|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | ERCP is s',ffe and ef- fective in patients 80 years of age and older compared with youn- ger patients显示文摘 | Fritz E0 Kirchgatterer A Hubner D | 2006 | Gastrointest Endosc2006，64，6： | 1 |
| 3 | Plant--Rhizosphere- Microflora Association during phytoremediation of PAH- contaminated soil显示文摘 | Muratova A Hubner T Tischer S | 2003 | Int J Phytoremediation2003，5，2： | 1 |
| 4 | Induction of chromosomal aberrations in the Syrian hamster by insecticides tested in vivo显示文摘 | Hubner H | 1986 | Arch Toxicol1986，58，： | 1 |
| 5 | The three sorCS genes are differentially expressed and regulated by synaptic activity显示文摘 | Hermey G Plath N Hubner C A | 2004 | J Neuro- chem2004，88，6： | 1 |
| 6 | Endoscopic retrograde cholangio-pancreatograph (ERCP)in patients 80 years of age and older:safe and effective显示文摘 | Fritz E Kirchgatterer A Hubner D | 2004 | Gastrointest Endosc2004，59，： | 1 |
| 7 | Tourist images of Greenland and the Arctic:a perception a-nalysis显示文摘 | HUBNER A | 2009 | Polar Record2009，45，233： | 1 |
| 8 | Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway显示文摘 | Hubner A Yang X Nolen DM | 2001 | Proce Nat Acad Sci USA2001，98，： | 1 |
| 9 | Surgical therapy of liver tumors : resection vs ablation显示文摘 | Hubner M McCormack L Clavien P A | 2005 | Schweiz Rundsch Med Prax2005，94，33： | 1 |
| 10 | ERCP is safe and effective in patients 80 years of age and older compared with younger patients显示文摘 | Fritz E Kirchqatterer A Hubner D | 2006 | Gastrointest Endosc2006，64，6： | 1 |
| 11 | Practical methods for measuring and managing operational risk in the financial sector: A clinical study 显示文摘 | Chapelle A Crama Y Hubner G Peters J | 2008 | Journal of Banking & Finance2008，32，6： | 1 |
| 12 | Chromium adsorption by Lignin显示文摘 | Lalvani S B Hubner A Wiltowski T S | 2000 | Energy Source2000，22，1： | 1 |
| 13 | Cross infection due to coagulase-negative staphylococci in high-risk patients显示文摘 | Hubner J Kropec A | 1995 | Zentyalbl Bakteriol1995，283，2： | 1 |
| 14 | Plant-rhizosphere-microflora association during phytoremediation of PAH-contaminated soil显示文摘 | MURATOVA A HUBNER T TISCHER S | 2003 | International Journal of Phytoremediation2003，5，2： | 1 |
| 15 | ERCP is safe and effective in patients 80 years of age and older compared with younger patients 显示文摘 | Fritz E Kirchgatterer A Hubner D | 2006 | Gastrointest Endosc2006，64，6： | 1 |
| 16 | The yeast nucleoporin Nup53p specifically interacts with Nic96p and is directly involved in nuclear protein import显示文摘 | Fahrenkrog B Hubner W Mandinova A | 2000 | Mol Biol Cell2000，11，： | 1 |
| 17 | JNK and PTEN cooperatively control the development of inva- sire adenocarcinoma of the prostate 显示文摘 | Hubner A Mulholland D J Standen C L | 2012 | Proc Natl Acad Sci U S A2012，109，12： | 1 |
| 18 | Experimental infection of calves with a gI, gE, US9 negative bovine herpesvirus type 5显示文摘 | Hubner S O Oliveira A P Franco A C | 2005 | Comp Immunol Microbiol Infect Dis2005，28，3： | 1 |
| 19 | Chromium adsorption by lignin显示文摘 | Lalvani S B Hubner A Wiltowski T | 2000 | Energy Resources2000，22，1： | 1 |
| 20 | Studies of the Efficacy of Alfalfa and Reed in the Phytoremediation of Hydrocarbon- Polluted Soil显示文摘 | Muratova A Y Turkovskaya O V Hubner T | 2003 | Applied Biochemistry and Microbiology2003，39，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员