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| 1 | Dual probiotic strains suppress high fructose-induced metabolic syndrome显示文摘AIM:To investigate the effect of novel probiotics on the clinical characteristics of high-fructose induced metabolic syndrome.METHODS:Male Wistar rats aged 4 wk were fed a 70% w/w high-fructose diet(n = 27) or chow diet(n = 9) for 3 wk to induce metabolic syndrome,the rats were then randomized into groups and administered probiotic [Lactobacillus curvatus(L.curvatus) HY7601 and Lactobacillus plantarum(L.plantarum) KY1032] at 109 cfu/d or 1010 cfu/d or placebo by oral gavage for 3 wk.Food intake and body weight were measured once a week.After 6 wk,the rats were fasted for 12 h,then anesthetized with diethyl ether and sacrificed.Blood samples were taken from the inferior vena cava for plasma analysis of glucose,insulin,C-peptide,totalcholesterol,triglycerides and thiobarbituric acid-reacting substances.Real-time polymerase chain reaction was performed using mouse-specific Taqman probe sets to assess genes related to fatty acid β-oxidation,lipogenesis and cholesterol metabolism in the liver.Target gene expression was normalized to the housekeeping gene,glyceraldehyde-3-phosphate dehydrogenase.RESULTS:Rodents fed a high-fructose diet developed clinical characteristics of the metabolic syndrome including increased plasma glucose,insulin,triglycerides,total cholesterol and oxidative stress levels,as well as increased liver mass and liver lipids compared to chow fed controls.Probiotic treatment(L.curvatus HY7601 and L.plantarum KY1032) at high(1010 cfu/d) or low dosage(109 cfu/d) lowered plasma glucose,insulin,triglycerides and oxidative stress levels.Only high-dose probiotic treatment reduced liver mass and liver cholesterol.Probiotic treatment reduced lipogenesis via downregulation of SREBP1,FAS and SCD1 mRNA levels and increased β-oxidation via up-regulation of PPARα and CPT2 mRNA levels.CONCLUSION:Probiotic L.curvatus HY7601 and L.plantarum KY1032 combined suppressed the clinical characteristics of high-fructose-induced metabolic syndrome,therefore,may provide a natural alternative for the treatment of diet-induced metabolic syndrome. | Do-Young Park Young-Tae Ahn Chul-Sung Huh Robin A McGregor Myung-Sook Choi | 2013 | World Journal of Gastroenterology2013，19，2： | 5 |
| 2 | Myeloid markers in adult acute lymphoblastic leukemia显示文摘 | Preti H A Huh Y O Brien O | 1995 | Cancer1995，76，12： | 1 |
| 3 | Hepatocyte growth factor/cmet signaling pathway is required for efficient liver regeneration and repair显示文摘 | Huh C G Factor V M Sanchez A | 2004 | Proc Natl Acad Sci USA2004，101，13： | 1 |
| 4 | Prognostic impact of intra-aortic balloon pump insertion before versus after car- diac surgical intervention in a veteran population 显示文摘 | Dhaliwal A S Chu D Huh J | 2009 | The American Journal of Surgery2009，198，5： | 1 |
| 5 | Macrophage inhibitory cytokine-1 regulates melanoma vascular development显示文摘 | Huh SJ Chung CY Sharma A | 2010 | Am J Pathol2010，176，6： | 1 |
| 6 | The microenvironment in breast cancer progression: biology and implications for treatment 显示文摘 | Place A E Jin Huh S Polyak K | 2011 | Breast Cancer Res2011，13，6： | 1 |
| 7 | The hnpact of the Alliance on the Partners: a Look at Cause- Brand Alliances 显示文摘 | Lafferty Barbara A Gold Smith Ronald E Huh G Tomas M | 2004 | Psychology & Marketing2004，21，7： | 1 |
| 8 | Total removal of parasagittal meninglomas of the posterior third of sagittal sinus and its repair by autogenous vein graft:Case report显示文摘 | Hakuba A Huh CW Tsujikawa S | | 0，，03： | 1 |
| 9 | Innovativeness: Its antecedents and impact on business performance显示文摘 | Huh G T M Hurley R F Knight G A | 2004 | Industrial Marketing Management2004，33，5： | 1 |
| 10 | History of lead pollution recorded in East China Sea sediments显示文摘 | HUH C A CHEN H Y | 1999 | Marine Pollution Bulletin1999，38，7： | 1 |
| 11 | Hepatocyte growth factor/c-met singaling pathway is required for efficient liver regeneration and repair显示文摘 | Huh CG Factor VM Sanchez A | 2004 | Proc Natl Acad Sci USA2004，101，13： | 1 |
| 12 | Isolation and characterization of antialgal allelochemicals from Arundo donax L显示文摘 | HONG Y HUH Y SAKODA A | 2010 | Allelopathy J2010，25，2： | 1 |
| 13 | Zn-Containing Ionic Liquids for the Extractive Denitrogenation of a Model Oil:A Mechanistic Consideration显示文摘 | Huh E S Zazybin A Palgunadi J | | 0，，06： | 1 |
| 14 | Theory-based illiquidity and asset pricing显示文摘 | Chordia T Huh S Subrahmanyam A | 2009 | Review of Financial Studies2009，22，9： | 1 |
| 15 | Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair显示文摘 | Huh CG Factor VM Sanchez A etal | 2004 | Proc Natl Acad Sci USA2004，101，13： | 1 |
| 16 | Multi-function realization using an integrated programmable E/H con- trol valve 显示文摘 | HUH B ZHANG Q ANDREW A | 2003 | Applied Engineering in Agriculture2003，19，3： | 1 |
| 17 | Radical hysterectomy and pelvic lymphadenectomy for stage IB2 cervical cancer显示文摘 | Laura J Havrilesky Charles A Leath Warner Huh Brian Calingaert Rex C Bentley John T Soper Angeles Alvarez Secord | 2004 | Gynecologic Oncology2004，，2： | 1 |
| 18 | T-cell large granular lympho- cytic (T-LGL) leukemia: experience in a single institution over 8 years显示文摘 | Aribi A Huh Y Keating M | 2007 | Leuk Res2007，31，7： | 1 |
| 19 | Novel reinforced polymers based on blends of polystyrene and a thermotropic liquid crystalline polymer显示文摘 | Huh Wansoo | 1987 | Polym Eng Sci1987，27，9： | 1 |
| 20 | An adaptive algorithm for finding the optimal base-stock policy in lost sales inventory systems with censored de- mand显示文摘 | Huh W T Janakiraman G Muckstadt J A | 2009 | Mathematics of Operations Research2009，34，2： | 1 |
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