compensation显示文摘By exploiting the sparsity of the imaging scene, compressed sensing(CS) imaging may provide an effective solution to cope with the tradeoff of high azimuth resolution and wide swath in synthetic aperture sonar imaging. However, existing CS imaging methods are based on narrowband signal model and the scaling effect on the echoes is normally omitted, which may seriously affect the ultimate image reconstruction performance.This paper establishes the wideband CS underwater sonar imaging model at first, where the scaling effect and Doppler frequency shift are jointly considered. Furthermore, two wideband CS imaging approaches are discussed in uniform scale-range space and velocity-range space, respectively. Besides, modified l1-norm minimization algorithms are proposed for the scene reconstruction in velocity-range space. Finally, numerical experiments are provided to demonstrate the effectiveness of the proposed model and the reconstruction algorithms. | YAN HuiChen XU Jia XIA Xiang-Gen LIU Feng PENG ShiBao ZHANG XuDong LONG Teng | 2015 | Science China(Information Sciences)2015，58，2： | 3 |
| 11 | Effects of System Pressure and Heat Flux on Bubble Nucleation and Growth显示文摘Characteristics of bubble nucleation and growth are critical for its application. It is affected by several factors including viscosity, surface tension and temperature. However, the effect of pressure on bubble nucleation and growth has been underreported, although it processes significant effect on above characteristics. In this work, a micro copper electrode is etched on a slab covered with copper to produce bubble on the surface by current input. The nucleation time of bubble is measured under different heat flux and system pressures. The nucleation and growth processes are recorded with a high speed camera in order to discuss the effects of heat flux and system pressure on bubble characteristics. The experiment results indicate that the micro electrode with higher heat flux produces more thermal energy, which makes the time of bubble nucleation shorter and the speed of bubble growth faster. Higher system pressure causes the increase of the critical nucleation temperature and also baffles the bubble nucleation and growth. Bubble growth includes the stages of rapid growth and dynamic equilibrium, with the speed being from fast to slow. In the former part of rapid growth, heat flux plays a dominant role in bubble growth. While the effect of system pressure on bubble growth becomes significant in the latter part of rapid growth. Both the nucleation time and bubble growth agree well with the theoretical analysis. The obtained results help to accurately control bubble nucleation and growth required in different application. | QIU Chao ZHANG Huichen | 2015 | Chinese Journal of Mechanical Engineering2015，28，5： | 2 |
| 12 | Thermography analyses of rock fracture due to excavation and overloading for tunnel in 30° inclined strata显示文摘Large-scale physical model test of 30°inclined strata was conducted to investigate the damage mechanisms during the excavation and overloading using infrared detection.The experiment results were presented with thermal images which were divided into three stages including a full face excavation stage,a staged excavation stage,and an overloading stage.The obtained results were compared with the previously reported results from horizontal,45?,60?,and vertical strata models.Infrared temperature(IRT)for 30°inclined strata model descended with multiple fluctuations during the full-face excavation.For the staged excavation,the excavation damage zone(EDZ)showed enhanced faulting-like strips as compared in the 45?,60?,and vertical models,indicating the intensified stress redistribution occurred in the adjacent rock mass.In contrast,EDZ for the horizontal strata existed in a plastic-formed manner.During the overloading,abnormal features in the thermal images were observed preceding the coalescence of the propagating cracks.The ultimate failure of the model was due primarily to the floor heave and the roof fall. | SUN XiaoMing XU HuiChen HE ManChao GONG WeiLi CHEN Feng | 2017 | Science China(Technological Sciences)2017，60，6： | 2 |
| 13 | LCF behavior and life prediction method of a single crystal nickel-based superalloy at high temperature显示文摘低周期疲劳测试在单个水晶上被进行基于镍的 superalloy, DD6,与不同结晶的取向(即,[001 ] ,[011 ] ,并且[111 ]) 并且紧张居住类型(即,张力,压缩,并且平衡类型) 在某个高温度。给材料 anisotropy 和平均数应力,两个取向因素和压力范围被介绍给铁匠,沃森,并且更最高(SWT ) 强调模型预言疲劳生活。试验性的结果显示 DD6 的疲劳性质取决于结晶的取向和装载类型。疲劳生活张力,压缩,并且因为,平衡紧张居住测试比没有紧张居住的连续骑车测试的那些缺少重要爬效果。建议修改 SWT 压力方法的预言的结果与试验性的数据同意很好。 | Zhihua ZHANG Huichen YU Chengli DONG | 2015 | Frontiers of Mechanical Engineering2015，10，4： | 2 |
| 14 | Determination of mixed-mode interfacial fracture toughness for thermal barrier coatings显示文摘In this work,a test method was developed to determine the interfacial fracture toughness of the air plasma sprayed (APS) thermal barrier coatings (TBCs) over a wide range of mode mixities.For this mixed-mode test method,the analytical expressions for the energy release rate and stress intensity factors were derived based on the energy theory and the concept of 'equivalence'.The fidelity of these expressions was affirmed by selected finite element analysis.The experimental results showed that the critical energy release rate increased with the increase of the positive mode mixity,which was mainly due to the increase in contact/friction effect and plastic work dissipation with increasing shear mode loading.Furthermore,an elliptical interfacial failure criterion in terms of the stress intensity factors was proposed.The agreement between the experimental results in the literature and those in our work indicated that our test method and the corresponding analytical solutions can well determine the interfacial fracture toughness of the TBCs over a wide range of mode mixities. | DENG HongXia SHI HuiJi YU HuiChen ZHONG Bin | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，4： | 2 |
| 15 | Deformation failure and countermeasures of deep tertiary extremely soft rock roadway in Liuhai coal mine显示文摘In view of failure phenomena with nonlinear large deformation including extensive damage,whole section destruction in short time,high rate of repair,most destruction forms occurred in the tertiary roadway of soft rocks engineering in Liuhai mine,according to the methods of geological survey,theoretical analysis,numerical calculation and in-situ test,the composite failure mechanism of molecular expansion,tectonic stress,gravity stress and engineering deviatoric stress,faults and random joint in this area is analyzed deeply,then an coupling support of double-layer-truss is proposed.The research results show that the first wave of deformation energy was released by bolt-mesh-cable fixed into the roof,floor and two sides of the roadway.While the second wave of deformation energy was released through the interface function between double-layer-truss and the surrounding rock.The double-layer-truss that characterized by high strength,good integrity can absorb high deformation energy of surrounding rocks,which led to the uniform distribution of the stress.Engineering practice shows this technology has been successfully applied to control the deformation failure of the tertiary extremely soft rock roadway. | Yang Jun Wang Dong Shi Haiyang Xu Huichen | 2015 | International Journal of Mining Science and Technology2015，25，2： | 2 |
| 16 | Regulation of lovastatin on a key inflammation-related microRNA in myocardial cells显示文摘 | Guo Weizao Liu Huichen Li Lin Yang Man Du Aihua | 2014 | Chinese Medical Journal2014，，16： | 2 |
| 17 | C/EBP β对APP基因的表达调控作用的研究显示文摘该研究成功地构建了C/EBP β过表达慢病毒载体,在体外人胚肾细胞(HEK293FT)进行病毒包装并感染小鼠海马神经元细胞(HT22)。通过荧光素酶报告基因实验(luciferase assay)检测C/EBPβ对淀粉样前体蛋白(amyloid precursor protein,APP)启动子活性的影响;通过实时荧光定量PCR(Q-PCR)来检测C/EBPβ对APP和Sp1在转录水平上的表达;通过蛋白免疫印迹分析(Western blot assay)检测C/EBPβ对APP和Sp1蛋白表达的作用。萤火虫荧光素酶分析结果显示,C/EBPβ对APP启动子的表达有正调控作用;Western blot和Q-PCR分析的结果表明,C/EBPβ对APP和Sp1基因的表达有正调控作用。C/EBPβ对APP基因表达的调控作用的机制可能在于C/EBPβ上调了内源性转录因子Sp1的基因表达,而Sp1基因表达的增强直接导致了APP基因表达的上调。 | 柴娟 李永玲 芦晓红 张茜 马琳 Huichen Wang 孙涛 崔建奇 | 2015 | 中国细胞生物学学报2015，37，4： | 2 |
| 18 | Bimetallic Rh-Ni/BN catalyst for methane reforming with CO2 显示文摘 | Wu Jeffrey C S Chou HuiChen | 2009 | Chemical Engineering Journal2009，148，23： | 1 |
| 19 | Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritis 显示文摘 | Hsu Huichen Zhou Tong Kim H | 2006 | Arthritis Rheum2006，54，： | 1 |
| 20 | Up‐regulation of BAALC gene may be an important alteration in AML‐M2 patients with t(8;21) translocation显示文摘 | XiaofeiQi YuepingShen JiannongCen HuiChen YanhuaSun HongjieSheng YuanyuanWang ZixingChen | 2008 | Journal of Cellular and Molecular Medicine (a)2008，，6： | 1 |
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